385 research outputs found

    A pseudo-spectral method based on reproducing kernel for solving the time-fractional diffusion-wave equation

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    In this paper, we focus on the development and study of the finite difference/pseudo-spectral method to obtain an approximate solution for the time-fractional diffusion-wave equation in a reproducing kernel Hilbert space. Moreover, we make use of the theory of reproducing kernels to establish certain reproducing kernel functions in the aforementioned reproducing kernel Hilbert space. Furthermore, we give an approximation to the time-fractional derivative term by applying the finite difference scheme by our proposed method. Over and above, we present an appropriate technique to derive the numerical solution of the given equation by utilizing a pseudo-spectral method based on the reproducing kernel. Then, we provide two numerical examples to support the accuracy and efficiency of our proposed method. Finally, we apply numerical experiments to calculate the quality of our approximation by employing discrete error norms. © 2022, The Author(s)

    Detection of atrial fibrillation in ECG hand-held devices using a random forest classifier

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    Atrial Fibrillation (AF) is characterized by chaotic electrical impulses in the atria, which leads to irregular heartbeats and can develop blood clots and stroke. Therefore, early detection of AF is crucial for increasing the success rate of the treatment. This study is focused on detection of AF rhythm using hand-held ECG monitoring devices, in addition to three other classes: normal or sinus rhythm, other rhythms, and too noisy to analyze. The pipeline of the proposed method consists of three major components: preprocessing and feature extraction, feature selection, and classification. In total, 491 hand-crafted features are extracted. Then, 150 features are selected in a feature ranking procedure. The selected features are from time, frequency, time-frequency domains, and phase space reconstruction of the ECG signals. In the final stage, a random forest classifier is used to classify the selected features into one of the four aforementioned ECG classes. Using the scoring mechanism provided by PhysioNet/Computing in Cardiology (CinC) Challenge 2017, the overall score (mean±std) of 81.9±2.6% is achieved over the training dataset in 10-fold cross-validation. The proposed algorithm tied for the first place in the PhysioNet/CinC Challenge 2017 with an overall score of 82.6% (rounded to 83%) on the unseen test dataset.Scopu

    Rebaudioside A inhibits pentylenetetrazol-induced convulsions in rats

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    AbstractThe safety of patients with epilepsy consuming sweetening agents, which is becoming increasingly prevalent for various reasons, is a topic that should be emphasized as sensitively as it is for other diseases. Patients with epilepsy consume sweetening agents for different reasons such being diabetic or overweight. They can occasionally be exposed to sweetening agents unrestrainedly through consuming convenience food, primarily beverages. This study aimed to investigate the effects of rebaudioside A (Reb-A), which is a steviol glycoside produced from the herb Stevia rebaudiana (Bertoni), on epileptic seizures and convulsions induced by pentylenetetrazole (PTZ). Forty-eight male rats were used. Twenty-four rats were administered 35 mg/kg PTZ to trigger epileptiform activity; the remaining 24 rats were administered 70 mg/kg PTZ to trigger the convulsion model. The epileptiform activity was evaluated by spike percentage, whereas convulsion was evaluated by Racine's Convulsion Scale and the onset time of the first myoclonic jerk. Statistical analysis revealed a statistically significant decrease in the Racine's Convulsion Scale score and increase in the latency of first myoclonic jerk in a dose-dependent manner for the rat groups in which PTZ epilepsy had been induced and Reb-A had been administered. For the groups that were administered Reb-A, the spike decrease was apparent in a dose-dependent manner, based on the spike percentage calculation. These results indicated that Reb-A has positive effects on PTZ-induced convulsions

    Lithium intoxication related multiple temporary ecg changes: A case report

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    Lithium is a widely used mood stabilizer, which may cause cardiac side effects. In this article, we present the case of a 39-year-old woman who had presented with pre-syncope and developed multiple ECG abnormalities that are caused by lithium intoxication and are disappeared after hemodialysis

