409 research outputs found
The Administration of Xultophy for Diabetic Patients on Hemodialysis
Background: Recent diabetic treatments include Insulin Degludec/ liraglutide (IDeg/Lira, Xultophy) in clinical practice. Authors have continued clinical research concerning diabetes, chronic renal failure, dialysis, and others.
Subjects and Methods: Ten patients with type 2 diabetes mellitus (T2DM) undergoing hemodialysis were investigated. They showed that ages 74.5 ± 5.9 years, M/F=6/4, BMI 21.1± 3.8kg/m2, hemodialysis duration 8.1 ± 5.7 years. At the beginning, fundamental data were Cre 8.2 ± 1.9 mg/dL, HbA1c 6.5 ± 0.8%. Xultophy was started on 5-12 doses and continued for 6 months with the same or 1-4 increased doses for better glycemic variability.
Results: Out of 10 subjects, the changes in HbA1c showed a decrease in 7, stable in 2, and an increase in 1. HbA1c value was 6.2 ± 0.8% in average at 6 months. There were no remarkable adverse effects by Xultophy for 6 months.
Discussion and Conclusion: Xultophy was started at 5-12 doses, which were remarkably lower doses than usual doses with satisfactory efficacy. One of the reasons may be from the characteristic of the patients, who were diabetic with undergoing hemodialysis. Another factor is possibly from liraglutide, which has hepatic clearance with potential vascular protective effects. These results are expected to become reference data for future research
Precise Measurements of Atmospheric Muon Fluxes with the BESS Spectrometer
The vertical absolute fluxes of atmospheric muons and muon charge ratio have
been measured precisely at different geomagnetic locations by using the BESS
spectrometer. The observations had been performed at sea level (30 m above sea
level) in Tsukuba, Japan, and at 360 m above sea level in Lynn Lake, Canada.
The vertical cutoff rigidities in Tsukuba (36.2 N, 140.1 E) and in Lynn Lake
(56.5 N, 101.0 W) are 11.4 GV and 0.4 GV, respectively. We have obtained
vertical fluxes of positive and negative muons in a momentum range from 0.6 to
20 GeV/c with systematic errors less than 3 % in both measurements. By
comparing the data collected at two different geomagnetic latitudes, we have
seen an effect of cutoff rigidity. The dependence on the atmospheric pressure
and temperature, and the solar modulation effect have been also clearly
observed. We also clearly observed the decrease of charge ratio of muons at low
momentum side with at higher cutoff rigidity region.Comment: 35 pages, 9 figures. Submitted to Astroparticle Physic
Design and experimental demonstration of a laser modulation system for future gravitational-wave detectors
Detuning the signal-recycling cavity length from a cavity resonance significantly improves the quantum noise beyond the standard quantum limit, while there is no km-scale gravitational-wave detector successfully implemented the technique. The detuning technique is known to introduce great excess noise, and such noise can be reduced by a laser modulation system with two Mach-Zehnder interferometers in series. This modulation system, termed Mach-Zehnder Modulator (MZM), also makes the control of the gravitational-wave detector more robust by introducing the third modulation field which is non-resonant in any part of the main interferometer. On the other hand, mirror displacements of the Mach-Zehnder interferometers arise a new kind of noise source coupled to the gravitational-wave signal port. In this paper, the displacement noise requirement of the MZM is derived, and also results of our proof-of-principle experiment is reported
Precision Measurement of Cosmic-Ray Antiproton Spectrum
The energy spectrum of cosmic-ray antiprotons has been measured in the range
0.18 to 3.56 GeV, based on 458 antiprotons collected by BESS in recent
solar-minimum period. We have detected for the first time a distinctive peak at
2 GeV of antiprotons originating from cosmic-ray interactions with the
interstellar gas. The peak spectrum is reproduced by theoretical calculations,
implying that the propagation models are basically correct and that different
cosmic-ray species undergo a universal propagation. Future BESS flights toward
the solar maximum will help us to study the solar modulation and the
propagation in detail and to search for primary antiproton components.Comment: REVTeX, 4 pages including 4 eps figure
Singular values of the Dirac operator in dense QCD-like theories
We study the singular values of the Dirac operator in dense QCD-like theories
at zero temperature. The Dirac singular values are real and nonnegative at any
nonzero quark density. The scale of their spectrum is set by the diquark
condensate, in contrast to the complex Dirac eigenvalues whose scale is set by
the chiral condensate at low density and by the BCS gap at high density. We
identify three different low-energy effective theories with diquark sources
applicable at low, intermediate, and high density, together with their
overlapping domains of validity. We derive a number of exact formulas for the
Dirac singular values, including Banks-Casher-type relations for the diquark
condensate, Smilga-Stern-type relations for the slope of the singular value
density, and Leutwyler-Smilga-type sum rules for the inverse singular values.
