Вибір способу управлінських дій за вузькофункціональним вартісним критерієм в управлінні економічною безпекою підприємства

Метою дослідження є розробка логічної схеми вибору способу управлінських дій в управлінні економічною безпекою підприємства на основі поєднання ідеології ризик-менеджменту та вузькофункціонального підходу в управлінні економічною безпекою підприємства

Reflectivity and Microwave Absorption in Crystals with Alternating Intrinsic Josephson Junctions

We compute the frequency and magnetic field dependencies of the reflectivity $R(\omega)$ in layered superconductors with two alternating intrinsic Josephson junctions with different critical current densities and quasiparticle conductivities for the electric field polarized along the c-axis. The parameter $\alpha$ describing the electronic compressibility of the layers and the charge coupling of neighboring junctions was extracted for the SmLa$_{1-x}$Sr$_{x}$CuO$_{4-\delta}$ superconductor from two independent optical measurements, the fit of the loss function $L(\omega)$ at zero magnetic field and the magnetic field dependence of the peak positions in $L(\omega)$. The experiments are consistent with a free electron value for $\alpha$ near the Josephson plasma frequencies.Comment: 4 pages, 4 postscript figures, misprints in table correcte

Optical Properties of Crystals with Spatial Dispersion: Josephson Plasma Resonance in Layered Superconductors

We derive the transmission coefficient, $T(\omega)$, for grazing incidence of crystals with spatial dispersion accounting for the excitation of multiple modes with different wave vectors ${\bf k}$ for a given frequency $\omega$. The generalization of the Fresnel formulas contains the refraction indices of these modes as determined by the dielectric function $\epsilon(\omega,{\bf k})$. Near frequencies $\omega_e$, where the group velocity vanishes, $T(\omega)$ depends also on an additional parameter determined by the crystal microstructure. The transmission $T$ is significantly suppressed, if one of the excited modes is decaying into the crystal. We derive these features microscopically for the Josephson plasma resonance in layered superconductors.Comment: 4 pages, 2 figures, epl.cls style file, minor change

Quasiparticle and Cooper Pair Tunneling in the Vortex State of Bi-2212

From measurements of the c-axis I-V characteristics of intrinsic Josephson junctions in Bi_2Sr_2CaCu_2O_{8+delta} (Bi-2212) mesas we obtain the field dependence (H || c) of the quasiparticle (QP) conductivity, sigma_q(H,T), and of the Josephson critical current density, J_c(H,T). The quasiparticle conductivity sigma_q(H) increases sharply with H and reaches a plateau at 0.05 T <H< 0.3 T. We explain such behavior by the dual effect of supercurrents around vortices. First, they enhance the QP DOS, leading to an increase of sigma_q with H at low H and, second, they enhance the scattering rate for specular tunneling as pancakes become disordered along the c-axis at higher H, leading to a plateau at moderate H.Comment: 4 pages, 4 figure

Accumulation of driver and passenger mutations during tumor progression

Major efforts to sequence cancer genomes are now occurring throughout the world. Though the emerging data from these studies are illuminating, their reconciliation with epidemiologic and clinical observations poses a major challenge. In the current study, we provide a novel mathematical model that begins to address this challenge. We model tumors as a discrete time branching process that starts with a single driver mutation and proceeds as each new driver mutation leads to a slightly increased rate of clonal expansion. Using the model, we observe tremendous variation in the rate of tumor development - providing an understanding of the heterogeneity in tumor sizes and development times that have been observed by epidemiologists and clinicians. Furthermore, the model provides a simple formula for the number of driver mutations as a function of the total number of mutations in the tumor. Finally, when applied to recent experimental data, the model allows us to calculate, for the first time, the actual selective advantage provided by typical somatic mutations in human tumors in situ. This selective advantage is surprisingly small, 0.005 +- 0.0005, and has major implications for experimental cancer research

Thermographic imaging in sports and exercise medicine: A Delphi study and consensus statement on the measurement of human skin temperature

