Evolution and study of a copycat effect in intimate partner homicides: A lesson from Spanish femicides

Objectives This paper focuses on the issue of intimate partner violence and, specifically, on the distribution of femicides over time and the existence of copycat effects. This is the subject of an ongoing debate often triggered by the social alarm following multiple intimate partner homicides (IPHs) occurring in a short span of time. The aim of this research is to study the evolution of IPHs and provide a far-reaching answer by rigorously analyzing and searching for patterns in data on femicides. Methods The study analyzes an official dataset, provided by the system VioGén of the Secretaría de Estado de Seguridad (Spanish State Secretariat for Security), including all the femicides occurred in Spain in 2007-2017. A statistical methodology to identify temporal interdepen-dencies in count time series is proposed and applied to the dataset. The same methodology can be applied to other contexts. Results There has been a decreasing trend in the number of femicides per year. No interdependen-cies among the temporal distribution of femicides are observed. Therefore, according to data, the existence of copycat effect in femicides cannot be claimed. Conclusions Around 2011 there was a clear change in the average number of femicides which has not picked up. Results allow for an informed answer to the debate on copycat effect in Spanish femicides. The planning of femicides prevention activities should not be a reaction to a perceived increase in their occurrence. As a copycat effect is not detected in the studied time period, there is no evidence supporting the need to censor media reports on femicides.The work by Torrecilla has been partially supported by Spanish Grant MTM2016-78751-P. The research of Liberatore has been supported by the Government of Spain, grant MTM2015-65803-R, and by the Government of Madrid, grant S2013/ICE-284

Integral field spectroscopy of the central regions of 3C 120: Evidence of a past merging event

Optical integral field spectroscopy (IFS), combined with Hubble Space Telescope (HST ) WFPC imaging, was used to characterize the central regions of the Seyfert 1 radio galaxy 3C 120. We carried out the analysis of the data, deriving intensity maps of different emission lines and the continua at different wavelengths from the observed spectra. Applying a two-dimensional modeling to the HST images, we decoupled the nucleus and the host galaxy and analyzed the host morphology. The host is a highly distorted bulge-dominated galaxy, rich in substructures. We developed a new technique to model the IFS data extending the two-dimensional modeling (hereafter threedimensional modeling). Using this technique, we separated the Seyfert nucleus and the host galaxy spectra and derived a residual data cube with spectral and spatial information of the different structures in 3C 120. Three continuum-dominated structures (named A, B, and C) and three other extended emission-line regions (EELRs, named E1, E2, and E3) are found in 3C 120, which does not follow the general behavior of a bulge-dominated galaxy. We also found shells in the central kiloparsec that may be remnants of a past merging event in this galaxy. The origin of E1 is most probably due to the interaction of the radio jet of 3C 120 with the intergalactic medium (Axon et al. 1989; Sa´nchez et al. 2004a). Structures A, B, and the shell at the southeast of the nucleus seem to correspond to a larger morphological clumpy structure that may be a tidal tail, a consequence of the past merging event. We found a bright EELR (E2) in the innermost part of this tidal tail, nearby the nucleus, which shows a high ionization level. The kinematics of the E2 region and its connection to the tidal tail suggest that the tail has channeled gas from the outer regions to the cente

Clean optical spectrum of the radio jet of 3C 120

We present integral field spectroscopy (IFS) of the central region of 3C 120. We have modeled the nuclear and host galaxy three-dimensional spectra using techniques normally applied to imaging, decoupling both components and obtaining a residual data cube. Using this residual data cube, we detected the extended emission line region associated with the radio jet. We obtained, for the first time, a clean spectrum of this region and found compelling evidence of a jet-cloud interaction. The jet compresses and splits the gas cloud, which is ionized by the active galactic nucleus (AGN ) and/or by the strong local UV photon field generated by a shock process. We cannot confirm the detection of an extended emission line region associated with the counterjet reported by Axon and coworkers.This project is part of the Euro3D RTN on IFS, funded by the EC under contract HPRN-CT-2002-00305. The WHT is operated on the island of La Palma by the Isaac Newton Group in the Spanish Observatorio del Roque de los Muchachos of the IAC. This project has used images obtained from the HST archive, using the ESO archiving facilities. We would like to thank R. C. Walker, who has kindly provided us with the radio maps of 3C 120. We would like to thank the anonymous referee, who has helped us to improve the quality of this paper with his/her remarks

