Multiple Subject Barycentric Discriminant Analysis (MUSUBADA): How to Assign Scans to Categories without Using Spatial Normalization

We present a new discriminant analysis (DA) method called Multiple Subject Barycentric Discriminant Analysis (MUSUBADA) suited for analyzing fMRI data because it handles datasets with multiple participants that each provides different number of variables (i.e., voxels) that are themselves grouped into regions of interest (ROIs). Like DA, MUSUBADA (1) assigns observations to predefined categories, (2) gives factorial maps displaying observations and categories, and (3) optimally assigns observations to categories. MUSUBADA handles cases with more variables than observations and can project portions of the data table (e.g., subtables, which can represent participants or ROIs) on the factorial maps. Therefore MUSUBADA can analyze datasets with different voxel numbers per participant and, so does not require spatial normalization. MUSUBADA statistical inferences are implemented with cross-validation techniques (e.g., jackknife and bootstrap), its performance is evaluated with confusion matrices (for fixed and random models) and represented with prediction, tolerance, and confidence intervals. We present an example where we predict the image categories (houses, shoes, chairs, and human, monkey, dog, faces,) of images watched by participants whose brains were scanned. This example corresponds to a DA question in which the data table is made of subtables (one per subject) and with more variables than observations

Recognizing people from dynamic and static faces and bodies: Dissecting identity with a fusion approach

AbstractThe goal of this study was to evaluate human accuracy at identifying people from static and dynamic presentations of faces and bodies. Participants matched identity in pairs of videos depicting people in motion (walking or conversing) and in “best” static images extracted from the videos. The type of information presented to observers was varied to include the face and body, the face-only, and the body-only. Identification performance was best when people viewed the face and body in motion. There was an advantage for dynamic over static stimuli, but only for conditions that included the body. Control experiments with multiple-static images indicated that some of the motion advantages we obtained were due to seeing multiple images of the person, rather than to the motion, per se. To computationally assess the contribution of different types of information for identification, we fused the identity judgments from observers in different conditions using a statistical learning algorithm trained to optimize identification accuracy. This fusion achieved perfect performance. The condition weights that resulted suggest that static displays encourage reliance on the face for recognition, whereas dynamic displays seem to direct attention more equitably across the body and face

HST Observations of the Host Galaxies of BL Lacertae Objects

Six BL Lac objects from the complete 1 Jy radio-selected sample of 34 objects were observed in Cycle 5 with the HST WFPC2 camera to an equivalent limiting flux of mu_I~26 mag/arcsec^2. Here we report results for the second half of this sample, as well as new results for the first three objects, discussed previously by Falomo et al. (1997). In addition, we have analyzed in the same way HST images of three X-ray-selected BL Lacs observed by Jannuzi et al. (1997). The ensemble of 9 BL Lac objects spans the redshift range from z=0.19 to ~1. Host galaxies are clearly detected in seven cases, while the other two, at z~0.258 (redshift highly uncertain) and z=0.997, are not resolved. The HST images constitute a homogeneous data set with unprecedented morphological information between a few tenths of an arcsecond and several arcseconds from the nucleus, allowing us in 6 of the 7 detected host galaxies to rule out definitively a pure disk light profile. The host galaxies are luminous ellipticals with an average absolute magnitude of M_I~-24.6 mag (with dispersion 0.7 mag), more than a magnitude brighter than L* and comparable to brightest cluster galaxies. The morphologies are generally smooth and have small ellipticities (epsilon<0.2). Given such roundness, there is no obvious alignment with the more linear radio structures. In the six cases for which we have HST WFPC2 images in two filters, the derived color profiles show no strong spatial gradients and are as expected for K-corrected passively evolving elliptical galaxies. The host galaxies of the radio-selected and X-ray-selected BL Lacs for this very limited sample are comparable in both morphology and luminosity.Comment: 23 pages, including 6 postscript figures and 3 tables (embedded). Latex requires aaspp4.sty and psfig.sty (not included). Accepted for publication in the Astrophysical Journa

