Effect of magnetically simulated zero-gravity and enhanced gravity on the walk of the common fruitfly†

Understanding the effects of gravity on biological organisms is vital to the success of future space missions. Previous studies in Earth orbit have shown that the common fruitfly (Drosophila melanogaster) walks more quickly and more frequently in microgravity, compared with its motion on Earth. However, flight preparation procedures and forces endured on launch made it difficult to implement on the Earth's surface a control that exposed flies to the same sequence of major physical and environmental changes. To address the uncertainties concerning these behavioural anomalies, we have studied the walking paths of D. melanogaster in a pseudo-weightless environment (0g*) in our Earth-based laboratory. We used a strong magnetic field, produced by a superconducting solenoid, to induce a diamagnetic force on the flies that balanced the force of gravity. Simultaneously, two other groups of flies were exposed to a pseudo-hypergravity environment (2g*) and a normal gravity environment (1g*) within the spatially varying field. The flies had a larger mean speed in 0g* than in 1g*, and smaller in 2g*. The mean square distance travelled by the flies grew more rapidly with time in 0g* than in 1g*, and slower in 2g*. We observed no other clear effects of the magnetic field, up to 16.5 T, on the walks of the flies. We compare the effect of diamagnetically simulated weightlessness with that of weightlessness in an orbiting spacecraft, and identify the cause of the anomalous behaviour as the altered effective gravity

Social, Clinical and Microbiological Differential Characteristics of Tuberculosis among Immigrants in Spain

BACKGROUND: To identify the differential tuberculosis (TB) characteristics within the immigrant population with respect to natives in Spain. METHODOLOGY/PRINCIPAL FINDINGS: A prospective cohort study design was implemented to examine the TB cases diagnosed and starting standard antituberculous treatment in Spain, between January 1st 2006 and March 31st 2007. A logistic regression analysis was performed to determine differential characteristics. 1,490 patients were included in the study population, 1,048 natives and 442 (29.7%) immigrants. According to the multivariate analysis, the following variables were significantly associated with immigrant TB cases: younger age (OR = 3.79; CI:2.16-6.62), living in group situation (OR = 7.61; CI:3.38-12.12), lower frequency of disabled (OR:0.08; CI:0.02-0.26) and retired (OR:0.21; CI:0.09-0.48) employment status, lower frequency of pulmonary disease presentation (OR = 0.47; CI:0.24-0.92), primary or emergency care admission (OR = 1.80; CI:1.05-3.06 and OR = 2.16; CI:1.36-3.45), drug resistance (OR = 1.86; CI:1.01-3.46), treatment default (OR:2.12; CI:1.18-3.81), lower frequency of alcohol and cigarette consumption (OR = 2.10; CI:1.42-3.11 and OR = 2.85; CI:2.10-3.87 respectively), more directly observed treatment (OR = 1.68; CI:1.04-2.69), and poor understanding of TB disease and its treatment (OR = 3.11; CI:1.86-5.20). The low percentage of primary MDR-TB in the native population (0.1% vs. 2.2% of immigrants) should be noted. CONCLUSIONS/SIGNIFICANCE: The differences show the need to introduce specific strategies in the management of TB within the immigrant population, including the improvement of social and work conditions

