Change it Now: eBay v. MercExchange-Business Method Patent Litigation Reaches Critical Juncture Concerning Remedies for Infringement

Visual simultaneous localization and mapping (SLAM) as field has been researched for ten years, but with recent advances in mobile performance visual SLAM is entering the consumer market in a completely new way. A visual SLAM system will however be sensitive to non cautious use that may result in severe motion, occlusion or poor surroundings in terms of visual features that will cause the system to temporarily fail. The procedure of recovering from such a fail is called relocalization. Together with two similar problems localization, to find your position in an existing SLAM session, and loop closing, the online reparation and perfection of the map in an active SLAM session, these can be grouped as visual location recognition (VLR). This thesis presents novel results by combining the scalability of FabMap and the precision of 13th Lab's tracking yielding high-precision VLR, +/- 10 cm, while maintaining above 99 % precision and 60 % recall for sessions containing thousands of images. Everything functional purely on a normal mobile phone. The applications of VLR are many. Indoors, where GPS is not functioning, VLR can still provide positional information and navigate you through big complexes like airports and museums. Outdoors, VLR can improve the precision of GPS tenfold yielding a new level of navigational experience. Virtual and augmented reality applications are other areas that benefit from improved positioning and localization

Twitter Technology Trampling Fashion Designs: The Effects of Twitter on the Fashion Industry.

The fashion industry continuously faces the issue of fashion piracy, retailers intentionally copying fashion designs from the runway and cheaply manufacturing them to sell at a low price. While large retailers are soaring, many young designers are struggling to survive. Fashion labels are turning to better marketing strategies and the use of social media to increase their popularity, image and revenue. This thesis covers the rise of Twitter, and how fashion designers, specifically Diane Von Furstenberg, Nanette Lepore, and Tory Burch, use Twitter and for what purpose. My goal is to determine if the use of Twitter fosters brand growth or is directly related to fashion piracy due to the multimedia content designers post

Corporate Cybersmear: Employers File John Doe Defamation Lawsuits Seeking the Identity of Anonymous Employee Internet Posters

Communications systems are now wide open and fully accessible, with no limits in range, scope or geography. Targeted audiences are accessible with pinpoint accuracy. Messages reach millions of readers with one click. There is a chat room for everyone. Most importantly, there is no limit on content. Therefore, employees can register their dissatisfaction by posting a message in a chat room. Moreover, the identity of the posting employee is not easily discoverable due to anonymous and pseudonymous communications capabilities. The nature of these online messages is qualitatively different from real-world communications. By way of example, newspapers have a responsibility regarding the veracity of the content that they print. Sponsors of online bulletin board services do not bear the same level of responsibility. In cyberspace chatrooms, everyone is a publisher; there are no editors. Online messages reflect this, too. The culture of online communications is vastly different from traditional discourse, in that the former tolerates and even encourages the use of hyperbole, crudeness, acronyms, misspellings, and misuse of language. It is a fast and loose atmosphere, emphasizing speed rather than accuracy. This is the current environment in which anonymous employees post negative statements about their employers. The questions raised in this article relate to management\u27s response, in the form of John Doe lawsuits, to this recent spate of negative Internet postings by employees. The emergence of the Internet as the medium of choice for such communications raises a myriad of questions that are new to courts. Questions arise regarding the extent to which employers may control the speech of current employees or former employees and, as a corollary to this, the extent to which such speech is protected, as well as whether this attempted speech control violates public policy. Such suits have just begun to reach the courts, and their resolution will form the contours of employee freedom of speech in the Internet age. John Doe suits implicate constitutional and common law issues ranging from the First Amendment to privacy, defamation, breach of employment agreement, and trade secret laws. Such suits involve statutes as well, including whistle-blower protections and Strategic Litigation Against Public Participation ( SLAPP ) laws. Negative postings by employees also correlate to general economic conditions. During the current two year downturn in the financial markets, for example, there has been a tremendous increase in such postings. Employers have just begun to reply to these allegedly defamatory postings--in the form of John Doe lawsuits. Because it is difficult to discern who is speaking in cyberspace, plaintiffs often file a lawsuit listing John Doe as the defendant. Plaintiffs then invoke the power of a subpoena to compel the Internet Service Provider ( ISP ) or Bulletin Board Service ( BBS ) on which the posting was made to identify the poster, thereby unmasking these anonymous and pseudonymous individuals. It is worth noting that plaintiffs have an alternative course of action, in that they could investigate the postings and discover for themselves who is posting the messages. It is not clear whether any more effort or expense is involved in this strategy than immediately invoking the assistance--and the power--of the judicial system. But it is fair to say that involving the judicial system at this earliest stage is a coercive, and effective, strategy

