Geometric Morphometrics of Gary Dart Points from the Davy Crockett National Forest

Three-dimensional scans of Gary dart points recovered from the Davy Crockett National Forest are employed in tests of basal morphology by site, size (allometry), and asymmetry. Variability in basal morphology for Gary points from sites on the Davy Crockett National Forest is presented and compared to specimens from the published type books. The hypothesis that Gary basal morphology differs between sites containing Woodland-era sand temped ceramics and those where no sand tempered ceramics were recovered is then tested and the results discussed

The HERMES Solar Atlas and the spectroscopic analysis of the seismic solar analogue KIC3241581

Solar-analog stars provide an excellent opportunity to study the Sun's evolution, i.e. the changes with time in stellar structure, activity, or rotation for solar-like stars. The unparalleled photometric data from the NASA space telescope Kepler allows us to study and characterise solar-like stars through asteroseismology. We aim to spectroscopically investigate the fundamental parameter and chromospheric activity of solar analogues and twins, based on observations obtained with the HERMES spectrograph and combine them with asteroseismology. Therefore, we need to build a solar atlas for the spectrograph, to provide accurate calibrations of the spectroscopically determined abundances of solar and late type stars observed with this instrument and thus perform differential spectral comparisons. We acquire high-resolution and high signal-to-noise spectroscopy to construct three solar reference spectra by observing the reflected light of Vesta and Victoria asteroids and Europa (100<S/N<450) with the \Hermes spectrograph. We then observe the Kepler solar analog KIC3241581 (S/N~170). We constructed three solar spectrum atlases from 385 to 900 nm obtained with the Hermes spectrograph from observations of two bright asteroids and Europa. A comparison between our solar spectra atlas to the Kurucz and HARPS solar spectrum shows an excellent agreement. KIC3241581 was found to be a long-periodic binary system. The fundamental parameter for the stellar primary component are Teff=5689+/-11K, logg=4.385+/-0.005, [Fe/H]=+0.22+/-0.01, being in agreement with the published global seismic values confirming its status of solar analogue. KIC 3241581 is a metal rich solar analogue with a solar-like activity level in a binary system of unknown period. The chromospheric activity level is compatible to the solar magnetic activity.Comment: 12 pages, 8 figures, accepted for publication in A&

Photospheric and chromospheric magnetic activity of seismic solar analogs. Observational inputs on the solar/stellar connection from Kepler and Hermes

We identify a set of 18 solar analogs among the seismic sample of solar-like stars observed by the Kepler satellite rotating between 10 and 40 days. This set is constructed using the asteroseismic stellar properties derived using either the global oscillation properties or the individual acoustic frequencies. We measure the magnetic activity properties of these stars using observations collected by the photometric Kepler satellite and by the ground-based, high-resolution Hermes spectrograph mounted on the Mercator telescope. The photospheric (Sph) and chromospheric (S index) magnetic activity levels of these seismic solar analogs are estimated and compared in relation to the solar activity. We show that the activity of the Sun is comparable to the activity of the seismic solar analogs, within the maximum-to-minimum temporal variations of the 11-year solar activity cycle 23. In agreement with previous studies, the youngest stars and fastest rotators in our sample are actually the most active. The activity of stars older than the Sun seems to not evolve much with age. Furthermore, the comparison of the photospheric, Sph, with the well-established chromospheric, S index, indicates that the Sph index can be used to provide a suitable magnetic activity proxy which can be easily estimated for a large number of stars from space photometric observations.Comment: Accepted for publication in A&

Heavy Lift Launch Capability with a New Hydrocarbon Engine

The Advanced Concepts Office at NASA's George C. Marshall Space Flight Center was tasked to define the thrust requirement of a new liquid oxygen rich staged combustion cycle hydrocarbon engine that could be utilized in a launch vehicle to meet NASA s future heavy lift needs. Launch vehicle concepts were sized using this engine for different heavy lift payload classes. Engine out capabilities for one of the heavy lift configurations were also analyzed for increased reliability that may be desired for high value payloads or crewed missions. The applicability for this engine in vehicle concepts to meet military and commercial class payloads comparable to current ELV capability was also evaluated

NASA Advanced Concepts Office, Earth-To-Orbit Team Design Process and Tools

The Earth-to-Orbit Team (ETO) of the Advanced Concepts Office (ACO) at NASA Marshall Space Flight Center (MSFC) is considered the pre-eminent go-to group for pre-phase A and phase A concept definition. Over the past several years the ETO team has evaluated thousands of launch vehicle concept variations for a significant number of studies including agency-wide efforts such as the Exploration Systems Architecture Study (ESAS), Constellation, Heavy Lift Launch Vehicle (HLLV), Augustine Report, Heavy Lift Propulsion Technology (HLPT), Human Exploration Framework Team (HEFT), and Space Launch System (SLS). The ACO ETO Team is called upon to address many needs in NASA s design community; some of these are defining extremely large trade-spaces, evaluating advanced technology concepts which have not been addressed by a large majority of the aerospace community, and the rapid turn-around of highly time critical actions. It is the time critical actions, those often limited by schedule or little advanced warning, that have forced the five member ETO team to develop a design process robust enough to handle their current output level in order to meet their customer s needs. Based on the number of vehicle concepts evaluated over the past year this output level averages to four completed vehicle concepts per day. Each of these completed vehicle concepts includes a full mass breakdown of the vehicle to a tertiary level of subsystem components and a vehicle trajectory analysis to determine optimized payload delivery to specified orbital parameters, flight environments, and delta v capability. A structural analysis of the vehicle to determine flight loads based on the trajectory output, material properties, and geometry of the concept is also performed. Due to working in this fast-paced and sometimes rapidly changing environment, the ETO Team has developed a finely tuned process to maximize their delivery capabilities. The objective of this paper is to describe the interfaces between the three disciplines used in the design process: weights and sizing, trajectory, and structural analysis. The tools used to perform such analysis are INtegrated Rocket Sizing (INTROS), Program to Optimize Simulated Trajectories (POST), and Launch Vehicle Analysis (LVA) respectively. The methods each discipline uses to streamline their particular part of the design process will also be discussed

