Trapping Dynamics with Gated Traps: Stochastic Resonance-Like Phenomenon

We present a simple one-dimensional trapping model prompted by the problem of ion current across biological membranes. The trap is modeled mimicking the ionic channel membrane behaviour. Such voltage-sensitive channels are open or closed depending on the value taken by a potential. Here we have assumed that the external potential has two contributions: a determinist periodic and a stochastic one. Our model shows a resonant-like maximum when we plot the amplitude of the oscillations in the absorption current vs. noise intensity. The model was solved both numerically and using an analytic approximation and was found to be in good accord with numerical simulations.Comment: RevTex, 5 pgs, 3 figure

Effect of Non Gaussian Noises on the Stochastic Resonance-Like Phenomenon in Gated Traps

We exploit a simple one-dimensional trapping model introduced before, prompted by the problem of ion current across a biological membrane. The voltage-sensitive channels are open or closed depending on the value taken by an external potential that has two contributions: a deterministic periodic and a stochastic one. Here we assume that the noise source is colored and non Gaussian, with a $q$-dependent probability distribution (where $q$ is a parameter indicating the departure from Gaussianity). We analyze the behavior of the oscillation amplitude as a function of both $q$ and the noise correlation time. The main result is that in addition to the resonant-like maximum as a function of the noise intensity, there is a new resonant maximum as a function of the parameter $q$.Comment: Communication to LAWNP01, Proceedings to be published in Physica D, RevTex, 8 pgs, 5 figure

Síndrome de Mazabraud: reporte de un caso

El síndrome de Mazabraud es una rara asociación de lesiones del sistema musculoesquelético. Resulta de la combinación de uno o varios mixomas intramusculares y displasia fibrosa. Presentamos a un hombre de 46 años con lesiones óseas compatibles con displasia fibrosa asociada a mixoma intramuscular configurando un síndrome de Mazabraud y una revisión de la bibliografía

Phase diagram for non-axisymmetric plasma balls

Plasma balls and rings emerge as fluid holographic duals of black holes and black rings in the hydrodynamic/gravity correspondence for the Scherk-Schwarz AdS system. Recently, plasma balls spinning above a critical rotation were found to be unstable against m-lobed perturbations. In the phase diagram of stationary solutions the threshold of the instability signals a bifurcation to a new phase of non-axisymmetric configurations. We find explicitly this family of solutions and represent them in the phase diagram. We discuss the implications of our results for the gravitational system. Rotating non-axisymmetric black holes necessarily radiate gravitational waves. We thus emphasize that it would be important, albeit possibly out of present reach, to have a better understanding of the hydrodynamic description of gravitational waves and of the gravitational interaction between two bodies. We also argue that it might well be that a non-axisymmetric m-lobed instability is also present in Myers-Perry black holes for rotations below the recently found ultraspinning instability.Comment: 1+22 pages, 3 figures. v2: minor corrections and improvements, matches published versio

Ensembles of jittered association rule classifiers

The ensembling of classifiers tends to improve predictive accuracy. To obtain an ensemble with N classifiers, one typically needs to run N learning processes. In this paper we introduce and explore Model Jittering Ensembling, where one single model is perturbed in order to obtain variants that can be used as an ensemble. We use as base classifiers sets of classification association rules. The two methods of jittering ensembling we propose are Iterative Reordering Ensembling (IRE) and Post Bagging (PB). Both methods start by learning one rule set over a single run, and then produce multiple rule sets without relearning. Empirical results on 36 data sets are positive and show that both strategies tend to reduce error with respect to the single model association rule classifier. A bias–variance analysis reveals that while both IRE and PB are able to reduce the variance component of the error, IRE is particularly effective in reducing the bias component. We show that Model Jittering Ensembling can represent a very good speed-up w.r.t. multiple model learning ensembling. We also compare Model Jittering with various state of the art classifiers in terms of predictive accuracy and computational efficiency.This work was partially supported by FCT project Rank! (PTDC/EIA/81178/2006) and by AdI project Palco3.0 financed by QREN and Fundo Europeu de Desenvolvimento Regional (FEDER), and also supported by Fundacao Ciencia e Tecnologia, FEDER e Programa de Financiamento Plurianual de Unidades de I & D. Thanks are due to William Cohen for kindly providing the executable code for the SLIPPER implementation. Our gratitude goes also to our anonymous reviewers who have helped to significantly improve this paper by sharing their knowledge and their informed criticism with the authors

