Chemistry of 2,4-Dioxothiazolidine. II. Ammonolysis of 2,4 Dioxothiazolidine and its Derivatives

It is found that the ammonolysis of 2,4-dioxothiazolidine gives 5-amino-2,3-dithiacaprohydroxamic·· add, while 3-plienyl-2,4-dioxothiazolidine is transformed in glycolic acid N-(2-amino-1-hydroxyethyl)- anilide. The product of ammonolysis of 3-(3-4-dichlorophenyl)- 2,4-dioxothiazolidine proved to be 3,4-dichlorophenylcarbamid

Hexaaqua­magnesium(II) bis­(d-camphor-10-sulfonate)

The structure of the title complex, [Mg(H2O)6](C10H15O4S)2, consists of regular octa­hedral [Mg(H2O)6]2+ cations and d-camphor-10-sulfonate anions. A three-dimensional supra­molecular architecture is formed via hydrogen-bond inter­actions [O—H⋯O = 2.723 (2)–2.833 (2) Å] to give alternating layers of [Mg(H2O)6]2+ cations and d-camphor-10-sulfonate anions. The title compound is isomorphous with the zinc, copper, cadmium and nickel analogues

Supplementary data for article: Čobeljić, B.; Pevec, A.; Turel, I.; Swart, M.; Mitić, D.; Milenković, M.; Marković, I.; Jovanović, M.; Sladić, D.; Jeremić, M.; et al. Synthesis, Characterization, DFT Calculations and Biological Activity of Derivatives of 3-Acetylpyridine and the Zinc(II) Complex with the Condensation Product of 3-Acetylpyridine and Semicarbazide. Inorganica Chimica Acta 2013, 404, 5–12. https://doi.org/10.1016/j.ica.2013.04.017

Supplementary material for: [https://doi.org/10.1016/j.ica.2013.04.017]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1367]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3539

Supplementary data for article: Čobeljić, B.; Pevec, A.; Turel, I.; Swart, M.; Mitić, D.; Milenković, M.; Marković, I.; Jovanović, M.; Sladić, D.; Jeremić, M.; et al. Synthesis, Characterization, DFT Calculations and Biological Activity of Derivatives of 3-Acetylpyridine and the Zinc(II) Complex with the Condensation Product of 3-Acetylpyridine and Semicarbazide. Inorganica Chimica Acta 2013, 404, 5–12. https://doi.org/10.1016/j.ica.2013.04.017

Supplementary material for: [https://doi.org/10.1016/j.ica.2013.04.017]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1367]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3539

Diagnostic challenge for ovarian malignant melanoma in premenopausal women: Primary or metastatic?

<p>Abstract</p> <p>Background</p> <p>In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer.</p> <p>Case report</p> <p>A 45-year-old premenopausal woman was incidentally found to have an abdominal mass, 3 years after removal of a cutaneous melanoma lesion. Ultrasound and CT scan revealed left two solid masses, which were found to be an ovarian tumor at laparotomy. Left oophorectomy was performed. Histopathology and immunohistochemistry showed melanoma metastasis to the ovary. Nine months later, the patient developed epilepsy and confusion. Magnetic Resonance Imaging showed unique Wright frontal lobe lesion. She underwent stereotactic radio surgery and dacarbazine monotherapy. For months later, the patient is died from disseminate disease progression.</p> <p>Conclusion</p> <p>Ovarian metastasis is an unusual presentation of cutaneous melanoma and the prognosis was dismal. As illustrated by this case report, a differential diagnosis of a metastatic malignant melanoma must be considered.</p

A review of clinical trials of cetuximab combined with radiotherapy for non-small cell lung cancer

Treatment of non-small cell lung cancer (NSCLC) is challenging in many ways. One of the problems is disappointing local control rates in larger volume disease. Moreover, the likelihood of both nodal and distant spread increases with primary tumour (T-) stage. Many patients are elderly and have considerable comorbidity. Therefore, aggressive combined modality treatment might be contraindicated or poorly tolerated. In many cases with larger tumour volume, sufficiently high radiation doses can not be administered because the tolerance of surrounding normal tissues must be respected. Under such circumstances, simultaneous administration of radiosensitizing agents, which increase tumour cell kill, might improve the therapeutic ratio. If such agents have a favourable toxicity profile, even elderly patients might tolerate concomitant treatment. Based on sound preclinical evidence, several relatively small studies have examined radiotherapy (RT) with cetuximab in stage III NSCLC. Three different strategies were pursued: 1) RT plus cetuximab (2 studies), 2) induction chemotherapy followed by RT plus cetuximab (2 studies) and 3) concomitant RT and chemotherapy plus cetuximab (2 studies). Radiation doses were limited to 60-70 Gy. As a result of study design, in particular lack of randomised comparison between cetuximab and no cetuximab, the efficacy results are difficult to interpret. However, strategy 1) and 3) appear more promising than induction chemotherapy followed by RT and cetuximab. Toxicity and adverse events were more common when concomitant chemotherapy was given. Nevertheless, combined treatment appears feasible. The role of consolidation cetuximab after RT is uncertain. A large randomised phase III study of combined RT, chemotherapy and cetuximab has been initiated

Stable population structure in Europe since the Iron Age, despite high mobility

Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000–3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.g. Armenia and France). We found that most regions show remarkable inter-individual heterogeneity. At least 7% of historical individuals carry ancestry uncommon in the region where they were sampled, some indicating cross-Mediterranean contacts. Despite this high level of mobility, overall population structure across western Eurasia is relatively stable through the historical period up to the present, mirroring geography. We show that, under standard population genetics models with local panmixia, the observed level of dispersal would lead to a collapse of population structure. Persistent population structure thus suggests a lower effective migration rate than indicated by the observed dispersal. We hypothesize that this phenomenon can be explained by extensive transient dispersal arising from drastically improved transportation networks and the Roman Empire’s mobilization of people for trade, labor, and military. This work highlights the utility of ancient DNA in elucidating finer scale human population dynamics in recent history

Session 17 Ecophysiology

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Discretization effects in the finite element simulation of seismic waves in elastic and elastic-plastic media

Presented here is a numerical investigation that (re-)appraises standard rules for space/time discretization in seismic wave propagation analyses. Although the issue is almost off the table of research, situations are often encountered where (established) discretization criteria are not observed and inaccurate results possibly obtained. In particular, a detailed analysis of discretization criteria is carried out for wave propagation through elastic and elastic-plastic media. The establishment of such criteria is especially important when accurate prediction of high-frequency motion is needed and/or in the presence of highly non-linear material models. Current discretization rules for wave problems in solids are critically assessed as a conditio sine qua non for improving verification/validation procedures in applied seismology and earthquake engineering. For this purpose, the propagation of shear waves through a 1D stack of 3D finite elements is considered, including the use of wide-band input motions in combination with both linear elastic and non-linear elastic-plastic material models. The blind use of usual rules of thumb is shown to be sometimes debatable, and an effort is made to provide improved discretization criteria. Possible pitfalls of wave simulations are pointed out by highlighting the dependence of discretization effects on time duration, spatial location, material model and specific output variable considered