156 research outputs found
The barycentric motion of exoplanet host stars: tests of solar spin-orbit coupling
Empirical evidence suggests a tantalising but unproven link between various
indicators of solar activity and the barycentric motion of the Sun. The latter
is exemplified by transitions between regular and more disordered motion
modulated by the motions of the giant planets, and rare periods of retrograde
motion with negative orbital angular momentum. An examination of the
barycentric motion of exoplanet host stars, and their stellar activity cycles,
has the potential of proving or disproving the Sun's motion as an underlying
factor in the complex patterns of short- and long-term solar variability
indices, by establishing whether such correlations exist in other planetary
systems. A variety of complex patterns of barycentric motions of exoplanet host
stars is demonstrated, depending on the number, masses and orbits of the
planets. Each of the behavioural types proposed to correlate with solar
activity are also evident in exoplanet host stars: repetitive patterns
influenced by massive multiple planets, epochs of rapid change in orbital
angular momentum, and intervals of negative orbital angular momentum. The study
provides the basis for independent investigations of the widely-studied but
unproven suggestion that the Sun's motion is somehow linked to various
indicators of solar activity. We show that, because of the nature of their
barycentric motions, the host stars HD168443 and HD74156 offer particularly
powerful tests of this hypothesis.Comment: 7 pages, 3 figures. Accepted for publication in A&
A Phase I trial of talazoparib in patients with advanced hematologic malignancies
Aim: The objective of this study was to establish the maximum tolerated dose (MTD), safety, pharmacokinetics, and anti-leukemic activity of talazoparib. Patients & methods: This Phase I, two-cohort, dose-escalation trial evaluated talazoparib monotherapy in advanced hematologic malignancies (cohort 1: acute myeloid leukemia/myelodysplastic syndrome; cohort 2: chronic lymphocytic leukemia/mantle cell lymphoma). Results: Thirty-three (cohort 1: n = 25; cohort 2: n = 8) patients received talazoparib (0.1-2.0 mg once daily). The MTD was exceeded at 2.0 mg/day in cohort 1 and at 0.9 mg/day in cohort 2. Grade ≥3 adverse events were primarily hematologic. Eighteen (54.5%) patients reported stable disease. Conclusion: Talazoparib is relatively well tolerated in hematologic malignancies, with a similar MTD as in solid tumors, and shows preliminary anti leukemic activity.Clinical trial registration: NCT01399840 (ClinicalTrials.gov)
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Quality control for next-generation liquefaction case histories
The Next-Generation Liquefaction (NGL) database is an open-source, global database of liquefaction and non-ground failure case-histories. The database is part of a multi-year research effort with the main goal of developing improved procedures to evaluate liquefaction susceptibility, triggering, and consequences. In NGL, a case-history is defined as the intersection of three components: (1) a site, (2) an earthquake event, and (3) post-earthquake observations. The NGL database hosts case-histories used to develop existing liquefaction models, as well as new data derived from recent earthquakes such as the 2010-2011 Canterbury earthquake sequence, the 2011 Tohoku-Oki earthquake, and the 2012 Emilia earthquake. The database also hosts lateral spread case-histories, and a substantial number of liquefaction sites characterized by the presence of co-located recording stations. All of the data present in the NGL database are reviewed by the NGL Database Working Group. The NGL formal vetting process is described for an example case-history
Solar active regions: a nonparametric statistical analysis
The sunspots and other solar activity indicators tend to cluster on the
surface of the Sun.These clusters very often occur at certain longitudes that
persist in time.It is of general interest to find new and simple ways to
characterize the observed distributions of different indicators and their
behaviour in time. In the present work we use Greenwich sunspot data to
evaluate statistical but not totally coherent stability of sunspot distribution
along latitudes as well as longitudes. The aim was to obtain information on the
longitudinal distribution of the underlying spot-generating mechanism rather
than on the distribution and migration of sunspots or sunspot groups on the
solar surface. Therefore only sunspot groups were included in the analysis, and
only the time of their first appearance was used. We use simple nonparametric
approach to reveal sunspot migration patterns and their persistency. Our
analysis shows that regions where spots are generated tend to rotate
differentially as the spots and spot groups themselves do. The activity areas,
however, tend to break down relatively fast, during 7-15 solar rotations. This
study provides a challenge for solar dynamo models, as our results are
consistent with the presence of a non-axisymmetric spot-generating mechanism
experiencing differential rotation (known as phase mixing in dynamo theory).