This is an accepted manuscript of an article published by Elsevier in Journal of Thermal Biology on 18/07/2017, available online: https://doi.org/10.1016/j.jtherbio.2017.07.006 The accepted version of the publication may differ from the final published version.© 2017 Elsevier Ltd The importance of using infrared thermography (IRT) to assess skin temperature (tsk) is increasing in clinical settings. Recently, its use has been increasing in sports and exercise medicine; however, no consensus guideline exists to address the methods for collecting data in such situations. The aim of this study was to develop a checklist for the collection of tsk using IRT in sports and exercise medicine. We carried out a Delphi study to set a checklist based on consensus agreement from leading experts in the field. Panelists (n  =  24) representing the areas of sport science (n = 8; 33%), physiology (n = 7; 29%), physiotherapy (n = 3; 13%) and medicine (n = 6; 25%), from 13 different countries completed the Delphi process. An initial list of 16 points was proposed which was rated and commented on by panelists in three rounds of anonymous surveys following a standard Delphi procedure. The panel reached consensus on 15 items which encompassed the participants’ demographic information, camera/room or environment setup and recording/analysis of tsk using IRT. The results of the Delphi produced the checklist entitled “Thermographic Imaging in Sports and Exercise Medicine (TISEM)” which is a proposal to standardize the collection and analysis of tsk data using IRT. It is intended that the TISEM can also be applied to evaluate bias in thermographic studies and to guide practitioners in the use of this technique.Published versio

Josephson Plasma Resonance in Tl2_2Ba2_2CaCu2_2O8_8 in a Magnetic Field Measured using THz Spectroscopy

We report the first measurements of the $c$-axis Josephson Plasma Resonance (JPR) in Tl$_2$Ba$_2$CaCu$_2$O$_8$ as a function of temperature with and without a $c$-axis magnetic field using terahertz time-domain spectroscopy in transmission. The JPR is sensitive to the alignment of pancake vortices along the $c$-axis, and is observed to decrease when applying a magnetic field as expected.Comment: 3 pages, 3 ps-figures (can also be obtained from [email protected]), to be published in Physica

The effect of an in-plane magnetic field on the interlayer transport of quasiparticles in layered superconductors

We consider the quasiparticle c-axis conductivity in highly anisotropic layered compounds in the presence of the magnetic field parallel to the layers. We show that at low temperatures the quasiparticle interlayer conductivity depends strongly on the orientation of the in-plane magnetic field if the excitation gap has nodes on the Fermi surface. Thus measurements of the angle-dependent c-axis (out-of-plane) magnetoresistance, as a function of the orientation of the magnetic field in the layers, provide information on the momentum dependence of the superconducting gap (or pseudogap) on the Fermi surface. Clean and highly anisotropic layered superconductors seem to be the best candidates for probing the existence and location of the nodes on the Fermi surface.Comment: 4 pages RevTeX, including 2 PostScript figures, to appear in Phys. Rev. Let

Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus

abstract: Surveillance of Barrett’s oesophagus allows us to study the evolutionary dynamics of a human neoplasm over time. Here we use multicolour fluorescence in situ hybridization on brush cytology specimens, from two time points with a median interval of 37 months in 195 non-dysplastic Barrett's patients, and a third time point in a subset of 90 patients at a median interval of 36 months, to study clonal evolution at single-cell resolution. Baseline genetic diversity predicts progression and remains in a stable dynamic equilibrium over time. Clonal expansions are rare, being detected once every 36.8 patient years, and growing at an average rate of 1.58 cm[superscript 2] (95% CI: 0.09–4.06) per year, often involving the p16 locus. This suggests a lack of strong clonal selection in Barrett’s and that the malignant potential of ‘benign’ Barrett’s lesions is predetermined, with important implications for surveillance programs.The final version of this article, as published in Nature Communications, can be viewed online at: https://www.nature.com/articles/ncomms1215

Interlayer Quasiparticle Transport in the Vortex State of Josephson Coupled Superconductors

We calculate the dependence of the interlayer quasiparticle conductivity, $\sigma_q$, in a Josephson coupled d-wave superconductor on the magnetic field B||c and the temperature T. We consider a clean superconductor with resonant impurity scattering and a dominant coherent interlayer tunneling. When pancake vortices in adjacent layers are weakly correlated at low T the conductivity increases sharply with B before reaching an extended region of slow linear growth, while at high T it initially decreases and then reaches the same linear regime. For correlated pancakes $\sigma_q$ increases much more strongly with the applied field.Comment: 4 pages, 3 figure