NGC 6819: testing the asteroseismic mass scale, mass loss, and evidence for products of non-standard evolution

We present an extensive peakbagging effort on Kepler data of $\sim$50 red giant stars in the open star cluster NGC 6819. By employing sophisticated pre-processing of the time series and Markov Chain Monte Carlo techniques we extracted individual frequencies, heights and linewidths for hundreds of oscillation modes. We show that the "average" asteroseismic parameter $\delta\nu_{02}$, derived from these, can be used to distinguish the stellar evolutionary state between the red giant branch (RGB) stars and red clump (RC) stars. Masses and radii are estimated using asteroseismic scaling relations, both empirically corrected to obtain self-consistency as well as agreement with independent measures of distance, and using updated theoretical corrections. Remarkable agreement is found, allowing the evolutionary state of the giants to be determined exclusively from the empirical correction to the scaling relations. We find a mean mass of the RGB stars and RC stars in NGC 6819 to be $1.61\pm0.02\,\textrm{M}_\odot$ and $1.64{\pm}0.02\,\textrm{M}_\odot$, respectively. The difference $\Delta M=-0.03\pm0.01\,\textrm{M}_\odot$ is almost insensitive to systematics, suggesting very little RGB mass loss, if any. Stars that are outliers relative to the ensemble reveal overmassive members that likely evolved via mass-transfer in a blue straggler phase. We suggest that KIC 4937011, a low-mass Li-rich giant, is a cluster member in the RC phase that experienced very high mass-loss during its evolution. Such over- and undermassive stars need to be considered when studying field giants, since the true age of such stars cannot be known and there is currently no way to distinguish them from normal stars.Comment: 21 pages, 11 figure

Soluble CD36-a marker of the (pathophysiological) role of CD36 in the metabolic syndrome?

CD36 is a class B scavenger receptor observed in many cell types and tissues throughout the body. Recent literature has implicated CD36 in the pathogenesis of metabolic dysregulation such as found in obesity, insulin resistance, and atherosclerosis. Genetic variation at the CD36 loci have been associated with obesity and lipid components of the metabolic syndrome, with risk of heart disease and type 2 diabetes. Recently, non-cell bound CD36 was identified in human plasma and was termed soluble CD36 (sCD36). In this review we will describe the functions of CD36 in tissues and address the role of sCD36 in the context of the metabolic syndrome. We will also highlight recent findings from human genetic studies looking at the CD36 locus in relation to metabolic profile in the general population. Finally, we present a model in which insulin resistance, oxLDL, low-grade inflammation and liver steatosis may contribute to elevated levels of sCD36

Oscillation mode linewidths and heights of 23 main-sequence stars observed by Kepler

Solar-like oscillations have been observed by Kepler and CoRoT in many solar-type stars, thereby providing a way to probe the stars using asteroseismology. We provide the mode linewidths and mode heights of the oscillations of various stars as a function of frequency and of effective temperature. We used a time series of nearly two years of data for each star. The 23 stars observed belong to the simple or F-like category. The power spectra of the 23 main-sequence stars were analysed using both maximum likelihood estimators and Bayesian estimators, providing individual mode characteristics such as frequencies, linewidths, and mode heights. We study the source of systematic errors in the mode linewidths and mode heights, and we present a way to correct these errors with respect to a common reference fit. Using the correction, we could explain all sources of systematic errors, which could be reduced to less than $\pm$15% for mode linewidths and heights, and less than $\pm$5% for amplitude, when compared to the reference fit. The effect of a different estimated stellar background and a different estimated splitting will provide frequency-dependent systematic errors that might affect the comparison with theoretical mode linewidth and mode height, therefore affecting the understanding of the physical nature of these parameters. All other sources of relative systematic errors are less dependent upon frequency. We also provide the dependence of the so-called linewidth dip, in the middle of the observed frequency range, as a function of effective temperature. We show that the depth of the dip decreases with increasing effective temperature. The dependence of the dip on effective temperature may imply that the mixing length parameter $\alpha$ or the convective flux may increase with effective temperature.Comment: Accepted by A&A, 38 pages, 35 figures, 26 table

Plasma CD36 and Incident Diabetes:A Case-Cohort Study in Danish Men and Women

BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.METHODS: We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).RESULTS: Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.CONCLUSION: Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.</p

A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve.

AimsThe mechanistic basis of the symptoms and signs of myocardial ischaemia in patients without obstructive coronary artery disease (CAD) and evidence of coronary microvascular dysfunction (CMD) is unclear. The aim of this study was to mechanistically test short-term late sodium current inhibition (ranolazine) in such subjects on angina, myocardial perfusion reserve index, and diastolic filling.Materials and resultsRandomized, double-blind, placebo-controlled, crossover, mechanistic trial in subjects with evidence of CMD [invasive coronary reactivity testing or non-invasive cardiac magnetic resonance imaging myocardial perfusion reserve index (MPRI)]. Short-term oral ranolazine 500-1000 mg twice daily for 2 weeks vs. placebo. Angina measured by Seattle Angina Questionnaire (SAQ) and SAQ-7 (co-primaries), diary angina (secondary), stress MPRI, diastolic filling, quality of life (QoL). Of 128 (96% women) subjects, no treatment differences in the outcomes were observed. Peak heart rate was lower during pharmacological stress during ranolazine (-3.55 b.p.m., P &lt; 0.001). The change in SAQ-7 directly correlated with the change in MPRI (correlation 0.25, P = 0.005). The change in MPRI predicted the change in SAQ QoL, adjusted for body mass index (BMI), prior myocardial infarction, and site (P = 0.0032). Low coronary flow reserve (CFR &lt;2.5) subjects improved MPRI (P &lt; 0.0137), SAQ angina frequency (P = 0.027), and SAQ-7 (P = 0.041).ConclusionsIn this mechanistic trial among symptomatic subjects, no obstructive CAD, short-term late sodium current inhibition was not generally effective for SAQ angina. Angina and myocardial perfusion reserve changes were related, supporting the notion that strategies to improve ischaemia should be tested in these subjects.Trial registrationclinicaltrials.gov Identifier: NCT01342029

