196 research outputs found
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
- Author
- Alison Budelsky
- Andreas Hochheimer
- Anh Leith
- Benxian Liu
- Brian Bennett
- David Powers
- Deanna Mohn
- Dirk Smith
- Esther Trueblood
- Esther Trueblood
- Esther Trueblood
- Gang Yu
- James A. Johnston
- Jian Jeffrey Chen
- John K. Sullivan
- John Whoriskey
- Jonathan Phillips
- Joseph G. McGivern
- Karl Kunzelmann
- Kathryn Henckels
- Katja Labitzke
- Kelly Hensley
- Kelly Hensley
- Kelly Hensley
- Kent Miner
- Kerstin Weikl
- Kevin Gaida
- Longbin Liu
- Mike Comeau
- Mike Fiorino
- Min Wong
- Oliver Homann
- Paul Wang
- Robin Elliott
- Sabine Escobar
- Teresa L. Born
- Xing-Zhong Xia
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 27/01/2018
- Field of study
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor ÎČ-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the Ca2+-activated Clâ channel, TMEM16A, offers a new mechanism to bronchodilate airways and block the multiple contractiles operating in severe disease. To identify TMEM16A antagonists we screened a library of âŒ580,000 compounds. The anthelmintics niclosamide, nitazoxanide, and related compounds were identified as potent TMEM16A antagonists that blocked airway smooth muscle depolarization and contraction. To evaluate whether TMEM16A antagonists resist use- and inflammatory-desensitization pathways limiting ÎČ-agonist action, we tested their efficacy under harsh conditions using maximally contracted airways or airways pretreated with a cytokine cocktail. Stunningly, TMEM16A antagonists fully bronchodilated airways, while the ÎČ-agonist isoproterenol showed only partial effects. Thus, antagonists of TMEM16A and repositioning of niclosamide and nitazoxanide represent an important additional treatment for patients with severe asthma and COPD that is poorly controlled with existing therapies. It is of note that drug repurposing has also attracted wide interest in niclosamide and nitazoxanide as a new treatment for cancer and infectious disease. For the first time we identify TMEM16A as a molecular target for these drugs and thus provide fresh insights into their mechanism for the treatment of these disorders in addition to respiratory disease
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
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- Adams D
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- Adenike O
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- Afshari A
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- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
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- Stevic D.
- Stewart K. E.
- Stylianides N. (Manchester Royal Infirmary)
- Stylianidis G. (Evaggelismos General Hospital)
- Subhi M. T. (Alkhadra Hospital)
- Subocius A.
- Subramaniam S. (Queen Elizabeth Hospital and Universiti Malaysia Sabah
- Sundaram Venkatesan G. (Glan Clwyd Hospital)
- SusztĂĄk N. (Szent BorbĂĄla KĂłrhĂĄz). India: Bhat G. A.
- Sutherland A. (Coffs Harbour Health Campus)
- Swinson B. (Royal Brisbane and Womenâs Hospital). Austria: Messner F.
- Syed W. A. S.
- Syllaios A.
- Szatmary P.
- Szubota I. (Hospital and Oncological Centre Novy Jicin). Denmark: EbbehĂžj A. L.
- SĂĄnchez del Pueblo C.
- SĂĄnchez Fuentes N.
- SĂĄnchez- Pernaute A.
- SĂĄnchez- Rubio M.
- SĂĄnchez-GarcĂa S.
- Taddei A.
- Tadic B.
- Taibi A. (Chu Limoges)
- Talal El-Abur I.
- Talwar R. (Luton and Dunstable University Hospital)
- Tammaro P.
- Tan J. A.
- Tan X. S.
- Tanal M.
- Tang A. M.
- Tanzanu M.
- Tartaglia D. (Azienda Ospedaliero Universitaria Pisana)
- Tasis N. (Athens Naval and Veterans Hospital)
- Tatar O. C.
- Tavares F.
- Tayeh S. (Homerton University Hospital)
- Tebala G. D.
- Teixeira J. (Centro Hospitalar UniversitĂĄrio do Algarve â Unidade de Faro)
- Teixeira M. (Centro Hospitalar do Tamega e Sousa)
- Tejero- Pintor F. J. (Hospital Universitario RĂo Hortega)
- Testa V. (Santa Croce E. Carle Hospital
- Tewari N. (University Hospitals Coventry and Warwickshire NHS Trusts)
- Tezas S. (Furness General Hospital)
- Thaha M.
- Thanapal M. R. (Hospital Kuala Lumpur)
- Theodosopoulos T.
- Theophilidou E. (Royal Derby Hospital)
- Thian A.
- Thomas A. (Royal Liverpool University Hospital)
- Thompson D. (Morriston Hospital Swansea)
- Thornhill M. (Dell Seton Medical Center at the University of Texas)
- Thrumurthy S. (Epsom and St Helier University Hospitals NHS Trust)
- Thulasiraman S. V.
