spl(2,1) dynamical supersymmetry and suppression of ferromagnetism in flat band double-exchange models

The low energy spectrum of the ferromagnetic Kondo lattice model on a N-site complete graph extended with on-site repulsion is obtained from the underlying spl(2,1) algebra properties in the strong coupling limit. The ferromagnetic ground state is realized for 1 and N+1 electrons only. We identify the large density of states to be responsible for the suppression of the ferromagnetic state and argue that a similar situation is encountered in the Kagome, pyrochlore, and other lattices with flat bands in their one-particle density of states.Comment: 7 pages, 1 figur

Nachhaltiger Konsum und entsprechende Produktion insbesondere von tierischen Nahrungsmitteln haben 1. Priorität hinsichtlich der Nährstoffnachhaltigkeit insbesondere von C, N, P, K, (S) des gesamten Ernährungsbereiches

Abweichend von den Zielsetzungen nachhaltiger Ernährung (Ernährungsberichte DGE,13/2017) erfordert der nichtnachhaltige Ernährungsbereich bei Mangel- bzw. Überschusssituation seine nachhaltige Intensivierung bzw. De-intensivierung. Ausschlaggebend sind hierbei der nachhaltige Konsum und die entsprechende Produktion von tierischen Nahrungsmitteln, z.B. toleriert von 23,4 kg Fleisch /Einwohner (E). a (DGE) anstelle in Deutschland einer Produktion von kg 60 Fleisch/E. a. So belegen die aktuellen Emissionsinventare von Deutschland vornehmlich durch die Tierproduktion verursachte 3-4fach zu hohe C-,N-,P-Emissionen der Landwirtschaft, zudem seit 1995 unvermindert nach erfolgter Reduktion der Tierbestände seit 1990 in den NBL um -60%.Demzufolge sind die Wohlfahrtsverluste (u.a.Internalisierung externer Kosten)des o.a. Ernährungsbereiches und insbesondere der Landwirtschaft durch ungesunde Ernährung, Lebensmittel-Verschwendung, Umweltschäden und kontraproduktiven Subventionen um ein mehrfaches höher als deren Wohlfahrtswirkungen. – Durch steuerliche Maßnahmen bewirkte Erhöhung der Agrarproduktpreise und somit Abschaffung der Subventionen sowie nur noch nachhaltige, d.h. bedarfsorientierte bzw. tolerierte(r) Ernährung / Konsum und demgemäß Produktion an tierischen Nahrungsmitteln entsprechend den DGE-Empfehlungen ergeben sich ein nur noch maximal tolerierbarer Tierbestand von 0,1 GV/E (50 kg LG-Tier/60 kg LG-E) sowie eine Tierbesatzdichte von max. 1,0 GV/ha mit Nährstoffen (C,N,P,K,S) versorgbarer LF (Isermann 1985-2017). Dies bedeutet für Deutschland eine notwendige Reduktion der aktuellen (2013) Tierbestände um -55% von 13,1 auf 5,8 Mio. GV (vergl. EU 28: -61 %: 92,7 auf 36,0 Mio. GV). Somit verhinderte(r) Massentier-Konsum und –Produktion bewirkt ursächlich u.a. zugleich die Vermeidung von Lebensmittelverschwendung und überernährungs(mit-)bedingter Krankheiten (80-100 Mrd. €/a) sowie eine Reduktion der Emissionen an reaktiven C, N, P, K, S in Pedo-, Hydro-,Atmo- und Biosphäre um ca. -60%, zusätzlich flankierend unterstützt durch hinreichende technische Minderungsmaßnahmen. – Ausgehend von der AGENDA 21 von Rio (1992) fordern dementsprechend nunmehr umsetzungsorientiert die aktuellen Agenden von UN (2015) und Deutschland (BMUB/SRU/UBA 2016) für nachhaltigen Konsum und der Klimaschutzplan 2050 (BMUB 2016) u.a. ebenfalls die o.a. nachhaltige Ernährung und dementsprechende Reduktion der Tierbestände, nicht aber das BMEL (Grünbuch und Ernährungsreport 2016

Do long-term hospitalised patients benefit from discharge into the community?

