Epilepsia do lobo temporal: mecanismos e perspectivas

The article presents a brief review of the historical findings, epidemiological, and therapeutic treatment for epilepsy, with a focus on temporal lobe epilepsy. Presents data from proteomic studies in epileptic brain tissue and highlights the importance of the application of this method in the search for new therapeutic targets for temporal lobe epilepsy.O artigo apresenta uma breve revisão sobre os achados históricos, epidemiológicos, tratamento e perspectivas terapêuticas para as epilepsias, com enfoque na epilepsia do lobo temporal. Apresenta dados obtidos com estudos de proteômica empregando tecido epiléptico e destaca a importância da aplicação desse método na busca de novos alvos terapêuticos.Universidade Federal de São Paulo (UNIFESP) Departamento de Neurologia e NeurocirurgiaComissão de Neurobiologia Liga Internacional de EpilepsiaUNIFESP, Depto. de Neurologia e NeurocirurgiaSciEL

Purpura is Not Always Caused by the Anticoagulant

Pigmented purpuric dermatosis is a chronic benign skin disorder of unknown aetiology. Although there are several other potential cofactors, drugs are the most frequent cause. This paper describes the case of a 71-year-old woman who was admitted in the emergency department with skin lesions on the lower extremities, characteristics of Schamberg's disease. After a medical study and treatment, it was concluded that the lesions were caused by amlodipine administration. To the authors’ knowledge, only one previous case describing an association between this disease and amlodipine administration has been reported in the medical literature

Processo industrial de polimerização e copolimerização da acrilonitrila : abordagem experimental e modelagem estatistica

Orientador: Edison BittencourtTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia QuimicaResumo: A terpolimerização da acrilonitrila com o acetato de vinila e com o metil-2 propeno-1 sulfonato de sódio em suspensão aquosa e a compolimerização da acrilonitrila com o acetato de vinila em suspensão aquosa, iniciada pelo sistema redox clorato de patássio/ bissulfito de sódio/ 'Fe POT. 2+¿, foram estudadas. Como variáveis importantes para o processo de terpolimerização e copolimorização foram consideradas a temperatura da reação, o tempo de residência e as concentrações molares da acrilonitrila, acetato de vinila , motil-2 propeno-1 sulfonato de sódio, NAHS¿O POT. 3¿, KCl¿O POT. 3¿ e de 'Fe POT. 2+¿ na estrada do reator. Como variáveis de resposta foram obtidas as taxas molares de consumo, as taxas de termopolimerização e copolimerizção, as massas, as taxas de termopolimerização, as massas moleculares ponderais médias dos terpolímeros e copolímeros obtidos, suas composições com relação aos termonômeros e comonômeros, a granulometria da suspensão de polímero e a produtividade do reator. Como variáveis de resposta foram obtidas as taxas molares de consumo, as taxas de terpolimerização e copolimerização, as massas moleculares ponderais médias dos terpolímeros e copolímeros obtidos, suas composições com relação aos termonômeros e comonômeros, a granulometria da suspensão de polímero e a produtividade do reator ...Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digitalAbstract: The terpolymerizatiion of acrylonitrile with vynil acetate and methyl ¿2 propene-1 sodium sulfonate in aqueous suspension and the copolymerization of acrylonitrile with vinyl acetate in aqueous suspension, initiated by the redox system potassium chlorate/ sodium bissufite/ 'Fe POT. 2¿,were studied. As important variables to the terpolumerzation and copolymerization process were considered the reaction temperature, the residence time and the input molar concentrationa of acrylonitrile, vinil acetate, methyl-2 propene-1 sodium sufonate, , NAHS¿O POT. 3¿, KCl¿O POT. 3¿ e de 'Fe POT. 2+¿. As response variables were obtained the monimer consuption rates, the terpolmerization or copolymerization rate, the weight-average molecular weight, their molar composition, the size of the polymer suspension and the reactor¿s productivity. Regression curves between the independent variables and the response variables were obtained. These equations compose the statistical kinetic model of the terpolymerization and copolymerization of acrylonitrile. In order to obtain these regression models, experiments were done in a pilote plant, consisting of a 227 l continuous stirred tank reactor and a stipping system to recover the non reacted monomersDoutoradoCiencia e Tecnologia de MateriaisDoutor em Engenharia Químic

Estudo preliminar de dispositivo de quebra e caracterização dos parametros fisicos do coco babaçu

Orientador: Waldemir Silva de LimaDissertação (mestrado profissional) - Universidade Estadual de Campinas, Faculdade de Engenharia MecanicaMestrad

Concentration and derivatization in silicone rubber traps for mass spectrometric and gas chromatographic analysis of air and water pollutants

Estrogens, alkylphenols and bisphenol-A, enter the environment through waste water systems and waste disposal of manufactured products e.g. detergents, paints, polycarbonates and flameretardants. These analytes disrupt the endocrine function of living organisms affecting their reproductive health and those of future generations. Gas phase low molecular- mass aldehydes and amines are typically eye, nose, and throat irritants. Formaldehyde is classified as a probable human carcinogen. Given their negative impact on human health it is urgent to monitor pollutants at extremely low levels in both air and water. The aqueous pollutants are often concentrated using solid phase extraction cartridges or liquid-liquid extraction followed by derivatization. Methods that can most effectively and selectively pre-concentrate aldehydes and amines involve in situ derivatization. Unfortunately, the derivatizing reagents as well as their associated solvents or adsorbents, are responsible for problems encountered with these methods. Polydimethylsiloxane (PDMS) has emerged as the ideal concentration and reaction medium for trace analysis. However the expensive commercial devices such as SPME and SBSE both require the samples to be returned to the laboratory for concentration. Due to the open tubular nature of the PDMS multichannel trap (MCT), developed in our laboratory, it is ideally suited for on-site and online sampling. The MCTs have a high analyte capacity owing to the large volume of PDMS available for concentration. The derivatization reaction can be performed in situ providing a “onepot concentration and reaction device”. This allows for reduced risk of contamination of / or losses of the sample and a sampling method that can cater for both air and water samples. To demonstrate the versatility of the PDMS MCT, two approaches for concentration in PDMS were investigated in this study, namely, 1) the on-line concentration and in situ derivatization of volatile polar analytes from air followed by REMPI-TOFMS detection, and 2) the concentration of phenolic lipophilic analytes from water requiring derivatization prior to analysis by GC/MS. 1) Analyte and derivatizing reagent were simultaneously introduced into the PDMS trap using a ypress- fit connector. The reaction occurs in situ followed by thermal desorption using a thermal modulator array alone or in conjunction with a thermal desorption unit. The aldehydes and amine derivatives were successfully detected by the REMPI-TOFMS. Reaction efficiencies were determined at room temperature without catalysts. Formaldehyde yielded a low reaction/concentration efficiency of 41 % with phenylhydrazine in PDMS, while acetaldehyde, acrolein and crotonal displayed much improved values of 92, 61 and 74 % respectively. Both propylamine and butylamine yielded 28 % reaction/concentration efficiency with benzaldehyde in the PDMS matrix. Detection limits obtained with this technique were significantly lower than the permissible exposure limits set by the Occupational Safety and Health Administration. It should be noted that the detection limits were not determined by actual measurement but by extrapolation from a larger signal. 2) Aqueous analytes were concentrated in the PDMS MCT using a gravity flow rate of ~50 ìl/min. The trap was dried and 5 ìl derivatizing reagent added. At room temperature and without the presence of a catalyst, the reaction of alkylphenols with trifluoroacetic acid anhydride in the PDMS matrix was 100% complete after 5 minutes. Bisphenol-A reacted less than 50 % to completion during this period, but the amount of derivative formed remained constant. This study revealed that extraction efficiencies of the alkylphenols and bisphenol-A off the PDMS trap have poor batch-tobatch repeatability indicating that the PDMS matrix was not homogenous. For two different PDMS batches: tert-octylphenol displayed an extraction efficiency of 70 and 79%, nonylphenol displayed 84 and 43% while Bisphenol-A displayed 10 and 26% respectively. The thermally desorbed derivatives were analysed by GC/MS. Despite background contamination in the desorption unit, detection limits were at the ppt level. Detection limits were not determined by actual measurement but by extrapolation from a larger signal.Thesis (PhD)--University of Pretoria, 2009.Chemistryunrestricte

Research Project: The Mentoring and Development of Emotional Competence in Nursing Students

Nursing care has a very intense emotional component. Nursing students, in addition to dealing with the frailties inherent in their life processes and personality development, are still subject to an emotionally and socially demanding academic experience. This negatively charged emotionality hinders the teaching-learning process and the academic course. The emotional management depends on perception and individual resources, and it may be necessary for this regulation support and guidance provided by a mentor. The mentoring programs developed in the Institutions of Higher Education contribute to the healthy integration of the student and, consequently, to their socialization and academic success. Mentors provide guidance to students and extrinsic emotional regulation, through support and discussion, and are a resource in managing emotions, contributing to the development of emotional competence in nursing students. This quantiquantitative approach research project aims to contribute to the construction of a mentoring program that promotes the development of emotional competence, essential to academic success and transformative learning in Nursing Degree

