Influencia de los fundos en los factores de calidad del mango Kent en la empresa Agrocosta en la campaña 2018-2020, Piura

La presente investigación se realizó con el principal objetivo de determinar la influencia de los fundos en los factores de calidad del mango Kent en la empresa Agrocosta, analizando de forma específica cada uno de estos factores, es decir; factor Brix; factor tamaño y factor descarte durante las campañas del año 2018 al 2020. El desarrollo de la investigación contempla una metodología de tipo aplicada, enfoque cuantitativo, con diseño no experimental, descriptiva y transversal, para la recolección de datos se recurrió al análisis documental, sobre los informes de producción solicitados a la empresa de las campañas 2018-2020, en los cuales registran la información de cada fundo proveedor en relación con los factores de calidad a analizar, así pues, una vez recopilada la información y siendo procesada aplicando el análisis de varianza, se obtuvo resultados que indicaron que no existió influencia significativa en ninguno de los factores analizados, puesto que los grados Brix del mango de cada proveedor, así como la producción de mango de los distintos calibres, o el porcentaje de descarte de mango proveniente de los distintos fundos no variaba de forma importante durante las tres campañas evaluada, por lo cual pudo concluir que los fundos no influyeron en los factores de calidad del mango Kent durante el periodo evaluado

Estrategias de Marketing digital y su relación con el posicionamiento de la empresa Detalles Jeans SAC – 2021

La presente investigación tiene como objetivo determinar la relación de las estrategias de Marketing digital y su relación con el posicionamiento de la empresa Detalles Jeans SAC, 2021. Se utilizó un diseño relacional y para ello se trabajó con una muestra de 195 clientes, se aplicó un muestreo probabilístico; asimismo la técnica es la encuesta y los instrumentos utilizados son los cuestionarios de marketing digital y posicionamiento, el cual fue validado por expertos en el tema. Los resultados fueron procesados en el programa SPSS versión 25.0 y se concluye que existe relación positiva y fuerte entre el marketing digital y el posicionamiento en los clientes de Detalles Jeans de Trujillo, 2021, con un Rho de Spearman de 0.804 y un nivel de significancia de p<0.01; por tanto, a medida que se incremente el Marketing digital, el posicionamiento también lo hará. Se identificó que el nivel de Marketing digital es alto en un 59.5%; en un 22.6% bajo, y en un 17.9% medio; asimismo presentan niveles altos de vigor, dedicación y absorción. El nivel de posicionamiento es alto en un 56.9%, bajo en un 22.6% y medio en un 20.5%; por tanto, existe en gran proporción un correcto posicionamiento por parte de las empresas hacia sus clientes en el año 2021. Se estableció, por último, que existe un relación positiva y fuerte entre las dimensiones, atracción con un Rho de Spearman de 0.801, retención con un Rho de Spearman de 0.805 y conversión con un Rho de Spearman de 0.773; y el posicionamiento con un nivel de significancia de p<0.01.This research aims to determine the relationship of digital marketing strategies and their relationship with the positioning of the company Detalles Jeans SAC, 2021. A relational design was used and for this we worked with a sample of 195 clients, a probabilistic sampling was applied; likewise the technique is the survey and the instruments used are the digital marketing and positioning questionnaires, which was validated by experts in the field. The results were processed in the SPSS program version 25.0 and it is concluded that there is a positive and strong relationship between digital marketing and positioning in the customers of Detalles Jeans de Trujillo, 2021, with a Spearman's Rho of 0.804 and a significance level of p<0.01; therefore, it is concluded that as digital marketing increases, positioning will also increase. It was identified that the level of digital marketing is high in 59.5%, low in 22.6% and medium in 17.9%; they also present high levels of vigor, dedication and absorption. The level of positioning is high in 56.9%, low in 22.6% and medium in 20.5%; therefore, there is in great proportion a correct positioning by the companies towards their clients in the year 2021. Finally, it was established that there is a positive and strong relationship between the dimensions, attraction with a Spearman's Rho of 0.801, retention with a Spearman's Rho of 0.805 and conversion with a Spearman's Rho of 0.773; and positioning with a significance level of p<0.01.Tesi

Costo operativo para la fijación de la tasa de interés en el microcrédito

Las instituciones de microfinanzas buscan, además de lograr la autosostenibilidad financiera, apoyar socialmente a los emprendedores que no consiguen financiamiento en entidades grandes, por lo que aplican tasas de interés justas. Por ello, cobran una vital importancia para estas entidades. Las tasas de interés tienen diversas variables determinantes, entre las que se encuentran las internas y las externas. En este documento se analizan los componentes que hacen parte de los costos de operación y la influencia que este factor ejerce en la definición de la tasa de interés activa. Para lograrlo, se organiza en cuatro secciones principales. En primer capítulo, se plantea el marco teórico sobre el cual se desenvuelven los microcréditos, y, los efectos que tienen estos y la tasa de interés en la entidad de microfinanzas y en la población. El segundo capítulo analiza comparativamente las variables y factores en microfinanzas, además de los tipos de instituciones de microfinanzas y microcrédito. El tercer capítulo compara la forma en la que se fija la tasa de interés en los microcréditos y cómo varía en relación con sus determinantes. El último capítulo explora el impacto de los costos operativos en la fijación de tasa de interés activa. La principal conclusión a la que llega este trabajo es que el costo operativo de las IMF sí resulta una variable en la fijación de las tasas de interés, aunque algunos autores encuentran que las nuevas plataformas digitales permiten ajustarlo y con ello una gran reducción que beneficie a los clientes de bajos recursos, su principal público objetivo.In order to achieving financial self-sustainability, microfinance institutions seek to provide social support to entrepreneurs who are unable to obtain financing from large institutions, which is why they apply fair interest rates. For this reason, interest rates are of vital importance for these entities. Interest rates have several determining variables, including internal and external ones. This paper analyzes the components that are part of the operating costs and the influence that this factor has on the definition of the lending rate. To achieve this, it is organized in four main sections. In the first chapter, the theoretical framework on which microcredits are developed is presented, as well as their effects and the interest rate on the microfinance institution and on the population. The second chapter analyzes comparatively the variables and factors in microfinance, as well as the types of microfinance and microcredit institutions. The third chapter compares how the interest rate in microcredit is set and how it varies in relation to its determinants. The last chapter explores the impact of operating costs on lending rate setting. The main conclusion reached in this paper is that the operating cost of MFIs is a variable in setting interest rates, although some authors find that the new digital platforms make it possible to adjust it and thus greatly reduce it to benefit low-income clients, their main target audience.Trabajo de Suficiencia Profesiona

