Gallium Substituted "114" YBaFe4O7: From a ferrimagnetic cluster glass to a cationic disordered spin glass

The study of the ferrites YBaFe4-xGaxO7 shows that the substitution of Ga for Fe in YBaFe4O7 stabilizes the hexagonal symmetry for 0.40 < x < 0.70, at the expense of the cubic one. Using combined measurements of a. c. and d. c. magnetization, we establish that Ga substitution for Fe in YBaFe4O7 leads to an evolution from a geometrically frustrated spin glass (for x = 0) to a cationic disorder induced spin glass (x = 0.70). We also find an intermediate narrow range of doping where the samples are clearly phase separated having small ferrimagnetic clusters embedded in a spin glass matrix. The origin of the ferrimagnetic clusters lies in the change in symmetry of the samples from cubic to hexagonal (and a consequent lifting of the geometrical frustration) as a result of Ga doping. We also show the presence of exchange bias and domain wall pinning in these samples. The cause of both these effects can be traced back to the inherent phase separation present in the samples.Comment: 25 pages, 10 figure

The Role of MicroRNAs in Breast Cancer Migration, Invasion and Metastasis

MicroRNAs (miRNAs) are a major class of small, noncoding RNA molecules that regulate gene expression by targeting mRNAs to trigger either translational repression or mRNA degradation. They have recently been more widely investigated due to their potential role as targets for cancer therapy. Many miRNAs have been implicated in several human cancers, including breast cancer. miRNAs are known to regulate cell cycle and development, and thus may serve as useful targets for exploration in anticancer therapeutics. The link between altered miRNA signatures and breast cancer development and metastasis can be observed either through the loss of tumor suppressor miRNAs, such as let-7s, miR-30a/31/34a/125s/200s/203/205/206/342 or the overexpression of oncogenic miRNAs, such as miR-10b/21/135a/155/221/222/224/373/520c in breast cancer cells. Some of these miRNAs have also been validated in tumor specimens of breast cancer patients, underscoring their potential roles in diagnostics, as well as targets for novel therapeutics for breast cancer. In this review article, we will provide an overview and update of our current understanding of the mode of action of several of these well characterized miRNAs in breast cancer models. Therefore, better understanding of the gene networks orchestrated by these miRNAs may help exploit the full potential of miRNAs in regards to cancer diagnosis, treatment, and therapeutics

Non-Gaussianity from violation of slow-roll in multiple inflation

Multiple inflation is a model based on N=1 supergravity wherein there are sudden changes in the mass of the inflaton because it couples to 'flat direction' scalar fields which undergo symmetry breaking phase transitions as the universe cools. The resulting brief violations of slow-roll evolution generate a non-gaussian signal which we find to be oscillatory and yielding f_NL ~ 5-20. This is potentially detectable by e.g. Planck but would require new bispectrum estimators to do so. We also derive a model-independent result relating the period of oscillations of a phase transition during inflation to the period of oscillations in the primordial curvature perturbation generated by the inflaton.Comment: 21 pages, 6 figures; Clarifying comments and references added; Accepted for publication in JCA

Passage of Time in a Planck Scale Rooted Local Inertial Structure

It is argued that the `problem of time' in quantum gravity necessitates a refinement of the local inertial structure of the world, demanding a replacement of the usual Minkowski line element by a 4+2n dimensional pseudo-Euclidean line element, with the extra 2n being the number of internal phase space dimensions of the observed system. In the refined structure, the inverse of the Planck time takes over the role of observer-independent conversion factor usually played by the speed of light, which now emerges as an invariant but derivative quantity. In the relativistic theory based on the refined structure, energies and momenta turn out to be invariantly bounded from above, and lengths and durations similarly bounded from below, by their respective Planck scale values. Along the external timelike world-lines, the theory naturally captures the `flow of time' as a genuinely structural attribute of the world. The theory also predicts expected deviations--suppressed quadratically by the Planck energy--from the dispersion relations for free fields in the vacuum. The deviations from the special relativistic Doppler shifts predicted by the theory are also suppressed quadratically by the Planck energy. Nonetheless, in order to estimate the precision required to distinguish the theory from special relativity, an experiment with a binary pulsar emitting TeV range gamma-rays is considered in the context of the predicted deviations from the second-order shifts.Comment: 17 pages; Diagram depicting "the objective flow of time" is replaced with a much-improved diagra