The new nonparametric method introduced here, completely independent of the
choice of the longitudinal distribution of sunspots, was found to be a very
powerful tool for spatio-temporal analysis of surface features.Comment: 8 pages, 11 figures, submitted to Astronomy and Astrophysic
Predicting the Amplitude of a Solar Cycle Using the North-South Asymmetry in the Previous Cycle: II. An Improved Prediction for Solar Cycle~24
Recently, using Greenwich and Solar Optical Observing Network sunspot group
data during the period 1874-2006, (Javaraiah, MNRAS, 377, L34, 2007: Paper I),
has found that: (1) the sum of the areas of the sunspot groups in 0-10 deg
latitude interval of the Sun's northern hemisphere and in the time-interval of
-1.35 year to +2.15 year from the time of the preceding minimum of a solar
cycle n correlates well (corr. coeff. r=0.947) with the amplitude (maximum of
the smoothed monthly sunspot number) of the next cycle n+1. (2) The sum of the
areas of the spot groups in 0-10 deg latitude interval of the southern
hemisphere and in the time-interval of 1.0 year to 1.75 year just after the
time of the maximum of the cycle n correlates very well (r=0.966) with the
amplitude of cycle n+1. Using these relations, (1) and (2), the values 112 + or
- 13 and 74 + or -10, respectively, were predicted in Paper I for the amplitude
of the upcoming cycle 24. Here we found that in case of (1), the north-south
asymmetry in the area sum of a cycle n also has a relationship, say (3), with
the amplitude of cycle n+1, which is similar to (1) but more statistically
significant (r=0.968) like (2). By using (3) it is possible to predict the
amplitude of a cycle with a better accuracy by about 13 years in advance, and
we get 103 + or -10 for the amplitude of the upcoming cycle 24. However, we
found a similar but a more statistically significant (r=0.983) relationship,
say (4), by using the sum of the area sum used in (2) and the north-south
difference used in (3). By using (4) it is possible to predict the amplitude of
a cycle by about 9 years in advance with a high accuracy and we get 87 + or - 7
for the amplitude of cycle 24.Comment: 21 pages, 7 figures, Published in Solar Physics 252, 419-439 (2008
Rehabilitation treatment specification system: identifying barriers, facilitators, and strategies for implementation in research, education, and clinical care
Accepted manuscrip
Success of an International Learning Health Care System in Hematopoietic Cell Transplantation: The American Society of Blood and Marrow Transplantation Clinical Case Forum
The ASBMT Clinical Case Forum (CCF) was launched in 2014 as an online secure tool to enhance interaction and communication among hematopoietic cell transplantation (HCT) professionals worldwide through the discussion of challenging clinical care issues. After 14 months, we reviewed clinical and demographical data on cases posted in the CCF from 1/29/2014 to 3/18/2015. A total of 137 cases were posted during the study period. Ninety-two cases (67%) were allogeneic HCT, 29 (21%) autologous HCT and in 16 (12%) the type of transplant (auto vs. allo) was still under consideration. The diseases most frequently discussed included non-Hodgkin lymphoma (NHL; n = 30, 22%), acute myeloid leukemia (AML; n = 23, 17%) and multiple myeloma (MM; n = 20, 15%). When compared with the US transplant activity reported by the US Department of Health and Human Services, NHL and acute lymphoblastic leukemia cases were overrepresented in the CCF while myeloma was underrepresented (P < 0.001). A total of 259 topics were addressed in the CCF with a median of two topics/case (range 1-6). Particularly common topics included whether transplant was indicated (n = 57, 41%), conditioning regimen choice (n = 44, 32%), and post-HCT complications after day 100 (n = 43, 31%). The ASBMT CCF is a successful tool for collaborative discussion of complex cases in the HCT community worldwide and may allow identification of areas of controversy or unmet need from clinical, educational and research perspectives
Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis
Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment for myelofibrosis. However, the optimal conditioning regimen either with reduced intensity conditioning (RIC) or myeloablative conditioning (MAC) is not well known. Using the Center for International Blood and Marrow Transplant Research database, we identified adults aged ≥18 years with myelofibrosis undergoing allo-HCT between 2008-2019 and analyzed the outcomes separately in the RIC and MAC cohorts based on the conditioning regimens used. Among 872 eligible patients, 493 underwent allo-HCT using RIC (Fludarabine/busulfan=166, Fludarabine/melphalan=327) and 379 using MAC (Fludarabine/busulfan=247, Busulfan/cyclophosphamide=132). In multivariable analysis with RIC, Fludarabine/melphalan was associated with inferior overall survival (HR 1.80, 95% CI 1.15-2.81, p=0.009), higher early non-relapse mortality (HR 1.81, 95% CI 1.12-2.91, p=0.01) and higher acute graft versus host disease (GVHD) (grade II-IV- HR 1.45, 95% CI 1.03-2.03, p=0.03; grade III-IV HR 2.21, 95%CI 1.28-3.83, p=0.004) compared to Fludarabine/busulfan. In the MAC setting, Busulfan/cyclophosphamide was associated with a higher acute GVHD (grade II-IV HR 2.33, 95% CI 1.67-3.25, p\u3c0.001; grade III-IV HR 2.31, 95% CI 1.52-3.52, p\u3c0.001) and inferior GVHD-free relapse-free survival (GRFS) (HR 1.94, 95% CI 1.49-2.53, p\u3c0.001) as compared to Fludarabine/busulfan. Hence, our study suggests that Fludarabine/busulfan is associated with better outcomes in RIC (better overall survival, lower early non-relapse mortality, lower acute GVHD) and MAC (lower acute GVHD and better GRFS) in myelofibrosis