The HST Survey of BL Lacertae Objects. II. Host Galaxies

We have used the HST WFPC2 camera to survey 132 BL Lac objects comprising seven complete radio-, X-ray-, and optically-selected samples. We obtained useful images for 110 targets spanning the redshift range 0 < z < 1.3. In two thirds of the BL Lac images, host galaxies are detected, including nearly all for z < 0.5 (58 of 63). The highest redshift host galaxy detected is in a BL Lac object at z=0.664. In 58 of the 72 resolved host galaxies, a de Vaucouleurs profile is significantly preferred, at >99% confidence, over a pure exponential disk; the two fits are comparable in the remaining 14 cases. These results limit the number of disk systems to at most 8% of BL Lacs (at 99% confidence), and are consistent with all BL~Lac host galaxies being ellipticals. The detected host galaxies are luminous ellipticals with a median absolute K-corrected magnitude of M_R= -23.7 +- 0.6 mag, at least one magnitude brighter than M* and comparable to brightest cluster galaxies. The galaxy morphologies are generally smooth and undisturbed, with small or negligible ellipticities (<0.2). There is no correlation between host galaxy and observed nuclear magnitude or estimated jet power corrected for beaming. If black hole mass is correlated linearly with bulge mass in general, this implies a large range in Eddington ratio. Present data strongly support the unification picture with FR I galaxies constituting the bulk of the parent population of BL Lac objects.Comment: Accepted for publication on ApJ. 38 pages, 8 figure

The HST Survey of BL Lacertae Objects. I. Surface Brightness Profiles, Magnitudes, and Radii of Host Galaxies

We report on a large HST imaging survey of BL Lac objects, at spatial resolution ~10 times better than previous ground-based surveys. We focus on data reduction and analysis, describing the procedures used to model the host galaxy surface brightness radial profiles. A total of 69 host galaxies were resolved out of 110 objects observed, including almost all sources at z < 0.5. We classify them morphologically by fitting with either an exponential disk or a de~Vaucouleurs profile; when one fit is preferred over the other, in 58 of 69 cases, it is invariably the elliptical morphology. This is a very strong result given the large number of BL Lac objects, the unprecedented spatial resolution, and the homogeneity of the data set. With the present reclassification of the host galaxy of 1418+546 as an elliptical, there remain no undisputed examples of a disk galaxy hosting a BL Lac nucleus. This implies that, at 99% confidence, fewer than 7% of BL Lacs can be in disk galaxies. The apparent magnitude of the host galaxies varies with distance as expected if the absolute magnitudes are approximately the same, with a spread of +-1 mag, out to redshift z < 0.5. At larger redshifts, only 6 of 23 BL Lacs are resolved so the present data do not constrain possible luminosity evolution of the host galaxies. The collective Hubble diagram for BL Lac host galaxies and radio galaxies strongly supports their unification.Comment: Accepted for publication on ApJS. 43 pages. 10 figures. Figure 1 can also be downloaded from http://icarus.stsci.edu/~scarpa/tmp/hst_figure1.ta

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data

Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential moderating variables. Data Sources: PubMed, EMBASE, and PsycINFO were searched from inception to February 10, 2016. Reference lists of previous reviews and meta-analyses and reports of randomized clinical trials were also checked. Study Selection: Studies were eligible for inclusion if they were (1) double-blind randomized clinical trials of DCS as an augmentation strategy for exposure-based cognitive behavior therapy and (2) conducted in humans diagnosed as having specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder, or posttraumatic stress disorder. Data Extraction and Synthesis: Raw data were obtained from the authors and quality controlled. Data were ranked to ensure a consistent metric across studies (score range, 0-100). We used a 3-level multilevel model nesting repeated measures of outcomes within participants, who were nested within studies. Results: Individual participant data were obtained for 21 of 22 eligible trials, representing 1047 of 1073 eligible participants. When controlling for antidepressant use, participants receiving DCS showed greater improvement from pretreatment to posttreatment (mean difference, -3.62; 95% CI, -0.81 to -6.43; P = .01; d = -0.25) but not from pretreatment to midtreatment (mean difference, -1.66; 95% CI, -4.92 to 1.60; P = .32; d = -0.14) or from pretreatment to follow-up (mean difference, -2.98, 95% CI, -5.99 to 0.03; P = .05; d = -0.19). Additional analyses showed that participants assigned to DCS were associated with lower symptom severity than those assigned to placebo at posttreatment and at follow-up. Antidepressants did not moderate the effects of DCS. None of the prespecified patient-level or study-level moderators was associated with outcomes. Conclusions and Relevance: D-cycloserine is associated with a small augmentation effect on exposure-based therapy. This effect is not moderated by the concurrent use of antidepressants. Further research is needed to identify patient and/or therapy characteristics associated with DCS response.2018-05-0

