98 research outputs found
The burden and treatment of HIV in tuberculosis patients in Papua Province, Indonesia: a prospective observational study
- Author
- AD Harries
- AJ Rodger
- American Thoracic Society
- Anna P Ralph
- AP Ralph
- AP Ralph
- Centres for Diseases Control and Prevention
- CT Kang'ombe
- D Benator
- Dina B Lolong
- E Losina
- EE Telzak
- EF Lyamuya
- EL Corbett
- EL Korenromp
- Emiliana Tjitra
- Enny Kenangalem
- F Mugusi
- F Scano
- FA Khan
- G Aderaye
- G Ramjee
- Govert Waramori
- GP Maguire
- Gysje J Pontororing
- JG Bartlett
- JR Glynn
- JR Poespoprodjo
- JY Wang
- K Jochelson
- L Wang
- M Ardian
- M Karyana
- M Palaci
- MC Raviglione
- National AIDS Commission
- Nicholas M Anstey
- PA Selwyn
- Paul M Kelly
- PM Kelly
- PV Shetty
- PW Jones
- PW Roche
- R Lumb
- R Lumb
- R Pellegrino
- Ric N Price
- S Allen
- Sandjaja
- SS Abdool Karim
- Standard Diagnostics Inc
- Statistics Indonesia and the Ministry of Health
- World Health Organisation
- World Health Organisation
- World Health Organisation
- World Health Organisation
- World Health Organisation
- World Health Organisation
- World Health Organisation UNAIDS, UNICEF
- World Health Organisation/Joint United Nations Programme for HIV/AIDS
- Y Mahendradhata
- Y Mahendradhata
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>New diagnoses of tuberculosis (TB) present important opportunities to detect and treat HIV. Rates of HIV and TB in Indonesia's easternmost Papua Province exceed national figures, but data on co-infection rates and outcomes are lacking. We aimed to measure TB-HIV co-infection rates, examine longitudinal trends, compare management with World Health Organisation (WHO) recommendations, and document progress and outcome.</p> <p>Methods</p> <p>Adults with newly-diagnosed smear-positive pulmonary TB managed at the Timika TB clinic, Papua Province, were offered voluntary counselling and testing for HIV in accordance with Indonesian National Guidelines, using a point-of-care antibody test. Positive tests were confirmed with 2 further rapid tests. Study participants were assessed using clinical, bacteriological, functional and radiological measures and followed up for 6 months.</p> <p>Results</p> <p>Of 162 participants, HIV status was determined in 138 (85.2%), of whom 18 (13.0%) were HIV+. Indigenous Papuans were significantly more likely to be HIV+ than Non-Papuans (Odds Ratio [OR] 4.42, 95% confidence interval [CI] 1.38-14.23). HIV prevalence among people with TB was significantly higher than during a 2003-4 survey at the same TB clinic, and substantially higher than the Indonesian national estimate of 3%. Compared with HIV- study participants, those with TB-HIV co-infection had significantly lower exercise tolerance (median difference in 6-minute walk test: 25 m, p = 0.04), haemoglobin (mean difference: 1.3 g/dL, p = 0.002), and likelihood of cavitary disease (OR 0.35, 95% CI 0.12-1.01), and increased occurrence of pleural effusion (OR 3.60, 95% CI 1.70-7.58), higher rates of hospitalisation or death (OR 11.80, 95% CI 1.82-76.43), but no difference in the likelihood of successful 6-month treatment outcome. Adherence to WHO guidelines was limited by the absence of integration of TB and HIV services, specifically, with no on-site ART prescriber available. Only six people had CD4+ T-cell counts recorded, 11 were prescribed co-trimoxazole and 4 received ART before, during or after TB treatment, despite ART being indicated in 14 according to 2006 WHO guidelines.</p> <p>Conclusions</p> <p>TB-HIV co-infection in southern Papua, Indonesia, is a serious emerging problem especially among the Indigenous population, and has risen rapidly in the last 5 years. Major efforts are required to incorporate new WHO recommendations on TB-HIV management into national guidelines, and support their implementation in community settings.</p
