839 research outputs found

    Addressing Dynamism in E-negotiations by Workflow Management Systems

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    Workflows (Wfs) are a major enabling technology for e-commerce. In our research, a Combined Negotiation (CN) is modeled and enacted using Wf technology. The modeling task captures the sequencing of the individual negotiations as well as the dependencies between them, and the enacting task runs the model. A CN support system (CONSENSUS) is used by the user to perform both tasks. Supporting dynamic modifications to the model during run-time should increase the benefits of our approach. In this paper, we highlight the need for such support by identifying the dynamic aspects that can occur while negotiating the different items of a package (i.e., the CN object). To address these aspects, we experimented using ADEPT, a Wf Management System supporting dynamism. This leads us to discuss the Wf Reference Model of the Wf Management Coalition, and suggest a "dynamic" extension to the current functional areas and architecture. La technologie des Workflows (Wfs) s'est avérée importante pour le commerce électronique. Dans le cadre de notre recherche, une négociation combinée (CN) est modélisée et exécutée utilisant un Wf. La phase de modélisation capture la séquence des différentes négociations ainsi que les dépendances qui existent entre elles. La phase d'exécution quant à elle, permet comme son nom l'indique, d'exécuter le modÚle. Un systÚme de support pour les CN (CONSENSUS) est utilisé pour accomplir ces deux tùches. Supporter les modifications dynamiques du modÚle lors de l'exécution devrait augmenter les bénéfices de notre approche. Dans cet article, nous mettons l'emphase sur le besoin d'un tel support, ceci en identifiant les aspects dynamiques qui peuvent apparaßtre lors de la négociation des différents items d'un package (i.e., l'objet de la CN). Nous utilisons ADEPT - un systÚme de gestion de Wf qui supporte le dynamisme - pour étudier ces aspects. Ceci nous mÚne à discuter le modÚle de référence de la Wf Management Coalition, et à proposer une extension "dynamique" à l'architecture actuelle.e-Negotiations, Sourcing, Workflows, Workflow management systems, Dynamism, Négociations électroniques, Approvisionnement, Workflows, SystÚmes de gestion de Workflow, Dynamisme

    Schoenus nigricans (Cyperaceae) xerophytic grasslands on the NE Adriatic islands Cres and Krk (Croatia)

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    Several xerophytic grasslands on the NE Adriatic islands Cres and Krk (Croatia) are dominated by tussock-forming Schoenus nigricans (Cyperaceae). All vegetation types reported are characterised by the degradation of the vegetation cover due to grazing. Phytosociologically, the vegetation is classified as the Danthonio-Scorzoneretum villosae subass. schoenetosum nigricantis H-i} 57 of the Scorzonerion villosae H-i} 49 alliance within the order Scorzonero-Chrysopogonetalia, but partly shows transitions to the Bromo-Chrysopogonetum grylli H-i} 60.We differentiated three variants: more xerophytic sites (on Cres), sites characterised by alternating soil humidity (mainly on Krk), and advanced succession stages. Physiognomically all variants are dominated by Schoenus nigricans tussocks, which are fostered by sheep grazing and the summer-dry conditions on the compacted soils. Comparison with Central European more humid habitats suggests the hypothesis of an ecotypic differentiation of Schoenus nigricans within its European distribution area

    13-Desmethyl Rhodopsin and 13-Desmethyl Isorhodopsin: Visual Pigment Analogues

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    ANANALYTICAL STUDY OF MARBLE CONSOLIDATION BY OXALATE PRECIPITATION USING DENSITY, FTIR AND POWDER-XRD MEASUREMENTS

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    oai:ojs2.www.jepm.rs.ba:article/28Our recent study on consolidation of marble samples with the purpose of culture heritage protection occurred by periodical calcium oxalate precipitation on top of quasi parallelepipedic samples. The overall process consisting of three stages of treatment, starting with 5 % calcium acetate solution for 60 minutes at 20°C, a draining step at 70°C for 30 min, followed by a treatment with 5 % ammonium sulfate solution, it followed with the third stage which includes the treatment with 5% ammonium oxalate solution revealed a continuous density increace, determined using ethanol. As the natural samples had an initial density of 2.5871 g/cm3 , it increased up to 2.6980 g/cm3 for 50 times treatments. The precipitation of oxalate on top of calcium carbonate substrate, in form of calcite, revealed two distinguished infra-red bands, at 1316 cm-1 and 1624 cm-1 unsymmetrically located around the carbonate one at 1426 cm-1 .The intensity of the bands was proportional to the number of treatments. The continuous surface coverage investigated in parallel by powder XRD evidenced the presence of whewellite crystallites deposited on top of calcite, and their intensity increasing as well with the number of treatments. This method exhibits a reliable oxalate coverage of marble sample surfaces which doesn’t influence considerably their water solubility

    Evaluation of changes in microbial populations on beef carcasses resulting from steam pasteurization

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    The steam pasteurization process (SPS 400) developed by Frigoscandia Food Process Systems (Bellevue, WA) was effective in reducing bacterial populations in both laboratory and commercial settings. The objective of steam pasteurization and other meat decontamination measures is to extend product shelf life and improve safety by inhibiting or inactivating pathogens, while at the same time maintaining acceptable meat quality characteristics. The effects of steam pasteurization on beef carcass bacterial populations were evaluated at two large commercial beef processing facilities. A shelf-life study also was conducted to determine the microbial profiles of vacuum packaged beef loins from pasteurized and non-pasteurized carcasses. Steam pasteurization greatly reduced total beef carcass bacterial populations and was most effective in reducing gram negative organisms, including potential enteric pathogens of fecal origin. Thus, the relative percentage of gram positive microflora on beef carcass surfaces, especially Bacillus spp. and Staphylococcus spp., increased

