Error control in simplification before generation algorithms for symbolic analysis of large analogue circuits

Circuit reduction is a fundamental first step in addressing the symbolic analysis of large analogue circuits. A new algorithm for simplification before generation is presented which is very efficient in terms of speed and the amount of circuit reduction, and solves the accuracy problems of previously reported approaches

An error-controlled methodology for approximate hierarchical symbolic analysis

Limitations of existing approaches for symbolic analysis of large analog circuits are discussed. To address their solution, a new methodology for hierarchical symbolic analysis is introduced. The combination of a hierarchical modeling technique and approximation strategies, comprising circuit reduction, graph-based symbolic solution of circuit equations and matrix-based error control, provides optimum results in terms of speech and quality of results.European Commission ESPRIT 21812Comisión Interministerial de Ciencia y Tecnología TIC97-058

The glaciation of Serra de Queixa-Invernadoiro and Serra do Gerês-Xurés, NW Iberia. A critical review and a cosmogenic nuclide (10Be and 21 Ne) chronology.

[Abstract]The Serras of Queixa-Invernadoiro and Gerês-Xurés in the NW of the Iberian Peninsula are two small mountain massifs located at low altitude that were glaciated in the Pleistocene. The prevailing granitic lithology was a problem for mapping glacial forms (in many cases interpreted as banal granite forms) and for the identification of the tills (misunderstood as remains of regolith). A combination of geomorphological techniques (genetic mapping of granite forms and deposits), the micromorphological study of till thin sections and the morphoscopy of quartz grains at the SEM enabled to establish a model of the geomorphological evolution complemented with the chronology by cosmogenic nuclides (21Ne and 10Be) of both glacial systems. The obtained results represent the glacial evolution of the area from circa 250 ka B.P

Activity of intestinal carbohydrases responds to multiple dietary signals in nestling House sparrows

The ‘adaptive modulation hypothesis’ predicts that activity of digestive enzymes should match the amount of their substrates in diet. Interestingly, many passerine birds do not adjust the activity of intestinal carbohydrases to dietary carbohydrate content. It is difficult to assess the generality of this rule, because in some studies passerines fed on low-carbohydrate and high-lipid diet showed reduced activity of intestinal carbohydrases. However, as carbohydrase activity may be inhibited by high dietary lipid content, it is unclear whether observed effects reflected lack of induction by the low carbohydrate levels or suppression by the high lipid levels. Here, we isolated the specific effects of dietary carbohydrate and lipid on carbohydrases. We hand-fed house sparrow nestlings on diets with 25% starch and 8% lipid (diet HS), no starch and 20% lipid (HL), or 25% starch and 20% lipid (HSL). Our results show that activity of intestinal carbohydrases is simultaneously induced by dietary carbohydrates and decreased by dietary lipid, although the latter effect seems stronger. Activities of maltase and sucrase summed over the total intestine decreased in the order HS>HSL>HL. We observed a complex interaction between diet composition and intestinal position for mass-specific activity of these enzymes, suggesting site-specific responses to changes in digesta composition along the intestines caused by digestion and absorption. We re-interpret results of earlier studies and conclude that there is no unequivocal example of adaptive modulation of intestinal carbohydrases by dietary carbohydrate in adult passerine birds, whereas the present experiment confirms that nestlings of at least some species possess such capacity.Fil: Brzek, Pawel. University of Wisconsin. Department of Forest and Wildlife Ecology; Estados UnidosFil: Kohl, Kevin D.. University of Wisconsin. Department of Forest and Wildlife Ecology; Estados UnidosFil: Caviedes Vidal, Enrique Juan Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. University of Wisconsin. Department of Forest and Wildlife Ecology; Estados Unidos. Universidad Nacional de San Luis. Facultad de Ciencias Humanas. Laboratorio de Biología "Profesor Enrique Cavides Codelia"; ArgentinaFil: Karasov, William H.. University of Wisconsin. Department of Forest and Wildlife Ecology; Estados Unido

Master in Water Engineering a “semi-attendance” University-specific degree with international participation

The Water Engineering Master Course is a university-specific degree at the University of Seville which nowadays can be coursed in two different modalities: “on line” and “semi-attendance”. Its first edition took place at 2000 and since then, the average of graduated students has been of 40 students per course. The semi-attendance mode offers the possibility of being followed in an on-line way from November to June. A Moodle platform provides all the documentation that is required to attend every module, at the end of each one some online questionnaires are also uploaded in order to evaluate the students. Only one of the 10 mandatory modules which make up the course have to be attended in a classroom mode. It takes place during 15 days in July and allows the students to come into contact with the lecturers, professionals of the sector and their own mates as well. During this period both, teachers and students, are lodged in the same residence and all of them have the chance of interchanging experiences in a full teaching-learning process, solving doubts and improving their skills thanks to specific courses, specially designed in function of the lack of knowledge which has been detected during de previous modules, o even, the suggestions received directly from students. Most of the students come from Hispanic countries and in less amount from African and European countries. Actually every July about 80 students and teachers from 25 different countries around the world, meet in Seville to attend this Master. The classes are given in Spanish with translator support if it’s necessary. Different environments, problematic and conditioning factors are studied and a large kind of solutions in water cycle are designed during these days. The requirements to elaborate the final master project are mainly that this one can be used to resolve a real local problem in the student’s origin place and moreover the student can obtain better marks if he/she finds financing to carry it out. In the last 8 years a useful module named “Tools for design” has been included in the program of the Master in order to enable the student in IT, specifically spreadsheets, cad, software for budgeting and measurement, topography and decision support systems. Students who graduate are able to evaluate the most proper technology from a social, technic and economic point of view, as well as, select the most efficient alternatives in order to achieve a sustainable development

Fully reversible phenotypic plasticity of digestive physiology in young house sparrows: lack of long-term effect of early diet composition

Feeding conditions during the nestling period may significantly affect whole-life fitness in altricial birds but little is known about the physiological mechanisms responsible for these effects. Permanent changes (irreversible developmental plasticity) in digestive physiology caused by the neonatal diet may form such a mechanism. We previously showed that the lack of starch in the diet of house sparrow (Passer domesticus) nestlings between 3 and 12 days post-hatching significantly decreased the activity of intestinal maltase, an enzyme essential for starch digestion. To check whether diet-induced variation in maltase activity in young house sparrows is reversible, we raised them under laboratory conditions from 3 until 30 days of age on diets with either 0% starch or 25% starch, with some individuals experiencing a switch in their assigned diet at 12 days of age. We found evidence for the presence of an internal, presumably genetic, program for changes in the activity of maltase and sucrase, which was, however, significantly affected by diet composition (i.e. environmental factor). Digestive enzyme activity in 30 day old birds was not influenced by diet composition prior to day 12 but instead depended only on diet that was fed between days 12 and 30. We conclude that plasticity in the activity of intestinal disaccharidases in house sparrow nestlings represents completely reversible phenotypic flexibility that can help young sparrows to cope with unpredictable variation in food composition during ontogeny without long-term effects on their digestive system. However, comparison with other species suggests that the magnitude of digestive flexibility in young passerines may be evolutionarily matched to species-specific variation in feeding conditions.Fil: Brzęk, Pawel. University of Wisconsin; Estados Unidos. University of Bialystok; PoloniaFil: Kohl, Kevin D.. University of Wisconsin; Estados Unidos. University of Utah; Estados UnidosFil: Caviedes Vidal, Enrique Juan Raul. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Karasov, William H.. University of Wisconsin; Estados Unido

Treatment strategy optimization for patients with non-small-cell lung cancer harboring EGFR mutation: a Delphi consensus

AIM: To stablish a consensus on the treatment strategy for advanced non-small-cell lung cancer (aNSCLC) with epidermal growth factor receptor mutation (EGFRm) in Spain. METHODS: After a systematic literature review, the scientific committee developed 33 statements in 4 fields: molecular diagnosis (10 items); histologic profile and patient clinical characteristics (7 items); first-line (1L) treatment in EGFRm aNSCLC (8 items); and subsequent-line treatment (8 items). A panel of 31 experts completed 2 Delphi online questionnaires rating their degree of agreement/disagreement for each statement through a 1-9 range scale (1-3 = disagree, 7-9 = agree). Consensus was reached if 2/3 of the participants are in the median range. RESULTS: In the first Delphi round consensus was achieved for 24/33 of the statements. One of the assertions was deleted, proceeding to a second round with the eight remaining questions with no consensus or in the range of indeterminacy. Determination of the EGFR status from tissue and analysis of the different biomarkers are two important variables that influenced treatment decision in patients with aNSCLC. 1L treatment should be the best therapeutic option, independently of the subsequent lines of treatment. For patients with the most common activating mutations osimertinib was considered the most efficient and safe 1L option. In case of disease progression, a new biopsy was needed. CONCLUSIONS: A consensus document is proposed to optimize the treatment strategy for untreated patients with a NSCLC with EGFR sensitizing mutations

Chemicals from Biomass: Selective Synthesis of N-Substituted Furfuryl Amines by the One-Pot Direct Reductive Amination of Furanic Aldehydes

