No hair for spherical black holes: charged and nonminimally coupled scalar field with self--interaction

We prove three theorems in general relativity which rule out classical scalar hair of static, spherically symmetric, possibly electrically charged black holes. We first generalize Bekenstein's no--hair theorem for a multiplet of minimally coupled real scalar fields with not necessarily quadratic action to the case of a charged black hole. We then use a conformal map of the geometry to convert the problem of a charged (or neutral) black hole with hair in the form of a neutral self--interacting scalar field nonminimally coupled to gravity to the preceding problem, thus establishing a no--hair theorem for the cases with nonminimal coupling parameter $\xi<0$ or $\xi\geq {1\over 2}$. The proof also makes use of a causality requirement on the field configuration. Finally, from the required behavior of the fields at the horizon and infinity we exclude hair of a charged black hole in the form of a charged self--interacting scalar field nonminimally coupled to gravity for any $\xi$.Comment: 30 pages, RevTeX. Sec.IV corrected, simplified and shortened. Corrections to Sec.IIA between Eqs. 2.7 and Eq.2.1. First two paragraphs of Sec. VC new. To appear Phys. Rev. D, Oct. 15, 199

A New Class of Exact Hairy Black Hole Solutions

We present a new class of black hole solutions with minimally coupled scalar field in the presence of a negative cosmological constant. We consider a one-parameter family of self-interaction potentials parametrized by a dimensionless parameter $g$. When $g=0$, we recover the conformally invariant solution of the Martinez-Troncoso-Zanelli (MTZ) black hole. A non-vanishing $g$ signals the departure from conformal invariance. All solutions are perturbatively stable for negative black hole mass and they may develop instabilities for positive mass. Thermodynamically, there is a critical temperature at vanishing black hole mass, where a higher-order phase transition occurs, as in the case of the MTZ black hole. Additionally, we obtain a branch of hairy solutions which undergo a first-order phase transition at a second critical temperature which depends on $g$ and it is higher than the MTZ critical temperature. As $g\to 0$, this second critical temperature diverges.Comment: 18 pages, 6 figures, minor changes, references added, published versio

Scalar hairy black holes and solitons in asymptotically flat spacetimes

A numerical analysis shows that a class of scalar-tensor theories of gravity with a scalar field minimally and nonminimally coupled to the curvature allows static and spherically symmetric black hole solutions with scalar-field hair in asymptotically flat spacetimes. In the limit when the horizon radius of the black hole tends to zero, regular scalar solitons are found. The asymptotically flat solutions are obtained provided that the scalar potential $V(\phi)$ of the theory is not positive semidefinite and such that its local minimum is also a zero of the potential, the scalar field settling asymptotically at that minimum. The configurations for the minimal coupling case, although unstable under spherically symmetric linear perturbations, are regular and thus can serve as counterexamples to the no-scalar-hair conjecture. For the nonminimal coupling case, the stability will be analyzed in a forthcoming paper.Comment: 7 pages, 10 postscript figures, file tex, new postscript figs. and references added, stability analysis revisite

Anthropogenic Space Weather

Anthropogenic effects on the space environment started in the late 19th century and reached their peak in the 1960s when high-altitude nuclear explosions were carried out by the USA and the Soviet Union. These explosions created artificial radiation belts near Earth that resulted in major damages to several satellites. Another, unexpected impact of the high-altitude nuclear tests was the electromagnetic pulse (EMP) that can have devastating effects over a large geographic area (as large as the continental United States). Other anthropogenic impacts on the space environment include chemical release ex- periments, high-frequency wave heating of the ionosphere and the interaction of VLF waves with the radiation belts. This paper reviews the fundamental physical process behind these phenomena and discusses the observations of their impacts.Comment: 71 pages, 35 figure

An unusual cause of gastrointestinal bleeding: duodenal lipoma.

‘The final, published version of this article is available at http://www.karger.com/ 10.1159/000327219Common causes of chronic upper gastrointestinal bleeding include oesophageal varices, gastroduodenal ulcers and malignancy, and patients mostly present with iron deficiency type anaemia. We present the case of a 60-year-old lady who presented with iron deficiency anaemia and on investigation was found to have a large duodenal polyp requiring surgical excision. On histological examination, the polyp was revealed to be a lipoma. We review the recent literature and formulate a management plan for this rare entity

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.

Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% validation rate. Integration of gene expression, copy number, and fusion annotation data revealed that fusions involving oncogenes tend to exhibit increased expression, whereas fusions involving tumor suppressors have the opposite effect. For fusions involving kinases, we found 1,275 with an intact kinase domain, the proportion of which varied significantly across cancer types. Our study suggests that fusions drive the development of 16.5% of cancer cases and function as the sole driver in more than 1% of them. Finally, we identified druggable fusions involving genes such as TMPRSS2, RET, FGFR3, ALK, and ESR1 in 6.0% of cases, and we predicted immunogenic peptides, suggesting that fusions may provide leads for targeted drug and immune therapy

A pair of sub-Neptunes transiting the bright K-dwarf TOI-1064 characterized with CHEOPS

Stars and planetary system

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types