Diastolic shock index and clinical outcomes in patients with septic shock

Background: Loss of vascular tone is a key pathophysiological feature of septic shock. Combination of gradual diastolic hypotension and tachycardia could reflect more serious vasodilatory conditions. We sought to evaluate the relationships between heart rate (HR) to diastolic arterial pressure (DAP) ratios and clinical outcomes during early phases of septic shock. Methods: Diastolic shock index (DSI) was defined as the ratio between HR and DAP. DSI calculated just before starting vasopressors (Pre-VPs/DSI) in a preliminary cohort of 337 patients with septic shock (January 2015 to February 2017) and at vasopressor start (VPs/DSI) in 424 patients with septic shock included in a recent randomized controlled trial (ANDROMEDA-SHOCK; March 2017 to April 2018) was partitioned into five quantiles to estimate the relative risks (RR) of death with respect to the mean risk of each population (assumed to be 1). Matched HR and DAP subsamples were created to evaluate the effect of the individual components of the DSI on RRs. In addition, time-course of DSI and interaction between DSI and vasopressor dose (DSI*NE.dose) were compared between survivors and non-survivors from both populations, while ROC curves were used to identify variables predicting mortality. Finally, as exploratory observation, effect of early start of vasopressors was evaluated at each Pre-VPs/DSI quintile from the preliminary cohort. Results: Risk of death progressively increased at gradual increments of Pre-VPs/DSI or VPs/DSI (One-way ANOVA, p < 0.001). Progressive DAP decrease or HR increase was associated with higher mortality risks only when DSI concomitantly increased. Areas under the ROC curve for Pre-VPs/DSI, SOFA and initial lactate were similar, while mean arterial pressure and systolic shock index showed poor performances to predict mortality. Time-course of DSI and DSI*NE.dose was significantly higher in non-survivors from both populations (repeated-measures ANOVA, p < 0.001). Very early start of vasopressors exhibited an apparent benefit at higher Pre-VPs/DSI quintile. Conclusions: DSI at pre-vasopressor and vasopressor start points might represent a very early identifier of patients at high risk of death. Isolated DAP or HR values do not clearly identify such risk. Usefulness of DSI to trigger or to direct therapeutic interventions in early resuscitation of septic shock need to be addressed in future studies

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism-related placental mRNAs in pregnant women who are obese : the DALI lifestyle randomised controlled trial

Objective: We aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity. Design: Multicentre randomised controlled trial. Setting: Hospitals in nine European countries. Population: A cohort of 112 pregnant women with placental tissue. Methods: Both ST and moderate-to-vigorous PA (MVPA) levels were measured objectively using accelerometry at three time periods during pregnancy. Main outcome measures: Placental mRNAs (FATP2, FATP3, FABP4, GLUT1 and PPAR-γ) were measured with NanoString technology. Maternal and fetal metabolic markers and neonatal adiposity were assessed. Results: Longer periods of ST, especially in early to middle pregnancy, was associated with lower placental FATP2 and FATP3 expression (P 0.05). Additionally, placental FATP2 expression was inversely associated with cord blood triglycerides and free fatty acids (FFAs; P < 0.01). No cord blood marker mediated neonatal adiposity except for cord blood leptin, which mediated the effects of PPAR-γ on neonatal sum of skinfolds (P < 0.05). Conclusions: In early to middle pregnancy, ST is associated with the expression of placental genes linked to lipid transport. PA is hardly related to transporter mRNAs. Strategies aimed at reducing sedentary behaviour during pregnancy could modulate placental gene expression, which may help to prevent unfavourable fetal and maternal pregnancy outcomes. Tweetable abstract: Reducing sedentary behaviour in pregnancy might modulate placental expression of genes related to lipid metabolism in women who are obese

Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis

BACKGROUND: Optimal timing for the start of vasopressors (VP) in septic shock has not been widely studied since it is assumed that fluids must be administered in advance. We sought to evaluate whether a very early start of VP, even without completing the initial fluid loading, might impact clinical outcomes in septic shock. METHODS: A total of 337 patients with sepsis requiring VP support for at least 6 h were initially selected from a prospectively collected database in a 90-bed mixed-ICU during a 24-month period. They were classified into very-early (VE-VPs) or delayed vasopressor start (D-VPs) categories according to whether norepinephrine was initiated or not within/before the next hour of the first resuscitative fluid load. Then, VE-VPs (n = 93) patients were 1:1 propensity matched to D-VPs (n = 93) based on age; source of admission (emergency room, general wards, intensive care unit); chronic and acute comorbidities; and lactate, heart rate, systolic, and diastolic pressure at vasopressor start. A risk-adjusted Cox proportional hazard model was fitted to assess the association between VE-VPs and day 28 mortality. Finally, a sensitivity analysis was performed also including those patients requiring VP support for less than 6 h. RESULTS: Patients subjected to VE-VPs received significantly less resuscitation fluids at vasopressor starting (0[0-510] vs. 1500[650-2300] mL, p < 0.001) and during the first 8 h of resuscitation (1100[500-1900] vs. 2600[1600-3800] mL, p < 0.001), with no significant increase in acute renal failure and/or renal replacement therapy requirements. VE-VPs was related with significant lower net fluid balances 8 and 24 h after VPs. VE-VPs was also associated with a significant reduction in the risk of death compared to D-VPs (HR 0.31, CI95% 0.17-0.57, p < 0.001) at day 28. Such association was maintained after including patients receiving vasopressors for < 6 h. CONCLUSION: A very early start of vasopressor support seems to be safe, might limit the amount of fluids to resuscitate septic shock, and could lead to better clinical outcomes

Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study

BRAF and MEK inhibitor, dabrafenib plus trametinib, adjuvant therapy is effective for high-risk resected melanoma patients with BRAF-V600 mutations. However, real-world evidence is limited. We aimed to determine the feasibility of this therapy in routine clinical practice. DESCRIBE-AD, a retrospective observational study, collected real-world data from 25 hospitals in Spain. Histologically confirmed and resected BRAF-mutated melanoma patients aged & GE;18 years who were previously treated with dabrafenib plus trametinib adjuvant therapy, were included. The primary objectives were treatment discontinuation rate and time to discontinuation. The secondary objectives included safety and efficacy. From October 2020 to March 2021, 65 patients were included. Dabrafenib and trametinib discontinuation rate due to treatment-related adverse events (TRAEs) of any grade was 9%. Other reasons for discontinuation included patients' decisions (6%), physician decisions (6%), unrelated adverse events (3%), disease progression (5%), and others (5%). The median time to treatment discontinuation was 9 months [95% confidence interval (CI), 5-11]. G3-4 TRAEs occurred in 21.5% of patients, the most common being pyrexia (3%), asthenia (3%), and diarrhoea (3%). Unscheduled hospitalisations and clinical tests occurred in 6 and 22% of patients, respectively. After 20-month median follow-up (95% CI, 18-22), 9% of patients had exitus due to disease progression, with a 12-month relapse-free survival and overall survival rates of 95.3% and 100%, respectively. Dabrafenib and trametinib adjuvant therapy proved effective for melanoma patients in a real-world setting, with a manageable toxicity profile. Toxicity frequencies were low leading to low incidence of unscheduled medical visits, tests, and treatment discontinuations

What's normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically.

Background: Human milk is a complex fluid comprised of myriad substances, with one of the most abundant substances being a group of complex carbohydrates referred to as human milk oligosaccharides (HMOs). There has been some evidence that HMO profiles differ in populations, but few studies have rigorously explored this variability.Objectives: We tested the hypothesis that HMO profiles differ in diverse populations of healthy women. Next, we examined relations between HMO and maternal anthropometric and reproductive indexes and indirectly examined whether differences were likely related to genetic or environmental variations.Design: In this cross-sectional, observational study, milk was collected from a total of 410 healthy, breastfeeding women in 11 international cohorts and analyzed for HMOs by using high-performance liquid chromatography.Results: There was an effect of the cohort (P 4 times higher in milk collected in Sweden than in milk collected in rural Gambia (mean ± SEM: 473 ± 55 compared with 103 ± 16 nmol/mL, respectively; P < 0.05), and disialyllacto-N-tetraose (DSLNT) concentrations ranged from 216 ± 14 nmol/mL (in Sweden) to 870 ± 68 nmol/mL (in rural Gambia) (P < 0.05). Maternal age, time postpartum, weight, and body mass index were all correlated with several HMOs, and multiple differences in HMOs [e.g., lacto-N-neotetrose and DSLNT] were shown between ethnically similar (and likely genetically similar) populations who were living in different locations, which suggests that the environment may play a role in regulating the synthesis of HMOs.Conclusions: The results of this study support our hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women. Targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation. A careful examination of sociocultural, behavioral, and environmental factors is needed to determine their roles in this regard. This study was registered at clinicaltrials.gov as NCT02670278

Geometría y pérdidas de carga en inyectores Venturi mediante la dinámica de fluidos computacional

