2,124 research outputs found
A genome-wide investigation of the worldwide invader Sargassum muticum shows high success albeit (almost) no genetic diversity
Twenty years of genetic studies of marine invaders have shown that successful invaders are often characterized by native and introduced populations displaying similar levels of genetic diversity. This pattern is presumably due to high propagule pressure and repeated introductions. The opposite pattern is reported in this study of the brown seaweed, Sargassum muticum, an emblematic species for circumglobal invasions. Albeit demonstrating polymorphism in the native range, microsatellites failed to detect any genetic variation over 1,269 individuals sampled from 46 locations over the Pacific-Atlantic introduction range. Single-nucleotide polymorphisms (SNPs) obtained from ddRAD sequencing revealed some genetic variation, but confirmed severe founder events in both the Pacific and Atlantic introduction ranges. Our study thus exemplifies the need for extreme caution in interpreting neutral genetic diversity as a proxy for invasive potential. Our results confirm a previously hypothesized transoceanic secondary introduction from NE Pacific to Europe. However, the SNP panel unexpectedly revealed two additional distinct genetic origins of introductions. Also, conversely to scenarios based on historical records, southern rather than northern NE Pacific populations could have seeded most of the European populations. Finally, the most recently introduced populations showed the lowest selfing rates, suggesting higher levels of recombination might be beneficial at the early stage of the introduction process (i.e., facilitating evolutionary novelties), whereas uniparental reproduction might be favored later in sustainably established populations (i.e., sustaining local adaptation).Agence Nationale de la Recherche - ANR-10-BTBR-04; European Regional Development Fund; Fundacao para a Ciencia e a Tecnologia - SFRH/BPD/107878/2015, UID/Multi/04326/2016, UID/Multi/04326/2019; Brittany Region;info:eu-repo/semantics/publishedVersio
Comparison of Information Structures and Completely Positive Maps
A theorem of Blackwell about comparison between information structures in
classical statistics is given an analogue in the quantum probabilistic setup.
The theorem provides an operational interpretation for trace-preserving
completely positive maps, which are the natural quantum analogue of classical
stochastic maps. The proof of the theorem relies on the separation theorem for
convex sets and on quantum teleportation.Comment: 12 pages. Substantial changes. Accepted for publication in Journal of
Physics
Variation Within the Species \u3cem\u3eMacroptilium atropurpureum\u3c/em\u3e Regarding Adaptation to Grazing
The twining legume Macroptilium atropurpureum cv. Siratro was released around 1960 (Hutton 1962) and the rust resistant cultivar Aztec was released in 1994 (Bray & Woodroffe 1995). The species showed great potential for pastures in northern Australia and was planted over some 220 Kha in the 1960\u27s and 70\u27s. The species was high yielding and readily eaten by cattle. However, by the early 1980\u27s the species had declined dramatically in grazed pastures. Clements (1989) showed that a major problem with Siratro was the frequency of removal of growing points. This leads to less regrowth after grazing, less seed set and hence less regenerative capacity. Accessions with greater branching characteristics may overcome this problem
Age-Related Increases in Verbal Knowledge Are Not Associated With Word Finding Problems in the Cam-CAN Cohort: What You Know Won't Hurt You.
