PRIORITY BASED TRAFFIC LIGHTS CONTROLLER USING WIRELESS SENSOR NETWORKS

Vehicular traffic is continuously increasing around the world, especially in large urban areas. The resulting congestion has become a major concern to transportation specialists and decision makers. The existing methods for traffic management, surveillance and control are not adequately efficient in terms of performance, cost, maintenance, and support. In this paper, the design of a system that utilizes and efficiently manages traffic light controllers is presented. In particular, we present an adaptive traffic control system based on a new traffic infrastructure using Wireless Sensor Network (WSN). These techniques are dynamically adaptive to traffic conditions on both single and multiple intersections. An intelligent traffic light controller system with a new method of vehicle detection and dynamic traffic signal time manipulation is used in the project. The project is also designed to control traffic over multiple intersections and follows international standards for traffic light operations. A central monitoring station is designed to monitor all access nodes.

A COMPARATIVE STUDY ON THE EFFICACY OF PRAPOUNDARIKADI TAILA AND BHRINGARAJA TAILA NASYA AND SHIROABYANGA ALONG WITH DHATRITILADIYOGA INTERNALLY IN AKALA PALITHYA

Skin and hair color have been at the center of attention of humans since ancient times. Premature greying is an important cause of low self-esteem, often interfering with socio-cultural adjustment. And it is a burning problem as large percent of population especially young men and women in present times are suffering. In Ayurveda premature graying of hair is called as Akalapalitya. The incidence of premature ageing along with Akala Palitya is on increase, particularly in tropical and developing countries. According to W.H.O in India, its incidence is high in the age group of 20-30 years. Hence premature graying has long attracted researchers and industry alike with scientific as well as commercial targets. Hair coloring involves the use of chemicals which can result in a range of adverse effects like allergic reaction. Yet, apart from various hair dyes of varying efficacy and duration, fully satisfactory solutions for the graying problem remain to be brought to market.In this study, Prapoundarikaditaila and Bhringarajataila was taken for Nasya and Shiroabhyanga which has been mentioned in classics for Urdhwajathrugata Rogas and Palithya. Also Dhatritiladiyoga having Rasayana property helps in blackening of hair told by Acharya Yogarathnakara. In the present study 40 diagnosed Akala Palithya cases were divided into two groups of 20 each. Group A was treated by Prapoundarikaditaila Prathimarsha Nasya and Shiroabyanga along with Dhatritiladiyoga internally twice daily for 90 days. Group B was treated by Bhringarajataila Prathimarsha Nasya and Shiroabyanga along with Dhatritiladiyoga internally twice daily for 90 days. In the present study it was observed that Group A showed better results compared to that of Group B. 

A Novel Machine Learning Approach for Bug Prediction

AbstractWith the growing complexities of the software, the number of potential bugs is also increasing rapidly. These bugs hinder the rapid software development cycle. Bugs, if left unresolved, might cause problems in the long run. Also, without any prior knowledge about the location and the number of bugs, managers may not be able to allocate resources in an efficient way. In order to overcome this problem, researchers have devised numerous bug prediction approaches so far. The problem with the existing models is that the researchers have not been able to arrive at an optimized set of metrics. So, in this paper, we make an attempt to select the minimal number of best performing metrics, thereby keeping the model both simple and accurate at the same time. Most of the bug prediction models use regression for prediction and since regression is a technique to best approximate the training data set, the approximations don’t always fit well with the test data set. Keeping this in mind, we propose an algorithm to predict the bug proneness index using marginal R square values. Though regressions are performed as intermediary steps in this algorithm, the underlying logic is different in nature when compared with the models using regressions alone

A study on seroprevalence of HIV among women attending obstetric care in a tertiary care hospital of South India with maternal and perinatal outcomes

Background: HIV is prevalent in epidemic proportions in India. Identifying the target population and effective intervention reduces chances of vertical transmission and new infection. Authors studied the seroprevalence of HIV among women attending obstetric care in a tertiary care hospital of South India and associated maternal and perinatal outcomes among seropositive women.Methods: Retrospective descriptive study of all women who were screened for HIV at Integrated Counselling and Testing Centre, Vani Vilas hospital, from January 2014 to December 2017 in their antenatal, intranatal and postnatal period. Demographic data of seropositive women, obstetric outcomes and status of children at 18months were obtained.Results: Of the 35,455 women who were screened, 0.28% were found positive for HIV. Percentage prevalence of HIV was highest in 2014 (0.32%). Majority of the seroprevalence belonged to age group of 25-29 years (44%), 32% illiterates, 82% homemakers and 79% belonged to urban areas. Unknown partner status in 22% and majority were diagnosed in antenatal period (66%). Of them 82% had favourable CD4 count. 74 % of them delivered live baby. Three maternal deaths were observed and anaemia (65%) was the major associated co-morbidity. Vaginal route was common mode of delivery (84%). Thirteen babies required NICU admission and 6 neonates deaths were encountered. Exclusive breastfeeding was practised in 91% of live births. 62% of children were found seronegative at 18 months follow up.Conclusions: Authors observed with adequate treatment to mother and prophylaxis to the baby, the burden of vertical transmission can be significantly reduced