Collagen XIX Alpha 1 improves prognosis in amyotrophic lateral sclerosis

The identification of more reliable diagnostic or prognostic biomarkers in age-related neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), is urgently needed. The objective in this study was to identify more reliable prognostic biomarkers of ALS mirroring neurodegeneration that could be of help in clinical trials. A total of 268 participants from three cohorts were included in this study. The muscle and blood cohorts were analyzed in two cross-sectional studies, while the serial blood cohort was analyzed in a longitudinal study at 6-monthly intervals. Fifteen target genes and fourteen proteins involved in muscle physiology and differentiation, metabolic processes and neuromuscular junction dismantlement were studied in the three cohorts. In the muscle biopsy cohort, the risk for a higher mortality in an ALS patient that showed high Collagen type XIX, alpha 1 (COL19A1) protein levels and a fast progression of the disease was 70.5% (P < 0.05), while in the blood cohort, this risk was 20% (P < 0.01). In the serial blood cohort, the linear mixed model analysis showed a significant association between increasing COL19A1 gene levels along disease progression and a faster progression during the follow-up period of 24 months (P < 0.05). Additionally, higher COL19A1 levels and a faster progression increased 17.9% the mortality risk (P < 0.01). We provide new evidence that COL19A1 can be considered a prognostic biomarker that could help the selection of homogeneous groups of patients for upcoming clinical trial and may be pointed out as a promising therapeutic target in ALS

Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA

The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and B-cell precursor acute lymphoblastic leukemia (ALL) Philadelphia (Ph)-positive patients. In this study, we present a novel DNA-based next-generation sequencing (NGS) methodology for KD ABL1 mutation detection and monitoring with a 1.0E-4 sensitivity. This approach was validated with a well-stablished RNA-based nested NGS method. The correlation of both techniques for the quantification of ABL1 mutations was high (Pearson r = 0.858, p < 0.001), offering DNA-DeepNGS a sensitivity of 92% and specificity of 82%. The clinical impact was studied in a cohort of 129 patients (n = 67 for CML and n = 62 for B-ALL patients). A total of 162 samples (n = 86 CML and n = 76 B-ALL) were studied. Of them, 27 out of 86 harbored mutations (6 in warning and 21 in failure) for CML, and 13 out of 76 (2 diagnostic and 11 relapse samples) did in B-ALL patients. In addition, in four cases were detected mutation despite BCR::ABL1 < 1%. In conclusion, we were able to detect KD ABL1 mutations with a 1.0E-4 sensitivity by NGS using DNA as starting material even in patients with low levels of disease

NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the Neotropics

Xenarthrans – anteaters, sloths, and armadillos – have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with 24 domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos, ten anteaters, and six sloths. Our dataset includes the families Chlamyphoridae (13), Dasypodidae (7), Myrmecophagidae (3), Bradypodidae (4), and Megalonychidae (2). We have no occurrence data on Dasypus pilosus (Dasypodidae). Regarding Cyclopedidae, until recently, only one species was recognized, but new genetic studies have revealed that the group is represented by seven species. In this data-paper, we compiled a total of 42,528 records of 31 species, represented by occurrence and quantitative data, totaling 24,847 unique georeferenced records. The geographic range is from the south of the USA, Mexico, and Caribbean countries at the northern portion of the Neotropics, to its austral distribution in Argentina, Paraguay, Chile, and Uruguay. Regarding anteaters, Myrmecophaga tridactyla has the most records (n=5,941), and Cyclopes sp. has the fewest (n=240). The armadillo species with the most data is Dasypus novemcinctus (n=11,588), and the least recorded for Calyptophractus retusus (n=33). With regards to sloth species, Bradypus variegatus has the most records (n=962), and Bradypus pygmaeus has the fewest (n=12). Our main objective with Neotropical Xenarthrans is to make occurrence and quantitative data available to facilitate more ecological research, particularly if we integrate the xenarthran data with other datasets of Neotropical Series which will become available very soon (i.e. Neotropical Carnivores, Neotropical Invasive Mammals, and Neotropical Hunters and Dogs). Therefore, studies on trophic cascades, hunting pressure, habitat loss, fragmentation effects, species invasion, and climate change effects will be possible with the Neotropical Xenarthrans dataset

Adelante / Endavant

Séptimo desafío por la erradicación de la violencia contra las mujeres del Institut Universitari d’Estudis Feministes i de Gènere "Purificación Escribano" de la Universitat Jaume