The original publication is available at www.springerlink.co

Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss

Gut microbiota-mediated inflammation promotes obesity-associated low-grade inflammation, which represents a hallmark of metabolic syndrome. To investigate if lifestyle-induced weight loss (WL) may modulate the gut microbiome composition and its interaction with the host on a functional level, we analyzed the fecal metaproteome of 33 individuals with metabolic syndrome in a longitudinal study before and after lifestyle-induced WL in a well-defined cohort. The 6-month WL intervention resulted in reduced BMI (−13.7%), improved insulin sensitivity (HOMA-IR, −46.1%), and reduced levels of circulating hsCRP (−39.9%), indicating metabolic syndrome reversal. The metaprotein spectra revealed a decrease of human proteins associated with gut inflammation. Taxonomic analysis revealed only minor changes in the bacterial composition with an increase of the families Desulfovibrionaceae, Leptospiraceae, Syntrophomonadaceae, Thermotogaceae and Verrucomicrobiaceae. Yet we detected an increased abundance of microbial metaprotein spectra that suggest an enhanced hydrolysis of complex carbohydrates. Hence, lifestyle-induced WL was associated with reduced gut inflammation and functional changes of human and microbial enzymes for carbohydrate hydrolysis while the taxonomic composition of the gut microbiome remained almost stable. The metaproteomics workflow has proven to be a suitable method for monitoring inflammatory changes in the fecal metaproteome

Circulating omentin as a novel biomarker for colorectal cancer risk: Data from the EPIC - Potsdam cohort study

Omentin is a novel biomarker shown to exert metabolic, inflammatory and immune-related properties, and thereby could be implicated in the risk of colorectal cancer (CRC). So far, the association between omentin and CRC risk has not been evaluated in prospective cohort studies. We investigated the association between pre-diagnostic plasma omentin concentrations and risk of CRC in a case-cohort comprising 251 incident CRC cases diagnosed over a mean follow-up time of 10.4 years and 2,295 persons who remained free of cancer in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Hazard ratios as a measure of relative risk (RR) and 95% confidence intervals (CI-s) were computed using a Prentice modified Cox regression. In a model adjusted for established CRC risk factors, age, sex, education, dietary and lifestyle factors, body mass index (BMI) and waist circumference, higher omentin concentrations were associated with a higher CRC risk (RRcontinuously per doubling of omentin concentrations=1.98, 95%CI: 1.45-2.73). Additional adjustment for metabolic biomarkers, including glycated hemoglobin, high-density lipoprotein cholesterol and C-reactive protein, did not alter the results. In stratified analyses, the positive association between omentin and CRC risk was retained in participants with BMI< 30 (RRcontinuously per doubling of omentin concentrations=2.26; 95%CI: 1.57-3.27), whereas among participants with BMI{greater than or equal to} 30 no association was revealed (RRcontinuously per doubling of omentin concentrations =1.07; 95%CI: 0.63-1.83; Pinteraction= 0.005). These novel findings provide the first lines of evidence for an independent association between pre-diagnostic omentin concentrations and CRC risk and suggest a potential interaction with the adiposity state of the individual

