Tabletop Roleplaying Games as Procedural Content Generators

Tabletop roleplaying games (TTRPGs) and procedural content generators can both be understood as systems of rules for producing content. In this paper, we argue that TTRPG design can usefully be viewed as procedural content generator design. We present several case studies linking key concepts from PCG research -- including possibility spaces, expressive range analysis, and generative pipelines -- to key concepts in TTRPG design. We then discuss the implications of these relationships and suggest directions for future work uniting research in TTRPGs and PCG.Comment: 9 pages, 2 figures, FDG Workshop on Procedural Content Generation 202

Iron bioavailability and cardiopulmonary function during ascent to very high altitude

Lette

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

Dendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the endosomal seclusion of nucleic acid–recognizing Toll-like receptors (TLRs). In psoriasis, however, plasmacytoid DCs (pDCs) sense self-DNA that is transported to endosomal TLR9 upon forming a complex with the antimicrobial peptide LL37. Whether LL37 also interacts with extracellular self-RNA and how this may contribute to DC activation in psoriasis is not known. Here, we report that LL37 can bind self-RNA released by dying cells, protect it from extracellular degradation, and transport it into endosomal compartments of DCs. In pDC, self-RNA–LL37 complexes activate TLR7 and, like self-DNA–LL37 complexes, trigger the secretion of IFN-α without inducing maturation or the production of IL-6 and TNF-α. In contrast to self-DNA–LL37 complexes, self-RNA–LL37 complexes also trigger the activation of classical myeloid DCs (mDCs). This occurs through TLR8 and leads to the production of TNF-α and IL-6, and the differentiation of mDCs into mature DCs. We also found that self-RNA–LL37 complexes are present in psoriatic skin lesions and are associated with mature mDCs in vivo. Our results demonstrate that the cationic antimicrobial peptide LL37 converts self-RNA into a trigger of TLR7 and TLR8 in human DCs, and provide new insights into the mechanism that drives the auto-inflammatory responses in psoriasis

Intended Consequences Statement in Conservation Science and Practice

As the biodiversity crisis accelerates, the stakes are higher for threatened plants and animals. Rebuilding the health of our planet will require addressing underlying threats at many scales, including habitat loss and climate change. Conservation interventions such as habitat protection, management, restoration, predator control, trans location, genetic rescue, and biological control have the potential to help threatened or endangered species avert extinction. These existing, well-tested methods can be complemented and augmented by more frequent and faster adoption of new technologies, such as powerful new genetic tools. In addition, synthetic biology might offer solutions to currently intractable conservation problems. We believe that conservation needs to be bold and clear-eyed in this moment of great urgency

Does Electoral Proximity Affect Security Policy?

Contains all files necessary to replicate analyses, re-assemble dataset, produce Tables and Figures in "Does Electoral Proximity Affect Security Policy?, as well as ancillary data not included in the main parts of the paper. We collected monthly data on troops in Afghanistan in two ways, producing an original dataset of troop commitments to Afghanistan from October 2001 through October 2011. First, we scraped the monthly contributions to ISAF from the official ISAF archive for January 2007 through October 2011. Second, we complemented these numbers with data from individual communication with foreign and defense ministries in each of the contributing states. In total, we gathered data on 50 different states

Framework for Predicting Failure in Polymeric Unidirectional Composites through Combined Experimental and Computational Mesoscale Modeling Techniques

As composites continue to be increasingly used, finite element material models that homogenize the composite response become the only logical choice as not only modeling the entire composite microstructure is computationally expensive but obtaining the entire suite of experimental data to characterize deformation and failure may not be possible. The focus of this paper is the development of a modeling framework where plasticity, damage, and failure-related experimental data are obtained for each composite constituent. Mesoscale finite elements models consisting of multiple repeating unit cells are then generated and used to represent a typical carbon fiber/epoxy resin unidirectional composite to generate the complete principal direction stress-strain curves. These models are subjected to various uniaxial states of stress and compared with experimental data. They demonstrate a reasonable match and provide the basic framework to completely define the composite homogenized material model that can be used as a vehicle for failure predictions

Oasis 2016

Literary Magazine with artwork, photographs submitted by students.English and Modern Languages DepartmentAngelo State Universit