Una nueva especie trifoliolada de Arachis (Fabaceae) y comentarios adicionales sobre la sección taxonómica Trierectoides

Se describe una nueva especie de Arachis, con hojas trifolioladas, A. sesquijuga. Esta se diferencia de las otras especies trifolioladas, ambas con folíolos ternados, por la presencia de un raquis evidente, lo que caracteriza a la hoja como pinnada. Datos históricos sobre la acumulación de conocimiento referente a las raras especies trifolioladas son comentados en secuencia cronológica

Uma tipografia de base elíptica e outros cruzamentos do design com a geometria das curvas cónicas

Através de alguns exemplos práticos, pretende-se defender que o conhecimento geométrico e, em particular, o conhecimento das curvas cónicas e suas aplicações, pode potenciar o trabalho projetual dos designers, diminuir os custos de hardware e software no ensino e no trabalho profissional, diminuir a necessidade de recurso a meios sofisticados e caros, reduzir a necessidade de permanente atualização dos meios tecnológicos, e de utilização de software que implique formação especializada e, sobretudo, que necessite de longos períodos de formação. Temos em vista contribuir para o reconhecimento da importância do estudo destas curvas e das superfícies por elas geradas, em especial no ensino da Geometria em cursos de Design. De facto, a partir da sistematização do conhecimento existente em outras áreas, como, por exemplo, a arquitetura e as engenharias, pelo aprofundamento da adaptação de propriedades das cónicas e de conhecimentos de áreas, como a geometria analítica ou a projetiva para a linguagem dos traçados geométricos, e pela contribuição com a sugestão de novos traçados, pode desenvolver-se a capacidade dos designers e estudantes de design resolverem problemas, no âmbito do projeto, na representação técnica e na comunicação externa com não peritos.Through some examples, we intend to argue that the knowledge of geometry and, in particular, the knowledge of conic curves and their applications, may potentiate the project work of designers, reducing the costs of hardware and software in teaching and professional work, reducing also the need for sophisticated and expensive means, and its continuous updating, and the use of software which involves specialized training, and especially requiring long training periods. We want to contribute to the recognition of the importance of the study of these curves and surfaces generated by them, especially in the teaching of Geometry in Design courses. In fact, from the systematization of existing knowledge in other areas, such as architecture and engineering, developing the adaptation of properties of conic curves and also the knowledge of areas such as analytic or projective geometry to the geometric design and contributing by suggesting new ways to draw the curves, we can develop the ability of designers and design students to solve problems in the context of the project, and others such as technical representation and external communication with non-experts

Toxicological Study Employing Repeated Doses of Garcinielliptone FC, a Polyisoprenylated-Benzophenone Isolated from Seed of Platonia Insignis Mart

The major constituent from the hexane extract of the seeds of P. insignis is GFC (garcinielliptone FC). Doses of 25, 50and 75 mg/kg of GFC were aseptically suspended in 0.05% Tween 80 dissolved in 0.9% saline (vehicle) and orally administered for30, 90 and 120 consecutive days to adult Swiss mice. In this work, the repeated oral administration, in animals of both sexes,demonstrates that this compound is not able to induce mortality and/or behavioral changes in adult mice. In addition, body weightgain, feed intake and disposal of excreta were not altered by the administration of this compound with repeated doses. Furthermore,no differences in weight and macroscopic structure of the brain, liver, kidney, lung, heart and spleen between groups of male andfemale adult mice were observed after treatment. During the periods of treatment, GFC produced no significant changes onhaematological and biochemical parameters in male and female mice treated with all doses used. The aim of this study was toinvestigate the toxicological potential of GFC through behavioral, hematological, biochemical and morphological parameters inanimals in order to ensure the safe use of Platonia insignis in folk medicine.Fil: Silva, Ana P.. Federal University of Piauí; BrasilFil: Filho, José Carlos C. L. S.. North Union of Parana; BrasilFil: da Costa Júnior, Joaquim S.. Federal Institute of Piauí; BrasilFil: Peláez, Walter José. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Faillace, Martín Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Falcão Ferraz, Alexandre de B.. Lutheran University of Brazil; BrasilFil: David, Jorge M.. Institute Of Chemistry, Federal University Of Bahia; Brasil. Universidade Federal da Bahia; BrasilFil: Freitas, Rivelilson M.. Federal University of Bahia; Brasi

Carcinogenic Ability of Schistosoma Haematobium Possibly through Oncogenic Mutation of KRAS Gene

Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer, although why is not clear. Previously, we have used CD-1 mice to show that Schistosoma haematobium total antigen (Sh) has a carcinogenic ability. Sh intravesically instillation induced the development of several urothelial lesions, namely nodular hyperplasia and dysplasia (LGIUN—Low Grade Intra-Urothelial Neoplasia) after 40 weeks of treatment. These results suggested that Sh induce urothelium malignization. Bladder carcinoma frequently harbours gene mutations that constitutively activate the receptor tyrosine kinase-Ras pathway for this reason we studied activating mutations in KRAS gene. Twenty percent of the bladders with dysplasia presented a KRAS mutation in codon 12 of exon 2. We concluded from these results that the parasite extract of S. haematobium has carcinogenic ability possibly through oncogenic mutation of KRAS gene

A multivariate randomized controlled experiment about the effects of mindfulness priming on EEG neurofeedback self-regulation serious games