    Phosphatidylinositol 3-kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of monospores from the marine red alga Porphyra yezoensis

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    The polarized distribution of F-actin is important in providing the driving force for directional migration in mammalian leukocytes and Dictyostelium cells, in which compartmentation of phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol phosphatase is critical for the establishment of cell polarity. Since monospores from the red alga Porphyra yezoensis are a real example of migrating plant cells, the involvement of the cytoskeleton and PI3K was investigated during their early development. Our results indicate that the asymmetrical localization of F-actin at the leading edge is fixed by the establishment of the anterior–posterior axis in migrating monospores, which is PI3K-dependent and protein synthesis-independent. After migration, monospores adhere to the substratum and then become upright, developing into multicellular thalli via the establishment of the apical–basal axis. In this process, F-actin usually accumulates at the bottom of the basal cell and development after migration requires new protein synthesis. These findings suggest that the establishment of anterior–posterior and apical–basal axes are differentially regulated during the early development of monospores. Our results also indicate that PI3K-dependent F-actin asymmetry is evolutionally conserved in relation to the establishment of cell polarity in migrating eukaryotic cells

    In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma

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    CXCR4 is a G-protein-coupled receptor that mediates recruitment of blood cells toward its ligand SDF-1. In cancer, high CXCR4 expression is frequently associated with tumor dissemination and poor prognosis. We evaluated the novel CXCR4 probe [(68)Ga]Pentixafor for in vivo mapping of CXCR4 expression density in mice xenografted with human CXCR4-positive MM cell lines and patients with advanced MM by means of positron emission tomography (PET). [(68)Ga]Pentixafor PET provided images with excellent specificity and contrast. In 10 of 14 patients with advanced MM [(68)Ga]Pentixafor PET/CT scans revealed MM manifestations, whereas only nine of 14 standard [(18)F]fluorodeoxyglucose PET/CT scans were rated visually positive. Assessment of blood counts and standard CD34(+) flow cytometry did not reveal significant blood count changes associated with tracer application. Based on these highly encouraging data on clinical PET imaging of CXCR4 expression in a cohort of MM patients, we conclude that [(68)Ga]Pentixafor PET opens a broad field for clinical investigations on CXCR4 expression and for CXCR4-directed therapeutic approaches in MM and other diseases

    Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis

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    It is well documented that ageing alters many aspects of immune responses; however, a causal relation between impaired immune functions in ageing individuals and the response to infection has not been established. Experimental leishmaniasis is an excellent model to analyse protective and pathological immune responses. Leishmania parasites are obligate intracellular pathogens and invade mainly macrophages, which have dual function: they can kill the parasites or promote their growth. We have recently shown that arginase, an enzyme induced in infected macrophages, is a key factor for parasite survival. Here, we show that ageing reduces the expression levels of arginase in macrophages, resulting in more efficient control of parasite growth. Our results suggest that age-related differences in the metabolism of arginase in macrophages might contribute to the higher susceptibility of children to leishmaniasis

    Towards analytical typologies of plot systems: quantitative profile of five European cities

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    The importance of the plot (also referred to as ‘property’) as one of the fundamental elements of urban form is well recognized within the field of urban morphology. Despite the fact that it is often described as the basic element in the pattern of land divisions, which are essential as organizational frameworks for urban form, studies offering comprehensive descriptions and classifications of plot systems are quite scant. The aim of the paper is to introduce a classification of plot systems into typologies based on five European cities, in order to distinguish particular spatial differences and similarities in terms of their plot structure. The proposed typologies are developed using unsupervised k-means cluster analysis based on numeric attributes derived from central theories in urban morphology. The introduced typologies are essentially configurational, allowing collective systematic properties of plot systems to be captured. Numeric attributes include plot differentiation (or plot size), plot frontage and compactness ratio, corresponding to essential qualities of plot systems such as the capacity to carry differences in space, the ability to operate as interface between street and building and providing a framework for evolution of built form over time. All three attributes are translated into configurational measures in order to capture the context of the plot system, rather than the parameters of individual plots. The combination of these deductively defined variables with algorithmically defined classification methods results in seven plot types that can be used to scale up traditional urban morphological analysis to whole city regions and conduct substantial comparison of patterns within, but also between these regions. Further, it also makes it possible to describe commonly recognized plot patterns and discover new ones

    Local Increase of Arginase Activity in Lesions of Patients with Cutaneous Leishmaniasis in Ethiopia

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    The leishmaniases are a complex of diseases caused by Leishmania parasites. Currently, the diseases affect an estimated 12 million people in 88 countries, and approximately 350 million more people are at risk. The leishmaniases belong to the most neglected tropical diseases, affecting the poorest populations, for whom access to diagnosis and effective treatment are often not available. Leishmania parasites infect cells of the immune system called macrophages, which have the capacity to eliminate the intracellular parasites when they receive the appropriate signals from other cells of the immune system. In nonhealing persistent leishmaniasis, lymphocytes are unable to transmit the signals to macrophages required to kill the intracellular parasites. The local upregulation of the enzyme arginase has been shown to impair lymphocyte effector functions at the site of pathology. In this study, we tested the activity of this enzyme in skin lesions of patients presenting with localized cutaneous leishmaniasis. Our results show that arginase is highly upregulated in these lesions. This increase in arginase activity coincides with lower expression of a signalling molecule in lymphocytes, which is essential for efficient activation of these cells. These results suggest that increased arginase expression in the localized cutaneous lesions might contribute to persistent disease in patients presenting with cutaneous leishmaniasis
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