[EN] To determine the influence of geometry on the hydrodynamic behavior of Venturi injectors, using computational fluid dynamics techniques, we studied, at the Universitat Politècnica de València, Valencia, Spain, the geometric parameters that exert the most influence on head losses: the relationship between throat diameter and nozzle (β), nozzle angle (α1) and diffuser angle (α2). In addition, three throat morphologies (B1: nozzle-throat and throat-diffuser with a sharp edge; B2: nozzle-diffuser with a zero-length, sharp-edge throat; B3: nozzle-throat and throat-diffuser with rounded edge). We analyzed their influence on the velocity distribution and differential pressure between inlet and throat (DP/γ), throat and outlet (Δhv/γ), and outlet and throat ((P3-P2)/γ). The development of the velocity profile from the throat is slower the greater β is and the lower α2 is. DP/γ decreases with β, increases with α1 and varies little with α2. Δhv/γ decreases with β and increases with α1 and α2. (P3-P2)/γ decreases with β and increases with α1 and α2. Geometry B3 decreases the losses and delays the onset of cavitation. Thus, the lower β and the higher α2, the greater the losses; however, the influence of α1 is less clear. The rounded edges produce lower head losses.[ES] Estudio de la influencia de la geometría en el comportamiento hidrodinámico de inyectores Venturi mediante técnicas de dinámica de fluidos computacional. Para determinar la influencia de la geometría en el comportamiento hidrodinámico de inyectores Venturi, mediante técnicas de dinámica de fluidos computacional, se estudió, en la Universitat Politècnica de València, Valencia, España, los parámetros geométricos que más influencian las pérdidas de carga: relación entre diámetro de la garganta y tobera (β), ángulo de la tobera (α1) y ángulo del difusor (α2). Además, tres morfologías de la garganta (B1: tobera-garganta y garganta-difusor en arista viva; B2: tobera-difusor con garganta de longitud nula y en arista viva; B3: tobera-garganta y garganta-difusor en arista redondeadas). Se ha analizado su influencia en la distribución de velocidad y en la presión diferencial entre entrada y garganta (DP/γ), garganta y salida (∆hv/γ), y salida y garganta ((P3-P2)/γ). El desarrollo del perfil de velocidades a partir de la garganta es más lento cuanto mayor es β y menor es α2. DP/γ disminuye con β, aumenta con α1 y es poco variable con α2. ∆hv/γ disminuye con β y aumenta con α1 y α2. (P3-P2)/γ disminuye con β y α1, yaumenta con y α2. La geometría B3 disminuye las pérdidas y retarda la aparición de la cavitación. Así, cuanto menor es β y cuanto mayor es α2, mayores son las pérdidas de carga, sin embargo, la influencia de α1 no es tan clara. Las aristas redondeadas producen menores perdidas de cargaThe authors would like to thank the “Conselleria d'Empresa, Universitat i Ciència” of Generalitat Valenciana – Spain.Manzano Juarez, J.; Palau, CV.; De Azevedo, BM.; Do Bomfim, GV.; Vasconcelos, DV. (2016). Geometry and head loss in Venturi injectors through Computational Fluid Dynamics. Engenharia Agrícola. 36(3):482-491. doi:10.1590/1809-4430-Eng.Agric.v36n3p482-491/2016S482491363Baylar, A., Aydin, M., Unsal, M., & Ozkan, F. (2009). Numerical Modeling of Venturi Flows for Determining Air Injection Rates Using Fluent V6.2. Mathematical and Computational Applications, 14(2), 97-108. doi:10.3390/mca14020097Chan, L., Chin, C., Soria, J., & Ooi, A. (2014). Large eddy simulation and Reynolds-averaged Navier-Stokes calculations of supersonic impinging jets at varying nozzle-to-wall distances and impinging angles. International Journal of Heat and Fluid Flow, 47, 31-41. doi:10.1016/j.ijheatfluidflow.2014.02.005Dantas Neto, J., Maciel, J. L., Alves, A. de S., Azevedo, C. A. V. de, Fernandes, P. D., & Lima, V. L. A. de. (2013). Teores de macronutrientes em folhas de goiabeira fertirrigada com nitrogênio. Revista Brasileira de Engenharia Agrícola e Ambiental, 17(9), 962-968. doi:10.1590/s1415-43662013000900008Rezende, R., Helbel Júnior, C., Souza, R. S. de, Antunes, F. M., & Frizzone, J. A. (2010). Crescimento inicial de duas cultivares de cafeeiro em diferentes regimes hídricos e dosagens de fertirrigação. Engenharia Agrícola, 30(3), 447-458. doi:10.1590/s0100-69162010000300009Sanderse, B., Pijl, S. P., & Koren, B. (2011). Review of computational fluid dynamics for wind turbine wake aerodynamics. Wind Energy, 14(7), 799-819. doi:10.1002/we.458Santos, L. D. C., Zocoler, J. L., Justi, A. L., Silva, A. O., & Correia, J. D. S. (2012). ESTUDO COMPARATIVO DA TAXA DE INJEÇÃO EM INJETOR DO TIPO VENTURI COM E SEM VÁLVULA DE RETENÇÃO. IRRIGA, 1(01), 145. doi:10.15809/irriga.2012v1n01p145Sun, Y., & Niu, W. (2012). Simulating the Effects of Structural Parameters on the Hydraulic Performances of Venturi Tube. Modelling and Simulation in Engineering, 2012, 1-7. doi:10.1155/2012/458368Uribe, R. A. M., Gava, G. J. de C., Saad, J. C. C., & Kölln, O. T. (2013). Ratoon sugarcane yield integrated drip-irrigation and nitrogen fertilization. Engenharia Agrícola, 33(6), 1124-1133. doi:10.1590/s0100-69162013000600005Vasata, D., Galante, G., Rizzi, R. L., & Zara, R. A. (2011). Solução computacional do problema da cavidade cúbica através das equações de Navier-Stokes tridimensionais. Revista Brasileira de Ensino de Física, 33(2), 1-10. doi:10.1590/s1806-11172011000200013Yeoh, G. H., Liu, C., Tu, J., & Timchenko, V. (2012). Computational Fluid Dynamics and Its Applications 2012. Modelling and Simulation in Engineering, 2012, 1-2. doi:10.1155/2012/61061

