43 research outputs found
The Cold Spot as a Large Void: Lensing Effect on CMB Two and Three Point Correlation Functions
The "Cold Spot" in the CMB sky could be due to the presence of an anomalous
huge spherical underdense region - a "Void" - of a few hundreds Mpc/h radius.
Such a structure would have an impact on the CMB two-point (power spectrum) and
three-point (bispectrum) correlation functions not only at low-l, but also at
high-l through Lensing, which is a unique signature of a Void. Modeling such an
underdensity with an LTB metric, we show that for the power spectrum the effect
should be visible already in the WMAP data only if the Void radius is at least
L \gtrsim 1 Gpc/h, while it will be visible by the Planck satellite if L
\gtrsim 500 Mpc/h. We also speculate that this could be linked to the high-l
detection of an hemispherical power asymmetry in the sky. Moreover, there
should be non-zero correlations in the non-diagonal two-point function. For the
bispectrum, the effect becomes important for squeezed triangles with two very
high l's: this signal can be detected by Planck if the Void radius is at least
L \gtrsim 300 Mpc/h, while higher resolution experiments should be able to
probe the entire parameter space. We have also estimated the contamination of
the primordial non-Gaussianity f_NL due to this signal, which turns out to be
negligible.Comment: v1: 18 pages, 12 figures; v2: 19 pages, 12 figures, calculation of
bispectrum improved, reference added, published version; v3: 19 pages, 12
figures, refined eq.(9) and related figures, conclusions strengthene
Cosmological Imprints of Pre-Inflationary Particles
We study some of the cosmological imprints of pre-inflationary particles. We
show that each such particle provides a seed for a spherically symmetric cosmic
defect. The profile of this cosmic defect is fixed and its magnitude is linear
in a single parameter that is determined by the mass of the pre-inflationary
particle. We study the CMB and peculiar velocity imprints of this cosmic defect
and suggest that it could explain some of the large scale cosmological
anomalies.Comment: 31 pages, 7 figure
A Theory of a Spot
We present a simple inflationary scenario that can produce arbitrarily large
spherical underdense or overdense regions embedded in a standard Lambda cold
dark matter paradigm, which we refer to as bubbles. We analyze the effect such
bubbles would have on the Cosmic Microwave Background (CMB). For super-horizon
sized bubble in the vicinity of the last scattering surface, a signal is
imprinted onto CMB via a combination of Sach-Wolfe and an early integrated
Sach-Wolfe (ISW) effects. Smaller, sub-horizon sized bubbles at lower redshifts
(during matter domination and later) can imprint secondary anisotropies on the
CMB via Rees-Sciama, late-time ISW and Ostriker-Vishniac effects. Our scenario,
and arguably most similar inflationary models, produce bubbles which are
over/underdense in potential: in density such bubbles are characterized by
having a distinct wall with the interior staying at the cosmic mean density. We
show that such models can potentially, with only moderate fine tuning, explain
the \emph{cold spot}, a non-Gaussian feature identified in the Wilkinson
Microwave Anisotropy Probe (WMAP) data by several authors. However, more
detailed comparisons with current and future CMB data are necessary to confirm
(or rule out) this scenario.Comment: 19 pages, 19 figures, added references and explanations, JCAP in
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Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
A century of trends in adult human height
Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries