1,517 research outputs found
Neutron scattering study of the long-range ordered state in CeRu2Al10
Elastic and inelastic neutron scattering measurements have been performed on
powder and single-crystal samples of orthorhombic CeRu2Al10. The order forming
below T0 = 27 K was identified as a long-range antiferromagnetic state with the
wave vector k = (1,0,0). The magnetic spectral response in the ordered phase,
measured on powder, is characterized by a spin gap and a pronounced peak at 8
meV, whose Q dependence suggests a magnetic origin. Both features are
suppressed when temperature is raised to T0, and a conventional relaxational
behavior is observed at 40 K. This peculiar spin dynamics is discussed in
connection with recent magnetization results for the same compound.Comment: 5 pages, 5 figures, International Conference on Heavy Electrons 2010
(Tokyo Metropolitan University, September 17 - 20, 2010), to be published in
Journal of the Physical Society of Japan. Typo corrected p. 3: "sites denoted
1 and 3" => "1 and 4
Beating quantum limits in interferometers with quantum locking of mirrors
The sensitivity in interferometric measurements such as gravitational-wave
detectors is ultimately limited by quantum noise of light. We discuss the use
of feedback mechanisms to reduce the quantum effects of radiation pressure.
Recent experiments have shown that it is possible to reduce the thermal motion
of a mirror by cold damping. The mirror motion is measured with an
optomechanical sensor based on a high-finesse cavity, and reduced by a feedback
loop. We show that this technique can be extended to lock the mirror at the
quantum level. In gravitational-waves interferometers with Fabry-Perot cavities
in each arms, it is even possible to use a single feedback mechanism to lock
one cavity mirror on the other. This quantum locking greatly improves the
sensitivity of the interferometric measurement. It is furthermore insensitive
to imperfections such as losses in the interferometer
Vaccine nationalism counterintuitively erodes public trust in leaders
Global access to resources like vaccines is key for containing the spread of infectious diseases. However, wealthy countries often pursue nationalistic policies, stockpiling doses rather than redistributing them globally. One possible motivation behind vaccine nationalism is a belief among policymakers that citizens will mistrust leaders who prioritize global needs over domestic protection. In seven experiments (total N = 4,215 adults), we demonstrate that such concerns are misplaced: Nationally representative samples across multiple countries with large vaccine surpluses (Australia, Canada, United Kingdom, and United States) trusted redistributive leaders more than nationalistic leadersâeven the more nationalistic participants. This preference generalized across different diseases and manifested in both self-reported and behavioral measures of trust. Professional civil servants, however, had the opposite intuition and predicted higher trust in nationalistic leaders, and a nonexpert sample also failed to predict higher trust in redistributive leaders. We discuss how policymakersâ inaccurate intuitions might originate from overestimating othersâ self-interest
Ultimate fast optical switching of a planar microcavity in the telecom wavelength range
We have studied a GaAs-AlAs planar microcavity with a resonance near 1300 nm
in the telecom range by ultrafast pump-probe reflectivity. By the judicious
choice of pump frequency, we observe a ultimate fast and reversible decrease of
the resonance frequency by more than half a linewidth due to the instantaneous
electronic Kerr effect. The switch-on and switch-off? of the cavity is only
limited by the cavity storage time of ?tcav = 0.3ps and not by intrinsic
material parameters. Our results pave the way to supra-THz switching rates for
on-chip data modulation and real-time cavity quantum electrodynamics.Comment: 3 pages, 3 figure
Quantum jumps of light recording the birth and death of a photon in a cavity
A microscopic system under continuous observation exhibits at random times
sudden jumps between its states. The detection of this essential quantum
feature requires a quantum non-demolition (QND) measurement repeated many times
during the system evolution. Quantum jumps of trapped massive particles
(electrons, ions or molecules) have been observed, which is not the case of the
jumps of light quanta. Usual photodetectors absorb light and are thus unable to
detect the same photon twice. They must be replaced by a transparent counter
'seeing' photons without destroying them3. Moreover, the light has to be stored
over a duration much longer than the QND detection time. We have fulfilled
these challenging conditions and observed photon number quantum jumps.