Breast cancer research output, 1945-2008: a bibliometric and density-equalizing analysis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
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- Aceto L
- Acevedo B
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- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
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- Aguilar M
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- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
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- Al-Khalili F
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- Zhou H
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- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Gender, Socioeconomic Status, and Time Use of Married and Cohabiting Parents during the Great Recession
- Author
- ---
- ---
- ?pek ?lkkaracan
- Ashley English
- Aysegul ?ahin
- Barbara Ehrenreich
- Caren Grown
- Charlene Kalenkoski
- Diane Elson
- Dominique Anxo
- Ebru Kongar
- Fukuda-Parr
- Gary Dymski
- G�nseli Berik
- H Hartmann
- Harriet B Presser
- Heather Boushey
- Jill Rubery
- John Irons
- Jon D Wisman
- Julie Nelson
- Kaya Bah�e
- Kimberly Christensen
- Lisa K Schwartz
- Lourdes Bener�a
- Lourdes Bener�a
- Lynne Casper
- Maria Enchautegui
- Maria Karamessini
- Mark Aguiar
- Mark Price
- Martha A Starr
- Melinda Morrill
- Nancy Folbre
- Nancy Folbre
- Niki Dickerson Vonlockette
- Oecd
- Rachel Connelly
- Randy Albelda
- Rania Antonopoulos
- Sarah Glynn
- Steven L Nock
- Steven Pressman
- Suzanne M Bianchi
- Suzanne M Bianchi
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors
- Author
- Agnieszka Lebek-Szatanska
- Ajith V Kumar
- Akira Matsuno
- Aled Rees
- Alex Bickerton
- Ali Imran
- Alia Munir
- Alper GĂĽrlek
- Amar Agha
- Amy Ronaldson
- Anand Kumar
- Andrew Green
- Andrew Levy
- Angelos Kyriaku
- Anna Aulinas-MasĂł
- Anna Spada
- Anne Katrin Lampe
- Anthony P Goldstone
- Antonia Brooke
- AntĂłnio Ribeiro de Oliveira
- Aparna Pal
- Ariel Barkan
- Arla Ogilivie
- Ashley B Grossman
- Astrid Weber
- Atik Baborie
- Attila PatĂłcs
- Barbara McGowan
- Barbara Mosterman
- Beatriz S Soares
- Beckers
- Bernard Khoo
- Bijay Vaidya
- Biju Jose
- Blair
- Brede Swantje
- Brew Atkinson
- Britt Edén-Engström
- Caimari
- Candy Sze
- Carmen Bernal-González
- Carmen Georgescu
- Caroline Brain
- Catherine Choong
- Catherine Gilkes
- Catherine Lyons
- Catherine Patterson
- Cathy Kiraly-Borri
- Cazabat
- Celia Rodd
- Chandi Idampitiya
- Charlotte Höybye
- Cheri Deal
- Chris Thompson
- Christian Strasburger
- Christina Daousi
- Christine Burren
- Christof Schöfl
- Chung Thong Lim
- Colin Johnston
- Corin Badiu
- Cuny
- Daly
- Daly
- Daly
- Daly
- Daly
- Damian G Morris
- Daniel Cuthbertson
- Darko Kastelan
- David A Hilton
- David Carty
- David Collier
- David Cove
- de Laat
- Debbie Shears
- Dinesh Nagi
- Dominic Cavlan
- Donato Iacovazzo
- Dragana Miljic
- Dutta
- Edward R Laws
- Elaine Tham
- Eleanor Hay
- Eleanor Lin
- Elena Aflorei
- Elizabeth Crowne
- Elizabeth Forsythe
- Ellard
- Emese Mezősi
- Evelien Gevers
- Farida Chentli
- Federico Roncaroli
- Felicity Kaplan
- Fiona Ryan
- Florian Wernig
- Francesca Pecori Giraldi
- Francesca Swords
- Francisca Caimari
- Fraser Pirie
- Freda
- Gina Twine
- Graeme Suthers
- Graham Dow
- Graham Leese
- Greenman
- Greg Hong
- Gregory Kaltsas
- Gul Bano
- Gábor L Kovács
- Hakan Widell
- Hamish Courtney
- Hani Marcus
- Harpal Randeva
- Harvinder S Chahal
- Helen L Storr
- Helen Spoudeas
- Hernández-RamĂrez
- Hilde Von Esch
- Hoong-Wei Gan
- Iacovazzo
- Imre Zoltan Kun
