Computer Vision for the Humanities: An Introduction to Deep Learning for Image Classification (Part 1)

This is the first of a two-part lesson introducing deep learning based computer vision methods for humanities research. Using a dataset of historical newspaper advertisements and the fastai Python library, the lesson walks through the pipeline of training a computer vision model to perform image classification

A HST study of the stellar populations in the cometary dwarf irregular galaxy NGC 2366

We present V and I photometry of the resolved stars in the cometary dwarf irregular galaxy NGC 2366, using Wide Field Planetary Camera 2 images obtained with the Hubble Space Telescope. The resulting color-magnitude diagram reaches down to I~26.0 mag. It reveals not only a young population of blue main-sequence stars (age <30 Myr) but also an intermediate-age population of blue and red supergiants (20 Myr<age<100 Myr), and an older evolved populations of asymptotic giant branch (AGB) stars (age >100 Myr) and red giant branch (RGB) stars (age >1 Gyr). The measured magnitude I=23.65+/-0.10 mag of the RGB tip results in a distance modulus m-M=27.67+/-0.10, which corresponds to a distance of 3.42+/-0.15 Mpc, in agreement with previous distance determinations. The youngest stars are associated with the bright complex of HII regions NGC 2363=Mrk 71 in the southwest extremity of the galaxy. As a consequence of the diffusion and relaxation processes of stellar ensembles, the older the stellar population is, the smoother and more extended is its spatial distribution. An underlying population of older stars is found throughout the body of NGC 2366. The most notable feature of this older population is the presence of numerous relatively bright AGB stars. The number ratio of AGB to RGB stars and the average absolute brightness of AGB stars in NGC 2366 are appreciably higher than in the BCD VII Zw 403, indicating a younger age of the AGB stars in NGC 2366. In addition to the present burst of age <100 Myr, there has been strong star formation activity in the past of NGC 2366, from ~100 Myr to <3 Gyr ago.Comment: 32 pages, 15 figures, accepted for publication in the Astrophysical Journa

Survival following surgical treatment for anorectal melanoma seems similar for local excision and extensive resection regardless of nodal involvement

Background: Anorectal melanoma is a rare malignancy with a dismal prognosis. The purpose of this study was to investigate whether the survival per stage is influenced by the surgical approaches (local excision or extensive resection), to assess prognostic factors of survival, and to answer the question whether the practiced surgical approaches changed over time. Methods: Dutch cancer registry organizations (IKNL and PALGA) were queried for all patients with a diagnosis of anorectal melanoma (1989-2019). Patients with disseminated disease at diagnosis were excluded. Survival outcomes were compared for the two surgical approaches stratified by stage (clinical node negative (cN0) and clinical node positive (cN+)) and date of diagnosis. Results: A total of 103 patients were included in this study. In both cN0 and cN+ patients the surgical strategy did not significantly influence survival (cN0: 21.7% 5-year survival, median 25 months for local excision versus 13.7% 5-year survival, median 17 months for extensive resection (p = 0.228), cN+: 11.1% 5-year survival for local excision, median 17 months versus 8.7% 5-year survival, median 14 months for extensive resection (p = 0.741)). Stage and date of diagnosis showed to be prognostic factors of survival. The ratio between the two surgical approaches was unchanged over three decades. Conclusions: Extensive resection does not seem to improve survival in both cN0 and cN+ anorectal melanoma patients compared to local excision. However in the past three decades no shift towards local excision has been found. cN+ stage and an older date of diagnosis are predictors for worse survival

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes

Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal N-methyl-D-aspartate (NMDA) receptors, and also act on group II metabotropic glutamate receptors. Oligodendrocytes and their precursors have recently been shown to express NMDA receptors, and activation of these receptors in ischaemia leads to the death of oligodendrocyte precursors and the loss of myelin. This raises the possibility that the failure to develop myelin, or demyelination, occurring in the leucodystrophies could reflect an action of NAAG or NAA on oligodendrocyte NMDA receptors. However, since the putative subunit composition of NMDA receptors on oligodendrocytes differs from that of neuronal NMDA receptors, the effects of NAAG and NAA on them are unknown. We show that NAAG, but not NAA, evokes an inward membrane current in cerebellar white matter oligodendrocytes, which is reduced by NMDA receptor block (but not by block of metabotropic glutamate receptors). The size of the current evoked by NAAG, relative to that evoked by NMDA, was much smaller in oligodendrocytes than in neurons, and NAAG induced a rise in [Ca^{2+}]i in neurons but not in oligodendrocytes. These differences in the effect of NAAG on oligodendrocytes and neurons may reflect the aforementioned difference in receptor subunit composition. In addition, as a major part of the response in oligodendrocytes was blocked by tetrodotoxin (TTX), much of the NAAG-evoked current in oligodendrocytes is a secondary consequence of activating neuronal NMDA receptors. Six hours exposure to 1 mM NAAG did not lead to the death of cells in the white matter. We conclude that an action of NAAG on oligodendrocyte NMDA receptors is unlikely to be a major contributor to white matter damage in the leucodystrophies