An Experimental Exploration of the QCD Phase Diagram: The Search for the Critical Point and the Onset of De-confinement

The QCD phase diagram lies at the heart of what the RHIC Physics Program is all about. While RHIC has been operating very successfully at or close to its maximum energy for almost a decade, it has become clear that this collider can also be operated at lower energies down to 5 GeV without extensive upgrades. An exploration of the full region of beam energies available at the RHIC facility is imperative. The STAR detector, due to its large uniform acceptance and excellent particle identification capabilities, is uniquely positioned to carry out this program in depth and detail. The first exploratory beam energy scan (BES) run at RHIC took place in 2010 (Run 10), since several STAR upgrades, most importantly a full barrel Time of Flight detector, are now completed which add new capabilities important for the interesting physics at BES energies. In this document we discuss current proposed measurements, with estimations of the accuracy of the measurements given an assumed event count at each beam energy.Comment: 59 pages, 78 figure

Observation of charge-dependent azimuthal correlations and possible local strong parity violation in heavy ion collisions

Parity-odd domains, corresponding to non-trivial topological solutions of the QCD vacuum, might be created during relativistic heavy-ion collisions. These domains are predicted to lead to charge separation of quarks along the orbital momentum of the system created in non-central collisions. To study this effect, we investigate a three particle mixed harmonics azimuthal correlator which is a \P-even observable, but directly sensitive to the charge separation effect. We report measurements of this observable using the STAR detector in Au+Au and Cu+Cu collisions at $\sqrt{s_{NN}}$=200 and 62~GeV. The results are presented as a function of collision centrality, particle separation in rapidity, and particle transverse momentum. A signal consistent with several of the theoretical expectations is detected in all four data sets. We compare our results to the predictions of existing event generators, and discuss in detail possible contributions from other effects that are not related to parity violation.Comment: 17 pages, 14 figures, as accepted for publication in Physical Review C

Longitudinal Spin Transfer to Λ\Lambda and Λˉ\bar{\Lambda} Hyperons in Polarized Proton-Proton Collisions at s\sqrt{s} = 200 GeV

The longitudinal spin transfer, $D_{LL}$, from high energy polarized protons to $\Lambda$ and $\bar{\Lambda}$ hyperons has been measured for the first time in proton-proton collisions at $\sqrt{s} = 200 \mathrm{GeV}$ with the STAR detector at RHIC. The measurements cover pseudorapidity, $\eta$, in the range $|\eta| < 1.2$ and transverse momenta, $p_\mathrm{T}$, up to $4 \mathrm{GeV}/c$. The longitudinal spin transfer is found to be $D_{LL}= -0.03\pm 0.13(\mathrm{stat}) \pm 0.04(\mathrm{syst})$ for inclusive $\Lambda$ and $D_{LL} = -0.12 \pm 0.08(\mathrm{stat}) \pm 0.03(\mathrm{syst})$ for inclusive $\bar{\Lambda}$ hyperons with $= 0.5$ and $= 3.7 \mathrm{GeV}/c$. The dependence on $\eta$ and $p_\mathrm{T}$ is presented.Comment: 5 pages, 4 figure

Studies of di-jet survival and surface emission bias in Au+Au collisions via angular correlations with respect to back-to-back leading hadrons

We report first results from an analysis based on a new multi-hadron correlation technique, exploring jet-medium interactions and di-jet surface emission bias at RHIC. Pairs of back-to-back high transverse momentum hadrons are used for triggers to study associated hadron distributions. In contrast with two- and three-particle correlations with a single trigger with similar kinematic selections, the associated hadron distribution of both trigger sides reveals no modification in either relative pseudo-rapidity or relative azimuthal angle from d+Au to central Au+Au collisions. We determine associated hadron yields and spectra as well as production rates for such correlated back-to-back triggers to gain additional insights on medium properties.Comment: By the STAR Collaboration. 6 pages, 2 figure