Statistics on clouds and their relation to thermodynamic conditions at Ny-Ålesund

The French–German Arctic research base AWIPEV (the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research – AWI – and the French Polar Institute Paul Emile Victor – PEV) at Ny-Ålesund, Svalbard, is a unique station for monitoring cloud-related processes in the Arctic. For the first time, data from a set of ground-based instruments at the AWIPEV observatory are analyzed to characterize the vertical structure of clouds. For this study, a 14-month dataset from Cloudnet combining observations from a ceilometer, a 94 GHz cloud radar, and a microwave radiometer is used. A total cloud occurrence of ∼81 %, with 44.8 % multilayer and 36 % single-layer clouds, was found. Among single-layer clouds the occurrence of liquid, ice, and mixed-phase clouds was 6.4 %, 9 %, and 20.6 %, respectively. It was found that more than 90 % of single-layer liquid and mixed-phase clouds have liquid water path (LWP) values lower than 100 and 200 g m−2, respectively. Mean values of ice water path (IWP) for ice and mixed-phase clouds were found to be 273 and 164 g m−2, respectively. The different types of single-layer clouds are also related to in-cloud temperature and the relative humidity under which they occur. Statistics based on observations are compared to ICOsahedral Non-hydrostatic (ICON) model output. Distinct differences in liquid-phase occurrence in observations and the model at different environmental temperatures lead to higher occurrence of pure ice clouds. A lower occurrence of mixed-phase clouds in the model at temperatures between −20 and −5 ∘C becomes evident. The analyzed dataset is useful for satellite validation and model evaluation

First-line fadrozole HCI (CGS 16949A) versus tamoxifen in postmenopausal women with advanced breast cancer: Prospective randomised trial of the Swiss Group for Clinical Cancer Research SAKK 20/88

Background: In a phase III randomized trial, we compared the effectiveness and tolerability of fadrozole (CGS 16949A), a non-steroidal aromatase inhibitor, to tamoxifen as first-line endocrine therapy in postmenopausal women with advanced breast cancer. Patients and methods: Two hundred twelve eligible patients were randomized to receive tamoxifen 20 mg daily, or fadrozole 1 mg twice daily orally until disease progression or the advent of undue toxicity. The treatments were to be discontinued upon disease progression. Results: Prognostic factors were well balanced between the treatment groups, except for sites of metastatic disease. Fadrozole-treated patients had significantly more visceral, especially liver, involvement and less bone-dominant disease. Response rates for fadrozole and tamoxifen were similar, 20% and 27% (95% Confidence Limits (CL): 13%-29% and 21%-35%), respectively. Time to treatment failure was longer in patients randomized to tamoxifen (8.5 months for tamoxifen vs. 6.1 months for fadrozole), but did not reach statistical significance after adjustment for prognostic factors (P=0.09). Fadrozole, for which a significantly lower percentage of clinically relevant toxic effects (WHO toxicity gradeij2) was recorded (27% vs. 13% respectively; P=0.009), was better tolerated than tamoxifen. Severe cardiovascular events including 3 fatalities were seen only in patients treated with tamoxifen. Eighty-two patients crossed over to tamoxifen and 66 patients to fadrozole. Crossover endocrine therapy led to response or stable disease in 64% of the patients. The overall survival times of the two treatment groups were similar. Conclusions: Fadrozole and tamoxifen showed similar efficacy as first-line treatments in postmenopausal patients with advanced breast cancer. Fadrozole was significantly better tolerated and may therefore be an appropriate alternative to tamoxifen, especially for patients predisposed to thromboembolic event

JOYCE: Jülich Observatory for cloud evolution

The Jülich Observatory for Cloud Evolution (JOYCE), located at Forschungszentrum Jülich in the most western part of Germany, is a recently established platform for cloud research. The main objective of JOYCE is to provide observations, which improve our understanding of the cloudy boundary layer in a midlatitude environment. Continuous and temporally highly resolved measurements that are specifically suited to characterize the diurnal cycle of water vapor, stability, and turbulence in the lower troposphere are performed with a special focus on atmosphere–surface interaction. In addition, instruments are set up to measure the micro- and macrophysical properties of clouds in detail and how they interact with different boundary layer processes and the large-scale synoptic situation. For this, JOYCE is equipped with an array of state-of-the-art active and passive remote sensing and in situ instruments, which are briefly described in this scientific overview. As an example, a 24-h time series of the evolution of a typical cumulus cloud-topped boundary layer is analyzed with respect to stability, turbulence, and cloud properties. Additionally, we present longer-term statistics, which can be used to elucidate the diurnal cycle of water vapor, drizzle formation through autoconversion, and warm versus cold rain precipitation formation. Both case studies and long-term observations are important for improving the representation of clouds in climate and numerical weather prediction models

Observing convective aggregation

Convective self-aggregation, the spontaneous organization of initially scattered convection into isolated convective clusters despite spatially homogeneous boundary conditions and forcing, was first recognized and studied in idealized numerical simulations. While there is a rich history of observational work on convective clustering and organization, there have been only a few studies that have analyzed observations to look specifically for processes related to self-aggregation in models. Here we review observational work in both of these categories and motivate the need for more of this work. We acknowledge that self-aggregation may appear to be far-removed from observed convective organization in terms of time scales, initial conditions, initiation processes, and mean state extremes, but we argue that these differences vary greatly across the diverse range of model simulations in the literature and that these comparisons are already offering important insights into real tropical phenomena. Some preliminary new findings are presented, including results showing that a self-aggregation simulation with square geometry has too broad a distribution of humidity and is too dry in the driest regions when compared with radiosonde records from Nauru, while an elongated channel simulation has realistic representations of atmospheric humidity and its variability. We discuss recent work increasing our understanding of how organized convection and climate change may interact, and how model discrepancies related to this question are prompting interest in observational comparisons. We also propose possible future directions for observational work related to convective aggregation, including novel satellite approaches and a ground-based observational network

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Atmospheric and Surface Processes, and Feedback Mechanisms Determining Arctic Amplification: A Review of First Results and Prospects of the (AC)3 Project

Mechanisms behind the phenomenon of Arctic amplification are widely discussed. To contribute to this debate, the (AC)3 project has been established in 2016. It comprises modeling and data analysis efforts as well as observational elements. The project has assembled a wealth of ground-based, airborne, ship-borne, and satellite data of physical, chemical, and meteorological properties of the Arctic atmosphere, cryosphere, and upper ocean that are available for the Arctic climate research community. Short-term changes and indications of long-term trends in Arctic climate parameters have been detected using existing and new data

SEM EBIC INVESTIGATIONS OF ZnO VARISTOR CERAMICS

Le courant induit (EBIC) obtenu sur des varistances à base d'oxyde de zinc est étudié au microscope électronique à balayage (SEM). On trouve que seuls des joints de grains particuliers produisent un signal EBIC et que l'intensité du signal enregistré sur une ligne, présente une forte variation avec la polarisation appliquée. Les résultats des expériences sont discutés en terme d'émission Schottky des porteurs majoritaires sur la barrière de potentiel des joints de grains.The electron beam induced conductivity (EBIC) of zinc oxide varistor ceramics is studied in the scanning electron microscope (SEM). It is found that only particular grain boundaries give rise to an EBIC signal and that the signal strength and its linescan profile show strong variation with bias voltage. The experimental results are discussed in terms of Schottky emission of majority carriers across the grain boundary potential barrier