Objective: We tested the claim that age-related increases in knowledge interfere with word retrieval, leading to word finding failures. We did this by relating a measure of crystallized intelligence to tip-of-the-tongue (TOT) states and picture naming accuracy. Method: Participants were from a large (N = 708), cross-sectional (aged 18-88 years), population-based sample from the Cambridge Centre for Ageing and Neuroscience cohort (Cam-CAN; www.cam-can.com). They completed (a) the Spot-the-Word Test (STW), a measure of crystallized intelligence in which participants circled the real word in word/nonword pairs, (b) a TOT-inducing task, and (c) a picture naming task. Results: Age and STW independently predicted TOTs, with higher TOTs for older adults and for participants with lower STW scores. Tests of a moderator model examining interactions between STW and age indicated that STW was a significant negative predictor of TOTs in younger adults, but with increasing age, the effect size gradually approached zero. Results using picture naming accuracy replicated these findings. Discussion: These results do not support the hypothesis that lifelong knowledge acquisition leads to interference that causes an age-related increase in TOTs. Instead, crystallized intelligence supports successful word retrieval, although this relationship weakens across adulthood
Demonstration project on epilepsy in Brazil - Outcome assessment
Purpose: To assess the outcome of patients with epilepsy treated at primary care health units under the framework of the demonstration project on epilepsy in Brazil, part of the WHO/ILAE/IBE Global Campaign Against Epilepsy. Method. We assessed the outcome of patients treated at four primary health units. The staff of the health units underwent information training in epilepsy. The outcome assessment was based on: 1) reduction of seizure frequency, 2) subjective perception from the patient's and the physician's point of view, 3) reduction of absenteeism, 4) social integration (school and work), and 5) sense of independence. Results: A total of 181 patients (93 women - 51%) with a mean age of 38 (range from 2 to 86) years were studied. The mean follow-up was 26 months (range from 1 to 38 months, 11 patients had follow-up of less than 12 months). Seizure frequency was assessed based on a score system, ranging from 0 (no seizure in the previous 24 months) to 7 (> 10 seizure/day). The baseline median seizure-frequency score was 3 (one to three seizures per month). At the end of the study the median seizure-frequency score was 1 (one to three seizures per year). The patients' and relatives' opinions were that in the majority (59%) the health status had improved a lot, some (19%) had improved a little, 20% experienced no change and in 2% the health status was worse. With regard to absenteeism, social integration and sense of independence, there were some modest improvements only. Discussion: The development of a model of epilepsy treatment at primary health level based on the existing health system, with strategic measures centred on the health care providers and the community, has proved to be effective providing important reductions in seizure frequency, as well as in general well being. This model can be applied nationwide, as the key elements already exist provided that strategic measures are put forward in accordance with local health providers and managers
Shigella flexneri serotype 1c derived from serotype 1a by acquisition of gtrIC gene cluster via a bacteriophage
BACKGROUND:
Shigella spp. are the primary causative agents of bacillary dysentery. Since its emergence in the late 1980s, the S. flexneri serotype 1c remains poorly understood, particularly with regard to its origin and genetic evolution. This article provides a molecular insight into this novel serotype and the gtrIC gene cluster that determines its unique immune recognition.
RESULTS:
A PCR of the gtrIC cluster showed that serotype 1c isolates from different geographical origins were genetically conserved. An analysis of sequences flanking the gtrIC cluster revealed remnants of a prophage genome, in particular integrase and tRNAPro genes. Meanwhile, Southern blot analyses on serotype 1c, 1a and 1b strains indicated that all the tested serotype 1c strains may have had a common origin that has since remained distinct from the closely related 1a and 1b serotypes. The identification of prophage genes upstream of the gtrIC cluster is consistent with the notion of bacteriophage-mediated integration of the gtrIC cluster into a pre-existing serotype.
CONCLUSIONS:
This is the first study to show that serotype 1c isolates from different geographical origins share an identical pattern of genetic arrangement, suggesting that serotype 1c strains may have originated from a single parental strain. Analysis of the sequence around the gtrIC cluster revealed a new site for the integration of the serotype converting phages of S. flexneri. Understanding the origin of new pathogenic serotypes and the molecular basis of serotype conversion in S. flexneri would provide information for developing cross-reactive Shigella vaccines
Maximum likelihood drift estimation for a threshold diffusion
We study the maximum likelihood estimator of the drift parameters of a
stochastic differential equation, with both drift and diffusion coefficients
constant on the positive and negative axis, yet discontinuous at zero. This
threshold diffusion is called drifted Oscillating Brownian motion.For this
continuously observed diffusion, the maximum likelihood estimator coincide with
a quasi-likelihood estimator with constant diffusion term. We show that this
estimator is the limit, as observations become dense in time, of the
(quasi)-maximum likelihood estimator based on discrete observations. In long
time, the asymptotic behaviors of the positive and negative occupation times
rule the ones of the estimators. Differently from most known results in the
literature, we do not restrict ourselves to the ergodic framework: indeed,
depending on the signs of the drift, the process may be ergodic, transient or
null recurrent. For each regime, we establish whether or not the estimators are
consistent; if they are, we prove the convergence in long time of the properly
rescaled difference of the estimators towards a normal or mixed normal
distribution. These theoretical results are backed by numerical simulations
Disruption of functional connectivity of M1 and cerebellum in Multiple sclerosis: a long-range functional dysconnection?
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