ECONOMY OF CULTURE OR CREATIVE ECONOMY: INTERSECTIONS AND CONCEPTUAL CHANGES IN BRAZILIAN CULTURAL PUBLIC ADMINISTRATION

The present paper aims to draw an outline contrasting the concepts of economy of culture and creative economy, examining the theoretical debate on the current importance of the economic value of cultural goods to guide the Brazilian Cultural Public Administration and the national plan of cultural policies. Therefore, it is necessary that the Government sets guidelines for their actions through qualitative and quantitative analyses of the creative industries, without which it would continue at the stage of timely, uncoordinated and unmonitored operation. With no data, it remains impossible to assess the effectiveness of any incentives and stimuli to the creative economy and its inclusion. That includes tariff plans, programs, and funding; as it also inefficient to justify its relevance within today's cultural Brazilian Public Administration. These are the justifications for the existence of an Information System and unified indicators, which encourage municipalities, along with the State and the Union, to establish parameters that can be assessed once they are properly fed

Etiologia do Bruxismo no Paciente Pediátrico

O Bruxismo caracteriza-se por contrações musculares rítmicas, com um grau elevado de força, que provoca atrito e ruídos ao ranger os dentes, sendo um hábito involuntário e sem intuito funcional. Durante a infância há uma maior frequência dos hábitos parafuncionais aliados ao facto das características estruturais e funcionais da dentição decídua. A nível da etiologia vários aspetos foram analisados como possíveis causas do buxismo: Ansiedade, Alterações no sono, Bacteriologia, Distúrbios Comportamentais, Hereditariedade, Hiperatividade e Défice de Atenção, Alterações Cognitivas, Autismo, Distúrbios Respiratórios, Postura Craniocervical, Distúrbios Temperomandibulares, Fatores Oclusais e Hábitos Parafuncionais. Nos dias de hoje ainda não há consenso em relação à prevalência, que muitos autores afirmam variar entre 7 e 88%, e etiologia do bruxismo, no entanto a etiologia é considerada multifatorial. É necessário realizar mais estudos para que se consiga obter uma base científica e clínica mais sólida que permita ao médico dentista chegar à etiologia do bruxismo e facilitar o seu diagnóstico e tratamento

Large desmoid tumors in familial adenomatous polyposis: a successful outcome

Desmoid tumors develop from connective tissue, fasciae, and aponeuroses, and may occur in the context of familial adenomatous polyposis or may arise sporadically; also, they may be extra-abdominal, intra-abdominal, or located in the abdominal wall. These benign tumors have a great aggressiveness with a high rate of local recurrence. Familial adenomatous polyposis is an inherited condition with autosomal dominant transmission, and is characterized by the development of multiple colonic and rectal adenomatous polyps, as well as desmoid tumors. We present the case of a 54-year-old woman with germline APC gene mutation, who underwent a total colectomy, subsequently developing two large infiltrative solid intra-abdominal lesions consistent with desmoid tumors. Medical treatment with Cox-2 inhibitors was initiated without result. She was submitted to resection for intestinal obstruction, but developed local recurrence. The lesions were also unresponsive to tamoxifen, and chemotherapy was initiated with dacarbazine plus doxorubicin, switching to vinorelbine plus methotrexate, achieving a good response in all lesions after 12 months. The approach to these intra-abdominal lesions should be progressive, beginning with observation, then a medical approach with non-steroidal anti-inflammatory drugs or with an anti-hormonal agent. Afterwards, if progression is still evident, chemotherapy should be started. Surgery should be reserved for resistance to medical treatment, in palliative situations, or for extra-abdominal or abdominal wall desmoids tumors

Prevalência e distribuição geográfica do Toxoplasma gondii em cães na área urbana de Botucatu, SP, Brasil