"This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry & Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.8b06631"[EN] N-substituted furfuryl amines are an important class of compounds due to their pharmaceutical activities that can be produced by reductive amination of furfuraldehydes derived from biomass. With supported Pd nanoparticles it is possible to obtain high activities and selectivities for the production of secondary amines. CO adsorption monitored by IR shows the importance of the Pd crystal size and crystal face on catalyst activity and selectivity. When using Pd on carbon the amount of unsaturated Pd sites is very much enhanced with the corresponding increase in selectivity. The role of carbon deposition on metal terraces on catalytic selectivity is discussed. The optimized catalyst has been successfully applied in the reductive amination of 5-hydroxymethylfurfural with different amines and ammonia as well as in the one-pot reductive amination starting from nitrobenzene instead of aniline, giving the different N-substituted-5-(hydroxymethyl)-2-furfuryl amines with excellent activity and selectivity.Spanish MICINN Project (CTQ-2015-67592-P) and Severo Ochoa Program (SEV-2016-0683) are gratefully acknowledged. AGO thanks Severo Ochoa Program for predoctoral fellowships.Garcia-Ortiz, A.; Vidal, JD.; Climent Olmedo, MJ.; Concepción Heydorn, P.; Corma Canós, A.; Iborra Chornet, S. (2019). Chemicals from Biomass: Selective Synthesis of N-Substituted Furfuryl Amines by the One-Pot Direct Reductive Amination of Furanic Aldehydes. ACS Sustainable Chemistry & Engineering. 7(6):6243-6250. https://doi.org/10.1021/acssuschemeng.8b06631S624362507

Design and assessment of a scalable and customizable low-cost tiled display system

© 2021 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.[EN] In this paper, a scalable hardware and software architecture for low-cost tiled display systems (a.k.a. videowalls), customizable through a dynamic web-based management and configuration service is presented and evaluated both objectively and subjectively. It has been designed for both stored and live broadcast/broadband content, in mosaic or warp distributions. The videowalls can be dynamically configured via web in different ways: the displays can create a single screen of a larger size, or they can be configured in a customized way in order to playout different media contents in different display combinations. As display renderers, low-cost devices are proposed as the main hardware element to obtain affordable videowall systems. As a proof of concept, two prototypes have been implemented, including an accurate synchronization mechanism. To evidence the good performance of the prototypes and configuration service, Both objective and subjective evaluations have been conducted regarding synchronization accuracy and usability of the configuration service, obtaining satisfactory results.This work has been funded by the Generalitat Valenciana, through the R&D Program "Grants for research groups to be consolidated, AICO/2017" under Project AICO/2017/059.Marfil, D.; Boronat, F.; González-Salinas, J.; Vidal Meló, A. (2021). Design and assessment of a scalable and customizable low-cost tiled display system. IEEE Latin America Transactions. 19(5):708-716. https://doi.org/10.1109/TLA.2021.9448284S70871619

Efficacy of glutamine in the prevention of acute radiation enteritis: a randomized controlled trial

[Abstract] Background: Acute radiation enteritis is a common adverse effect related to radiotherapy (RT). Glutamine is an immune modulator and antioxidant amino acid that can exert a protective role in patients receiving abdominal or pelvic radiation. The aim of this study was to test if glutamine prevents radiation enteritis during RT. Materials and Methods: Double-blind, randomized, controlled trial including 69 patients who needed RT because of pelvic or abdominal malignancies and received glutamine (30 g/d) or placebo (casein, 30 g/d). Enteritis was evaluated according to the Radiation Therapy Oncology Group scale, intestinal inflammation using fecal calprotectin, and gut integrity with citrulline. The incidence of enteritis was analyzed by Kaplan-Meier curves, and the hazard ratio (HR) was calculated using Cox regression. Results: Patients were predominantly male (65.2%), with an average (SD) age of 66.6 (9.9) years, with urologic (44.9%), rectal (24.6%), or gynecological cancer (23.1%). More patients developed enteritis with glutamine than with the placebo (55.9% vs 22.0%; P =.002), with an HR of 1.59 (95% confidence interval, 0.62-4.05). There were no differences in final calprotectin levels (glutamine, 57.9 [85.8] mg/kg vs placebo, 54.0 [57.7] mg/kg; P =.182) or the number of patients with values >50 mg/kg (glutamine, 58.1% vs placebo, 54.6%; P =.777). Final citrulline levels were similar between groups (glutamine, 26.31 [10.29] mmol/L vs placebo, 27.69 [12.31] mmol/L; P =.639), without differences in the number of patients with <20 mmol/L (glutamine, 24.1% vs placebo, 25.0%; P =.938). Citrulline concentration was reduced during RT with placebo but remained unchanged with glutamine. Conclusion: Glutamine does not prevent the development of enteritis during RT. © 2013 American Society for Parenteral and Enteral Nutrition.Castilla y León. Consejería de Sanidad, SACYL GRS 326/B/0