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions

A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the expression of surface anticoagulant molecules involved in the protein C anticoagulant pathway. Congenital deficiencies in this natural anticoagulant pathway are known to induce thrombotic complications such as purpura fulimans and spontaneous necrosis. Mycolactone profoundly decreased thrombomodulin (TM) expression on the surface of human dermal microvascular endothelial cells (HDMVEC) at doses as low as 2ng/ml and as early as 8hrs after exposure. TM activates protein C by altering thrombin's substrate specificity, and exposure of HDMVEC to mycolactone for 24 hours resulted in an almost complete loss of the cells' ability to produce activated protein C. Loss of TM was shown to be due to a previously described mechanism involving mycolactone-dependent blockade of Sec61 translocation that results in proteasome-dependent degradation of newly synthesised ER-transiting proteins. Indeed, depletion from cells determined by live-cell imaging of cells stably expressing a recombinant TM-GFP fusion protein occurred at the known turnover rate. In order to determine the relevance of these findings to BU disease, immunohistochemistry of punch biopsies from 40 BU lesions (31 ulcers, nine plaques) was performed. TM abundance was profoundly reduced in the subcutis of 78% of biopsies. Furthermore, it was confirmed that fibrin deposition is a common feature of BU lesions, particularly in the necrotic areas. These findings indicate that there is decreased ability to control thrombin generation in BU skin. Mycolactone's effects on normal endothelial cell function, including its ability to activate the protein C anticoagulant pathway are strongly associated with this. Fibrin-driven tisischemia could contribute to the development of the tissue necrosis seen in BU lesions

Set optimization - a rather short introduction

Recent developments in set optimization are surveyed and extended including various set relations as well as fundamental constructions of a convex analysis for set- and vector-valued functions, and duality for set optimization problems. Extensive sections with bibliographical comments summarize the state of the art. Applications to vector optimization and financial risk measures are discussed along with algorithmic approaches to set optimization problems