Neurofeedback training (NFT) is a technique often proposed to train brain activity SR with promising results. However, some criticism has been raised due to the lack of evaluation, reliability, and validation of its learning effects. The current work evaluates the hypothesis that SR learning may be improved by priming the subject before NFT with guided mindfulness meditation (MM). The proposed framework was tested in a two-way parallel-group randomized controlled intervention with a single session alpha NFT, in a simplistic serious game design. Sixty-two healthy naïve subjects, aged between 18 and 43 years, were divided into MM priming and no-priming groups. Although both the EG and CG successfully attained the up-regulation of alpha rhythms (F(1,59) = 20.67, p ηp2 = 0.26), the EG showed a significantly enhanced ability (t(29) = 4.38, p t(29) = 1.18, p > 0.1). Furthermore, EG superior performance on NFT seems to be explained by the subject’s lack of awareness at pre-intervention, less vigour at post-intervention, increased task engagement, and a relaxed non-judgemental attitude towards the NFT tasks. This study is a preliminary validation of the proposed assisted priming framework, advancing some implicit and explicit metrics about its efficacy on NFT performance, and a promising tool for improving naïve “users” self-regulation ability.This work is co-financed by the ERDF—European Regional Development Fund through the Operational Program for Competitiveness and Internationalisation—COMPETE 2020 (ref.: POCI01-0145-FEDER-007043; ref: POCI-01-0145-FEDER-007038), the North Portugal Regional Operational Program—NORTE 2020 (ref.: NORTE-01-0145-FEDER-000045) and by the Portuguese Foundation for Science and Technology – FCT under MIT Portugal (author Ph.D. grant ref.: PD/BD/114033/2015) and within the R&D Units Project Scope (ref.: UIDB/00319/2020)

Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms

Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expected, but we found exclusively male worms, no female worms nor eggs. Interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms alone in the golden hamster, characteristic of schistosome eggs. Samples from liver, kidneys, lungs, bladder and gastrointestinal tract were collected during necropsy to evaluate injuries induced by S. haematobium. Notably we observed hepatitis in the liver of infected hamsters, no lesions were found in other organs. We also found liver fibrosis in infected hamsters. This study provides further experimental evidence for the role that schistosome worms, and their derived antigens, may play in the pathology of the infection and modulation of liver chronic inflammation in the murine model of schistosomiasis

Independent early predictors of mortality in polytrauma patients: a prospective, observational, longitudinal study

OBJECTIVES: Trauma is an important public health issue and associated with substantial socioeconomic impacts and major adverse clinical outcomes. No single study has previously investigated the predictors of mortality across all stages of care (pre-hospital, emergency room, surgical center and intensive care unit) in a general trauma population. This study was designed to identify early predictors of mortality in severely injured polytrauma patients across all stages of care to provide a better understanding of the physiologic changes and mechanisms by which to improve care in this population. METHODS: A longitudinal, prospective, observational study was conducted between 2010 and 2013 in São Paulo, Brazil. Patients submitted to high-energy trauma were included. Exclusion criteria were as follows: injury severity scor

Intrinsic and extrinsic resistive switching in a planar diode based on silver oxide nanoparticles

Resistive switching is investigated in thin-film planar diodes using silver oxide nanoparticles capped in a polymer. The conduction channel is directly exposed to the ambient atmosphere. Two types of switching are observed. In air, the hysteresis loop in the current–voltage characteristics is S-shaped. The high conductance state is volatile and unreliable. The switching is mediated by moisture and electrochemistry. In vacuum, the hysteresis loops are symmetric, N-shaped and exhibit a negative differential resistance region. The conductance states are non-volatile with good data retention, programming cycling endurance and large current modulation ratio. The switching is attributed to electroforming of silver oxide clusters

Extração radicular de água e Kc em cultura de café

Basic information for a rational soil-water management of the coffee crop is still insufficient, particularly under irrigated conditions. Of great importance for the estimation of water requirements of coffee crops are their root distribuition and evapotranspiration crop coefficients. This study compares soil water extraction by roots of coffee plants of the variety Catuaí Vermelho (IAC-44), grown in Piracicaba, SP, Brazil, 3 to 5 years old, with direct measurements of root dry matter, showing a good agreement between both approaches, and confirming that most of the root system is distributed in the top soil layer (0-0.3 m) and that less than 10% of the root system reaches depths greater than 1.0 m. Calculated evapotranspiration crop coefficients are in agreement with those found in the literature, with an average of 1.1, independent of shoot dry matter, plant height and leaf area index.A informação básica para o manejo racional de água e solo na cultura de café ainda é insuficiente, sobretudo em condições de cultura irrigada. A distribuição radicular e os coeficientes de cultura para evapotranspiração são de grande importância para a estimativa da necessidade de água na cultura café. Este estudo compara a extração radicular de água de plantas de café, variedade Catuaí Vermelho (IAC-44), cultivado em Piracicaba, SP, Brasil, de 3 a 5 anos de idade, com medidas diretas de material seca de raiz, mostrando boa relação entre as metodologias e confirmando que a maioria do sistema radicular está distribuída na camada superficial de solo (0-0,3 m) e que menos de 10% do sistema radicular atingem profundidades maiores que 1,0 m. Os coeficientes de cultura medidos estão de acordo com aqueles encontrados na literatura, com média de 1,1, independentemente da matéria seca, altura de planta e índice de área foliar

Planar non-volatile memory based on metal nanoparticles

Resistive switching properties of silver nanoparticles hosted in an insulating polymer matrix (poly(N-vinyl-2-pyrrolidone) are reported. Planar devices structures using interdigitated gold electrodes were fabricated. These devices have on/off resistance ratio as high as 103 , retention times reaching to months and good endurance cycles. Temperature-dependent measurements show that the charge transport is weakly thermal activated (73 meV) for both states suggesting that nanoparticles will not aggregate into a metallic filament