Discovery of a high state AM CVn binary in the Galactic Bulge Survey

We report on the discovery of a hydrogen-deficient compact binary (CXOGBS J175107.6-294037) belonging to the AM CVn class in the Galactic Bulge Survey. Deep archival X-ray observations constrain the X-ray positional uncertainty of the source to 0.57 arcsec, and allow us to uniquely identify the optical and UV counterpart. Optical spectroscopic observations reveal the presence of broad, shallow He i absorption lines while no sign of hydrogen is present, consistent with a high state system. We present the optical lightcurve from Optical Gravitational Lensing Experiment monitoring, spanning 15 years. It shows no evidence for outbursts; variability is present at the 0.2 mag level on timescales ranging from hours to weeks. A modulation on a timescale of years is also observed. A Lomb-Scargle analysis of the optical lightcurves shows two significant periodicities at 22.90 and 23.22 min. Although the physical interpretation is uncertain, such timescales are in line with expectations for the orbital and superhump periods. We estimate the distance to the source to be between 0.5 - 1.1 kpc. Spectroscopic follow-up observations are required to establish the orbital period, and to determine whether this source can serve as a verification binary for the eLISA gravitational wave mission.Comment: Accepted for publication in MNRAS Letter

The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients

Introduction: The Standardized Uptake Value (SUV) in single lesions on F-18-FDG PET/CT scans and serum S-100B concentrations are inversely associated with disease-free survival in stage IV melanoma. The aim of this study was to assess the association between biomarkers (S-100B, LDH) and the PET-derived metrics SUVmean/max, metabolic active tumor volume (MATV), and total lesion glycolysis (TLG) in stage IV melanoma in order to understand what these biomarkers reflect and their possible utility for follow-up. Methods: In 52 stage IV patients the association between PET-derived metrics and the biomarkers S-100B and LDH was assessed and the impact on survival analyzed. Results: S-100B was elevated (>0.15 mu g/l) in 37 patients (71%), LDH in 11 (21%). There was a correlation between S-100B and LDH (R-2 = 0.19). S-100B was correlated to both MATV (R-2 = 0.375) and TLG (R-2 = 0.352), but LDH was not. Higher MATV and TLG levels were found in patients with elevated S-100B (p 250 U/l) (p <0.001). There was no association between the biomarkers and SUVmean/max. Survival analysis indicated that LDH was the only predictor of melanoma-specific survival. Conclusion: In newly diagnosed stage IV melanoma patients S-100B correlates with F-18-FDG PET/CT derived MATV and TLG in contrast to LDH, is more often elevated than LDH (71% vs. 21%) and seems to be a better predictor of disease load and disease progression. However, elevated LDH is the only predictor for survival. The biomarkers, S-100B and LDH appear to describe different aspects of the extent of metastatic disease and of tumornecrosis. (C) 2020 The Authors. Published by Elsevier Ltd

A 180 Kpc Tidal Tail in the Luminous Infrared Merger Arp 299

We present VLA HI observations and UH88 deep optical B- and R-band observations of the IR luminous merger Arp 299 (= NGC 3690 + IC 694). These data reveal a gas-rich, optically faint tidal tail with a length of over 180 kpc. The size of this tidal feature necessitates an old interaction age for the merger (~750 Myr since first periapse), which is currently experiencing a very young star burst (~20 Myr). The observations reveal a most remarkable structure within the tidal tail: it appears to be composed of two parallel filaments separated by ~20 kpc. One of the filaments is gas rich with little if any starlight, while the other is gas poor. We believe that this bifurcation results from a warped disk in one of the progenitors. The quantities and kinematics of the tidal HI suggest that Arp 299 results from the collision of a retrograde Sab-Sb galaxy (IC 694) and a prograde Sbc-Sc galaxy (NGC 3690) that occurred 750 Myr ago and which will merge into a single object in ~60 Myr. We suggest that the present IR luminous phase in this system is due in part to the retrograde spin of IC 694. Finally, we discuss the apparent lack of tidal dwarf galaxies within the tail.Comment: LaTex, 14 pages, 11 figures, 4 tables, uses emulateapj.sty. Accepted to AJ for July 1999. For version with full-resolution images see http://www.cv.nrao.edu/~jhibbard/a299/HIpaper/a299HI.htm