Neuromuscular Responses during Knee Extension Exercise in Combination with Different Blood Flow Restriction Initial Pressures

Specifications of blood flow restriction training technique have been widely discussed to create a valid and reliable protocol. One of the unexplored variables is the effect of different initial restrictive pressures (tightness of cuffs, IRP) in combination with resistance exercise on neuromuscular responses and strength. PURPOSE: The purpose of this study was to determine any differences in amplitude (RMS) and median frequency (MDF) of electromyography (EMG) signals, as well as changes in strength during knee extension exercises with IRPs of 40-45 mmHg and 60-65 mmHg. METHODS: Twenty male subjects (age = 25.7 ± 4.3 yrs), participated in this study. They were required to attend the lab on 3 different occasions, with the first one being a familiarization session. On the subsequent sessions, participant\u27s upper leg was measured starting from the lateral epicondyle to the greater trochanter of the femur. An EMG electrode was placed at one-third the distance over the longitudinal axis of the vastus lateralis (VL) after shaving, abrading and cleaning with isopropyl alcohol. Initial restrictive pressure was randomly selected and participants completed a pre-exercise maximum voluntary contraction (MVC) test to determine their torque. For dynamic exercises, load was set at 20% MVC and each participant performed one set of 30 repetitions and three sets of 15 repetitions, separated by one minute rest. Post-exercise MVC was performed to assess the changes in leg strength following exercises. RESULTS: Results showed significant main effects (p\u3c0.01) in leg strength for condition (40-45 mmHg vs. 60-65 mmHg) and trial (pre vs. post MVC). A significant main effect was observed for condition for MVC EMG amplitude (p\u3c0.01). In addition, there were significant main effects for contractions (p\u3c0.01) in both EMG amplitude and MDF during dynamic exercises. CONCLUSION: The significant decreases in knee extension strength at IRP of 60-65 mmHg compared to IRP of 40-45mmHg from pre- to post-exercise suggest that subjects experienced more fatigue at 60-65 mmHg because of the decreased availability of oxygen to the working muscle. The use of different IRP will affect the level of blood flow and oxygen supply to skeletal muscle possibly causing variation in neuromuscular adaptation due to changes in total and type of muscle fiber recruitment

Magnetic variability in the young solar analog KIC 10644253: Observations from the Kepler satellite and the HERMES spectrograph

The continuous photometric observations collected by the Kepler satellite over 4 years provide a whelm of data with an unequalled quantity and quality for the study of stellar evolution of more than 200000 stars. Moreover, the length of the dataset provide a unique source of information to detect magnetic activity and associated temporal variability in the acoustic oscillations. In this regards, the Kepler mission was awaited with great expectation. The search for the signature of magnetic activity variability in solar-like pulsations still remained unfruitful more than 2 years after the end of the nominal mission. Here, however, we report the discovery of temporal variability in the low-degree acoustic frequencies of the young (1 Gyr-old) solar analog KIC 10644253 with a modulation of about 1.5 years with significant temporal variations along the duration of the Kepler observations. The variations are in agreement with the derived photometric activity. The frequency shifts extracted for KIC 10644253 are shown to result from the same physical mechanisms involved in the inner sub-surface layers as in the Sun. In parallel, a detailed spectroscopic analysis of KIC 10644253 is performed based on complementary ground-based, high-resolution observations collected by the HERMES instrument mounted on the MERCATOR telescope. Its lithium abundance and chromospheric activity S-index confirm that KIC 10644253 is a young and more active star than the Sun.Comment: Accepted for publication in A&A, 12 pages, 8 figure

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma.

Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive suffer severe long-term side effects as a consequence of treatment. Thus, more effective and less toxic therapies for MB are critically important. Development of such therapies depends in part on identification of genes that are necessary for growth and survival of tumor cells. Survivin is an inhibitor of apoptosis protein that regulates cell cycle progression and resistance to apoptosis, is frequently expressed in human MB and when expressed at high levels predicts poor clinical outcome. Therefore, we hypothesized that Survivin may have a critical role in growth and survival of MB cells and that targeting it may enhance MB therapy. Here we show that Survivin is overexpressed in tumors from patched (Ptch) mutant mice, a model of Sonic hedgehog (SHH)-driven MB. Genetic deletion of survivin in Ptch mutant tumor cells significantly inhibits proliferation and causes cell cycle arrest. Treatment with small-molecule antagonists of Survivin impairs proliferation and survival of both murine and human MB cells. Finally, Survivin antagonists impede growth of MB cells in vivo. These studies highlight the importance of Survivin in SHH-driven MB, and suggest that it may represent a novel therapeutic target in patients with this disease