Modelling vehicles acceleration during overtaking manoeuvres

[EN] Abstract: Overtaking manoeuvre is a key issue for two-lane rural roads. These roads should provide sufficient overtaking sight distance (OSD) at certain locations to allow faster vehicles to pass slower ones. However, overtaking requires occupying the opposing lane, which represents a serious safety concern. Severity of overtaking related crashes is very high, compared with other manoeuvres. The development of advanced driver assistance systems (ADAS) for overtaking is being a complex task. Only few systems have been developed, but are not still in use. This research incorporated accurate data of real manoeuvres to improve the knowledge of the phenomenon. The trajectory of the overtaking vehicles on the left lane was observed. An instrumented vehicle measured the overtaking time and distance, the abreast position, and the initial and final speed of 180 drivers that passed it during a field experiment. Six different kinematic models (such as uniform acceleration or linear variation of acceleration) were calibrated. Generally, drivers started to accelerate before changing to the opposing lane. These models may be applied to ADAS, to estimate OSD and to improve microsimulation models.Part of this research was included in the project 'Desarrollo de modelos de distancias de visibilidad de adelantamiento', with reference code TRA2010-21736 and subsidised by the Spanish Ministery of Economy and Competitivity. The authors also thank Prof Dr Sayed, from University of British Columbia, for his valuable review.Llorca Garcia, C.; Moreno, AT.; García García, A. (2016). Modelling vehicles acceleration during overtaking manoeuvres. IET Intelligent Transport Systems. 10(3):206-215. https://doi.org/10.1049/iet-its.2015.0035S206215103Gray, R., & Regan, D. M. (2005). Perceptual Processes Used by Drivers During Overtaking in a Driving Simulator. 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P. (1998). New Model for Passing Sight Distance on Two-Lane Highways. Journal of Transportation Engineering, 124(6), 536-545. doi:10.1061/(asce)0733-947x(1998)124:6(536)Sparks, G. A., Neudorf, R. D., Robinson, J. B. L., & Good, D. (1993). Effect of Vehicle Length on Passing Operations. Journal of Transportation Engineering, 119(2), 272-283. doi:10.1061/(asce)0733-947x(1993)119:2(272)Hanley, P. F., & Forkenbrock, D. J. (2005). Safety of passing longer combination vehicles on two-lane highways. Transportation Research Part A: Policy and Practice, 39(1), 1-15. doi:10.1016/j.tra.2004.09.001Khoury, J. E., & Hobeika, A. G. (2012). Integrated Stochastic Approach for Risk and Service Estimation: Passing Sight Distance Application. Journal of Transportation Engineering, 138(5), 571-579. doi:10.1061/(asce)te.1943-5436.0000366Jenkins, J. M., & Rilett, L. R. (2004). Application of Distributed Traffic Simulation for Passing Behavior Study. Transportation Research Record: Journal of the Transportation Research Board, 1899(1), 11-18. doi:10.3141/1899-02Rakha, H., Ahn, K., & Trani, A. (2004). Development of VT-Micro model for estimating hot stabilized light duty vehicle and truck emissions. Transportation Research Part D: Transport and Environment, 9(1), 49-74. doi:10.1016/s1361-9209(03)00054-3Polus, A., Livneh, M., & Frischer, B. (2000). Evaluation of the Passing Process on Two-Lane Rural Highways. Transportation Research Record: Journal of the Transportation Research Board, 1701(1), 53-60. doi:10.3141/1701-07Harwood, D. W., Gilmore, D. K., & Richard, K. R. (2010). Criteria for Passing Sight Distance for Roadway Design and Marking. Transportation Research Record: Journal of the Transportation Research Board, 2195(1), 36-46. doi:10.3141/2195-05Hegeman, G., Tapani, A., & Hoogendoorn, S. (2009). Overtaking assistant assessment using traffic simulation. Transportation Research Part C: Emerging Technologies, 17(6), 617-630. doi:10.1016/j.trc.2009.04.010Milanés, V., Llorca, D. F., Villagrá, J., Pérez, J., Fernández, C., Parra, I., … Sotelo, M. A. (2012). Intelligent automatic overtaking system using vision for vehicle detection. Expert Systems with Applications, 39(3), 3362-3373. doi:10.1016/j.eswa.2011.09.024Isermann, R., Mannale, R., & Schmitt, K. (2012). Collision-avoidance systems PRORETA: Situation analysis and intervention control. Control Engineering Practice, 20(11), 1236-1246. doi:10.1016/j.conengprac.2012.06.003Petrov, P., & Nashashibi, F. (2014). Modeling and Nonlinear Adaptive Control for Autonomous Vehicle Overtaking. IEEE Transactions on Intelligent Transportation Systems, 15(4), 1643-1656. doi:10.1109/tits.2014.2303995Llorca, C., & García, A. (2011). Evaluation of Passing Process on Two-Lane Rural Highways in Spain with New Methodology Based on Video Data. Transportation Research Record: Journal of the Transportation Research Board, 2262(1), 42-51. doi:10.3141/2262-05Llorca, C., Moreno, A. T., García, A., & Pérez-Zuriaga, A. M. (2013). Daytime and Nighttime Passing Maneuvers on a Two-Lane Rural Road in Spain. Transportation Research Record: Journal of the Transportation Research Board, 2358(1), 3-11. doi:10.3141/2358-01Llorca, C., Moreno, A. T., Pérez-Zuriaga, A. M., & García, A. (2013). Influence of age, gender and delay on overtaking dynamics. IET Intelligent Transport Systems, 7(2), 174-181. doi:10.1049/iet-its.2012.0147Khoury, J. E., & Hobeika, A. (2007). Incorporating Uncertainty into the Estimation of the Passing Sight Distance Requirements. Computer-Aided Civil and Infrastructure Engineering, 22(5), 347-357. doi:10.1111/j.1467-8667.2007.00491.xRakha, H., Snare, M., & Dion, F. (2004). Vehicle Dynamics Model for Estimating Maximum Light-Duty Vehicle Acceleration Levels. Transportation Research Record: Journal of the Transportation Research Board, 1883(1), 40-49. doi:10.3141/1883-05Fitzpatrick, K., Chrysler, S. T., & Brewer, M. (2012). Deceleration Lengths for Exit Terminals. Journal of Transportation Engineering, 138(6), 768-775. doi:10.1061/(asce)te.1943-5436.000038