Morphological changes, beach inundation and overwash caused by an extreme storm on a low-lying embayed beach bounded by a dune system (NW Mediterranean)

The geomorphological evolution of a low-lying, micro-tidal sandy beach in the western Mediterranean, Pals beach, was characterized using airborne Light Detection and Ranging (LiDAR) data. Data were collected in prior to and six months after the impact of an extreme storm with a return period of approx. 50 years, with the aim of characterizing the beach's response to the storm. The use of repeated high-resolution topographic data to quantify beach geomorphic changes has allowed assessment of the accuracy of different proxies for estimating beach volume changes. Results revealed that changes in the shoreline position cannot accurately reproduce beach volume changes on low-lying beaches where overwash processes are significant. Observations also suggested that volume estimations from beach profiles do not accurately represent subaerial volume changes at large profile distances on beaches with significant alongshore geomorphological variability. Accordingly, the segmentation of the beach into regularly spaced bins is proposed to assess alongshore variations in the beach volume with the accuracy of the topographic data. The morphological evolution of Pals beach during the study period showed a net shoreline retreat (- 4 m) and a significant sediment gain on the subaerial beach (+ 7.5 m3/m). The net gain of sediment is mostly due to the impact of the extreme storm, driving significant overwash processes that transport sediment landwards, increasing volume on the backshore and dunes. The increase of volume on the foreshore and the presence of cuspate morphologies along the shoreline also evidence post-storm beach recovery. Observed morphological changes exhibit a high variability along the beach related to variations in beach morphology. Changes in the morphology and migration of megacusps result in a high variability in the shoreline position and foreshore volume changes. On the other hand, larger morphological changes on the backshore and larger inundation distances occur when the beach and the dunes are lower, favouring the dominance of overwash. The observed storm-induced morphological changes differ from predicted beach storm impacts because of spatial and temporal variations in the beach morphology, suggesting that detailed morphological parameters and indicators used for predicting beach vulnerability to storms should be regularly updated in order to represent the pre-storm beach conditions. Finally, observed morphological changes in Pals Bay evidenced a different behaviour between natural and urban areas, with better post-storm beach recovery on natural areas where the beach is not artificially narrowed.Peer ReviewedPostprint (author's final draft

Development of procedures to assess problem-solving competence in computing engineering

In the context of higher education, a competence may be understood as the combination of skills, knowledge, attitudes, values, and abilities that underpin effective and/or superior performance in a professional area. The aim of the work reported here was to design a set of procedures to assess a transferable competence, i.e., problem solving, that is basic for learning, in both academic and professional life, and crucial for engineering. The study involved a total of 71 students enrolled at three universities at two different stages of their studies. The development phases of the assessment device included an analysis of the competence and its facets, the design of the assessment task, the development of criteria to rate student performance, and the analysis of the basic psychometric properties for assessment methods in the area of education. The conclusion was drawn that the training process and the elaboration of scoring criteria are costly but necessary if objectivity in the interpretation of results is to be guaranteed. The main achievement of this project was the development of a procedure that measures learning outcomes and, more specifically, problem solvin

Expert consensus of the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the determination of biomarkers in pancreatic and biliary tract cancer

Biliary tract cancer; Predictive value; Targeted therapiesCáncer de vías biliares; Valor predictivo; Terapias dirigidasCàncer de vies biliars; Valor predictiu; Teràpies dirigidesPancreatic cancer and biliary tract cancer have a poor prognosis. In recent years, the development of new diagnostic techniques has enabled the identification of the main genetic alterations involved in the development of these tumours. Multiple studies have assessed the ability of certain biomarkers, such as BRCA in pancreatic cancer, IDH1 or FGFR2 in biliary tract cancer and microsatellite instability or NTRK fusions in an agnostic tumour fashion, to predict response to treatment. In this consensus, a group of experts selected by the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) reviewed the role played by these mutations in the process of carcinogenesis and their clinical implications. As a result, this article proposes a series of recommendations to optimize the determination of these biomarkers to help standardize the diagnosis and treatment of these tumours.SEOM and SEAP acknowledge the financial support for this project in the form of unrestricted collaboration in the logistics from AstraZeneca

A strategic reflection for the management and implementation of CAR-T therapy in Spain: an expert consensus paper