FORMULATION AND EVALUATION OF MOUTH-DISSOLVING FILM OF AN H1 ANTIHISTAMINE DRUG

Objective: The objective of present work was to develop a Mouth dissolving film of Levocetirizine dihydrochloride drug by Solvent casting method using different natural polymers. The best polymer was selected on the basis of the release of the drug and disintegration time. Methods: Sodium alginate and Guar gum are used as a natural polymers. Starch is used as a disintegrant. Glycerol is used as a plasticizer. Citric acid is usedas a saliva-stimulating agent. Mannitol is used as a sweetener. Peppermint oil as a flavoring agent. Mouth-dissolving films were prepared by using the solvent casting method. Results: The compatibility study of the drug with different natural polymers was carried out. The IR spectral studies showed no interaction between drug and polymers. Obtained satisfactory results for Preformulation and post-formulation tests. Formulation F6 containing sodium alginate, F9 containing guar gum and F14 containing a combination ratio of (Sodium alginate: guar gum) showed good results throughout the study. The stability studies on the formulations F6, F9 and F14 indicates that there is no significant change in physical appearance, disintegration time and drug content release study. Conclusion: From the results, it was concluded that the Mouth dissolving films of Levocetirizine dihydrochloride containing natural polymer sodium alginate (F6) showed the least disintegration time (14.28 sec), highest dissolution rate (98.24%) than the formulation containing natural polymer guar gum and combination ratio of (Sodium alginate: guar gum)

The modulatory effect of septilin on cytotoxicity of cisplatin in a human breast adenocarcinoma cell line

Cisplatin (Csp) is a recurrently used chemotherapeutic drug but its use is inadequate due to undesirable adverse effects. In search of alternative medicine more attention has been given to phytochemicals. Septilin (Spt), a polyherbal drug and its therapeutic potential is huge but there is a scarcity of studies on its cytotoxic potential on cancer cells. The current study was designed to examine the effects of Spt in combination with Csp on human breast adenocarcinoma (MCF-7) and normal human breast epithelial (MCF-10A) cell lines. Cell viability for Spt treated cells was studied using MTT assay. IC50 value of Csp on MCF-7 cells was found to be 10 μg/mL at 24 h. This dose was further used to study the combined effects of Csp with Spt on MCF-7 and MCF-10A cell lines. Maximum cytotoxicity of Spt on MCF-7 cells was observed at Spt 5 μg/mL. The mechanism of Spt induced cytotoxicity was studied using apoptosis assay. Spt did not show any cytotoxic effects on MCF-10 A normal human breast epithelial cells, indicating Spt has no effect on normal cells. Our findings suggest that Spt can be used in combination with an anticancer drug Csp to increase its efficacy and/or to minimize its side effects on normal cells

Pharmaceutical evaluation of Madhutailika Basti formulation prepared by Classical and Modified Methods

Madhutailika Basti’, is a type of ‘Aasthapana Basti’ also termed as ‘Niruha Basti’. The formulation of Madhutailika Basti comprises of Madhu, Lavana, Taila, Kalka and Kwatha. These ingredients are not easily miscible with each other. But to get the optimum therapeutic action from the formulation homogenious mixture of ingredients is necessary.Homogeneity of final mixture is assessed with certain features like, non- spreading, not-staying as a lump, not retaining its markings when it is placed on the palm.As this process needs creation of vigorous shear force within the mass material usage of sophisticated equipment for mixing may make the preparation processing easier and convenient, especially in large scale work.Hence it is planned to conduct the study on Madhutailika Basti formulation prepared by classical and modified methods. An effort is been put to know the reason behind serial order of mixing and difference between classical and modified methods of mixing Madhutailika Basti formulation

PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF THE DRUG SAHADEVI (CYANTHILLIUM CINEREUM (L.) H. ROB.)

Sahadevi (Cyanthillium cinereum (L.) H.Rob.) (Family Asteraceae) commonly known as Purple Fleabane in English, Sahadei in Hindi and Poovankurunthila in Malayalam, an erect annual branched herb with pubescent cylindrical stem found as a weed throughout India is extensively used in folkore medicine. The present paper highlights the pharmacognostical and phytochemical characters of the plant to give clear standards for identification of the drug. Microscopic evaluation of root, stem and leaf as well powder microscopy of the plant were carried out. Physicochemical parameters like moisture content, total ash, water insoluble ash, acid insoluble ash, volatile oil content, sugar content, fibre content, alcohol soluble extractive and water soluble extractive were studied. Preliminary phytochemical analysis of the plant Sahadevi [Cyanthillium cinereum (L.) H.Rob.] showed the presence of steroid, flavonoid, glycoside, saponins and tannin. The present study signifies the use of TLC and HPTLC fingerprint profiles of aqueous and alcoholic extracts of the drug for determining the identity, purity of the drug and also for developing standards. The findings drawn from the study substantiates the genuineness of the drug Sahadevi [Cyanthillium cinereum (L.) H.Rob.], which is at par with the descriptions available in the authentic books

Evaluation of locomotor activity of pioglitazone in albino mice

Background: Pioglitazone (PIO), a Peroxisome Proliferator Activated Receptor γ (PPAR-γ) agonist, is an oral anti-diabetic agent belonging to the group of thiazolidinediones-TZDs used for the treatment of diabetes mellitus type 2 in monotherapy and in combination with a sulfonylurea, metformin, or insulin.Methods: All animals were allowed to acclimatize with laboratory conditions at least two weeks before starting the experiment and they were maintained under the same condition throughout the experiment. They were given food and water ad libitum. The experiments were performed as per the Committee for the Purpose of Control and Supervision on Experiments on Animals (CPCSEA) guidelines. The animals were subjected to experimentation between 0900-1600 hours in noise free atmosphere with ambient temperature 23-300ºC.Results: There was no significant reduction in the within group comparisons of the basal and final scores in locomotor activity.Conclusions: The standard and test groups failed to produce any significant reduction in locomotor activity in the intergroup comparison as well as compared to normal control