- Ioana Lambrescu
- Ionela Pascanu
- Isabelle Suter-Widmer
- Jacob Dal
- James Ahlquist
- James E Goldman
- James Sperber
- Janet Lo
- Janos Vadasz
- Jo Blair
- Joan Grieve
- Joel Capraro
- John A Wass
- John Barton
- John Monson
- John Newell-Price
- John S Bevan
- Joshi
- JoĂŁo Anselmo
- Judit DĂ©nes
- Julian Barwell
- Julian Davis
- Juliana Drummond
- Juliet Taylor
- Justin Davies
- Karen K Miller
- Karen Stals
- Karin Bradley
- Katalin Horváth
- Kate Ellis
- Katie Snape
- Katsuhiko Yoshimoto
- Katznelson
- Ken Darzy
- Kesson Magid
- Kevin Shotliff
- Kevin Yuen
- Khash Nikookam
- Korbonits
- Krystallenia Alexandraki
- Krzysztof Lewandowski
- Larisa Dzeranova
- Laura C Hernández-RamĂrez
- Laura de Marinis
- Lisa Bradley
- Lisa Nachtigall
- Louise Emmerson
- Louise Izatt
- Luis Gustavo Perez-Rivas
- Luis V Syro
- Luiz Griz
- Lynette Penney
- Lynn Greenhalgh
- Madalina Musat
- Mangupli
- Maralyn Druce
- Marek Bolanowski
- Marek Niedziela
- Margaret de Castro
- Maria Elfving
- Maria Elisabeth Street
- Maria Fleseriu
- Maria Stelmachowska-Banas
- Marianne Elston
- Marija Pfeifer
- Marinella Tzanela
- Mark Cohen
- Mark E Molitch
- Mark Gurnell
- Marques
- Marques
- Martin O´Weickert
- Mary Gainsborough
- Mary Lee Vance
- Mehtap Cakir
- Mehul Dattani
- Melanie Kershaw
- Michael Besser
- Michael Buchfelder
- Michael O Thorner
- Michael Powell
- Michaela Davies
- Michelle Katz
- MiklĂłs GĂłth
- MiklĂłs TĂłth
- Miles J Levy
- Milica Medic-Stojanoska
- Mirjam Christ-Crain
- Mirtha Guitelman
- Mohamad Maghnie
- Moisés Mercado-Atri
- Molitch
- Mona Waterhouse
- Mothojakan
- Márta Korbonits
- MĂłnica Gadelha
- Nadezhda Dalantaeva
- Naomi Fersht
- Narendra Reddy
- Natalie Canham
- Neil Dorward
- Niamh Martin
- Nicola N Zammitt
- Nicola Poplawski
- Nieman
- Nigel Glynn
- Nigel Mendoza
- Niki Karavitaki
- Niki Maartens
- Nina Musolino
- Noel Somasundaram
- Oriola
- Pamela Freda
- Patricia Gallego
- Patrick J Morrison
- Patrick Yap
- Paul Carroll
- Paul Dimitri
- Pedro Marques
- Peter Bates
- Peter Clayton
- Peter J Trainer
- Peter Pullan
- Peter Shane Hamblin
- Philip Harding
- Philip Yeoh
- Philippa Carter
- Philippe F Backeljauw
- Pierre Bouloux
- Pinaki Dutta
- Prakash Abraham
- Preda
- PĂ©ter Igaz
- Rajesh V Thakker
- Ramesh Nair
- Rasa Verkauskiene
- Richard J M Ross
- Richard N Clayton
- Richard Nelson
- Richard Quinton
- Richards
- Robert D Murray
- Robert Skelly
- Robertas Knispelis
- Roberto Salvatori
- Roger Brown
- Ronald M Lechan
- Rosalind Eeles
- Rostomyan
- Sachith Mettananda
- Salenave
- Scott A Akker
- Sema Yarman
- Serban Radian
- Shereen Ezzat
- Shozo Yamada
- Sian Ellard
- Silvia Modenesi
- Simon H Pearce
- Simon Howell
- Simon J Aylwin
- Simona Fica
- Siobhán E McQuaid
- Stefan Fischli
- Stephanie Baldeweg
- Stephen Gallacher
- Steve Ball
- Steve M Orme
- Steven Hunter
- Stylianos Tsagarakis
- Sujatha Jagadeesh
- Susan Stewart
- Susan Webb
- Svetozar Damjanovic
- Sándor Alföldi
- Taffy Makaya
- Takeo Iwata
- Tara Kearney
- Teng-Teng Chung
- Thakker
- Theodore Friedman
- Tichomirowa
- Tim Cheetham
- Trevor A Howlett
- Tristan Richardson
- Vaclav Hana
- Valerie Renals
- Vera Popovic
- Vierimaa
- Vladimir Vaks
- Warrick J Inder
- Wiebke Arlt
- William Drake
- William Foulkes
- Williams
- Winnie Ho
- Wu
- Publication venue
- 'The Endocrine Society'
- Publication date
- 01/06/2020
- Field of study
Context
Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).
Objective
To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.
Design
12-year prospective, observational study.
Participants & Setting
We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases.
Interventions & Outcome
AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310).
Results
Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650).
Conclusions
Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course
The Physiologic Effects of Pain on the Endocrine System
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- A Bateman
- A Grossman
- A Munck
- AG Mensah-Nyagan
- AM Aloisi
- AM Aloisi
- AM Aloisi
- BS McEwen
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- C Jorgensen
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- T Yoshihara
- TA Matoushek
- U Russell
- VG Kimonides
- W Mayo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Perinatal Distress in Women in Low- and Middle-Income Countries: Allostatic Load as a Framework to Examine the Effect of Perinatal Distress on Preterm Birth and Infant Health
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- 'Springer Science and Business Media LLC'
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- Field of study
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
- Henshall D.
- Hernandez F.
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- Heslop P.
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- Jaime F.
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- Jameson J.
- Janes K.
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- Jeebun V.
- Jeffery Katie
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- Jenkins P.
- Jennings F.
- Jennings V.
- Jerry D.
- Jimenez Gil A.
- Johal S.
- John A.
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- Johnstone E.
- Jones A.
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- Jordache R.
- Jose S.
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- Josiah B.
- Ju Wen Kwek A.
- Judge P.
- Juszczak Edmund
- Kailey A.
- Kalayi R.
- Kamath P.
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- Lipscomb G.
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- Liu P.
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- Lloyd A.
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- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
- Locke T.
- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
- Lomme K.
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- Mackay L.
- MacKenzie J.
- Mackey A.
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- Madeja N.
- Mafham Marion
- Magnaye L.
- Maharajh A.
- Mahaveer A.
- Mahdi H.
- Maheswaran A.
- Mahmood W.
- Mahmood Z.
- Mahony E.
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- Mair L.
- Majekdunmi T.
- Majumdar Jaydip
- Malein Flora
- Mancinelli R.
- Mandal S.
- Manderson L.
- Mandeville J.
- Mane T.
- Manso K.
- Mansour M.
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- Maren D.
- Margabanthu G.
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- Maria del Rocio F.
- Mariano V.
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- Marriott C.
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- Martin H.
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- Matovu E.
- Matthews C.
- May P.
- Mayanagao I.
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- McCorkindale A.
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- McEvoy E.
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- Mears K.
- Mediana A.
- Medine R.
- Meghani N.
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- Mehar A.
- Mehra R.
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- Melville A.
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- Mendonca C.
- Mentzer A.
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- Merron P.
- Metcalfe B.
- Metryka A.
- Mew L.
- Mguni N.
- Miah N.
- Micallef D.
- Michalak N.
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- Mitchelmore P.
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- Mohamed O.
