2,971 research outputs found
Performance evaluation of the Boron Coated Straws detector with Geant4
The last decade has witnessed the development of several alternative neutron
detector technologies, as a consequence of upcoming neutron sources and
upgrades, as well the world-wide shortage of He. One branch of development
is the family of B-based gaseous detectors. This work focuses on the
boron coated straws (BCS) by Proportional Technologies Inc., a commercial
solution designed for use in homeland security and neutron science. A detailed
Geant4 simulation study of the BCS is presented, which investigates various
aspects of the detector performance, e.g. efficiency, activation, absorption
and the impact of scattering on the measured signal. The suitability of the BCS
detector for Small Angle Neutron Scattering (SANS), direct chopper spectrometry
and imaging is discussed.Comment: 50 pages, 37 figures, minor changes after review, results unchange
Suppression of intrinsic neutron background in the Multi-Grid detector
One of the key requirements for neutron scattering instruments is the
Signal-to-Background ratio (SBR). This is as well a design driving requirement
for many instruments at the European Spallation Source (ESS), which aspires to
be the brightest neutron source of the world. The SBR can be effectively
improved with background reduction. The Multi-Grid, a large-area thermal
neutron detector with a solid boron carbide converter, is a novel solution for
chopper spectrometers. This detector will be installed for the three
prospective chopper spectrometers at the ESS. As the Multi-Grid detector is a
large area detector with a complex structure, its intrinsic background and its
suppression via advanced shielding design should be investigated in its
complexity, as it cannot be naively calculated. The intrinsic scattered neutron
background and its effect on the SBR is determined via a detailed Monte Carlo
simulation for the Multi-Grid detector module, designed for the CSPEC
instrument at the ESS. The impact of the detector vessel and the neutron
entrance window on scattering is determined, revealing the importance of an
optimised internal detector shielding. The background-reducing capacity of
common shielding geometries, like side-shielding and end-shielding is
determined by using perfect absorber as shielding material, and common
shielding materials, like BC and Cd are also tested. On the basis of the
comparison of the effectiveness of the different shielding topologies and
materials, recommendations are given for a combined shielding of the Multi-Grid
detector module, optimised for increased SBR.Comment: 26 pages, 18 figures, revise
Metal-bending brake facilitates lightweight, close-tolerance fabrication
A lightweight, metal bending brake ensures very accurate bends. Features of the brake that adapt it for making complex reverse bends to close tolerances are a pronounced relief or cutaway of the underside of the bodyplate combined with modification in the leaf design and its suspension
A 10B-based neutron detector with stacked Multiwire Proportional Counters and macrostructured cathodes
We present the results of the measurements of the detection efficiency for a
4.7 \r{A} neutron beam incident upon a detector incorporating a stack of up to
five MultiWire Proportional Counters (MWPC) with Boron-coated cathodes. The
cathodes were made of Aluminum and had a surface exhibiting millimeter-deep
V-shaped grooves of 45{\deg}, upon which the thin Boron film was deposited by
DC magnetron sputtering. The incident neutrons interacting with the converter
layer deposited on the sidewalls of the grooves have a higher capture
probability, owing to the larger effective absorption film thickness. This
leads to a higher overall detection efficiency for the grooved cathode when
compared to a cathode with a flat surface. Both the experimental results and
the predictions of the GEANT4 model suggests that a 5-counter detector stack
with coated grooved cathodes has the same efficiency as a 7-counter stack with
flat cathodes. The reduction in the number of counters in the stack without
altering the detection efficiency will prove highly beneficial for large-area
position-sensitive detectors for neutron scattering applications, for which the
cost-effective manufacturing of the detector and associated readout electronics
is an important objective. The proposed detector concept could be a
technological option for one of the new chopper spectrometers and other
instruments planned to be built at the future European Spallation Source in
Sweden. These results with macrostructured cathodes generally apply not just to
MWPCs but to other gaseous detectors as well.Comment: 14 pages, 9 figure
Exact harmonic coefficients for a magnetic ring head
©1999 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.The magnetic field of a ring head has been analyzed by Westmijze [1953], using a conformal mapping, and by Fan [1961], using Fourier techniques. Here these methods are reexamined and combined to give, for the first time, an explicit analytic expression for the harmonic coefficients in the Fan solution
Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction
Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse model of DMD. Utrophin is subject to miRNA mediated repression by several miRNAs including let-7c. Inhibition of utrophin: let-7c interaction is predicted to 'repress the repression' and increase utrophin expression. We developed and tested the ability of an oligonucleotide, composed of 2'-O-methyl modified bases on a phosphorothioate backbone, to anneal to the utrophin 3'UTR and prevent let-7c miRNA binding, thereby upregulating utrophin expression and improving the dystrophic phenotype in vivo. Suppression of utrophin: let-7c interaction using bi-weekly intraperitoneal injections of let7 site blocking oligonucleotides (SBOs) for 1 month in the mdx mouse model for DMD, led to increased utrophin expression along with improved muscle histology, decreased fibrosis and increased specific force. The functional improvement of dystrophic muscle achieved using let7-SBOs suggests a novel utrophin upregulation-based therapeutic strategy for DMD
- …