Validating differential volatilome profiles in Parkinson’s disease

Contains fulltext : 231972.pdf (Publisher’s version ) (Open Access

Soil conservation issues in India

Despite years of study and substantial investment in remediation and prevention, soil erosion continues to be a major environmental problem with regard to land use in India and elsewhere around the world. Furthermore, changing climate and/or weather patterns are exacerbating the problem. Our objective was to review past and current soil conservation programmes in India to better understand how production-, environmental-, social-, economic- and policy-related issues have affected soil and water conservation and the incentives needed to address the most critical problems. We found that to achieve success in soil and water conservation policies, institutions and operations must be co-ordinated using a holistic approach. Watershed programmes have been shown to be one of the most effective strategies for bringing socio-economic change to different parts of India. Within both dryland and rainfed areas, watershed management has quietly revolutionized agriculture by aligning various sectors through technological soil and water conservation interventions and land-use diversification. Significant results associated with various watershed-scale soil and water conservation programmes and interventions that were effective for reducing land degradation and improving productivity in different parts of the country are discussed

Non-volatile memory devices beyond process-scaled planar Flash technology

Mainstream non-volatile memory technology dominated by the planar Flash transistor with continuous floating-gate has been historically improved in density and performance primarily by means of process scaling, but is currently faced with significant hindrances to its future scaling due to fundamental constraints of electrostatics and reliability. This dissertation is based on exploring two pathways for circumventing scaling limitations of the state-of-the-art Flash memory technology. The first part of the dissertation is based on demonstrating a vertical Flash memory transistor with nanocrystal floating-gate, while the second part is based on developing fundamental understanding of the operation of Phase Change Memory. A vertical Flash transistor can allow the theoretical minimum cell area and a nanocrystal floating-gate on the sidewalls is shown to allow a thinner gate-stack further conducive to scaling while still providing good reliability. Subsequently, the application of a technique of protein-mediated assembly of preformed nanocrystals to the sidewalls of the vertical Flash transistor is also demonstrated and characterized. This technique of ordering pre-formed nanocrystals is beneficial towards achieving reproducible nanocrystal size uniformity and ordering especially in a highly scaled vertical Flash cell, rendering it more amenable to scaling and manufacturability. In both forms, the vertical Flash memory cell is shown to have good electrical characteristics and reliability for the viability of this cell design and implementation. In the remaining part of this dissertation, studies are undertaken towards developing fundamental understanding of the operational characteristics of Phase Change Memory (PCM) technology that is expected to replace floating-gate Flash technology based on its potential for scaling. First, a phenomenon of improving figures of merit of the PCM cell with operational cycles is electrically characterized. Based on the electrical characterization and published material characterization data, a physical model of an evolving "active region" of the cell is proposed to explain the improvement of the cell parameters with operational cycles. Then, basic understanding is developed on early and erratic retention failure in a statistically significant number of cells in a large array and, electrical characterization and physical modeling is used to explain the mechanism behind the early retention failure.Electrical and Computer Engineerin

Engineering the electromagnetic environment in a nanostructure to study single-electron tunneling

In this research the electromagnetic environment in a ballistic semiconductor nanostructure is engineered to study single electron tunneling oscillations: the repetitive tunneling of individual electrons through an energy barrier causing a saw-tooth variation in the voltage across the barrier. In this work, novel use of staggered arrays of quantum point contacts as ballistic resistors in a two-dimensional electron gas provides a high impedance environment for a tunnel barrier placed between the arrays. Since instantaneous establishment of charge equilibrium with the potential source is prevented, strong Coulomb charging is observed for the barrier. This approach circumvents problems faced by metallic thin-film resistors, for which stray capacitive shunting occurs at the high frequencies relevant to single electron tunneling. By using an integrated Radio frequency Single Electron Transistor as a fast electrometer, single electron tunneling oscillations may therefore be directly observed