Cross-border cooperation (CBC) in Southern Europe-An iberian case study. The eurocity Elvas-Badajoz

The experiences of cross-border cooperation (CBC), undertaken not only in Europe but throughout the world, have enabled areas to gain greater importance in recent decades at an international level, showing potential for integrative functions and joint development as exemplified by several CBC projects. The present paper assesses the impact of CBC projects by analyzing a protocol established in 2013 between the cities of Elvas and Badajoz, which induced the creation of the Eurocity Elvas-Badajoz. The paper kicks off with a critical review on territorial factors for success in CBC areas, considering the analysis of several case studies throughout Europe. The lessons learned, taken from the analyzed case studies, and the identified territorial success factors were used as assessment points for the investigation of the target study area, the Eurocity Elvas-Badajoz. The investigation explores public participation perceptions towards the identification of what changes with respect to standards of life with the CBC project, providing the current state of affairs and identifying where to place efforts in order to reach sustainable development for the region. While being a transition area, it presents several opportunities for growth. These opportunities have not yet been object of analysis and debate with respect to lasting, sustainable successful growth. The present research enables the identification of several territorial factors for success in the study area, such as the connectivity/movement between cities and strong political commitment. From the identified critical factors, it was possible to highlight the importance of public transportation as a priority for achieving success in this CBC project.National Funds - FCT-Foundation for Science and Technology [UID/SOC/04020/2013

Determinação da aptidão biogeofísica do território EUROACE para a utilização agroflorestal

É consensual que a escolha dos usos mais adequados às aptidões edafo-climáticas, complementada com critérios socioeconómicos, promove uma utilização sustentável dos espaços rurais. Existem, no entanto, diferentes metodologias utilizadas para a definição da capacidade e potencialidade do solo para a implementação de usos agroflorestais ou manutenção de ecossistemas naturais e seminaturais, nomeadamente culturas agrícolas, povoamentos florestais, territórios agro-silvo-pastoris e áreas prioritárias para a conservação da natureza. Muitas dessas metodologias recorrem a sistemas de apoio à decisão, baseados na análise espacial multicritério. Neste estudo pretendeu-se determinar os diferentes níveis de aptidão para a utilização agroflorestal no território transfronteiriço que abrange o Alentejo, Extremadura e o Centro (Euro-região EUROACE). Para o efeito recorreu-se a um conjunto de variáveis edáficas e topográficas. Foram igualmente incorporadas as condicionantes legais e a ocupação do solo. A avaliação da aptidão foi efetuada com recurso ao método de análise espacial multicritério Analytic Hierarchy Process (AHP). O resultado obtido com esta metodologia, confrontado com a matriz de uso existente, permite identificar as áreas onde a ocupação e gestão está de acordo com a aptidão do espaço, bem como as áreas onde o uso deverá ser alvo de uma reconversão ou apenas a uma alteração de modo de gestão

Simultaneous concentration of nutrients from anaerobically digested sludge centrate and pre-treatment of industrial effluents by forward osmosis

[EN] In the last years, forward osmosis (FO) has gained increasing prominence, new membranes are being developed and new applications are being considered. In this study, the recovery of nitrogen and phosphorus of the anaerobically digested sludge centrate was studied by FO using two industrial effluents characterized by high osmotic pressure (residual stream from an absorption process for ammonia elimination and brine from a seawater desalination facility) as draw solutions. The experiments were carried out in a laboratory plant testing two FO membranes (CTA-NW and Aquaporin Inside membrane). Results showed that nitrogen concentration was achieved with both membranes and both draw solutions. The use of the effluent from ammonia absorption enhanced of the nitrogen concentration in the feed stream to the FO membrane. The reached concentration factor in the laboratory tests was 1.61 when Aquaporin membrane was used. Phosphorus could not be concentrated because of its precipitation as calcium phosphate (confirmed by EDX analysis) as a consequence of the high calcium concentration of the municipal wastewater.This study was supported by the Spanish Ministry of Economy and Competitiveness through the project RTC-2015-3582-5-AR.Soler Cabezas, JL.; Mendoza Roca, JA.; Vincent Vela, MC.; Lujan Facundo, MJ.; Pastor Alcañiz, L. (2018). Simultaneous concentration of nutrients from anaerobically digested sludge centrate and pre-treatment of industrial effluents by forward osmosis. Separation and Purification Technology. 193:289-296. https://doi.org/10.1016/j.seppur.2017.10.058S28929619

A comparative study of the influence of salt concentration on the performance of an osmotic membrane bioreactor and a sequencing batch reactor

[EN] BACKGROUNDAn osmotic membrane bioreactor (OMBR) is a wastewater treatment technique that presents low energy requirements, low membrane fouling and high removal of nutrients and organic matter. However, reverse salt flux is the main disadvantage because it causes conductivity increase in the bioreactor. This study compares the performance of a sequencing batch reactor (SBR) and an OMBR in terms of chemical oxygen demand (COD) removal, soluble microbial products (SMP) and extracellular polymeric substances (EPS) production. For that, the influent conductivity in the SBR was increased as this increases conductivity in the osmotic membrane bioreactor. RESULTSComparing the results obtained at two mixed liquor suspended solids (MLSS) concentrations in terms of membrane fouling, a concentration of 5 g L-1 of MLSS was chosen for the comparison with the SBR. The SBR achieved slightly higher COD removal efficiencies than the OMBR is spite of the accumulation of cellular debris in the membrane bioreactor. The accumulation of SMP and EPS in the OMBR was also higher than in the SBR due to the cellular debris and organic matter accumulation. In both reactors the microbial activity measured in terms of standard oxygen uptake rate decreased due to the increase of salt concentration in the bioreactor. CONCLUSIONSAs a conclusion, OMBR will be especially feasible when the draw solution is a residual stream of the same industry, like tannery wastewater or table olive processing. (c) 2017 Society of Chemical IndustryThis study was supported by the Spanish Ministry of Economy and Competitiveness through the project RTC-2015-3582-5-AR.Soler Cabezas, JL.; Lujan Facundo, MJ.; Mendoza Roca, JA.; Vincent Vela, MC.; Pastor Alcañiz, L. (2018). A comparative study of the influence of salt concentration on the performance of an osmotic membrane bioreactor and a sequencing batch reactor. Journal of Chemical Technology & Biotechnology. 93(1):72-79. https://doi.org/10.1002/jctb.5321S727993