- Mohammed O.
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- Montasser M.
- Montgomery Alan
- Moon A.
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- Morrow A.
- Moss S.
- Moth G.
- Motherwell N.
- Moulton H.
- Mounce G.
- Mtuwa S.
- Muazzam A.
- Mudawi D.
- Mulcahy M.
- Mulligan S.
- Mumford Andrew
- Munavvar Mohammed
- Munt S.
- Murphy S.
- Murray C.
- Murray D.
- Murray I.
- Murray K.
- Murray L.
- Murthy M.
- Mutch C.
- Muzengi N.
- Mwaura E.
- Nafei M.
- Nagarajan T.
- Naglik L.
- Naguib M.
- Naicker K.
- Naisbitt J.
- Nandani A.
- Nandwani T.
- Nasa S.
- Natarajan N.
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- Navarra H.
- Naveed S.
- Naz M.
- Neal A.
- Nelson B.
- Nelson S.
- Nethercott D.
- Newby D.
- Newman T.
- Newport R.
- Ng S.
- Ngumo A.
- Nicholas N.
- Nicholas P.
- Nickson I.
- Nicol R.
- Nightingale T.
- Nilsson A.
- Ninan P.
- Nirmalan M.
- Nixon J.
- Nizam Ud Din K.
- Noe H.
- Norton R.
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- Oliver A.
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- Oliver Z.
- Oomatia A.
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- Osadcow A.
- Osanlou R.
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- Osborne R.
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- Osei-Bobie J.
- Oxlade R.
- O’Brien R.
- O’Callaghan C.
- O’Connor G.
- O’Donovan C.
- O’Farrell S.
- O’Riordan D.
- O’Sullivan E.
- Padden G.
- Page I.
- Page S.
- Pagett K.
- Pajak S.
- Pakou G.
- Palacios A.
- Palfrey H.
- Pandya T.
- Panes A.
- Pantin C.
- Parambil V.
- Parashar S.
- Parekh A.
- Parekh D.
- Parker B.
- Parker J.
- Parker S.
- Parkinson A.
- Passby L.
- Passey S.
- Patachako J.
- Patel M.
- Patel P.
- Patel S.
- Patience A.
- Patten S.
- Patterson C.
- Patterson L.
- Pauls L.
- Paulus S.
- Payne B.
- Payne E.
- Payne R.
- Peacock L.
- Pearce J.
- Pearson K.
- Peasley A.
- Peggie H.
- Pelham C.
- Penman C.
- Penman J.
- Penman R.
- Percival R.
- Perez E.
- Periyasamy L.
- Perry A.
- Perry M.
- Pessoa-Amorim Guilherme
- Peters C.
- Peterson A.
- Peto Leon
- Petrova B.
- Pezard-Snell M.
- Phelan P.
- Philbin J.
- Phillips N.
- PI M.
- Pick S.
- Pickard J.
- Pickering G.
- Piercy C.
- Pinches H.
- Pine K.
- Pinjala M.
- Pitchford M.
- Pleass R.
- Plowright M.
- Plumptre C.
- Pomery F.
- Poole L.
- Porter D.
- Porter L.
- Potter A.
- Potts J.
- Poustie V.
- Power N.
- Poyner E.
- Pradhan V.
- Prady H.
- Prasath S.
- Pratt A.
- Pratt S.
- Preiss D.
- Prest C.
- Price A.
- Price C.
- Price D.
- Price K.
- Price L.
- Price V.
- Price-Eland R.
- Priest A.
- Prince C.
- Pringle S.
- Pristopan V.
- Priyash V.
- Prudon Benjamin
- Pugh L.
- Purdue C.
- Purdy R.
- Pursell M.
- Purvis S.
- Putensen D.
- Pyart E.
- Quek E.
- Quigley J.
- Quindoyos J.
- Quinn T.
- Rabinowicz S.
- Rafique J.
- Rahman M.
- Rai S.
- Raithatha A.
- Rajasri A.
- Ramanan A.
- Ramasamy M.
- Ramchandani A.
- Ramirez J.
- Rampling T.
