54 research outputs found
Higgs decay with monophoton + MET signature from low scale supersymmetry breaking
We study the decay of a standard model-like Higgs boson into a gravitino and
a neutralino, which subsequently decays promptly into another gravitino and a
photon. Such a decay can be important in scenarios where the supersymmetry
breaking scale is of the order of a few TeV, and in the region of low
transverse momenta of the photon, it may provide the dominant contribution to
the final state with a photon and two gravitinos. We estimate the relevant
standard model backgrounds and the prospects for discovering this Higgs decay
through a photon and missing transverse energy signal at the LHC in terms of a
simplified model. We also give an explicit model with manifest, but
spontaneously broken, supersymmetry in which the usual MSSM soft terms are
promoted to supersymmetric operators involving a dynamical goldstino
supermultiplet. This model can give rise to a SM-like CP-even neutral Higgs
particle with a mass of 125 GeV, without requiring substantial radiative
corrections, and with couplings sufficiently large for a signal discovery
through the above mentioned Higgs decay channel with the upcoming data from the
LHC.Comment: 28 pages, 5 figures, 4 tables; v2: updated to JHEP version,
references adde
The MSSM Higgs Sector with a Dynamical Goldstino Supermultiplet
We consider a supersymmetric realization of the MSSM Higgs sector, where the
soft terms are promoted to supersymmetric operators and a minimal weakly
coupled hidden sector is included. The model exhibits long-lived meta-stable
vacua in which supersymmetry and electroweak symmetry are spontaneously broken.
The spectrum contains, in addition to the usual MSSM particles and the
goldstino fermion, a CP-even and a CP-odd scalar in the neutral Higgs sector
corresponding to the complex sgoldstino scalar. By treating all the components
of the goldstino supermultiplet dynamically and taking into account their
interactions with the Higgs fields, additional couplings beyond those of the
MSSM are induced. When the supersymmetry breaking scale is low, these couplings
can raise the masses of all the Higgs particles above the LEP bound, already at
tree level and for any value of tan(beta). The model includes a scenario where,
for any choice of the supersymmetry breaking scale, the set of parameters is
reduced to the standard set (mu, Bmu, tan(beta)) of the MSSM Higgs sector but
where novel decays of doublet-like states into sgoldstino-like states are
kinematically allowed.Comment: 24 pages; v2: references adde
Room temperature coherent control of coupled single spins in solid
Coherent coupling between single quantum objects is at the heart of modern
quantum physics. When coupling is strong enough to prevail over decoherence, it
can be used for the engineering of correlated quantum states. Especially for
solid-state systems, control of quantum correlations has attracted widespread
attention because of applications in quantum computing. Such coherent coupling
has been demonstrated in a variety of systems at low temperature1, 2. Of all
quantum systems, spins are potentially the most important, because they offer
very long phase memories, sometimes even at room temperature. Although precise
control of spins is well established in conventional magnetic resonance3, 4,
existing techniques usually do not allow the readout of single spins because of
limited sensitivity. In this paper, we explore dipolar magnetic coupling
between two single defects in diamond (nitrogen-vacancy and nitrogen) using
optical readout of the single nitrogen-vacancy spin states. Long phase memory
combined with a defect separation of a few lattice spacings allow us to explore
the strong magnetic coupling regime. As the two-defect system was well-isolated
from other defects, the long phase memory times of the single spins was not
diminished, despite the fact that dipolar interactions are usually seen as
undesirable sources of decoherence. A coherent superposition of spin pair
quantum states was achieved. The dipolar coupling was used to transfer spin
polarisation from a nitrogen-vacancy centre spin to a nitrogen spin, with
optical pumping of a nitrogen-vacancy centre leading to efficient
initialisation. At the level anticrossing efficient nuclear spin polarisation
was achieved. Our results demonstrate an important step towards controlled spin
coupling and multi-particle entanglement in the solid state
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells.
