Neolithic in ‘La Pileta’ Cave (Benaoján, Málaga)

Cueva de la Pileta es uno de los enclaves clásicos en la historiografía de la Prehistoria del sur de Iberia, sobre todo por las representaciones de arte rupestre. No obstante, el yacimiento también dispone de una amplia secuencia estratigráfica del Cuaternario reciente (p. ej., 7 m de potencia en la sala de los Murciélagos) que apenas ha recibido atención bibliográfica. Este trabajo se centra en la historiografía de los trabajos en el yacimiento y en el estudio de los materiales neolíticos. La colección cerámica y sus paralelos técnicos y estilísticos en el contexto del Mediterráneo y sur ibérico permiten integrar La Pileta dentro del primer Neolítico en Andalucía con una edad encuadrada en la segunda mitad del 8º milenio cal BP.Cave of La Pileta is a key site in southern Iberia prehistoric historiography. It’s mainly known for its rock art paintings, but the archaeological site also has a wide stratigraphic sequence of Recent Quaternary period (e.g. 7 meters in ‘Murciélagos’ Room) that has scarcely been studied. This paper focuses on historiographical analysis of worked areas and Neolithic materials. Ceramics and its stylistic and technical parallels in the Mediterranean and southern Iberian context allow us to classify Pileta in the first Neolithic period of Andalusia, second half of 8th millenium cal BP

Kinetic Modelling of ELM-induced Fast-ion Transport and Acceleration in the ASDEX Upgrade Tokamak

Universidad de Sevilla PP2016-7145EUROfusion Consortium 63305

Evaluación del riesgo de deslizamientos superficiales para proyectos de infraestructura: caso de análisis en vereda El Cabuyal

In this paper an assessment of the hazard, the vulnerability and the risk associated with shallow landslides in a watershed of the Valle de Aburra is carried out. The TRIGRS model with a Monte Carlo simulation to estimate the probability of failure in the watershed using water table depth as the trigger factor is implemented, which allows the assessment of the hazard along with its annual probability of occurrence. Additionally, a quantitative model for physical vulnerability of structures which takes into account landslide intensity and resistance of exposed elements is used. The annual risk is estimated for a house of the study site as the product of the hazard and the damage costs due to the occurrence of the catastrophic event, which considers vulnerability. The methodology used focuses on the shallow landslide occurred on October 26, 2016 on a slope within the study site, which affected the house that is being analyzed.Este artículo presenta un análisis y evaluación cuantitativa de la amenaza, la vulnerabilidad y el riesgo asociados a deslizamientos superficiales en una subcuenca del Valle de Aburrá (Colombia). Se integra el modelo TRIGRS mediante una simulación de Montecarlo para la estimación de la probabilidad de falla en la subcuenca empleando una altura del nivel freático como factor desencadenante, que junto con su probabilidad de ocurrencia anual permiten la evaluación de la amenaza. Se emplea un modelo que cuantifica la vulnerabilidad física de estructuras basándose en la intensidad del deslizamiento y la resistencia del elemento expuesto. El riesgo anual se estima para una vivienda del sitio de estudio como el producto de la amenaza y el valor de la pérdida dado el evento catastrófico, considerando la vulnerabilidad. La metodología empleada se enfoca en el deslizamiento ocurrido el 26 de octubre de 2016 en un talud dentro del sitio de estudio que afectó la vivienda que es objeto de análisis

STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway

Background & Aims Besides their physiological role in bile formation and fat digestion, bile acids (BAs) synthesised from cholesterol in hepatocytes act as signalling molecules that modulate hepatocellular carcinoma (HCC). Trafficking of cholesterol to mitochondria through steroidogenic acute regulatory protein 1 (STARD1) is the rate-limiting step in the alternative pathway of BA generation, the physiological relevance of which is not well understood. Moreover, the specific contribution of the STARD1-dependent BA synthesis pathway to HCC has not been previously explored. Methods STARD1 expression was analyzed in a cohort of human non-alcoholic steatohepatitis (NASH)-derived HCC specimens. Experimental NASH-driven HCC models included MUP-uPA mice fed a high-fat high-cholesterol (HFHC) diet and diethylnitrosamine (DEN) treatment in wild-type (WT) mice fed a HFHC diet. Molecular species of BAs and oxysterols were analyzed by mass spectrometry. Effects of NASH-derived BA profiles were investigated in tumour-initiated stem-like cells (TICs) and primary mouse hepatocytes (PMHs). Results Patients with NASH-associated HCC exhibited increased hepatic expression of STARD1 and an enhanced BA pool. Using NASH-driven HCC models, STARD1 overexpression in WT mice increased liver tumour multiplicity, whereas hepatocyte-specific STARD1 deletion (Stard1ΔHep) in WT or MUP-uPA mice reduced tumour burden. These findings mirrored the levels of unconjugated primary BAs, β-muricholic acid and cholic acid, and their tauroconjugates in STARD1-overexpressing and Stard1ΔHep mice. Incubation of TICs or PMHs with a mix of BAs mimicking this profile stimulated expression of genes involved in pluripotency, stemness and inflammation. Conclusions The study reveals a previously unrecognised role of STARD1 in HCC pathogenesis, wherein it promotes the synthesis of primary BAs through the mitochondrial pathway, the products of which act in TICs to stimulate self-renewal, stemness and inflammation. Lay summary Effective therapy for hepatocellular carcinoma (HCC) is limited because of our incomplete understanding of its pathogenesis. The contribution of the alternative pathway of bile acid (BA) synthesis to HCC development is unknown. We uncover a key role for steroidogenic acute regulatory protein 1 (STARD1) in non-alcoholic steatohepatitis-driven HCC, wherein it stimulates the generation of BAs in the mitochondrial acidic pathway, the products of which stimulate hepatocyte pluripotency and self-renewal, as well as inflammation.We acknowledge support from grants PID2019-111669RB-100, SAF2017-85877R and SAF2015-73579-JIN from Plan Nacional de I+D funded by the Agencia Estatal de Investigación (AEI), the Fondo Europeo de Desarrollo Regional (FEDER) and CIBEREHD; the center grant P50AA011999 Southern California Research Center for ALPD and Cirrhosis funded by NIAAA / NIH; as well as support from AGAUR of the Generalitat de Catalunya SGR-2017-1112, European Cooperation in Science & Technology (COST) ACTION CA17112 Prospective European Drug-Induced Liver Injury Network, the ‘ER stress-mitochondrial cholesterol axis in obesity-associated insulin resistance and comorbidities’-Ayudas FUNDACION BBVA and the Red Nacional 2018-102799-T de Enfermedades Metabólicas y Cáncer, and Project 201916/31 "Contribution of mitochondrial oxysterol and bile acid metabolism to liver carcinogenesis" 2019 by Fundació Marato TV3. We also acknowledge the support from the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI16/00598, co-funded by European Regional Development Fund / European Social Fund, ‘Investing in your future’) and Centro Internacional sobre el Envejecimiento (OLD-HEPAMARKER, 0348_CIE_6_E), Spain. We also acknowledge support from R01 CA2344128 and U01 AA022614 grants to M.K.Peer reviewe

Non-destructive Techniques Methodologies for the Detection of Ancient Structures under Heritage Buildings

[EN] Structures and elements buried beneath heritage buildings are frequent but are often unknown and inaccessible. Therefore, they are difficult to locate in general if an archaeological excavation is not carried out, with the economic cost and time involved. It is important to discover them in order to increase our knowledge of cultural heritage, as well as to know, recover and improve the state of conservation of the materials that make up these structures. This paper presents methodologies for locating old structures using a low-cost NDT approach, with a qualitative and quantitative analysis of GPR profiles in heritage buildings. Small perforations are performed at critical points and introducing an endoscope for verification. Various crypts have been located using the proposed methodologies in a real study case: The Church of the Asución of Llíria in Spain.Gil Benso, E.; Mas Tomas, MDLA.; Lerma Elvira, C.; Torner, ME.; Vercher Sanchis, J. (2021). Non-destructive Techniques Methodologies for the Detection of Ancient Structures under Heritage Buildings. International journal of architectural heritage (electronic). 15(10):1457-1473. https://doi.org/10.1080/15583058.2019.1700320S14571473151

Lower expression of plasma-derived exosome miR-21 levels in HIV-1 elite controllers with decreasing CD4 T cell count

Exosome-derived miR-21 was independently associated with CD4 T cell decline in HIV-1-infected elite controllers (OR 0.369, 95% CI 0.137-0.994, p = 0.049). Also, a negative correlation between miR-21 expression and MCP-1 level was found (r = −0.649, p = 0.020), while no correlation between soluble biomarkers or cellular immune activation was found

Geometría 3d, Estructura y formación de la cuenca del Duero en el contexto geodinámico del orógeno pirenaico

The Duero foreland basin is characterized by a large synformal geometry formed by the lithospheric flexure and northward subduction of the Iberian crust underneath the Cantabrian-European crust. Basin structure is represented by high-angle faults that involve both basement and cover units, and that did not generate large amounts of horizontal displacement. The northern deformation front is represented by a series of S-directed faults that probably sole into middle-lower crustal levels. Growth strata within the basin interior indicate that basement faulting occurred during the uppermost Cretaceous to Paleocene, previous to the onset of the foreland stage, while the Orogen uplift and the northern deformation front activity took place mainly between the Eocene-Oligocene, locally protracting until Miocene times. The Duero Basin behaved as an orogenic scale buttress due to the lack of an inherited Late Jurassic-Early Cretaceous extensional architecture associated with the opening of the Bay of Biscay. Hence, most of the Alpine contraction had a major impact where Mesozoic extension was more important, like the North Iberian Margin and the system of Mesozoic extensional basins of the Pyrenean rif

Development and installation of a scintillator based detector for fast-ion losses in the MAST-U tokamak

Trabajo presentado en el 45th EPS Conference on Plasma Physics, celebrada en Praga (República Checa), del 2 al 6 de julio de 2018Peer reviewe