- Ramsay J.
- Ramshaw A.
- Rana G.
- Rand J.
- Rank H.
- Rankhelawon R.
- Rasheed A.
- Ratcliffe S.
- Raw J.
- Razvi Z.
- RECOVERY Collaborative Group
- Redknap I.
- Redman N.
- Rees A.
- Rees M.
- Rees S.
- Rehman Z.
- Reilly M.
- Reith C.
- Renshaw S.
- Rey S.
- Reynard C.
- Reynolds H.
- Rhodes J.
- Rice E.
- Rice M.
- Rice N.
- Richardson E.
- Richardson N.
- Rigby L.
- Riley M.
- Riley P.
- Ripley D.
- Rishton C.
- Riste M.
- Ritchings A.
- Rivera Ortega P.
- Robbins E.
- Roberts V.
- Robertson C.
- Robertson J.
- Robertson N.
- Robinson J.
- Robinson L.
- Robinson S.
- Robson S.
- Roderick M.
- Rodger A.
- Rodgers A.
- Rodgers N.
- Rodgers P.
- Roehr C.
- Rogers J.
- Rogers S.
- Rogers T.
- Rook C.
- Rooney L.
- Rosby E.
- Rose A.
- Rose Z.
- Ross I.
- Rothman A.
- Rothwell J.
- Roughley L.
- Rowan Kathryn
- Rowan N.
- Rowe A.
- Rowe N.
- Rowley M.
- Rudenko A.
- Rule R.
- Rushmer J.
- Ryan A.
- Ryan L.
- Ryan P.
- Rybka E.
- Ryder S.
- Salberg A.
- Saleh M.
- Salih H.
- Salman R.
- Salmon R.
- Sam M.
- Sam S.
- Saminathan S.
- Sammons E.
- Sammut D.
- Sampson J.
- Samuel M.
- Samuel Y.
- Sanchez Gonzalez A.
- Sanchez V.
- Sandercock Peter
- Sangombe M.
- Sanju M.
- Santosh R.
- Sarfatti A.
- Sarkar R.
- Sarwar Z.
- Sathyanarayanan L.
- Saunderson A.
- Scaletta D.
- Scanlon D.
- Scarratt L.
- Scattergood S.
- Schadenberg A.
- Schafers J.
- Schneblen W.
- Schofield E.
- Schumacher N.
- Schunke N.
- Scobie A.
- Scoones T.
- Scott A.
- Scott C.
- Scullion A.
- Seaton I.
- Sedano J.
- Segovia M.
- Selby F.
- Sellers K.
- Sen N.
- Sengupta A.
- Sewdin T.
- Seymour J.
- Shah H.
- Shah R.
- Shah S.
- Shaibu A.
- Shanahan T.
- Sharaf H.
- Sharma B.
- Sharma O.
- Sharma S.
- Sharp L.
- Sharratt P.
- Shaw D.
- Shaw J.
- Shawcross A.
- Shea D. O.
- Sheffield J.
- Shehata Z.
- Shenton J.
- Shepherd A.
- Shepherd K.
- Shepherd L.
- Sheppeard R.
- Sheridan H.
- Sheridan R.
- Sherwin S.
- Shibly S.
- Shiham F.
- Shilladay C.
- Shillitoe B.
- Shioi C.
- Shirley K.
- Shurlock J.
- Shurmer Jack
- Siamia L.
- Siddle E.
- Sime R.
- Simpson A.
- Simpson D.
- Simpson J.
- Simpson M.
- Simpson P.
- Sinclair S.
- Singh C.
- Singh S.
- Singhal P.
- Sithiravel S.
- Sivanadarajah S.
- Skaria A.
- Skehan N.
- Skinner T.
- Skinner V.
- Skorko A.
- Slack A.
- Slade H.
- Small E.
- Smallridge A.
- Smart B.
- Smith C.
- Smith E.
- Smith H.
- Smith J.
- Smith L.
- Smith M.
- Smith N.
- Smith P.
- Smith R.
- Smith S.
- Smith T.
- Smith V.
- Snell D.