Detection of solar-like oscillations in relics of the Milky Way: asteroseismology of K giants in M4 using data from the NASA K2 mission

Asteroseismic constraints on K giants make it possible to infer radii, masses and ages of tens of thousands of field stars. Tests against independent estimates of these properties are however scarce, especially in the metal-poor regime. Here, we report the detection of solar-like oscillations in 8 stars belonging to the red-giant branch and red-horizontal branch of the globular cluster M4. The detections were made in photometric observations from the K2 Mission during its Campaign 2. Making use of independent constraints on the distance, we estimate masses of the 8 stars by utilising different combinations of seismic and non-seismic inputs. When introducing a correction to the Delta nu scaling relation as suggested by stellar models, for RGB stars we find excellent agreement with the expected masses from isochrone fitting, and with a distance modulus derived using independent methods. The offset with respect to independent masses is lower, or comparable with, the uncertainties on the average RGB mass (4-10%, depending on the combination of constraints used). Our results lend confidence to asteroseismic masses in the metal poor regime. We note that a larger sample will be needed to allow more stringent tests to be made of systematic uncertainties in all the observables (both seismic and non-seismic), and to explore the properties of RHB stars, and of different populations in the cluster.Comment: 6 pages, 3 figures, accepted for publication in MNRA

Planarian regeneration: achievements and future directions after 20 years of research.

Planarians can undergo dramatic changes in body size and regenerate their entire body plan from small pieces after cutting. This remarkable morphological plasticity has made them an excellent model in which to analyze phenomena such as morphogenesis, restoration of pattern and polarity, control of tissue proportions and tissue homeostasis. They have a unique population of pluripotent stem cells in the adult that can give rise to all differentiated cell types, including the germ cells. These cellular characteristics provide an excellent opportunity to study the mechanisms involved in the maintenance and differentiation of cell populations in intact and regenerating animals. Until recently, the planarian model system lacked opportunities for genetic analysis; however, this handicap was overcome in the last decade through the development of new molecular methods which have been successfully applied to planarians. These techniques have allowed analysis of the temporal and spatial expression of genes, as well as interference with gene function, generating the first phenotypes by loss or gain of function. Finally, the sequencing of the planarian genome has provided the essential tools for an in-depth analysis of the genomic regulation of this model system. In this review, we provide an overview of planarians as a model system for research into development and regeneration and describe new lines of investigation in this area

Oscillation mode frequencies of 61 main sequence and subgiant stars observed by Kepler

Solar-like oscillations have been observed by Kepler and CoRoT in several solar-type stars, thereby providing a way to probe the stars using asteroseismology. We provide the mode frequencies of the oscillations of various stars required to perform a comparison with those obtained from stellar modelling. We used a time series of nine months of data for each star. The 61 stars observed were categorised in three groups: simple, F-like and mixed-mode. The simple group includes stars for which the identification of the mode degree is obvious. The F-like group includes stars for which the identification of the degree is ambiguous. The mixed-mode group includes evolved stars for which the modes do not follow the asymptotic relation of low-degree frequencies. Following this categorisation, the power spectra of the 61 main sequence and subgiant stars were analysed using both maximum likelihood estimators and Bayesian estimators, providing individual mode characteristics such as frequencies, linewidths, and mode heights. We developed and describe a methodology for extracting a single set of mode frequencies from multiple sets derived by different methods and individual scientists. We report on how one can assess the quality of the fitted parameters using the likelihood ratio test and the posterior probabilities. We provide the mode frequencies of 61 stars (with their 1-sigma error bars), as well as their associated echelle diagrams.Comment: 83 pages, 17 figures, 61 tables, paper accepted by Astronomy and Astrophysic

Atmospheric parameters of 82 red giants in the Kepler field

Context: Accurate fundamental parameters of stars are essential for the asteroseismic analysis of data from the NASA Kepler mission. Aims: We aim at determining accurate atmospheric parameters and the abundance pattern for a sample of 82 red giants that are targets for the Kepler mission. Methods: We have used high-resolution, high signal-to-noise spectra from three different spectrographs. We used the iterative spectral synthesis method VWA to derive the fundamental parameters from carefully selected high-quality iron lines. After determination of the fundamental parameters, abundances of 13 elements were measured using equivalent widths of the spectral lines. Results: We identify discrepancies in log g and [Fe/H], compared to the parameters based on photometric indices in the Kepler Input Catalogue (larger than 2.0 dex for log g and [Fe/H] for individual stars). The Teff found from spectroscopy and photometry shows good agreement within the uncertainties. We find good agreement between the spectroscopic log g and the log g derived from asteroseismology. Also, we see indications of a potential metallicity effect on the stellar oscillations. Conclusions: We have determined the fundamental parameters and element abundances of 82 red giants. The large discrepancies between the spectroscopic log g and [Fe/H] and values in the Kepler Input Catalogue emphasize the need for further detailed spectroscopic follow-up of the Kepler targets in order to produce reliable results from the asteroseismic analysis.Comment: 16 Pages, 12 Figures, accepted for publication in A&