Increasing Students Vocabulary in Efl Class

After reviewing the literature, this work tries to show the importance of teaching vocabulary fõr students’ literacy skills, especially, reading comprehension. Many researchers suggest that the greatest amount of vocabulary growth occurs through incidental word learning in wide reading, and, research indicates that vocabulary instruction is an important vehicle for vocabulary learning. (Anderson& Nagy, as cited in Harmon, 1992, p.306). Word knowledge is one of the best ways of successful reading and comprehension. “Reading enhancement correlates with reader’s vocabulary” (Im, 1994, p.12). Therefore, today’s language teachers and researchers have realized the important role of vocabulary in reading comprehension. A survey carried out on 10th, 11th and 12th grade students, regarding their reading comprehension, shows that unknown words is one of the factors which influences their ability to read and comprehend a passage. It also shows that students feel the need to be instructed on strategy when encountering new words and consequently improving their vocabulary. This inhibits their understanding of a reading selection. As a result it is crucial that teachers equip students with methodological tools to be employed when they encounter unknown words. There are a lot systematic approaches for discerning which skills and words a teacher should focus on and meaningful classroom activities to reinforce the words and strategies that teachers can use to help students increase their word knowledge. Finally research indicates that developing students’ vocabulary correlates with success in all areas of curriculum (Edger, 1999, p.14). The success of vocabulary development depends on students’ active process of learning and strategies used by teachers

Salt efflorescences in the iberian pyrite belt: occurrence and distribution

The evolution of sulfide wastes promotes acid mine drainage and phenomena of supergenic neoformation. These contribute to a secondary paragenesis, often dominated by salt efflorescences. These can be used as mineralogical indicators of reactivity conditions and of AMD potential. The present study shows the salt efflorescences that develop in the Spanish sector of the Iberian Pyrite Belt, as a result of the strong acid mine drainage observed in this region. The obtained results showed dominance of metallic sulfates. Depending on the proximity to the sulfide sources, there are different types of assemblages. Iron and cooper minerals dominate inside the mining areas, whereas magnesium sulfates occur more abundantly in the receiving river networkFinancial support was provided by the Andalusian Autonomous Government Excellence Project, code P06-RNM-02167. This work was also co-funded by the European Union through the European Regional Development Fund, based on COMPETE 2020 (Programa Operacional da Competitividade e Internacionalização), project ICT (UID/GEO/04683/2013) with reference POCI-01-0145-FEDER- 007690 and national funds provided by Fundação para a Ciência e Tecnologia.info:eu-repo/semantics/publishedVersio

Preface

Universidade Federal Fluminense Faculdade de Medicina Departamento de Medicina ClínicaInstitutos de Nefrologia de Mogi das Cruzes e de SuzanoUniversidade Federal de São Paulo (UNIFESP)UNIFESPSciEL

Optimization of oil recovery from Japonica luna rice bran by supercritical carbon dioxide applying design of experiments: characterization of the oil and mass transfer modeling

This study presents an optimization strategy for recovery of oil from Japonica Luna rice bran using supercritical carbon dioxide (scCO2), based on design of experiments (DoE). Initially, a 24−1 two level fractional factorial design (FFD) was used, and pressure, temperature, and scCO2 flow rate were determined as the significant variables; while the yield, total flavonoids content (TFC), and total polyphenols content (TPC) were the response functions used to analyze the quality of the extracts recovered. Subsequently, central composite design (CCD) was applied to examine the effects of the significant variables on the responses and create quadratic surfaces that optimize the latter. The following values of pressure = 34.35 MPa, temperature = 339.5 K, and scCO2 flow rate = 1.8 × 10−3 kg/min were found to simultaneously optimize the yield (6.83%), TPC (61.28 μmol GAE/g ext), and TFC (1696.8 μmol EC/g ext). The fatty acid profile of the oils was characterized by GC-FID. It was demonstrated that the acids in largest quantities are C16:0 (15–16%), C18:1 (41%), and C18:2 (38–39%). Finally, three mass transfer models were applied to determine the mass transfer coefficients and assess the cumulative extraction curves, with an AAD% of 4.16, for the best model.info:eu-repo/semantics/publishedVersio