- Sobande T.
- Sobrino Diaz A.
- Solly R.
- Soni G.
- Soor P.
- Soothill G.
- Soren J.
- Spiller W.
- Spring O.
- Squires G.
- Squires J.
- Squires R.
- Srinivasan R.
- Stagg W.
- Stanton A.
- Staplin Natalie
- Starnes D.
- Steer J.
- Stefania V.
- Stefanowska P.
- Stephens A.
- Stephensen D.
- Stephenson E.
- Sterrenburg M.
- Stevens W.
- Stevenson A.
- Stevenson S.
- Steward M.
- Stewart C.
- Stewart K.
- Stewart Richard
- Stickley J.
- Stirrup S.
- Stock S.
- Stockdale A.
- Stone B.
- Stone S.
- Storey I.
- Stratton E.
- Stratton J.
- Stubbs A.
- Stuttard M.
- Subudhi C.
- Sugden P.
- Sukumaran A.
- Sundar S.
- Surtees M.
- Sutherland R.
- Sutherland S.
- Sutu M.
- Swanson-Low C.
- Swart T.
- Swift E.
- Swist-Szulik K.
- Sykes D.
- Sykes E.
- Symon D.
- Syndercombe A.
- T-Michael H.
- Tadros M.
- Tague L.
- Tahir H.
- Tait J.
- Talbot P.
- Tallent R.
- Tallon B.
- Tanney C.
- Tanton E.
- Taribagil P.
- Tarr E.
- Tasiou A.
- Tate A.
- Taylor C.
- Taylor J.
- Taylor K.
- Taylor L.
- Taylor R.
- Taylor-Siddons M.
- Teasdale F.
- Teasdale J.
- Teasdale K.
- Tebbutt J.
- Telfer A.
- Tempany J.
- Tereszkowski-Kaminski R.
- Tewkesbury D.
- Thake M.
- Thakker M.
- Thamu B.
- Thet P.
- Thomas A.
- Thomas E.
- Thomas K.
- Thomas R.
- Thomas S.
- Thompson E.
- Thompson J.
- Thompson K.
- Thompson R.
- Thornton D.
- Thornton J.
- Thornton S.
- Thorpe S.
- Thrasyvoulou L.
- Thraves H.
- Thu-Ta P.
- Thwaites Guy
- Tilbey S.
- Timerick J.
- Timmins A.
- Tinkler H.
- Tipper J.
- Tivenan H.
- Todd S.
- Tohfa M.
- Toohey C.
- Topham K.
- Topping M.
- Tousis R.
- Trevelyan M.
- Trewick N.
- Truell R.
- Tsakiridou K.
- Tsang C.
- Tucker S.
- Tufail A.
- Tuff J.
- Tully R.
- Turbitt K.
- Turgut T.
- Turner G.
- Turner K.
- Turner S.
- Turner-Bone I.
- Turney S.
- Tyer A.
- UK National Institute for Health Research Clinical Research Network (for the RECOVERY Collaborative Group)
- Ul Haq M.
- Ul Hassan W.
- Underwood C.
- Unsworth A.
- Uriel Alison
- Usher R.
- Ustianowski A.
- Vankayalapati P.
- Van’t Hoff W.
- Varghese M.
- Varnier G.
- Vasu V.
- Vatish M.
- Veerasamy S.
- Velankar S.
- Vella N.
- Velugupati A.
- Venables I.
- Venditti M.
- Veres M.
- Vergnano S.
- Vernall R.
- Verula J.
- Vethanayagam N.
- Vettikumaran S.
- Victoria S.
- Vinay S.
- Vincent O.
- Vincent R.
- Vyras E.
- Wade P.
- Waite A.
- Walden A.
- Walker I.
- Walker K.
- Walker S.
- Wallace G.
- Wallendszus K.
- Wallis G.
- Walsh D.
- Walters J.
- Walton E.
- Walton O.
- Wang N.
- Wang R.
- Wang S.
- Warburton S.
- Ward J.
- Ward L.
- Ward R.
- Wardle S.
- Warmington J.
- Warner C.
- Warran S.
