Kinetic energy storage using a dual braking system for unmanned parallel hybrid electric vehicle

In this paper a novel regenerative dual braking strategy is proposed for utility/goods delivery unmanned vehicles in public roads, which improves the regenerative energy capturing ability and consequently improves the fuel use of parallel hybrid power train configurations for land unmanned vehicles where the priority is not comfort but extending the range. Furthermore, the analysis takes into account the power handling ability of the electric motor and the power converters. In previous research a plethora of regenerative braking strategies is shown, for this paper the key contribution is that the vehicle electric regeneration is related to a fixed braking distance in relation to the energy storage capabilities specifically for unmanned utility type land vehicles where passenger comfort is not a concern but pedestrian safety is of critical importance. Furthermore, the vehicle’s power converter capabilities facilitate the process of extending the braking time via introducing a variable deceleration profile. The proposed approach has therefore resulted in a regenerative algorithm which improves the vehicle’s energy storage capability without considering comfort since this analysis is applicable to unmanned vehicles. The algorithm considers the distance as the key parameter, which is associated to safety, therefore it allows the braking time period to be extended thus favouring the electric motor generation process while sustaining safety. This method allows the vehicle to brake for longer periods rather than short bursts hence resulting in a more effective regeneration with reduced use of the dual (i.e. caliper/stepper motor brake system). The regeneration method and analysis is addressed in the following paper sections. The simulation results show that the proposed regenerative braking strategy has improved significantly the energy recapturing ability of the hybrid power train configuration. The paper is also supported with experimental data that verify the theoretical development and the simulation results. The two strategies developed and implemented are Constant Braking Torque (CBT) and Constant Braking Power (CBP). Both methods were limited to a fixed safety-based distance. Overall the results demonstrate that the CBT method results in better energy-based savings

Informed finite element modelling for wire and arc additively manufactured metallics—a case study on modular building connections

The use of 3D printing in modular building connections is a novel and promising technique. However, the performance of 3D printed steel modular building connections has not been investigated adequately to date. Therefore, this paper presents a three-dimensional finite element model (FEM), using the multi-purpose software Abaqus, to study the effect of different geometrical and material parameters on the ultimate behaviour of modular building connections (herein named 3DMBC) using a wire and arc additive manufacturing (WAAM) method, as part of the UK’s 3DMBC (3D Modular Building Connections) project. The proposed model considers material and geometrical non-linearities, initial imperfections, and the contact between adjacent surfaces. The finite element results are compared with the currently available experimental results and validated to ensure developed FEM can be used to analyse the behaviour of 3DMBC with some adjustments. Case studies were investigated using the validated model to analyse the ultimate behaviour with different nominal and WAAM-produced materials under various loading arrangements. Based on the results, it is recommended to conservatively use the treated or untreated WAAM material properties obtained in θ = 90◦ print orientation in the finite element modelling of 3DMBCs considering the complex component arrangements and multi-directional loading in the modular connections. It is also noted that the thickness of beams and columns of fully 3D printed connections can be increased to achieve the same level of performance as traditional modular connections. For the 3DMBCs printed using untreated WAAM, the thickness increment was found to be 50% in this study

Towards understanding the variability in biospheric CO2 fluxes:Using FTIR spectrometry and a chemical transport model to investigate the sources and sinks of carbonyl sulfide and its link to CO2

Understanding carbon dioxide (CO2) biospheric processes is of great importance because the terrestrial exchange drives the seasonal and interannual variability of CO2 in the atmosphere. Atmospheric inversions based on CO2 concentration measurements alone can only determine net biosphere fluxes, but not differentiate between photosynthesis (uptake) and respiration (production). Carbonyl sulfide (OCS) could provide an important additional constraint: it is also taken up by plants during photosynthesis but not emitted during respiration, and therefore is a potential means to differentiate between these processes. Solar absorption Fourier Transform InfraRed (FTIR) spectrometry allows for the retrievals of the atmospheric concentrations of both CO2 and OCS from measured solar absorption spectra. Here, we investigate co-located and quasi-simultaneous FTIR measurements of OCS and CO2 performed at five selected sites located in the Northern Hemisphere. These measurements are compared to simulations of OCS and CO2 using a chemical transport model (GEOS-Chem). The coupled biospheric fluxes of OCS and CO2 from the simple biosphere model (SiB) are used in the study. The CO2 simulation with SiB fluxes agrees with the measurements well, while the OCS simulation reproduced a weaker drawdown than FTIR measurements at selected sites, and a smaller latitudinal gradient in the Northern Hemisphere during growing season when comparing with HIPPO (HIAPER Pole-to-Pole Observations) data spanning both hemispheres. An offset in the timing of the seasonal cycle minimum between SiB simulation and measurements is also seen. Using OCS as a photosynthesis proxy can help to understand how the biospheric processes are reproduced in models and to further understand the carbon cycle in the real world

Finite Element Modelling to Predict the Fire Performance of Bio-Inspired 3D-Printed Concrete Wall Panels Exposed to Realistic Fire