- Timbrell S.
- Tirloni L.
- Titu S. (Prof. Dr. Ion Chiricuta Institute of Oncology). Russia: Garmanova T.
- Tonini V. (S. Orsola-Malpighi Hospital)
- Torres A. (Hospital ClĂnico de Madrid)
- Torres Arcos C.
- Townson A.
- Trabulsi N. (King Abdulaziz University Hospital)
- Travaglio E. (Regina Montis Regalis Hospital
- Tribillon E. (Institut Mutualiste Montsouris)
- Troncoso Pereira P. (Hospital Mateu Orfila)
- Tropeano F. P. (Federico II University Hospital)
- Trujillo DĂaz J.
- Tsai L.
- Tsarkov P.
- Tsiamalou I.
- Tsiaoussis I.
- TU Dresden)
- Tucci R. (Azienda Ospedaliera Universitaria Careggi)
- Tufo A. (Ospedale del Mare)
- Tugmen C.
- Tulina I. (Clinic of Coloproctology and Minimally Invasive Surgery
- Tuncer K.
- Turnbull A. (Victoria Hospital Kirkcaldy)
- Turrado-Rodriguez V.
- Turri G. (Azienda Ospedaliera Universitaria Integrata di Verona)
- Tweedle E. (Addenbrookeâs Hospital)
- Ugarte-Sierra B. (Hospital Universitario de Galdakao)
- UludaÄ S. S.
- Umair M.
- Universiti Sains Malaysia)
- University of Amsterdam)
- UniversitĂ di Ferrara)
- Université Mohammed V Rabat). Netherlands: Hompes R.
- Uras C. (Acibadem Maslak Hospital)
- Urbani A. (Azienda Ospedaliero Universitaria Sanâanna)
- Urbieta A. (Hospital Universitario la Paz)
- Uslu G.
- Utkan N. Z.
- Uyanik M. S. (Samsun Training and Research Hospital)
- Uzunoglu F. G. (University Medical Center HamburgâEppendorf). Greece: Antonakis P.
- Vaccarella G. (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello)
- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
- Valero Soriano M. (Hospital General Reina SofĂa)
- Valle Rubio A. (Getafe University Hospital)
- Valverde S. (Hospital Clinic Barcelona)
- Van den Eynde J.
- Van den Eynde R. (Uz Leuven). Bulgaria: Sokolov M. (University Hospital Alexandrovska). Canada: Boutros M.
- Varma M. (University of California
- VasljeviÄ J.
- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e UniversitĂĄrio de SĂŁo JoĂŁo)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University âMagna Graeciaâ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). RĂ©union: Kassir R.
- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- VĂĄzquez FernĂĄndez A. (Hospital ClĂnico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (Kingâs Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St Georgeâs Hospital)
- Wilson M. (Forth Valley Royal Hospital)
- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Prenatal ethanol exposure alters core body temperature and corticosterone rhythms in adult male rats
- Author
- Abel
- Allen
- Allen
- Allen
- Arjona
- Barron
- Barron
- Blaine
- Buijs
- Buijs
- Buijs
- Card
- Chen
- Damian G. Zuloaga
- Duncan
- Durgan
- Farnell
- Gabriel
- Gerhold
- Goodlett
- Handa
- Handa
- Hard
- Hashimoto
- Hellstrom
- Honma
- Ishida
- Joseph
- Kalamatianos
- Kennaway
- Koehl
- Lee
- McGivern
- McGivern
- McGivern
- McGivern
- McGivern
- McGivern
- Miller
- Miller
- Monk
- Moore
- Oster
- Pecoraro
- Pu
- Robert F. McGivern
- Robert J. Handa
- Rojas
- Rudeen
- Rusak
- Scheer
- Schneider
- Scott
- Sei
- Silhol
- Sparber
- Suess
- Tajuddin
- Taylor
- van Esseveldt
- Watanabe
- Weinberg
- Weinberg
- Weinert
- Weitzman
- Wilcoxon
- Zaretskaia
- Zimmerberg
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Advantages of voltage-gated ion channels as drug targets
- Author
- Publication venue
- 'Informa Healthcare'
- Publication date
- Field of study
PreproTRH178â199 and Two Novel Peptides (pFQ7 and pSE14) Derived from Its Processing, Which Are Produced in the Paraventricular Nucleus of the Rat Hypothalamus, Are Regulated during Suckling**This work was supported by the National Science Foundation (Grant No. IBN-9507952 to E.A.N.).