Rheumatoid arthritis miRNA biomarker detection by means of LMR based fiber-optic biosensor

Development of miRNA optical biosensors for disease diagnosis and monitoring has acquired relevance in recent years, due to the clinical importance of miRNA and the inherent advantages of optical sensors. Here, we present the utilization of a fiber optic sensor based on Lossy Mode Resonance (LMR) for the detection of miRNA hsa-miR-223, a promising biomarker for the diagnosis of rheumatoid arthritis (RA).This research was funded by the Spanish Agencia Estatal de Investigación (AEI) (PID2019-106231RB-I00), the Public University of Navarra (PJUPNA26), and the Spanish Ministry of Universities (FPU18/03087). In addition, this project has received funding from the ATTRACT call financed by the European Union's Horizon 2020 research and innovation program under grant agreement No 777222

Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”

The relevance of the immune system in cancer has long been studied. Autologous adoptive T cell therapies, based on the use of tumor infiltrating lymphocytes (TILs), have made great progress in recent years for the treatment of solid tumors, especially melanoma. However, further work is needed to isolate tumor-reactive T cells among patients diagnosed with hematologic malignancies. The dynamics of the interaction between T cells and antigen presenting cells (APC) dictate the quality of the immune responses. While stable joints between target cells and T lymphocytes lead to the induction of T cell activation and immune response, brief contacts contribute to the induction of immune-tolerance. Taking advantage of the strong interaction between target cell and activated T-cells, we show the feasibility to identify and isolate tumor-specific cytotoxic T lymphocytes (CTLs) from acute myeloid leukemia (AML) patients by flow cytometry. Using this technology, CTLs bound through T cell receptor (TCR) to tumor cells can be identified in peripheral blood and bone marrow and subsequently selected and isolated by FACS-based cell sorting. These CTLs display higher percentage of effector cells and marked cytotoxic activity against AML blasts. In conclusion, we have developed a new procedure to identify and select specific cytotoxic T cells in patients diagnosed with acute myeloid leukemia.Instituto de Salud Carlos III PFIS-FI12/00189Instituto de Salud Carlos III ISCIII PI14/02074Instituto de Salud Carlos III PI11/02366Instituto de Salud Carlos III PI17/02177European Union (ERDF/ESF, Investing in your future)CIBER CB16/12/0048

Focusing dielectric slabs for the optimization of heating patterns in single mode microwave applicators

[EN] A new approach based on dielectric slabs with adjustable position is proposed as near-field focusing lenses inside a single-mode microwave applicator to provide specific temperature distributions within a material heated by microwaves. Numerical and experimental results in a TE101 rectangular cavity at 915 MHz have been used to evaluate the capability of these focusing dielectrics to optimize the temperature profile of Polyethylene terephthalate (PET) preforms. Measurements of the temperature profile on the preforms verified the strong effect of the slabs on the electric field distribution, allowing the optimization of the heating patterns with great flexibility. The successful application applied to PET preforms with different sizes and geometries showed the versatility of this approach which can be extended to the application of other type of loads and microwave cavities.García-Baños, B.; Plaza González, PJ.; Sánchez-Marín, JR.; Steger, S.; Feigl, A.; Penaranda-Foix, FL.; Catalá Civera, JM. (2022). Focusing dielectric slabs for the optimization of heating patterns in single mode microwave applicators. Applied Thermal Engineering. 201:1-10. https://doi.org/10.1016/j.applthermaleng.2021.11784511020

Androgen receptor gene polymorphism influence fat accumulation: a longitudinal study from adolescence to adult age.