Corporate Cybersmear: Employers File John Doe Defamation Lawsuits Seeking the Identity of Anonymous Employee Internet Posters

Communications systems are now wide open and fully accessible, with no limits in range, scope or geography. Targeted audiences are accessible with pinpoint accuracy. Messages reach millions of readers with one click. There is a chat room for everyone. Most importantly, there is no limit on content. Therefore, employees can register their dissatisfaction by posting a message in a chat room. Moreover, the identity of the posting employee is not easily discoverable due to anonymous and pseudonymous communications capabilities. The nature of these online messages is qualitatively different from real-world communications. By way of example, newspapers have a responsibility regarding the veracity of the content that they print. Sponsors of online bulletin board services do not bear the same level of responsibility. In cyberspace chatrooms, everyone is a publisher; there are no editors. Online messages reflect this, too. The culture of online communications is vastly different from traditional discourse, in that the former tolerates and even encourages the use of hyperbole, crudeness, acronyms, misspellings, and misuse of language. It is a fast and loose atmosphere, emphasizing speed rather than accuracy. This is the current environment in which anonymous employees post negative statements about their employers. The questions raised in this article relate to management\u27s response, in the form of John Doe lawsuits, to this recent spate of negative Internet postings by employees. The emergence of the Internet as the medium of choice for such communications raises a myriad of questions that are new to courts. Questions arise regarding the extent to which employers may control the speech of current employees or former employees and, as a corollary to this, the extent to which such speech is protected, as well as whether this attempted speech control violates public policy. Such suits have just begun to reach the courts, and their resolution will form the contours of employee freedom of speech in the Internet age. John Doe suits implicate constitutional and common law issues ranging from the First Amendment to privacy, defamation, breach of employment agreement, and trade secret laws. Such suits involve statutes as well, including whistle-blower protections and Strategic Litigation Against Public Participation ( SLAPP ) laws. Negative postings by employees also correlate to general economic conditions. During the current two year downturn in the financial markets, for example, there has been a tremendous increase in such postings. Employers have just begun to reply to these allegedly defamatory postings--in the form of John Doe lawsuits. Because it is difficult to discern who is speaking in cyberspace, plaintiffs often file a lawsuit listing John Doe as the defendant. Plaintiffs then invoke the power of a subpoena to compel the Internet Service Provider ( ISP ) or Bulletin Board Service ( BBS ) on which the posting was made to identify the poster, thereby unmasking these anonymous and pseudonymous individuals. It is worth noting that plaintiffs have an alternative course of action, in that they could investigate the postings and discover for themselves who is posting the messages. It is not clear whether any more effort or expense is involved in this strategy than immediately invoking the assistance--and the power--of the judicial system. But it is fair to say that involving the judicial system at this earliest stage is a coercive, and effective, strategy

Early MRI results and odds of attaining 'no evidence of disease activity' status in MS patients treated with interferon β-1a in the EVIDENCE study

Abstract Introduction 'No evidence of disease activity' (NEDA) is increasingly used as a treatment target with disease-modifying drugs for relapsing multiple sclerosis. Methods This post-hoc analysis of the randomised EVIDENCE trial compared interferon beta-1a injected subcutaneously three times weekly (IFN β-1a SC tiw) with interferon β-1a injected intramuscularly once weekly (IFN β-1a IM qw) on NEDA and clinical activity-free (CAF) status. The influence of the frequency of magnetic resonance imaging (MRI) scanning on NEDA and the effect of baseline T1 gadolinium-enhancing (Gd +) lesions on NEDA and CAF were also investigated. Results More patients in the IFN β-1a SC tiw group achieved NEDA compared with the IFN β-1a IM qw group, although rates were lower when monthly MRI scans through 24 weeks were included (35.0% vs. 21.6%, respectively; p p p = 0.022), and CAF through Week 48 in patients receiving IFN β-1a SC tiw ( p = 0.024). Conclusions IFN β-1a SC tiw was associated with significantly higher rate of NEDA status compared with IFN β-1a IM qw. Baseline Gd + lesions augured less frequent CAF or NEDA status. Inclusion of more MRI scans in the analysis reduced rates of NEDA status

Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial

BACKGROUND: Evidence for efficacy of disease-modifying drugs in multiple sclerosis (MS) comes from trials of short duration. We report results from a 16 y, retrospective follow-up of the pivotal interferon beta-1b (IFNB-1b) study. METHODS: The 372 trial patients were randomly assigned to placebo (n=123), IFNB-1b 50 microg (n=125) or IFNB-1b 250 microg (n=124) subcutaneously every other day for at least 2 y. Some remained randomised for up to 5 y but, subsequently, patients received treatment according to physicians' discretion. Patients were re-contacted and asked to participate. Efficacy related measures included MRI parameters, relapse rate, the Expanded Disability Status Scale, the Multiple Sclerosis Functional Composite Measure and conversion to secondary progressive MS. RESULTS: Of the 88.2% (328/372) of patients who were identified, 69.9% (260/372) had available case report forms. No differences in outcome between original randomisation groups could be discerned using standard disability and MRI measures. However, mortality rates among patients originally treated with IFNB-1b were lower than in the original placebo group (18.3% (20/109) for placebo versus 8.3% (9/108) for IFNB-1b 50 microg and 5.4% (6/111) for IFNB-1b 250 microg). CONCLUSIONS: The original treatment assignment could not be shown to influence standard assessments of long-term efficacy. On-study behaviour of patients was influenced by factors that could not be controlled with the sacrifice of randomisation and blinding. Mortality was higher in patients originally assigned to placebo than those who had received IFNB-1b 50 microg or 250 microg. The dataset provides important resources to explore early predictors of long-term outcome

Assessing variations of extreme indices inducing weather-hazards on critical infrastructures over Europe?the INTACT framework

Extreme weather events are projected to be more frequent and severe across the globe because of global warming. This poses challenging problems for critical infrastructures, which could be dramatically affected (or disrupted), and may require adaptation plans to the changing climate conditions. The INTACT FP7-European project evaluated the resilience and vulnerability of critical infrastructures to extreme weather events in a climate change scenario. To identify changes in the hazard induced by climate change, appropriate extreme weather indicators (EWIs), as proxies of the main atmospheric features triggering events with high impact on the infrastructures, were defined for a number of case studies and different approaches were analyzed to obtain local climate projections. We considered the influence of weighting and bias correction schemes on the delta approach followed to obtain the resulting projections, considering data from the Euro-CORDEX ensemble of regional future climate scenarios over Europe. The aim is to provide practitioners, decision-makers, and administrators with appropriate methods to obtain actionable and plausible results on local/regional future climate scenarios. Our results show a small sensitivity to the weighting approach and a large sensitivity to bias correcting the future projections.This work has been carried out within the activities of INTACT project, receiving funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° FP7-SEC-2013-1-606799. The information and views set out in this paper are those of the authors and do not necessarily reflect the opinion of the European Union. We acknowledge the World Climate Research Programme's Working Group on Regional Climate, and the Working Group on Coupled Modelling, former coordinating body of CORDEX and responsible panel for CMIP5

Functional Imaging of Pheochromocytoma with 68Ga-DOTATOC and 68C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia

Rats affected by the MENX multitumor syndrome develop pheochromocytoma (100%). Pheochromocytomas are uncommon tumors and animal models are scarce, hence the interest in MENX rats to identify and preclinically evaluate novel targeted therapies. A prerequisite for such studies is a sensitive and noninvasive detection of MENXassociated pheochromocytoma. We performed positron emission tomography (PET) to determine whether rat pheochromocytomas are detected by tracers used in clinical practice, such as 68Ga-DOTATOC (somatostatin analogue) or 11C-Hydroxyephedrine (HED), a norepinephrine analogue. We analyzed four affected and three unaffected rats. The PET scan findings were correlated to histopathology and immunophenotype of the tumors, their proliferative index, and the expression of genes coding for somatostatin receptors or the norepinephrine transporter. We observed that mean 68Ga-DOTATOC standard uptake value (SUV) in adrenals of affected animals was 23.3 ± 3.9, significantly higher than in control rats (15.4 ± 7.9; P = .03). The increase in mean tumor-to-liver ratio of 11C-HED in the MENX-affected animals (1.6 ± 0.5) compared to controls (0.7 ± 0.1) was even more significant (P = .0016). In a unique animal model, functional imaging depicting two pathways important in pheochromocytoma biology discriminated affected animals from controls, thus providing the basis for future preclinical work with MENX rats