Toxoplasmose é uma zoonose de distribuição mundial causada pelo Toxoplasma gondii, que pode infectar uma grande variedade de animais, inclusive seres humanos. Animais domésticos podem ser sentinelas importantes para infecções na comunidade. Ocorrência de infecção pelo T. gondii foi avaliada em cães na área urbana de Botucatu (SP, Brasil). Para amostragem, considerou-se uma taxa de erro na estimativa de 10%, um intervalo de confiança de 95% e um nível de significância de 5%. As amostras de sangue dos cães foram coletadas durante uma campanha de vacinação antirrábica e processadas usando-se o teste de aglutinação modificado (MAT). Foram coletadas 670 amostras de sangue, com distribuição homogênea em cinco regiões da área urbana, representando 3.74% dos 17.910 cães vacinados. Dessa amostra, 17,3% (116/670) dos cães, sendo 58,6% (68/116) fêmeas e 41,4% (48/116) machos, foram positivos para infecção pelo T. gondii (p<0,03). Entre os cães infectados 4,6%; (4/88) deles tinham idade menor e 95,4% (84/88) maior que um ano (p<0,01); em 28 animais positivos a idade não era conhecida Os títulos séricos de anticorpos anti-T. gondii estavam distribuídos entre 16 (69,8%; 81/116), 64 (13,8%; 16/116), 256 (15,5%; 18/116) e 1024 (0,9%; 1/116). Os animais positivos estavam distribuídos nas regiões Norte 14,2% (19/134), Sul 18,0% (31/172), Leste 15,7% (19/121), Oeste 21,6% (27/125) e Centro 16,9% (20/118) do município (p=0,5). Em todas essas regiões, fêmeas e animais com mais de um ano de idade tiveram maior taxa de positividade para a infecção (p<0.05).Toxoplasmosis is a worldwide zoonosis caused by Toxoplasma gondii, and can infect a wide variety of animals including humans. Domestic animals can be an important sentinel population for infection in the community. Occurrence of T. gondii infection was assessed in dogs in the urban area of Botucatu city, SP, Brazil. In the sample, 10% rate for error estimate, 95% confidence interval, and 5% significance level were established. Serum samples were collected from dogs during a rabies vaccination campaign, and were processed using modified agglutination test (MAT). Blood samples were collected from 670 dogs, with homogeneous distribution in five regions in the urban area, representing 3.74% of 17,910 animals vaccinated. In this sample, 17.3% (116/670) dogs (68 – 58.6% female and 48 – 41.4% male) were positive for T. gondii infection (p<0.03). Regarding age of the infected dogs 4.6% (4/88) were younger and 95.4% (84/88) were older than one year (p<0.01); the age of 28 positive animals were undetermined. The serum titers of anti-T. gondii antibodies were: 16 (69.8%; 81/116), 64 (13.8%; 16/116), 256 (15.5%; 18/116), and 1024 (0.9%; 1/116). Prevalence was distributed among the North 14.2% (19/134), South 18.0% (31/172), East 15.7% (19/121), West 21.6% (27/125), and Central 16.9% (20/118) regions of the municipality (p=0.5). In all these regions, females and dogs aged more than one year showed a higher occurrence of T. gondii infection (p<0.05)

Mechanistic insights into the electrochemical reduction of CO2 to CO on Ni(salphen) complexes

LA/P/0056/2020. The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project No 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). FCT is acknowledged for PTDCQUI-QIN0252_2021 (PNM). The CARISMA COST action CM1205 is acknowledged. MJC thanks N. A. G. Bandeira for technical assistance. The CATSUS doctoral programme is also acknowledged. Publisher Copyright: © 2023 The Royal Society of Chemistry.Cyclic voltammetry and bulk electrolysis showed that [Ni(ii)(salphen)] [1], [Ni(ii)(tBu-salphen)] [2], and a binuclear Ni(ii) compound combining salphen and tBu-salphen [3] react with CO2 to yield a metal-carbonyl species that is stable under an oxygen free atmosphere. Upon exposure to air, a stoichiometric amount of CO is released (detected by gas chromatography) and protonation regenerates the initial complex. To shed light on the mechanism of CO2 reduction and O2-dependent CO release by [1], UV-vis, EPR and SEC-IR spectroscopy studies complemented with DFT calculations were performed. It is proposed that the mono reduced [Ni(i)(salphen)]−, 2[1]−, formed a CO2 complex, 2[1(CO2)]−, which was then further reduced to 3[1(CO2)]2−. After addition of two protons, the coordinated CO2 was reduced to CO and released, regenerating 1[1]. Alternatively, 2[1(CO2)]− is protonated and then reduced to the same intermediate as before, continuing the same way. In the second cycle, the CO released competed with CO2 and coordinated to 2[1]− much more strongly, thereby deactivating the system. The new 2[1(CO)]− was reduced to 3[1(CO)]2− which was identified by comparison of experimental spectroscopic (UV-vis, EPR, SEC-IR) data with DFT calculated parameters.publishersversionpublishe

Inspeção a sistemas de climatização e conceção de um sistema de gestão da manutenção aplicado em edifícios universitários