Cellular and Molecular Mechanisms of Methotrexate Resistance in Melanoma

Endocrinolog

Differentiation of Epoxide Enantiomers in the Confined Spaces of an Homochiral Cu(II) MOF by Kinetic Resolution

TAMOF-1, a homochiral metal-organic framework (MOF) constructed from an amino acid derivative and Cu(II), was investigated as a heterogeneous catalyst in kinetic resolutions involving the ring opening of styrene oxide with a set of anilines. The branched products generated from the ring opening of styrene oxide with anilines and the unreacted epoxide were obtained with moderately high enantiomeric excesses. The linear product arising from the attack on the non-benzylic position of styrene oxide underwent a second kinetic resolution by reacting with the epoxide, resulting in an amplification of its final enantiomeric excess and a concomitant formation of an array of isomeric aminodiols. Computational studies confirmed the experimental results, providing a deep understanding of the whole process involving the two successive kinetic resolutions. Furthermore, TAMOF-1 activity was conserved after several catalytic cycles. The ring opening of a mesoepoxide with aniline catalyzed by TAMOF-1 was also studied and moderate enantioselectivities were obtained

Generation and Applications of Extreme-Ultraviolet Vortices

Vortex light beams are structures of the electromagnetic field with a spiral phase ramp around a point-phase singularity. These vortices have many applications in the optical regime, ranging from optical trapping and quantum information to spectroscopy and microscopy. The extension of vortices into the extreme-ultraviolet (XUV)/X-ray regime constitutes a significant step forward to bring those applications to the nanometer or even atomic scale. The recent development of a new generation of X-ray sources, and the refinement of other techniques, such as harmonic generation, have boosted the interest of producing vortex beams at short wavelengths. In this manuscript, we review the recent studies in the subject, and we collect the major prospects of this emerging field. We also focus on the unique and promising applications of ultrashort XUV/X-ray vortex pulsesA.P. acknowledges support from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 702565. C.H.-G. acknowledges support from the Marie Curie International Outgoing Fellowship within the EU Seventh Framework Programme for Research and Technological Development (2007-2013), under REA grant Agreement No 328334. We acknowledge support and from Junta de Castilla y León (Project SA046U16) and MINECO (FIS2013-44174-P, FIS2015-71933-REDT, FIS2016-75652-P)

Interactions between surrounding landscape biodiversity and intermittent rivers in mediterranean environments – case study of the Caia River

Landscape is a dynamic mosaic of various structures interacting together. Neglecting or overusing one part of this mosaic may boost up or damage the development of others. For instance, overgrazing may increase soil erosion process which may clog a river/stream. In this regard land use changes, climate change and landscape management may lead to increase the intermittency of the surface watercourses, as well as in the ecosystem services provided by riverscapes for humans. Therefore, the present research focus on the existing interactions between the Caia River, an intermittent river located in the Mediterranean region, and its surrounding agricultural and natural landscapes. The performed analyses considered the identification of the existing interaction between natural and agricultural landscapes with the Caia River defining the predictable ecosystem services provided by each element of the landscape and assessing the potential decrease of the ecosystem services provided in case of landscape changes, which according to the performed research might enclose significant impacts both in ecologic and socioeconomic terms.info:eu-repo/semantics/publishedVersio

Silk fibroin nanoparticles constitute a vector for controlled release of resveratrol in an experimental model of inflammatory bowel disease in rats.

Purpose: We aimed to evaluate the intestinal anti-inflammatory properties of silk fibroin nanoparticles, around 100 nm in size, when loaded with the stilbene compound resveratrol, in an experimental model of rat colitis. Methods: Nanoparticles were loaded with resveratrol by adsorption. The biological effects of the resveratrol-loaded nanoparticles were tested both in vitro, in a cell culture of RAW 264.7 cells (mouse macrophages), and in vivo, in the trinitrobenzenesulfonic acid model of rat colitis, when administered intracolonically. Results: The resveratrol liberation in 1× phosphate-buffered saline (PBS; pH 7.4) was characterized by fast liberation, reaching the solubility limit in 3 hours, which was maintained over a period of 80 hours. The in vitro assays revealed immunomodulatory properties exerted by these resveratrol-loaded nanoparticles since they promoted macrophage activity in basal conditions and inhibited this activity when stimulated with lipopolysaccharide. The in vivo experiments showed that after evaluation of the macroscopic symptoms, inflammatory markers, and intestinal barrier function, the fibroin nanoparticles loaded with resveratrol had a better effect than the single treatments, being similar to that produced by the glucocorticoid dexamethasone. Conclusion: Silk fibroin nanoparticles constitute an attractive strategy for the controlled release of resveratrol, showing immunomodulatory properties and intestinal anti-inflammatory effects