Improved survival after acute graft-
A cute graft- versus -host disease remains a major threat to a successful outcome after allogeneic hematopoietic cell transplantation. While improvements in treatment and supportive care have occurred, it is unknown whether these advances have resulted in improved outcome specifically among those diagnosed with acute graft- versus -host disease. We examined outcome following diagnosis of grade II-IV acute graft- versus -host disease according to time period, and explored effects according to original graft- versus -host disease prophylaxis regimen and maximum overall grade of acute graft- versus -host disease. Between 1999 and 2012, 2,905 patients with acute myeloid leukemia (56%), acute lymphoblastic leukemia (30%) or myelodysplastic syndromes (14%) received a sibling (24%) or unrelated donor (76%) blood (66%) or marrow (34%) transplant and developed grade II-IV acute graft- versus -host disease (n=497 for 1999-2001, n=962 for 2002-2005, n=1,446 for 2006-2010). The median (range) follow-up was 144 (4-174), 97 (4-147) and 60 (8-99) months for 1999-2001, 2002-2005, and 2006-2010, respectively. Among the cohort with grade II-IV acute graft- versus -host disease, there was a decrease in the proportion of grade III-IV disease over time with 56%, 47%, and 37% for 1999-2001, 2002-2005, and 2006-2012, respectively ( P <0.001). Considering the total study population, univariate analysis demonstrated significant improvements in overall survival and treatment-related mortality over time, and deaths from organ failure and infection declined. On multivariate analysis, significant improvements in overall survival ( P =0.003) and treatment-related mortality ( P =0.008) were only noted among those originally treated with tacrolimus-based graft- versus -host disease prophylaxis, and these effects were most apparent among those with overall grade II acute graft- versus -host disease. In conclusion, survival has improved over time for tacrolimus-treated transplant recipients with acute graft- versus -host disease
Female Genital Mutilation: perceptions of healthcare professionals and the perspective of the migrant families
<p>Abstract</p> <p>Background</p> <p>Female Genital Mutilation (FGM) is a traditional practice which is harmful to health and is profoundly rooted in many Sub-Saharan African countries. It is estimated that between 100 and 140 million women around the world have been victims of some form of FGM and that each year 3 million girls are at risk of being submitted to these practices. As a consequence of the migratory phenomena, the problems associated with FGM have extended to the Western countries receiving the immigrants. The practice of FGM has repercussions on the physical, psychic, sexual and reproductive health of women, severely deteriorating their current and future quality of life. Primary healthcare professionals are in a privileged position to detect and prevent these situations of risk which will be increasingly more present in Spain.</p> <p>Methods/Design</p> <p>The objective of the study is to describe the knowledge, attitudes and practices of the primary healthcare professionals, working in 25 health care centres in Barcelona and Girona regions, regarding FGM, as well as to investigate the perception of this subject among the migrant communities from countries with strong roots in these practices. A transversal descriptive study will be performed with a questionnaire to primary healthcare professionals and migrant healthcare users.</p> <p>Using a questionnaire specifically designed for this study, we will evaluate the knowledge, attitudes and skills of the healthcare professionals to approach this problem. In a sub-study, performed with a similar methodology but with the participation of cultural mediators, the perceptions of the migrant families in relation to their position and expectancies in view of the result of preventive interventions will be determined.</p> <p>Variables related to the socio-demographic aspects, knowledge of FGM (types, cultural origin, geographic distribution and ethnicity), evaluation of attitudes and beliefs towards FGM and previous contact or experience with cases or risk situations will be obtained.</p> <p>Discussion</p> <p>Knowledge of these harmful practices and a preventive approach from a transcultural perspective may represent a positive intervention model for integrative care of immigrants, respecting their values and culture while also being effective in eliminating the physical and psychic consequences of FGM.</p
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