Design and prediction performance of Venturi injectors in drip irrigation

[EN] The design and prediction performance of four Venturi injector prototypes have been studied using Computational Fluid Dynamics (CFD) techniques. Results were compared with experimental tests carried out in the laboratory of the Universitat Politecnica de Valencia, Valencia, Spain. The analysed and selected geometries for each prototype were used to simulate the operation without nutrient injection (G1) and with nutrient injection (G2). In first case (G1), the results were presented in the form of pressure profile at the injector axe under different velocities and the pressure distribution in the whole geometry. Additionally, this paper analysed the evolution of pressures and head loss versus main water flow in the different prototypes. The relative error was estimated to compare CFD and experimental results. The second case (G2), the graphical representation for the relations between the nutrient aspiration flow and water main flow were obtained for numerical and experiment approaches. In conclusion, CFD techniques appear as a suitable tool for the analysis of the Venturi injector operation, but its validation with experimental data is recommended.[ES] En la Universitat Politècnica de València, Valencia, España, se ha estudiado el diseño y funcionamiento de cuatro prototipos del inyector Venturi con técnicas de Dinámica de Fluidos Computacional (CFD), comparándo las con ensayos en laboratorio. Para cada prototipo, las geometrías definidas y analizadas han permitido simular el funcionamiento sin (G1) y con inyección (G2) para quimigación. En el caso G1, se presentan los gráficos del perfil de presiones en el eje del inyector para diversas velocidades, así como la distribución del campo de presiones y de la evolución de las diferencias de presión y pérdidas de carga frente al caudal principal. Para comparar los resultados obtenidos con CFD frente al resultado experimental, se calculó el error relativo. En el caso G2, se obtuvo la representación gráfica del el caudal de inyección frente al caudal principal. Las técnicas CFD exigen un buen ajuste del modelo para dar un resultado aceptable. Son interesantes para comparar geometrías, analizar sus variantes, realizar prediseños y aproximar ordenes de magnitud, pero es recomendable su ensayo en laboratorio para validar los resultados.Manzano Juarez, J.; De Azevedo, BM.; Do Bomfim, GV.; Royuela, A.; Palau Estevan, CV.; Viana, TVDA. (2014). Diseño y predicción del funcionamiento de inyectores Venturi en riego localizado. Revista Brasileira de Engenharia Agrícola e Ambiental - Agriambi. 18(12):1209-1217. doi:10.1590/1807-1929/agriambi.v18n12p1209-1217S120912171812Baylar, A., Aydin, M., Unsal, M., & Ozkan, F. (2009). Numerical Modeling of Venturi Flows for Determining Air Injection Rates Using Fluent V6.2. Mathematical and Computational Applications, 14(2), 97-108. doi:10.3390/mca14020097CIPOLLA, E., Silva, F., FILHO, G., & BARROS, R. (2011). Avaliação da Distribuição de Velocidades em Uma Bomba Centrífuga Radial Utilizando Técnicas de CFD. Revista Brasileira de Recursos Hídricos, 16(3), 71-79. doi:10.21168/rbrh.v16n3.p71-79Davis, J. A., & Stewart, M. (2002). Predicting Globe Control Valve Performance—Part I: CFD Modeling. Journal of Fluids Engineering, 124(3), 772-777. doi:10.1115/1.1490108Coutier-Delgosha, O., Fortes-Patella, R., & Reboud, J. L. (2003). Evaluation