A major challenge in single-molecule imaging is tracking the dynamics of proteins or complexes for long periods of time in the dense environments found in living cells. Here, we introduce the concept of using FRET to enhance the photophysical properties of photo-modulatable (PM) fluorophores commonly used in such studies. By developing novel single-molecule FRET pairs, consisting of a PM donor fluorophore (either mEos3.2 or PA-JF549) next to a photostable acceptor dye JF646, we demonstrate that FRET competes with normal photobleaching kinetic pathways to increase the photostability of both donor fluorophores. This effect was further enhanced using a triplet-state quencher. Our approach allows us to significantly improve single-molecule tracking of chromatin-binding proteins in live mammalian cells. In addition, it provides a novel way to track the localization and dynamics of protein complexes by labeling one protein with the PM donor and its interaction partner with the acceptor dye
Pharmacokinetics of recombinant human erythropoietin applied subcutaneously to children with chronic renal failure
High dose vitamin D supplementation does not affect biochemical bone markers in multiple sclerosis – a randomized controlled trial
Molecular Phylogeny of the Astrophorida (Porifera, Demospongiaep) Reveals an Unexpected High Level of Spicule Homoplasy
Background: The Astrophorida (Porifera, Demospongiae(rho)) is geographically and bathymetrically widely distributed. Systema Porifera currently includes five families in this order: Ancorinidae, Calthropellidae, Geodiidae, Pachastrellidae and Thrombidae. To date, molecular phylogenetic studies including Astrophorida species are scarce and offer limited sampling. Phylogenetic relationships within this order are therefore for the most part unknown and hypotheses based on morphology largely untested. Astrophorida taxa have very diverse spicule sets that make them a model of choice to investigate spicule evolution.
Methodology/Principal Findings: With a sampling of 153 specimens (9 families, 29 genera, 89 species) covering the deep- and shallow-waters worldwide, this work presents the first comprehensive molecular phylogeny of the Astrophorida, using a cytochrome c oxidase subunit I (COI) gene partial sequence and the 59 end terminal part of the 28S rDNA gene (C1-D2 domains). The resulting tree suggested that i) the Astrophorida included some lithistid families and some Alectonidae species, ii) the sub-orders Euastrophorida and Streptosclerophorida were both polyphyletic, iii) the Geodiidae, the Ancorinidae and the Pachastrellidae were not monophyletic, iv) the Calthropellidae was part of the Geodiidae clade (Calthropella at least), and finally that v) many genera were polyphyletic (Ecionemia, Erylus, Poecillastra, Penares, Rhabdastrella, Stelletta and Vulcanella).
Conclusion: The Astrophorida is a larger order than previously considered, comprising ca. 820 species. Based on these results, we propose new classifications for the Astrophorida using both the classical rank-based nomenclature (i.e., Linnaean classification) and the phylogenetic nomenclature following the PhyloCode, independent of taxonomic rank. A key to the Astrophorida families, sub-families and genera incertae sedis is also included. Incongruences between our molecular tree and the current classification can be explained by the banality of convergent evolution and secondary loss in spicule evolution. These processes have taken place many times, in all the major clades, for megascleres and microscleres
Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters
Background: Myocardial infarction is the leading cause of death in fire fighters and has been linked with exposure to air pollution and fire suppression duties. We therefore investigated the effects of wood smoke exposure on vascular vasomotor and fibrinolytic function, and thrombus formation in healthy fire fighters. Methods: In a double-blind randomized cross-over study, 16 healthy male fire fighters were exposed to wood smoke (~1 mg/m3 particulate matter concentration) or filtered air for one hour during intermittent exercise. Arterial pressure and stiffness were measured before and immediately after exposure, and forearm blood flow was measured during intra-brachial infusion of endothelium-dependent and -independent vasodilators 4–6 hours after exposure. Thrombus formation was assessed using the ex vivo Badimon chamber at 2 hours, and platelet activation was measured using flow cytometry for up to 24 hours after the exposure. Results: Compared to filtered air, exposure to wood smoke increased blood carboxyhaemoglobin concentrations (1.3% versus 0.8%; P < 0.001), but had no effect on arterial pressure, augmentation index or pulse wave velocity (P > 0.05 for all). Whilst there was a dose-dependent increase in forearm blood flow with each vasodilator (P < 0.01 for all), there were no differences in blood flow responses to acetylcholine, sodium nitroprusside or verapamil between exposures (P > 0.05 for all). Following exposure to wood smoke, vasodilatation to bradykinin increased (P = 0.003), but there was no effect on bradykinin-induced tissue-plasminogen activator release, thrombus area or markers of platelet activation (P > 0.05 for all). Conclusions: Wood smoke exposure does not impair vascular vasomotor or fibrinolytic function, or increase thrombus formation in fire fighters. Acute cardiovascular events following fire suppression may be precipitated by exposure to other air pollutants or through other mechanisms, such as strenuous physical exertion and dehydration.Originally included in thesis in manuscript form.</p
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