CAR-T cell therapy represents a therapeutic revolution in the prognosis and treatment of patients with certain types of hematological cancer. However, they also pose new challenges in the healthcare, regulatory and financial fields. The aim of the RET-A project was to undertake a strategic reflection on the management of CAR-T therapies within the Spanish National Health System, to agree on recommendations that will help to better deal with the new context introduced by these cell therapies in the present and in the future. This think tank involved 40 key agents and opinion leaders. The experts identified three great challenges for implementing advanced therapies in Spain: therapeutic individualisation, with a multidisciplinary approach; acceleration of access times, by minimizing bureaucracy; and increase in the number of centers qualified to manage the CAR-T therapies in the NHS. The experts agreed on the ideal criteria for designating those qualified centers. They also agreed on a comprehensive CAR-T care pathway with the timings and roles which would ideally be involved in each part of the process.This study was funded by Gilead Sciences, Inc.Peer reviewe

ANÁLISIS DE LAS TASAS DE INTERÉS DE PRÉSTAMOS EN COLOMBIA - Analysis of loan interest rates in Colombia

El propósito de este trabajo es realizar una caracterización de las actividades de crédito, realizando énfasis en las tasas de interés ofrecidas por los agentes que proporcionan estos recursos como lo son los intermediarios financieros, los fondos de empleados e inclusive los créditos informales en Colombia. La metodología utilizada es cualitativa, especialmente métodos descriptivos y documentales, a partir del análisis realizado se identifica que los agentes de créditos con mayor cobertura son los bancos a pesar de que la tasa de interés es más alta

El Diseño: 7 visiones transversales

El diseño ha evolucionado de manera sorprendente en las últimos años gracias a la tecnología, potenciando diferentes disciplinas y especializaciones en las que influyen aspectos técnicos y de percepción de la imagen. El trabajo de los diseñadores demanda por tanto unos conocimientos de dominio de códigos y contexto. Este volumen centra sus capítulos en siete áreas convergentes tratadas con voluntad didáctica: la gestión del diseño, el diseño de productos, el diseño para la imprenta, la estética en el diseño, el diseño para la web, el diseño publicitario y finalmente la identidad visual corporativa. El diseño, 7 visiones transversales, se dirige a estudiantes y personas que se inician en el mundo del diseño, por lo que se trata de una publicación básica y fundamental que toca no solo aspectos teóricos del diseño, si no también aspectos prácticos de una temática que se aplica día a día a nuevos campos y nuevas tecnologías

Problemas encontrados en el proceso de traducción del Manual de procedimientos logísticos ACTED Monde problemas lingüísticos en la traducción

El manual de procedimientos logísticos ACTED es un documento especializado que cuenta con 115 páginas. En este documento se pueden apreciar diferentes temas relacionados al campo de la logística. Para la traducción de este manual se realizaron arduas investigaciones que permitieron adquirir nuevos conocimientos sobre palabras y términos utilizados en logística. La traducción de este manual de procedimientos logísticos es importante, ya que será de gran ayuda a personas que estén realizando algún tipo de trabajo relacionado a la logística e incluso a estudiantes que puedan apoyarse en este manual que por primera vez se ha traducido. Por otra parte, esta traducción proporcionará información de gran utilidad a diferentes ONG’S (Organizaciones no gubernamentales) que intervienen en Nicaragua. Gracias a los estudiantes de quinto año de la carrera de Traducción e Interpretación Francesa se realizó la traducción de este manual, a través de este ejercicio se adquirió experiencias a nivel profesional y personal. Además, se desarrollaron las relaciones interpersonales en el colectivo de traducción, se aprendió a trabajar en equipo, a tomar decisiones en conjunto, así como respetar las opiniones de cada uno. Un factor importante de esta tarea fue la constante comunicación que permitió la resolución de problemas y la culminación de esta traducción

Susceptibility of Human Lymphoid Tissue Cultured ex vivo to Xenotropic Murine Leukemia Virus-Related Virus (XMRV) Infection

Xenotropic murine leukemia virus-related virus (XMRV) was generated after a recombination event between two endogenous murine leukemia viruses during the production of a prostate cancer cell line. Although the associations of the XMRV infection with human diseases appear unlikely, the XMRV is a retrovirus of undefined pathogenic potential, able to replicate in human cells in vitro. Since recent studies using animal models for infection have yielded conflicting results, we set out an ex vivo model for XMRV infection of human tonsillar tissue to determine whether XMRV produced by 22Rv1 cells is able to replicate in human lymphoid organs. Tonsil blocks were infected and infection kinetics and its pathogenic effects were monitored XMRV, though restricted by APOBEC, enters and integrates into the tissue cells. The infection did not result in changes of T or B-cells, immune activation, nor inflammatory chemokines. Infectious viruses could be recovered from supernatants of infected tonsils by reinfecting DERSE XMRV indicator cell line, although these supernatants could not establish a new infection in fresh tonsil culture, indicating that in our model, the viral replication is controlled by innate antiviral restriction factors. Overall, the replication-competent retrovirus XMRV, present in a high number of laboratories, is able to infect human lymphoid tissue and produce infectious viruses, even though they were unable to establish a new infection in fresh tonsillar tissue. Hereby, laboratories working with cell lines producing XMRV should have knowledge and understanding of the potential biological biohazardous risks of this virus