Large-scale additive manufacturing (AM), also known as 3D concrete printing, is becoming well-recognized and, therefore, has gained intensive research attention. However, this technology requires appropriate specifications and standard guidelines. Furthermore, the performance of printable concrete in elevated temperature circumstances has not yet been explored extensively. Hence, the authors believe that there is a demand for a set of standardized findings obtained with the support of experiments and numerical modelling of the fire performance of 3D-printed concrete structural elements. In general, fire experiments and simulations focus on ISO 834 standard fire. However, this may not simulate the real fire behaviour of 3D-printed concrete walls. With the aim of bridging this knowledge disparity, this article presents an analysis of the fire performance of 3D-printed concrete walls with biomimetic hollow cross sections exposed to realistic individual fire circumstances. The fire performance of the non-load-bearing 3D-printed concrete wall was identified by developing a suitable numerical heat transfer model. The legitimacy of the developed numerical model was proved by comparing the time–temperature changes with existing results derived from fire experiments on 3D-printed concrete walls. A parametric study of 96 numerical models was consequently performed and included different 3D-printed concrete wall configurations under four fire curves (standard, prolonged, rapid, and hydrocarbon fire). Moreover, 3D-printed concrete walls and mineral wool cavity infilled wall panels showed enhanced fire performance. Moreover, the cellular structures demonstrated superior insulation fire ratings compared to the other configurations

Scientific, Back-Illuminated CCD Development for the Transiting Exoplanet Survey Satellite

We describe the development of the fully depleted, back illuminated charge coupled devices for the Transiting Exoplanet Survey Satellite, which includes a set of four wide angle telescopes, each having a 2x2 array of CCDs. The devices are fabricated on the newly upgraded 200-mm wafer line at Lincoln Laboratory. We discuss methods used to produce the devices and present early performance results from the 100- micron thick, 15x15-microns, 2k x 4k pixel frame transfer CCDs

Development of CCDs for REXIS on OSIRIS-REx

The Regolith x-ray Imaging Spectrometer (REXIS) is a coded-aperture soft x-ray imaging instrument on the OSIRIS-REx spacecraft to be launched in 2016. The spacecraft will fly to and orbit the near-Earth asteroid Bennu, while REXIS maps the elemental distribution on the asteroid using x-ray fluorescence. The detector consists of a 2×2 array of backilluminated 1k×1k frame transfer CCDs with a flight heritage to Suzaku and Chandra. The back surface has a thin p[superscript +]-doped layer deposited by molecular-beam epitaxy (MBE) for maximum quantum efficiency and energy resolution at low x-ray energies. The CCDs also feature an integrated optical-blocking filter (OBF) to suppress visible and near-infrared light. The OBF is an aluminum film deposited directly on the CCD back surface and is mechanically more robust and less absorptive of x-rays than the conventional free-standing aluminum-coated polymer films. The CCDs have charge transfer inefficiencies of less than 10[superscript -6], and dark current of 1e-/pixel/second at the REXIS operating temperature of –60 °C. The resulting spectral resolution is 115 eV at 2 KeV. The extinction ratio of the filter is ~10[superscript 12] at 625 nm.United States. National Aeronautics and Space Administration. Strategic Astrophysics Technology Program (Grant NNX12AF22G)United States. National Aeronautics and Space Administration (Contract NNG12FD70C)United States. National Aeronautics and Space Administration (IPR NNG12FC01I)United States. National Aeronautics and Space Administration. Strategic Astrophysics Technology Program (IPR NNH12AU04I)United States. Air Force (Contract FA8721-05-C-0002

CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved]

Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity. CD28 is an important co-stimulatory receptor expressed on T cells that, upon specific ligand binding, delivers signals essential for full T-cell activation and for the development and homeostasis of suppressive regulatory T cells. Many in vivo mouse models have been used for understanding the role of CD28 in the maintenance of immune homeostasis, thus leading to the development of CD28 signaling modulators that have been approved for the treatment of some autoimmune diseases. Despite all of this progress, a deeper understanding of the differences between the mouse and human receptor is required to allow a safe translation of pre-clinical studies in efficient therapies. In this review, we discuss the role of CD28 in tolerance and autoimmunity and the clinical efficacy of drugs that block or enhance CD28 signaling, by highlighting the success and failure of pre-clinical studies, when translated to humans

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress

Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in germ cell, breast and lung malignancies, oxaliplatin is instead used almost exclusively to treat colorectal and other gastrointestinal cancers. Here we utilize a unique, multi-platform genetic approach to study the mechanism of action of these clinically established platinum anti-cancer agents, as well as more recently developed cisplatin analogs. We show that oxaliplatin, unlike cisplatin and carboplatin, does not kill cells through the DNA-damage response. Rather, oxaliplatin kills cells by inducing ribosome biogenesis stress. This difference in drug mechanism explains the distinct clinical implementation of oxaliplatin relative to cisplatin, and it might enable mechanistically informed selection of distinct platinum drugs for distinct malignancies. These data highlight the functional diversity of core components of front-line cancer therapy and the potential benefits of applying a mechanism-based rationale to the use of our current arsenal of anti-cancer drugs

Characterization of a New Mouse Model for Peripheral T Cell Lymphoma in Humans

Peripheral T cell lymphomas (PTCLs) are associated with a poor prognosis due to often advanced disease at the time of diagnosis and due to a lack of efficient therapeutic options. Therefore, appropriate animal models of PTCL are vital to improve clinical management of this disease. Here, we describe a monoclonal CD8+ CD4− αβ T cell receptor Vβ2+ CD28+ T cell lymphoma line, termed T8-28. T8-28 cells were isolated from an un-manipulated adult BALB/c mouse housed under standard pathogen-free conditions. T8-28 cells induced terminal malignancy upon adoptive transfer into syngeneic BALB/c mice. Despite intracellular expression of the cytotoxic T cell differentiation marker granzyme B, T8-28 cells appeared to be defective with respect to cytotoxic activity as read-out in vitro. Among the protocols tested, only addition of interleukin 2 in vitro could partially compensate for the in vivo micro-milieu in promoting growth of the T8-28 lymphoma cells