We construct random matrix theories and determine the form of the microscopic
spectral correlation functions of the singular values for all nonzero quark
densities. We also derive a rigorous index theorem for non-Hermitian Dirac
operators. Our results can in principle be tested in lattice simulations.Comment: 3 references added, version published in JHE
Measurement of Cosmic-Ray Proton and Antiproton Spectra at Mountain Altitude
Cosmic-ray proton and antiproton spectra were measured at mountain altitude,
2770 m above sea level. We observed more than 2 x 10^5 protons and 10^2
antiprotons in a kinetic energy range between 0.25 and 3.3 GeV. The
zenith-angle dependence of proton flux was obtained. The observed spectra were
compared with theoretical predictions.Comment: 10 pages, 5 figures, Submitted to Phys. Lett.
Vacuum decay in quantum field theory
We study the contribution to vacuum decay in field theory due to the
interaction between the long and short-wavelength modes of the field. The field
model considered consists of a scalar field of mass with a cubic term in
the potential. The dynamics of the long-wavelength modes becomes diffusive in
this interaction. The diffusive behaviour is described by the reduced Wigner
function that characterizes the state of the long-wavelength modes. This
function is obtained from the whole Wigner function by integration of the
degrees of freedom of the short-wavelength modes. The dynamical equation for
the reduced Wigner function becomes a kind of Fokker-Planck equation which is
solved with suitable boundary conditions enforcing an initial metastable vacuum
state trapped in the potential well. As a result a finite activation rate is
found, even at zero temperature, for the formation of true vacuum bubbles of
size . This effect makes a substantial contribution to the total decay
rate.Comment: 27 pages, RevTeX, 1 figure (uses epsf.sty
Vacuum decay in quantum field theory
We study the contribution to vacuum decay in field theory due to the
interaction between the long and short-wavelength modes of the field. The field
model considered consists of a scalar field of mass with a cubic term in
the potential. The dynamics of the long-wavelength modes becomes diffusive in
this interaction. The diffusive behaviour is described by the reduced Wigner
function that characterizes the state of the long-wavelength modes. This
function is obtained from the whole Wigner function by integration of the
degrees of freedom of the short-wavelength modes. The dynamical equation for
the reduced Wigner function becomes a kind of Fokker-Planck equation which is
solved with suitable boundary conditions enforcing an initial metastable vacuum
state trapped in the potential well. As a result a finite activation rate is
found, even at zero temperature, for the formation of true vacuum bubbles of
size . This effect makes a substantial contribution to the total decay
rate.Comment: 27 pages, RevTeX, 1 figure (uses epsf.sty
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19). Control of the structure and function of the extracellular matrix (ECM) is a central theme of the biology of the ADAMTS, as exemplified by the actions of the procollagen-N-propeptidases in collagen fibril assembly and of the aggrecanases in the cleavage or modification of ECM proteoglycans. Defects in certain family members give rise to inherited genetic disorders, while the aberrant expression or function of others is associated with arthritis, cancer and cardiovascular disease. In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur. The basic ADAMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determining substrate specificity and the localization of the protease and its interaction partners; ancillary domains probably also have independent biological functions. Focusing primarily on the aggrecanases and proteoglycanases, this review provides a perspective on the evolution of the ADAMTS family, their links with developmental and disease mechanisms, and key questions for the future
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