- Warren R.
- Warren Y.
- Warris Adilia
- Wasson E.
- Waterfall H.
- Waters D.
- Watson A.
- Watson E.
- Watson J. G. R.
- Watson L.
- Watson R.
- Watterson D.
- Watts M.
- Waugh V.
- Wayman E.
- Weatherhead M.
- Webb C.
- Webster I.
- Weerakoon R.
- Weetman M.
- Wei S.
- Welch J.
- Welch S.
- Wels R.
- Welters I.
- Welton R.
- Wentworth L.
- West R.
- West S.
- Western L.
- Westhead R.
- Weston H.
- Wetherill B.
- White A.
- Whitehead C.
- Whitehouse A.
- Whitehouse T.
- Whiteley J.
- Whiteley S.
- Whittaker E.
- Whittle H.
- Whittle R.
- Wignall C.
- Wilcock D.
- Wilcock E.
- Wild S.
- Wilding L.
- Wilding P.
- Wildsmith T.
- Wiles J.
- Wilkins S.
- Wilkinson S.
- Wilkinson T.
- Williams A.
- Williams E.
- Williams J.
- Williams K.
- Williams M.
- Williams P.
- Williams S.
- Williams T.
- Williamson D.
- Williamson J.
- Willis E.
- Willis H.
- Willis J.
- Wilson B.
- Wilson K.
- Wilson L.
- Win K.
- Winder L.
- Winter H.
- Wishlade T.
- Witele E.
- Withers N.
- Wittes Janet
- Wong A.
- Wong C.
- Wong E.
- Wong N.
- Wood A.
- Wood C.
- Wood J.
- Wood L.
- Woodfield R.
- Woodford E.
- Woodford J.
- Woodhead L.
- Woodward Z.
- Wooldridge G.
- Woollen L.
- Wootton D.
- Worton S.
- Wren L.
- Wright F.
- Wright R.
- Wubetu J.
- Xavier B.
- Yaqoob N.
- Yasmin S.
- Yates Bryan
- Yates T.
- Yelnoorkar F.
- Yeoh A.
- Younes Ibrahim A.
- Young L.
- Yu C.
- Zaki K.
- Zammit-Mangion M.
- Zayed M.
- Zhu D.
- Zia M.
- Zitter L.
- Zuhra N.
- Zullo C.
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Oak canopy arthropod communities: which factors shape its structure?
- Author
- A Challenger
- A Feurdean
- A Floren
- A Floren
- A Floren
- A González-RodrĂguez
- A Hastings
- A Kause
- A LĂłpez-Caamal
- A Mitchell
- AA Agrawal
- AA Agrawal
- AA Agrawal
- AJ Hamilton
- AJ Tack
- AJ Tack
- AL Curtu
- AM Ellison
- AS Wymore
- AT Whittemore
- B Castagneyrol
- B Gunnarsson
- BJ Cooke
- BJ Kopper
- BO Poulsen
- C Glynn
- C Kremen
- CD Thomas
- CG Hochwender
- CG Jones
- CG Jones
- CJ Southwell
- CMP Ozanne
- CMP Ozanne
- CMP Ozanne
- CR Townsend
- CT Yarnes
- CT Yarnes
- D Burchsted
- D Cheng
- D Magri
- DH Janzen
- DJ Howard
- DL Wagner
- DR Strong
- DU Hooper
- DW Tallamy
- E Mäntylä
- E Siemann
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- E Tovar-Sánchez
- EfraĂn Tovar-Sánchez
- EI Hersch-Green
- EM Bernays
- EN Wold
- F Dziock
- G Hartvigsen
- GA Polis
- GC Parker
- GD Martinsen
- GM Crutsinger
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- H Kagata
- HB Rinker
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- HG Wang
- HS Dungey
- HT Ishii
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- M Auerbach
- M Begon
- M Frenzel
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- M Laitinen
- M Murakami
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- NM Nadkarni
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- P Feeny
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- SB Hill
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- SH Faeth
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- SR Leather
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- T Cornelissen
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- 'Springer Science and Business Media LLC'
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