Os requisitos legais impostos ao processo de manutenção das instalações de AVAC em edifícios evoluíram nos últimos 10 anos no sentido de uma crescente exigência, obrigando à existência de planos de manutenção preventiva, livros de ocorrências, inspeções obrigatórias a equipamentos, auditorias ou certi cações energéticas. Para os responsáveis da gestão da manutenção de edifícios, em particular para os que gerem uma quantidade signi cativa de equipamentos e instalações, fazê-lo sem o auxílio de uma ferramenta informática é um desa o considerável. Este trabalho visou a arquitetura de um sistema de gestão da manutenção de edifícios que foi aplicado a um caso real, nomeadamente o campus de Azurém da Universidade do Minho. Foi desenvolvida uma metodologia de inspeção, recolha e tratamento da informação para os sistemas técnicos de AVAC existentes nos edifícios. Esta metodologia foi implementada numa aplicação informática que permite aos técnicos responsáveis pela manutenção uma agilização de tarefas, resultado de um vasto conjunto de informações e de ferramentas desenvolvidas propositadamente, facilmente acessíveis através da rede Wi-Fi universitária. A integração das tarefas de manutenção na aplicação informática permitirá aumentar o grau de e ciência e e cácia nas atividades inerentes à manutenção, aumentando o grau de satisfação dos técnicos envolvidos no processo e dos utentes dos edifícios. O registo das tarefas de manutenção realizadas e dos respetivos custos em bases de dados, tornará também possível a geração de relatórios que sustentarão decisões mais assertivas. A implementação na aplicação informática dos seis módulos estruturais do Sistema de Gestão da Manutenção e Consumos Energéticos, SGMCE, permitirá atingir um nível de gestão da manutenção mais elevado, criando condições para o efetuar o comissionamento. O comissionamento prolonga-se por toda a vida do edifício, permitindo atingir os objetivos designados pelo seu promotor, dentro de patamares de custos de exploração energéticos e de custos optimizados de manutenção.Regulatory requirements of the maintenance process of HVAC facilities in buildings developed over the last 10 years towards a greater demand, requiring the existence of preventive maintenance plans, occurrence registration books, equipments mandatory inspections, energy audits and energy certi cates. For the building maintenance management technicians, in particular for those who manage a signi cant amount of equipments and facilities, to do so, without the aid of a software tool, it is a considerable challenge. This work aimed at the architecture of a management system for building maintenance that was applied to a real case, namely Azurém campus of the University of Minho. An inspection methodology, collection and data processing for the existing HVAC technical systems in buildings was developed. This methodology was implemented on a computer application that enables maintenance technicians to speed up maintenance tasks, due to a wide range of information and fully purpose developed tools that are easily accessible via the university Wi-Fi network. The integration of maintenance tasks on the informatics application will enhance the ef ciency and e ectiveness in the maintenance activities, increasing the level of satisfaction of the technicians involved in this process and users of buildings. The recording of maintenance tasks and related costs in databases will enable to generate reports that will sustain more assertive decisions of maintenance managers. The informatics application of the six structural modules of the maintenance management system and energy consumption, SGMCE, will achieve an even higher level in maintenance management, creating conditions to carry out the commissioning of buildings. Commissioning extends throughout the life of the building and allows to achieve the goals designed by the owner's, within controlled thresholds of energy operating costs and optimized maintenance costs

Academic performance and perceptions of undergraduate medical students in case-based learning compared to other teaching strategies: a systematic review with meta-analysis

Case-based learning (CBL) is a teaching method centered on active student learning that can overcome the limitations of traditional teaching methods used in undergraduate medical education. The aim of this systematic review was to compare the effectiveness of CBL against other teaching methodologies in terms of academic performance and perceptions (intra-individual, interpeer and student–faculty) of undergraduate medical students. Literature searches were performed using PubMed, EMBASE and Web of Science databases up to 28 April 2021. We included studies that quantitatively compared the academic performance and perception outcomes of CBL against other teaching methodologies in undergraduate medical students. The risk of bias was judged using the RoBANS tool and certainty of evidence using the GRADE framework. Meta-analyses were conducted using a random-effects model and reported as standardized mean differences (SMD) with 95% confidence intervals (CI). Of a total of 4470 records, 41 studies comprising 7667 undergraduate medical students fulfilled the eligibility criteria and were included in our systematic review. The CBL group was superior to the other teaching method groups in terms of academic performance measured by exam scores (SMD = 2.37, 95% CI 1.25–3.49, large effect, very low certainty) and interest and motivation (SMD = 0.79, 95% CI 0.13–1.44, moderate effect, very low certainty). Other academic performance or perception outcomes were not statistically different between CBL and other teaching methods when considering the pooled effect. Still, they were often superior in the CBL group for specific subgroups. CBL showed superior academic performance (especially compared to didactic lectures and tutorial-based teaching) and interest and motivation compared to other teaching methods used with undergraduate medical students. However, the certainty of evidence was very low and further studies are warranted before a stronger and more definitive conclusion can be drawn

REACTION OF NATIVE FRUIT TREES FROM BRAZILIAN AMAZON TO Meloidogyne enterolobii

This research was conducted in a greenhouse from Department of Fitossanity at São Paulo State University, Jaboticabal, SP, to evaluate the reaction of four Amazon’s native fruits tree species [“Abiu” (Pouteria caimito), “Araça Pera” (Psidium acutangulum), “Camu-camu” (Myrciaria dubia) and “Bacuri” (Platonia insignis)] and one from Central America, Sapodilla (Achras zapota) to the root-knot nematode Meloidogyne enterolobii Yang & Eisenback, 1983 (Meloidogynidae: Heteroderidae). Seedlings of each fruit trees averaging 12 months of age were planted in ceramic pots containing autoclaved soil and sand. They were inoculated, with addition of 10 cm3 of 400 eggs and J2 in suspension per cm3 to the root system, with a total initial population (IP) of 4000 eggs and J2 of M. enterolobii. The nematode population was obtained from roots of guava tree (Psidium guajava) in the city of Vista Alegre do Alto, SP. The assessment was carried out after 150 days at inoculation with the recovery and counting of the final nematode population (FP) in the root system of the fruit trees. The reaction of the fruit species was given by the factor of nematode reproduction (RF) according to the equation FP / IP, where RF > 1 was considered susceptible and RF < 1, resistant. The “Araça Pera” was susceptible to M. enterolobii and the others fruits plant were not favorable host to M. enterolobii. This study reports the first infection in P. acutangulum by M. enterolobii in greenhouse conditions