- Author
- Abe
- Ashworth
- Benjannet
- Benjannet
- Benjannet
- Bowers
- Brakch
- Bruhn
- Bruhn
- Callahan
- Cheng
- De Greef
- Devi
- Dymshitz
- Eduardo A. Nillni
- Fraser Aird
- Friedman
- Griffiths
- Grosvenor
- Haasteren
- Hall
- Harris
- Hoflehner
- Hooi
- Hyde
- James I. Koenig
- Joseph-Bravo
- Lin
- Lonstein
- McGivern
- McGivern
- McGivern
- Morley
- Nabil G. Seidah
- Nillni
- Nillni
- Nillni
- Nillni
- Nillni
- Nillni
- Nillni
- Perez de la Cruz
- Redei
- Reid
- Roberta B. Todd
- Roussel
- Samson
- Scanlon
- Schaner
- Seidah
- Sheward
- Steiner
- Takahara
- Vijayan
- Wilber
- Yang
- Zhu
- Publication venue
- 'The Endocrine Society'
- Publication date
- Field of study
Alkylperoxy Radical Photochemistry in Organic Aerosol Formation Processes
- Author
- Alicia J. Kalafut-Pettibone
- Ase P.
- Atkinson R.
- Atkinson R.
- Atkinson R.
- Atkinson R.
- Atkinson R.
- Baboul A. G.
- Baer T.
- Benson S. W.
- Bhattacharya D.
- Carter W. P. L.
- Chettur G.
- Cohen S. D.
- Crounse J. D.
- Crounse J. D.
- Curran H. J.
- Curtiss L. A.
- Davis A. C.
- Deno N. C.
- Donald R. Burgess
- Frisch M. J.
- Frost G. J.
- George I. J.
- Georgiou S.
- Golden D. M.
- Goodwin D. G.
- Hardwidge E. A.
- Hartmann D.
- Heazlewood B. R.
- Heimann G.
- Heinmöller P.
- Hindmarsh A. C.
- Joseph P. Klems
- Kalafut-Pettibone A. J.
- Kang E.
- Kessler S. H.
- Klots C. E.
- Kroll J. H.
- Krupenie P. H.
- Lee J. B.
- Monks P. S.
- Orlando J. J.
- Parmenter C. S.
- Paulsen D.
- Pergushov V. I.
- Poutsma M. L.
- Presto A. A.
- Ross P. L.
- Salisbury G.
- Salisbury G.
- Simmie J. M.
- Tsang W.
- Villano S. M.
- Villano S. M.
- W. Sean McGivern
- Ziemann P. J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
The 10th Oxbridge varsity medical ethics debate-should we fear the rise of direct-to-consumer genetic testing?
- Author
- A Antoniou
- AA van der Klaauw
- AC Antoniou
- AE Clark
- C Gamble
- C Marchetti
- Christian Michael Armstrong Holland
- CJ Johnson
- CS Bloss
- CS Bloss
- DL Boeldt
- E Check Hayden
- E Messias
- Edward Harry Arbe-Barnes
- Euan Joseph McGivern
- FJ Elgar
- G Ackley
- GD Smith
- I Dar-Nimrod
- KAB Goddard
- KB Kuchenbaecker
- KE Pickett
- KE Pickett
- L Dohany
- L Festinger
- LC Hartmann
- LD Atwood
- LF Cherkas
- M Gymrek
- M Wabitsch
- MD Tobin
- MG Butler
- NM Ries
- NR Buttrick
- P Su
- Q Xia
- R Layte
- R Pabayo
- Ruairidh Mungo Connor Forgan
- S Saadatmand
- SE Singletary
- T Caulfield
- U Francke
- WS Ribeiro
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ab Initio Study of Key Branching Reactions in Biodiesel and FischerâTropsch Fuels
- Author
- Alexander C. Davis
- Awan I. A.
- Babushok V. I.
- Bankiewicz B.
- Bar G.
- Barker J. R.
- Benson S. W.
- Carey F. A.
- Cohen N.
- Curran H. J.
- Curran H. J.
- Curtiss L. A.
- Curtiss L. A.
- Curtiss L. A.
- Davis A. C.
- Davis A. C.
- Dry M. E.
- Eliseev O. L.
- Endrenyi L.
- Evans M. G.
- Frisch M. J.
- Hardwidge E. A.
- Hayes C. J.
- Jitariu L. C.
- Jitariu L. C.
- Joseph S. Francisco
- Larson C. W.
- Matheu D. M.
- McGivern W. S.
- Miyoshi A.
- Ochterski J. W.
- Ochterski J. W.
- Pitz W. J.
- Ratkiewicz A.
- Sefton V. B.
- Simmie J. M.
- Sumathi R.
- Tsang W.
- Tsang W.
- Tsang W.
- Viskolcz B.
- Viskolcz B.
- Viskolcz B.
- Watkins K. W.
- Watkins K. W.
- Watkins K. W.
- Westbrook C. K.
- Westbrook C. K.
- Yamauchi N.
- Zheng J. J.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
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