of the Turbulence Model Influence on the Numerical Simulations of Unsteady Cavitation. Journal of Fluids Engineering, 125(1), 38-45. doi:10.1115/1.1524584Franklin, R. E., & Wallace, J. M. (1970). Absolute measurements of static-hole error using flush transducers. Journal of Fluid Mechanics, 42(1), 33-48. doi:10.1017/s0022112070001052Guo, B., Langrish, T. A. ., & Fletcher, D. F. (2002). CFD simulation of precession in sudden pipe expansion flows with low inlet swirl. Applied Mathematical Modelling, 26(1), 1-15. doi:10.1016/s0307-904x(01)00041-5Hatano, S., Kang, D., Kagawa, S., Nohmi, M., & Yokota, K. (2014). Study of Cavitation Instabilities in Double-Suction Centrifugal Pump. International Journal of Fluid Machinery and Systems, 7(3), 94-100. doi:10.5293/ijfms.2014.7.3.094Lindau, J. W., Kunz, R. F., Boger, D. A., Stinebring, D. R., & Gibeling, H. J. (2002). High Reynolds Number, Unsteady, Multiphase CFD Modeling of Cavitating Flows. Journal of Fluids Engineering, 124(3), 607-616. doi:10.1115/1.1487360Norton, T., Sun, D.-W., Grant, J., Fallon, R., & Dodd, V. (2007). Applications of computational fluid dynamics (CFD) in the modelling and design of ventilation systems in the agricultural industry: A review. Bioresource Technology, 98(12), 2386-2414. doi:10.1016/j.biortech.2006.11.025Palau-Salvador, G., Gonzalez Altozano, P., & Arviza-Valverde, J. (2007). Numerical modeling of cavitating flows for simple geometries using FLUENT V6.1. Spanish Journal of Agricultural Research, 5(4), 460. doi:10.5424/sjar/2007054-269Palau-Salvador, G., González-Altozano, P., & Arviza-Valverde, J. (2007). Three-Dimensional Modeling and Geometrical Influence on the Hydraulic Performance of a Control Valve. Journal of Fluids Engineering, 130(1). doi:10.1115/1.2813131Reader-Harris, M. ., Brunton, W. ., Gibson, J. ., Hodges, D., & Nicholson, I. . (2001). Discharge coefficients of Venturi tubes with standard and non-standard convergent angles. Flow Measurement and Instrumentation, 12(2), 135-145. doi:10.1016/s0955-5986(01)00007-3Singhal, A. K., Athavale, M. M., Li, H., & Jiang, Y. (2002). Mathematical Basis and Validation of the Full Cavitation Model. Journal of Fluids Engineering, 124(3), 617-624. doi:10.1115/1.1486223Sun, Y., & Niu, W. (2012). Simulating the Effects of Structural Parameters on the Hydraulic Performances of Venturi Tube. Modelling and Simulation in Engineering, 2012, 1-7. doi:10.1155/2012/458368Teruel, B. J. (2010). Controle automatizado de casas de vegetação: variáveis climáticas e fertigação. Revista Brasileira de Engenharia Agrícola e Ambiental, 14(3), 237-245. doi:10.1590/s1415-43662010000300001Vortmann, C., Schnerr, G. H., & Seelecke, S. (2003). Thermodynamic modeling and simulation of cavitating nozzle flow. International Journal of Heat and Fluid Flow, 24(5), 774-783. doi:10.1016/s0142-727x(03)00003-1Wei, Q., Shi, Y., Dong, W., Lu, G., & Huang, S. (2006). Study on hydraulic performance of drip emitters by computational fluid dynamics. Agricultural Water Management, 84(1-2), 130-136. doi:10.1016/j.agwat.2006.01.016Xing, T., & Frankel, S. H. (2002). Effect of Cavitation on Vortex Dynamics in a Submerged Laminar Jet. AIAA Journal, 40(11), 2266-2276. doi:10.2514/2.1563Yeoh, G. H., Liu, C., Tu, J., & Timchenko, V. (2012). Computational Fluid Dynamics and Its Applications 2012. Modelling and Simulation in Engineering, 2012, 1-2. doi:10.1155/2012/61061