1,917 research outputs found
A membrane network of receptors and enzymes for adenine nucleotides and nucleosides
AbstractMost cells express more than one receptor plus degrading enzymes for adenine nucleotides or nucleosides, and cellular responses to purines are rarely compatible with the actions of single receptors. Therefore, these receptors are viewed as components of a combinatorial receptor web rather than self-dependent entities, but it remained unclear to what extent they can associate with each other to form signalling units. P2Y1, P2Y2, P2Y12, P2Y13, P2X2, A1, A2A receptors and NTPDase1 and -2 were expressed as fluorescent fusion proteins which were targeted to membranes and signalled like the unlabelled counterparts. When tested by FRET microscopy, all the G protein-coupled receptors proved able to form heterooligomers with each other, and P2Y1, P2Y12, P2Y13, A1, A2A, and P2X2 receptors also formed homooligomers. P2Y receptors did not associate with P2X, but G protein-coupled receptors formed heterooligomers with NTPDase1, but not NTPDase2. The specificity of prototypic interactions (P2Y1/P2Y1, A2A/P2Y1, A2A/P2Y12) was corroborated by FRET competition or co-immunoprecipitation. These results demonstrate that G protein-coupled purine receptors associate with each other and with NTPDase1 in a highly promiscuous manner. Thus, purinergic signalling is not only determined by the expression of receptors and enzymes but also by their direct interaction within a previously unrecognized multifarious membrane network
Evidence for Different Freeze-Out Radii of High- and Low-Energy Pions Emitted in Au+Au Collisions at 1 GeV/nucleon
Double differential production cross sections of negative and positive pions
and the number of participating protons have been measured in central Au+Au
collisions at 1 GeV per nucleon incident energy. At low pion energies the pi^-
yield is strongly enhanced over the pi^+ yield. The energy dependence of the
pi^-/pi^+ ratio is assigned to the Coulomb interaction of the charged pions
with the protons in the reaction zone. The deduced Coulomb potential increases
with increasing pion c.m. energy. This behavior indicates different freeze-out
radii for different pion energies in the c.m.~frame.Comment: IKDA is the Institute for Nuclear Physics in Darmstadt/German
Enhanced Out-of-plane Emission of K+ Mesons observed in Au+Au Collisions at 1 AGeV
The azimuthal angular distribution of K+ mesons has been measured in Au + Au
collisions at 1 AGeV. In peripheral and semi-central collisions, K+ mesons
preferentially are emitted perpendicular to the reaction plane. The strength of
the azimuthal anisotropy of K+ emission is comparable to the one of pions. No
in-plane flow was found for K+ mesons near projectile and target rapidity.Comment: Accepted for publication in Phys. Rev.Let
Photoproduction at collider energies: from RHIC and HERA to the LHC
We present the mini-proceedings of the workshop on ``Photoproduction at
collider energies: from RHIC and HERA to the LHC'' held at the European Centre
for Theoretical Studies in Nuclear Physics and Related Areas (ECT*, Trento)
from January 15 to 19, 2007. The workshop gathered both theorists and
experimentalists to discuss the current status of investigations of high-energy
photon-induced processes at different colliders (HERA, RHIC, and Tevatron) as
well as preparations for extension of these studies at the LHC. The main
physics topics covered were: (i) small- QCD in photoproduction studies with
protons and in electromagnetic (aka. ultraperipheral) nucleus-nucleus
collisions, (ii) hard diffraction physics at hadron colliders, and (iii)
photon-photon collisions at very high energies: electroweak and beyond the
Standard Model processes. These mini-proceedings consist of an introduction and
short summaries of the talks presented at the meeting
ISSUES IN HIGH-RESOLUTION ATMOSPHERIC MODELING IN COMPLEX TOPOGRAPHY --THE HiRCoT WORKSHOP
During the past years the atmospheric modeling community, both from the application and pure research perspectives, has been facing the challenge of high resolution numerical modeling in places with complex topography. In February 2012, as a result of the collaborative efforts of the Institute of Meteorology of the University of Natural Resources and Life Sciences (BOKUMet), the Arctic Region Supercomputing Center (ARSC), the Institute of Meteorology and Geophysics of the University of Innsbruck (IMG) and the enthusiasm of the scientific community, the HiRCoT workshop was held in Vienna, Austria. HiRCoT objectives were to: 1) Identify the problems
encountered with numerical modeling at grid spacing lower than 1 km over complex terrain, that is, understand the key areas that are troublesome and formulate the key questions about them; 2) Map out possibilities on how to address these issues; 3) Allow the researchers to discuss the issues on a shared platform (online through a wikipage and face-to-face). This manuscript presents an overview of the topics and research priorities discussed in the workshop
Transition Radiation Spectroscopy with Prototypes of the ALICE TRD
We present measurements of the transition radiation (TR) spectrum produced in
an irregular radiator at different electron momenta. The data are compared to
simulations of TR from a regular radiator.Comment: 4 pages, 5 Figures, Proceedings for "TRDs for the 3rd millennium"
(Sept. 4-7, 2003, Bari, Italy
Heavy-flavour and quarkonium production in the LHC era: from proton-proton to heavy-ion collisions
This report reviews the study of open heavy-flavour and quarkonium production
in high-energy hadronic collisions, as tools to investigate fundamental aspects
of Quantum Chromodynamics, from the proton and nucleus structure at high energy
to deconfinement and the properties of the Quark-Gluon Plasma. Emphasis is
given to the lessons learnt from LHC Run 1 results, which are reviewed in a
global picture with the results from SPS and RHIC at lower energies, as well as
to the questions to be addressed in the future. The report covers heavy flavour
and quarkonium production in proton-proton, proton-nucleus and nucleus-nucleus
collisions. This includes discussion of the effects of hot and cold strongly
interacting matter, quarkonium photo-production in nucleus-nucleus collisions
and perspectives on the study of heavy flavour and quarkonium with upgrades of
existing experiments and new experiments. The report results from the activity
of the SaporeGravis network of the I3 Hadron Physics programme of the European
Union 7th Framework Programme
Position Reconstruction in Drift Chambers operated with Xe, CO2 (15%)
We present measurements of position and angular resolution of drift chambers
operated with a Xe,CO(15%) mixture. The results are compared to Monte Carlo
simulations and important systematic effects, in particular the dispersive
nature of the absorption of transition radiation and non-linearities, are
discussed. The measurements were carried out with prototype drift chambers of
the ALICE Transition Radiation Detector, but our findings can be generalized to
other drift chambers with similar geometry, where the electron drift is
perpendicular to the wire planes.Comment: 30 pages, 18 figure
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