Monopole Vacuum in Non-Abelian Theories

It is shown that, in the theory of interacting Yang -Mills fields and a Higgs field, there is a topological degeneracy of Bogomol'nyi-Prasad-Sommerfield (BPS) monopoles and that there arises, in this case, a chromoelectric monopole characterized by a new topological variable that describes transitions between topological states of the monopole in the Minkowski space (in just the same way as an instanton describes such transitions in the Euclidean space). The limit of an infinitely large mass of the Higgs field at a finite density of the BPS monopole is considered as a model of the stable vacuum in the pure Yang-Mills theory. It is shown that, in QCD, such a monopole vacuum may lead to a rising potential, a topological confinement and an additional mass of the $\eta_0$ meson. The relationship between the result obtained here for the generating functional of perturbation theory and Faddeev-Popov integral is discussed

Bogolyubov Quasiparticles in Constrained Systems

The paper is devoted to the formulation of quantum field theory for an early universe in General Relativity considered as the Dirac general constrained system. The main idea is the Hamiltonian reduction of the constrained system in terms of measurable quantities of the observational cosmology: the world proper time, cosmic scale factor, and the density of matter. We define " particles" as field variables in the holomorphic representation which diagonalize the measurable density. The Bogoliubov quasiparticles are determined by diagonalization of the equations of motion (but not only of the initial Hamiltonian) to get the set of integrals of motion (or conserved quantum numbers, in quantum theory). This approach is applied to describe particle creation in the models of the early universe where the Hubble parameter goes to infinity.Comment: 13 pages, Late

Pion Polarizability in the NJL model and Possibilities of its Experimental Studies in Coulomb Nuclear Scattering

The charge pion polarizability is calculated in the Nambu-Jona-Lasinio model, where the quark loops (in the mean field approximation) and the meson loops (in the $1/N_c$ approximation) are taken into account. We show that quark loop contribution dominates, because the meson loops strongly conceal each other. The sigma-pole contribution $(m^2_\sigma-t)^{-1}$ plays the main role and contains strong t-dependence of the effective pion polarizability at the region $|t|\geq 4M_\pi^2$. Possibilities of experimental test of this sigma-pole effect in the reaction of Coulomb Nuclear Scattering are estimated for the COMPASS experiment.Comment: 11 pages, 8 figure

Heavy--light mesons in a bilocal effective theory

Heavy--light mesons are described in an effective quark theory with a two--body vector--type interaction. The bilocal interaction is taken to be instantaneous in the rest frame of the bound state, but formulated covariantly through the use of a boost vector. The chiral symmetry of the light flavor is broken spontaneously at mean field level. The framework for our discussion of bound states is the effective bilocal meson action obtained by bosonization of the quark theory. Mesons are described by 3--dimensional wave functions satisfying Salpeter equations, which exhibit both Goldstone solutions in the chiral limit and heavy--quark symmetry for $m_Q\rightarrow\infty$. We present numerical solutions for pseudoscalar $D$-- and $B$--mesons. Heavy--light meson spectra and decay constants are seen to be sensitive to the description of chiral symmetry breaking (dynamically generated vs.\ constant quark mass).Comment: (34 p., standard LaTeX, 7 PostScript figures appended) UNITUE-THEP-17/9

Inertial mechanism: dynamical mass as a source of particle creation

A kinetic theory of vacuum particle creation under the action of an inertial mechanism is constructed within a nonpertrubative dynamical approach. At the semi-phenomenological level, the inertial mechanism corresponds to quantum field theory with a time-dependent mass. At the microscopic level, such a dependence may be caused by different reasons: The non-stationary Higgs mechanism, the influence of a mean field or condensate, the presence of the conformal multiplier in the scalar-tensor gravitation theory etc. In what follows, a kinetic theory in the collisionless approximation is developed for scalar, spinor and massive vector fields in the framework of the oscillator representation, which is an effective tool for transition to the quasiparticle description and for derivation of non-Markovian kinetic equations. Properties of these equations and relevant observables (particle number and energy densities, pressure) are studied. The developed theory is applied here to describe the vacuum matter creation in conformal cosmological models and discuss the problem of the observed number density of photons in the cosmic microwave background radiation. As other example, the self-consistent evolution of scalar fields with non-monotonic self-interaction potentials (the W-potential and Witten - Di Vecchia - Veneziano model) is considered. In particular, conditions for appearance of tachyonic modes and a problem of the relevant definition of a vacuum state are considered.Comment: 51 pages, 18 figures, submitted to PEPAN (JINR, Dubna); v2: added reference

Unconstrained Hamiltonian Formulation of SU(2) Gluodynamics

SU(2) Yang-Mills field theory is considered in the framework of the generalized Hamiltonian approach and the equivalent unconstrained system is obtained using the method of Hamiltonian reduction. A canonical transformation to a set of adapted coordinates is performed in terms of which the Abelianization of the Gauss law constraints reduces to an algebraic operation and the pure gauge degrees of freedom drop out from the Hamiltonian after projection onto the constraint shell. For the remaining gauge invariant fields two representations are introduced where the three fields which transform as scalars under spatial rotations are separated from the three rotational fields. An effective low energy nonlinear sigma model type Lagrangian is derived which out of the six physical fields involves only one of the three scalar fields and two rotational fields summarized in a unit vector. Its possible relation to the effective Lagrangian proposed recently by Faddeev and Niemi is discussed. Finally the unconstrained analog of the well-known nonnormalizable groundstate wave functional which solves the Schr\"odinger equation with zero energy is given and analysed in the strong coupling limit.Comment: 20 pages REVTEX, no figures; final version to appear in Phys. Rev. D; minor changes, notations simplifie

State sampling dependence of the Hopfield network inference

The fully connected Hopfield network is inferred based on observed magnetizations and pairwise correlations. We present the system in the glassy phase with low temperature and high memory load. We find that the inference error is very sensitive to the form of state sampling. When a single state is sampled to compute magnetizations and correlations, the inference error is almost indistinguishable irrespective of the sampled state. However, the error can be greatly reduced if the data is collected with state transitions. Our result holds for different disorder samples and accounts for the previously observed large fluctuations of inference error at low temperatures.Comment: 4 pages, 1 figure, further discussions added and relevant references adde

The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain

BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent the association of SMRT with BCL6, inhibit transcriptional repression and cause apoptosis of lymphoma cells in vitro and in vivo. In order to discover compounds, which have the potential to be developed into BCL6 inhibitors, we screened a natural product library. The ansamycin antibiotic, rifamycin SV, inhibited BCL6 transcriptional repression and NMR spectroscopy confirmed a direct interaction between rifamycin SV and BCL6. To further determine the characteristics of compounds binding to BCL6-POZ we analyzed four other members of this family and showed that rifabutin, bound most strongly. An X-ray crystal structure of the rifabutin-BCL6 complex revealed that rifabutin occupies a partly non-polar pocket making interactions with tyrosine58, asparagine21 and arginine24 of the BCL6-POZ domain. Importantly these residues are also important for the interaction of BLC6 with SMRT. This work demonstrates a unique approach to developing a structure activity relationship for a compound that will form the basis of a therapeutically useful BCL6 inhibitor