    Sector Expansion and Elliptical Modeling of Blue-Gray Ovoids for Basal Cell Carcinoma Discrimination in Dermoscopy Images

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    Background: Blue-gray ovoids (B-GOs), a critical dermoscopic structure for basal cell carcinoma (BCC), offer an opportunity for automatic detection of BCC. Due to variation in size and color, B-GOs can be easily mistaken for similar structures in benign lesions. Analysis of these structures could afford accurate characterization and automatic recognition of B-GOs, furthering the goal of automatic BCC detection. This study utilizes a novel segmentation method to discriminate B-GOs from their benign mimics. Methods: Contact dermoscopy images of 68 confirmed BCCs with B-GOs were obtained. Another set of 131 contact dermoscopic images of benign lesions possessing B-GO mimics provided a benign competitive set. A total of 22 B-GO features were analyzed for all structures: 21 color features and one size feature. Regarding segmentation, this study utilized a novel sector-based, non-recursive segmentation method to expand the masks applied to the B-GOs and mimicking structures. Results: Logistic regression analysis determined that blue chromaticity was the best feature for discriminating true B-GOs in BCC from benign, mimicking structures. Discrimination of malignant structures was optimal when the final B-GO border was approximated by a best-fit ellipse. Using this optimal configuration, logistic regression analysis discriminated the expanded and fitted malignant structures from similar benign structures with a classification rate as high as 96.5%. Conclusions: Experimental results show that color features allow accurate expansion and localization of structures from seed areas. Modeling these structures as ellipses allows high discrimination of B-GOs in BCCs from similar structures in benign images

    Annual Clovers Around the World: Current Status and Future Prospects

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    This paper reviews the distribution and importance of annual clover (Trifolium) species for pasture and fodder production systems globally. Of the 158 recorded annual Trifolium species, 65.2% are endemic to the Mediterranean basin and surrounding areas, 14.6% to sub-Saharan Africa, 17.7% to the United States of America and 2.5% to Chile. Fourteen species have been commercialised, while other endemic and naturalised annual clovers are also utilised. Key species for self-regenerating pastures include T. subterraneum, T. michelianum and T. respinatum var. resupinatum, while major dual-purpose grazing and fodder species include T. incarnatum, T. vesiculosum, T. alexandrinum and T. respinatum var. majus. Less important commercial species include T. hirtum, T. squarrosum, T. nigrescens and T. cherleri. Australian scientists have also recently domesticated T. glanduliferum, T. spumosum, T. purpureum and T. dasyurum. The areas sown to annual clovers may increase in future years, due to increasing nitrogen (N) fertiliser costs, environmental concerns with N runoff. Climate change brings new challenges and opportunities for annual clovers. The forage plant genetic resource centres will be crucial for developing new adapted cultivars

    Exploration of 2-deoxy-D-ribose and 17β-Estradiol as alternatives to exogenous VEGF to promote angiogenesis in tissue-engineered constructs

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    Aim: In this study, we explored the angiogenic potential and proangiogenic concentration ranges of 2-deoxy-D-ribose (2dDR) and 17β-Estradiol (E2) in comparison with VEGF. The 2dDR and E2 were then loaded into tissue engineering (TE) scaffolds to investigate their proangiogenic potential when released from fibers. Materials & methods:Ex ovo chick chorioallantoic membrane (CAM) assay was used to evaluate angiogenic activity of 2dDR and E2. Both factors were then introduced into scaffolds via electrospinning to assess their angiogenic potential when released from fibers. Results: Both factors were approximately 80% as potent as VEGF and showed a dose-dependent angiogenic response. The sustained release of both agents from the scaffolds stimulated neovascularization over 7 days in the chorioallantoic membrane assay. Conclusion: We conclude that both 2dDR and E2 provide attractive alternatives to VEGF for the functionalization of tissue engineering scaffolds to promote angiogenesis in vivo
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