Microwave photons are stored in a superconducting cavity for times in the
second range. They are repeatedly probed by a stream of non-absorbing atoms. An
atom interferometer measures the atomic dipole phase shift induced by the
non-resonant cavity field, so that the final atom state reveals directly the
presence of a single photon in the cavity. Sequences of hundreds of atoms
highly correlated in the same state, are interrupted by sudden
state-switchings. These telegraphic signals record, for the first time, the
birth, life and death of individual photons. Applying a similar QND procedure
to mesoscopic fields with tens of photons opens new perspectives for the
exploration of the quantum to classical boundary
Vitamin D5 in Arabidopsis thaliana
Abstract Vitamin D3 is a secosterol hormone critical for bone growth and calcium homeostasis, produced in vertebrate skin by photolytic conversion of the cholesterol biosynthetic intermediate provitamin D3. Insufficient levels of vitamin D3 especially in the case of low solar UV-B irradiation is often compensated by an intake of a dietary source of vitamin D3 of animal origin. Small amounts of vitamin D3 were described in a few plant species and considered as a peculiar feature of their phytochemical diversity. In this report we show the presence of vitamin D5 in the model plant Arabidopsis thaliana. This plant secosterol is a UV-B mediated derivative of provitamin D5, the precursor of sitosterol. The present work will allow a further survey of vitamin D distribution in plant species
Alternative proteins are functional regulators in cell reprogramming by PKA activation
Abstract
It has been recently shown that many proteins are lacking from reference databases used in mass spectrometry analysis, due to their translation templated on alternative open reading frames. This questions our current understanding of gene annotation and drastically expands the theoretical proteome complexity. The functions of these alternative proteins (AltProts) still remain largely unknown. We have developed a large-scale and unsupervised approach based on cross-linking mass spectrometry (XL-MS) followed by shotgun proteomics to gather information on the functional role of AltProts by mapping them back into known signalling pathways through the identification of their reference protein (RefProt) interactors. We have identified and profiled AltProts in a cancer cell reprogramming system: NCH82 human glioma cells after 0, 16, 24 and 48 h Forskolin stimulation. Forskolin is a protein kinase A activator inducing cell differentiation and epithelialâmesenchymal transition. Our data show that AltMAP2, AltTRNAU1AP and AltEPHA5 interactions with tropomyosin 4 are downregulated under Forskolin treatment. In a wider perspective, Gene Ontology and pathway enrichment analysis (STRING) revealed that RefProts associated with AltProts are enriched in cellular mobility and transfer RNA regulation. This study strongly suggests novel roles of AltProts in multiple essential cellular functions and supports the importance of considering them in future biological studies
Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate
Parkinsonâs disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism, efficacy, biodistribution, and transcriptional impact of canine adenovirus type 2 (CAV-2) vectors in the brain of Microcebus murinus, a nonhuman primate that naturally develops neurodegenerative lesions. We show that introducing helper-dependent (HD) CAV-2 vectors results in long-term, neuron-specific expression at the injection site and in afferent nuclei. Although HD CAV-2 vector injection induced a modest transcriptional response, no significant adaptive immune response was generated. We then generated and tested HD CAV-2 vectors expressing LRRK2 (leucine-rich repeat kinase 2) and LRRK2 carrying a G2019S mutation (LRRK2G2019S), which is linked to sporadic and familial autosomal dominant forms of PD. We show that HD-LRRK2G2019S expression induced parkinsonian-like motor symptoms and histological features in less than 4 months
A review of selected indicators of particle, nutrient and metal inputs in coral reef lagoon systems
This review presents environmental and biological indicators of the impact of three major categories of inputs in coral reef lagoons i.e. particles, nutrients and metals. Information was synthesized to extract well established indicators together with some interesting new concepts currently under development, and to provide the reader with an assessment of their respective advantages and drawbacks. The paper has been organized according to the capacity of three categories of indicators to respond either in a specific or a non specific way to a given source of input. The first section focuses on abiotic indicators which main interest is to respond instantaneously and in a truly specific way to a given source of input. The second and third sections present informations on bioindicators either at the sub-individual level or at the individual to community level, indicator specificity generally decreasing as a direct function of biological or ecological complexity. This review showed that even though significant work has already been done on coral reef ecosystems, much more scientific studies are still needed to answer the growing local demands for simple and truly validated tools to be used in environmental surveys. It is further stressed that, due to the biological and environmental diversity of coral reef lagoons, a preliminary step of on-site validation must be considered as an absolute prerequisite when indicators are planned to be used in the frame of a local environmental monitoring programme
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