Enzyme replacement therapy for the treatment of Hunter disease: A systematic review with narrative synthesis and meta-analysis

Background: In the last 10 years enzyme replacement therapy (ERT) has become an alternative for the treatment of patients with Hunter disease (HD). Nevertheless, the information regarding efficacy and safety is scarce and mainly based on the pivotal trials. This scarcity is especially evident for adults and severe forms of HD. Methods: A systematic review of publications in the electronic databases PUBMED, EMBASE and Cochrane Central was undertaken. Clinical trials and observational studies were included. The data about efficacy and security were retrieved and analysed with Review Manager version 5.3. Results: 677 records were found, 559 remaining after the removal of duplicates. By title and abstract review, 427 were excluded. Full reading of the rest was made (122 publications) and 42 were finally included. It was not possible to perform meta-analysis of all the endpoints due to high heterogeneity in the reporting and measuring of variables in each publication. Eight clinical trials were included, 6 with high risk of bias. The quality of the other studies was low in 12%, average in 68% and good in 21%. Main findings were: a reduction in the elimination of glycosaminoglycans (GAG) in urine in all the studies (26/26), decrease in liver and spleen size (18/18), increase of 52.59 m (95% CI, 36, 42-68.76, p < .001) in the 6-min walk test (TM6M), increase in forced vital capacity (FVC) of 9.59% (95% CI 4.77-14.51, p < .001), reduction of the left ventricular mass index of 3.57% (95% CI 1.2-5.93) and reduction in mortality (OR) of 0.44 (0.27-0.71). Discussion: The data suggests a clear and consistent effect of ERT in HD reducing the accumulation of GAGs in the body, demonstrated by the reduction of its urinary excretion, as well as by the reduction of its deposits (spleen, liver and heart). Likewise, there is an improvement in physical and respiratory function. In addition, a reduction in mortality has been observed. Lack of studies, small size of the samples, and methodological deficiencies are the main limitations to establish definite conclusions. Conclusions: The data suggests that ERT is effective and safe in the treatment of HD. There is a need to evaluate patient-centred outcomes and the impact on quality of life

Activity of imipenem/relebactam against Enterobacterales and Pseudomonas aeruginosa in Spain. SMART 2016-2020

Objectives. To determine susceptibility to the novel β-lactam/β-lactamase inhibitor combination imipenem/relebactam in clinical isolates recovered from intra-abdominal (IAI), urinary (UTI), respiratory (RTI) and bloodstream (BSI) infections in the SMART (Study for Monitoring Antimicrobial Resistance Trends) study in SPAIN during 2016 – 2020. Methods. Broth microdilution MICs for imipenem/relebactam and comparators were determined by a central laboratory against isolates of Enterobacterales and Pseudomonas aeruginosa. MICs were interpreted using EUCAST-2021 breakpoints. Results. In total, 5,210 Enterobacterales and 1,418 P. aeruginosa clinical isolates were analyzed. Imipenem/relebactam inhibited 98.8% of Enterobacterales. Distinguishing by source of infection susceptibility was 99.1% in BSI, 99.2% in IAI, 97.9% in RTI, and 99.2% in UTI. Of intensive care unit isolates (ICU) 97.4% were susceptible and of non-ICU isolates 99.2% were susceptible. In Enterobacterales, activity against Class A, Class B and Class D carbapenemases was 96.2%, 15.4% and 73.2%, respectively. In P. aeruginosa, imipenem/relebactam was active in 92.2% of isolates. By source of infection it was 94.8% in BSI, 92.9% in IAI, 91.7% in RTI, and 93.1% in UTI. An 88.7% of ICU isolates and 93.6% of non-ICU isolates were susceptible to imipenem/relebactam. Imipenem/relebactam remained active against P. aeruginosa ceftazidime-resistant (76.3%), cefepime-resistant (73.6%), imipenem-resistant (71.5%) and piperacillin-resistant (78.7%) isolates. Of all multidrug-resistant or difficult-to-treat resistance P. aeruginosa isolates, 75.1% and 46.2%, respectively, were susceptible to imipenem/relebactam. Conclusions. Imipenem/relebactam showed high rates of susceptibility in Enterobacterales and P. aeruginosa isolates from different sources of infection as well as depending on patients’ location (ICU or non-ICU scenarios)