Rheumatoid arthritis miRNA biomarker detection by means of LMR based fiber-optic biosensor

Abstract

Development of miRNA optical biosensors for disease diagnosis and monitoring has acquired relevance in recent years, due to the clinical importance of miRNA and the inherent advantages of optical sensors. Here, we present the utilization of a fiber optic sensor based on Lossy Mode Resonance (LMR) for the detection of miRNA hsa-miR-223, a promising biomarker for the diagnosis of rheumatoid arthritis (RA).This research was funded by the Spanish Agencia Estatal de Investigación (AEI) (PID2019-106231RB-I00), the Public University of Navarra (PJUPNA26), and the Spanish Ministry of Universities (FPU18/03087). In addition, this project has received funding from the ATTRACT call financed by the European Union's Horizon 2020 research and innovation program under grant agreement No 777222