To determine the influence of androgen receptor CAG and GGN repeat polymorphisms on fat mass and maximal fat oxidation (MFO), CAG and GGN repeat lengths were measured in 128 young boys, from which longitudinal data were obtained in 45 of them [mean?±?SD: 12.8?±?3.6 years old at recruitment, and 27.0?±?4.8 years old at adult age]. Subjects were grouped as CAG short (CAGS ) if harboring repeat lengths ?21, the rest as CAG long (CAGL ); and GGN short (GGNS ) if GGN repeat lengths ?23, or long if >?23 (GGNL ). CAGS and GGNS were associated with lower adiposity than CAGL or GGNL (P?<?0.05). There was an association between the logarithm of CAG repeats polymorphism and the changes of body mass (r?=?0.34, P?=?0.03). At adult age, CAGS men showed lower accumulation of total body and trunk fat mass, and lower resting metabolic rate (RMR) and MFO per kg of total lean mass compared with CAGL (P?<?0.05). GGNS men also showed lower percentage of body fat (P?<?0.05). In summary, androgen receptor CAG and GGN repeat polymorphisms are associated with RMR, MFO, fat mass, and its regional distribution in healthy male adolescents, influencing fat accumulation from adolescence to adult age

Interaction of 8 He with 208Pb at near-barrier energies: 4 He and 6 He production

Spanish Ministry of Economy and Competitiveness-FPA-2010-22131-CO2-01 (FINURA) y FPA2013-47327-C2-1-RMinistry of Science and Higher Education of Poland-N202 033637National Science Centre of Poland-2013/08/M/ST2/00257 (LEA-COPIGAL) y 2014/14/M/ST2/00738 (COPIN-INFN Collaboration)European Science Foundation-EUI2009-04163432 (EUROGENESIS

Chemoselective and stereoselective lithium carbenoid mediated cyclopropanation of acyclic allylic alcohols

The reaction of geraniol with different lithium carbenoids generated from n-BuLi and the corresponding dihaloalkane has been evaluated. The reaction occurs in a chemo and stereoselective manner, which is consistent with a directing effect from the oxygen of the allylic moiety. Furthermore, a set of polyenes containing allylic hydroxyl or ether groups were chemoselectively and stereoselectively converted into the corresponding gem-dimethylcyclopropanes in one single step in moderate to good yields mediated by a lithium carbenoid generated in situ by the reaction of n-BuLi and 2,2-dibromopropane

Biomarkers and inorganic proxies in the paleoenvironmental reconstruction of mires: The importance of landscape in Las Conchas (Asturias, Northern Spain)

We determined the lipid distributions (n-alkanes, n-alkan-2-ones, n-alkanoic acids), total organic carbon (TOC), total nitrogen (TN), Ca/Mg and ash content in Las Conchas mire, a 3.2 m deep bryophyte-dominated mire in Northern Spain covering 8000 cal yr BP. Bog conditions developed in the bottom 20 cm of the profile, and good preservation of organic matter (OM) was inferred from n-alkanoic acid distribution, with the exception of the uppermost 20 cm (last ca. 200 yr). Microbial synthesis of long chain saturated fatty acids from primary OM likely produced a dominance of short chain n-alkanoic acids with a bimodal distribution, as well as the lack of correspondence between the n-alkane and n-alkanoic acid profiles in the upper 20 cm. This was accompanied by an increase in ash content, a decrease in TOC and variation in n-alkane ratios, thereby suggesting significant changes in the mire, namely drainage and transformation to a meadow, in the last ca. 200 yr. The distribution of n-alkan-2-ones indicated an increase in bacterial source from the bottom of the record to 94 cm, whereas their distribution in the upper part could be attributed mainly to plant input and/or the microbial oxidation of n-alkanes. The different n-alkane proxies showed variations, which we interpreted in terms of changes in vegetation (Sphagnum vs. non-Sphagnum dominated phases) during the last 8000 cal yr BP. C23 was the most abundant homolog throughout most of the record, thereby suggesting dominant humid conditions alternating with short drier phases. However, such humid conditions were not linked to paleoclimatic variation but rather to geomorphological characteristics: Las Conchas mire, at the base of the Cuera Range, receives continuous runoff—even during drier periods—which is not necessarily accompanied by additional mineral input to peat, producing the development of Sphagnum moss typical of waterlogged ecotopes and damp habitats. Thus, although geochemical proxies indicated an ombrotrophic regime in the mire, geomorphological characteristics may make a considerable contribution to environmental conditions