A Critical Study of Information System Use in Ghana\u27s Public Sector

This paper uses a critical perspective (i.e., one that is grounded in historical conditions) via the actor network theory (ANT) framing and methodological approach to explain innovation adoption process of a novel data and knowledge management system in a public sector context of Ghana, West Africa

Genetic associations with childhood brain growth, defined in two longitudinal cohorts

Genome-wide association studies (GWASs) are unraveling the genetics of adult brain neuroanatomy as measured by cross-sectional anatomic magnetic resonance imaging (aMRI). However, the genetic mechanisms that shape childhood brain development are, as yet, largely unexplored. In this study we identify common genetic variants associated with childhood brain development as defined by longitudinal aMRI. Genome-wide single nucleotide polymorphism (SNP) data were determined in two cohorts: one enriched for attention-deficit/hyperactivity disorder (ADHD) (LONG cohort: 458 participants; 119 with ADHD) and the other from a population-based cohort (Generation R: 257 participants). The growth of the brain's major regions (cerebral cortex, white matter, basal ganglia, and cerebellum) and one region of interest (the right lateral prefrontal cortex) were defined on all individuals from two aMRIs, and a GWAS and a pathway analysis were performed. In addition, association between polygenic risk for ADHD and brain growth was determined for the LONG cohort. For white matter growth, GWAS meta-analysis identified a genome-wide significant intergenic SNP (rs12386571, P = 9.09 × 10-9 ), near AKR1B10. This gene is part of the aldo-keto reductase superfamily and shows neural expression. No enrichment of neural pathways was detected and polygenic risk for ADHD was not associated with the brain growth phenotypes in the LONG cohort that was enriched for the diagnosis of ADHD. The study illustrates the use of a novel brain growth phenotype defined in vivo for further study

Using MODIS EVI to detect vegetation damage caused by the 2008 ice and snow storms in south China

This study develops a new method for detecting areas with severe vegetation damage caused by a serious ice and snow storm event that occurred in southern China over the period of 10 January to 2 February 2008. The new method adopts one of the Moderate Resolution Imaging Spectroradiometer (MODIS) MOD13A1 products, the enhanced vegetation index (EVI). Using a series of 16 day EVI maps at the 500 m spatial resolution in the 2008 growing season, the vegetation damage due to the event could be observed at a great number of patches, most of which are located outside of the regions with a flat topography. From a comparison of the MODIS Leaf Area Index (LAI), the Land Surface Temperature (LST) products, and the Landsat images obtained before and after the event, the severe vegetation damage is substantiated by a decreasing LAI, an increasing LST, and the "browning" of green vegetation in these patches. The analysis of topographic features discloses that the locations with the severe vegetation damage are mainly on slopes with easterly, southerly, and southeasterly aspects and in the moderate elevation region of between 500 and 700 m. During the event period, most of the patches that exhibited vegetation damage had a minimum temperature slightly above 0°C, experienced a minimum relative humidity of more than 75%, and accumulated a precipitation depth of more than 130 mm. Copyright 2010 by the American Geophysical Union.published_or_final_versio

Delinquency and reputational orientations of adolescent at-risk and not-at-risk males and females

This research investigated differences in delinquent activities and the reputational orientations of at-risk and not-at-risk male and female adolescents. Initially, we sought to establish that adolescent males and females differed in these respects. This was found to be the case: males (n = 722) scored significantly higher than females (n = 738) on seven self-reported delinquency variables and on eight reputation enhancement variables pertaining to social deviance, non-conforming reputation, and power/evaluation private identity. When a sample of 31 at-risk females was subsequently pair-wise age matched with 31 not-at-risk females, at-risk females scored significantly higher on all delinquency variables other than school misdemeanors. These at-risk females also scored significantly higher on four reputation enhancement variables relating to social deviance and non-conformity. Given that at-risk females did not differ from their not-at-risk counterparts in level of involvement in school misdemeanors, we sought to determine whether this was also the case for at-risk and not-at-risk males. An age-matched sample of 91 pairs revealed that at-risk males reported significantly higher involvement than not-at-risk males in all aspects of delinquency, including school misdemeanors. They also sought a more non-conforming reputation. To explore the relationships between delinquency and reputation enhancement, a canonical correlation analysis was performed. All findings are discussed in the light of reputation enhancement theory. © 2008 Taylor & Franci

Academic freedom: in justification of a universal ideal

This paper examines the justification for, and benefits of, academic freedom to academics, students, universities and the world at large. The paper surveys the development of the concept of academic freedom within Europe, more especially the impact of the reforms at the University of Berlin instigated by Wilhelm von Humboldt. Following from this, the paper examines the reasons why the various facets of academic freedom are important and why the principle should continue to be supported

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts.

[This corrects the article DOI: 10.1038/s42003-018-0226-0.]

Public sector commissioning and the third sector: Old wine in new bottles?

Public sector commissioning has risen rapidly to prominence as the central mechanism for the ‘purchase’ of services in an increasingly mixed economy of public services in the UK and this has wide-ranging consequences for non-state actors including those in the third sector. Academic consideration of commissioning has been rather fragmented, concerned with particular service fields or sectors. This paper provides an overview, with a focus on the relationship between the state and the third sector. The paper begins by questioning whether commissioning is really ‘new’ or a continuation of exist- ing trends around procurement and contracting and whether it constitutes a genuinely transformative relationship between the state and third sector. It considers some core debates about the likely impact of commissioning on the third sector and its relationship with the state. In doing so, the paper advances two main arguments: that commissioning remains highly fragmented in policy and practice, between different localities and scales of government; and that there is a tension within commissioning policy between the ‘rhetoric’ of the ‘full cycle’ approach based on needs assessment and planning, and what appears to be an emerging reality of resource-constrained, large-scale and Payment by Results-based contracting. These raise real concerns for organizational and service quality outcomes