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence. Here, we show that Agd3 deacetylates GAG in a metal-dependent manner, and is the founding member of carbohydrate esterase family CE18. The active site is formed by four catalytic motifs that are essential for activity. The structure of Agd3 includes an elongated substrate-binding cleft formed by a carbohydrate binding module (CBM) that is the founding member of CBM family 87. Agd3 homologues are encoded in previously unidentified putative bacterial exopolysaccharide biosynthetic operons and in other fungal genomes. The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.Bio-organic Synthesi

Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population

Haptoglobin's (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations. We previously demonstrated that preeclampsia risk was doubled in white Hp 2-1 women, compared to Hp 1-1 women. Our objectives were to determine whether we could reproduce this finding in a larger cohort, and to determine whether Hp phenotype influences lack of efficacy of antioxidant vitamins in preventing preeclampsia and serious complications of pregnancy-associated hypertension (PAH). This is a secondary analysis of a randomized controlled trial in which 10,154 low-risk women received daily vitamin C and E, or placebo, from 9-16 weeks gestation until delivery. Hp phenotype was determined in the study prediction cohort (n = 2,393) and a case-control cohort (703 cases, 1,406 controls). The primary outcome was severe PAH, or mild or severe PAH with elevated liver enzymes, elevated serum creatinine, thrombocytopenia, eclampsia, fetal growth restriction, medically indicated preterm birth or perinatal death. Preeclampsia was a secondary outcome. Odds ratios were estimated by logistic regression. Sampling weights were used to reduce bias from an overrepresentation of women with preeclampsia or the primary outcome. There was no relationship between Hp phenotype and the primary outcome or preeclampsia in Hispanic, white/other or black women. Vitamin supplementation did not reduce the risk of the primary outcome or preeclampsia in women of any phenotype. Supplementation increased preeclampsia risk (odds ratio 3.30; 95% confidence interval 1.61-6.82, p<0.01) in Hispanic Hp 2-2 women. Hp phenotype does not influence preeclampsia risk, or identify a subset of women who may benefit from vitamin C and E supplementation to prevent preeclampsia

Diversity of culturable nocardioform actinomycetes from wastewater treatment plants in Spain and their role in the biodegradability of aromatic compounds

[EN] Currently, municipal and industrial wastewater treatment plants (WWTPs) are mainly focusing on reduction of biological oxygen demand and on the removal of nutrients. However, there are microorganisms that interfere with the process. In this environment, there is a large diversity of microorganisms that have not been studied in detail and that could provide real and practical solutions to the foaming problems. Among such microorganisms, Gram-positive actinomycete bacteria are of special interest because they are known for producing secondary metabolites as well as chemically diverse compounds and for their capacity to degrade recalcitrant pollutants. Three different media were chosen to isolate actinomycetes from 28 WWTPs in Spain. A total of 189 activated sludge samples were collected; 126 strains were isolated and identified to belong to 1 suborder, i.e. Corynebacterineae, and 7 genera, i.e. Corynebacterium, Dietzia, Gordonia, Mycobacterium, Rhodococcus, Tsukamurella and Williamsia. Furthermore, 71 strains were capable of biodegrading at least 1 aromatic product, and that 27 of them amplified for catA gene. The results of this research help us understand the complexity of the foam-forming microbial populations in Spain and it shows that WWTPs can be a good source of microorganisms that can degrade phenol or naphthalene.This work was supported by grants from Entidad Publica de Saneamiento de Aguas Residuales (EPSAR) de la Comunitat Valenciana.Soler Hernández, A.; García Hernández, J.; Zornoza-Zornoza, AM.; Alonso Molina, JL. (2017). Diversity of culturable nocardioform actinomycetes from wastewater treatment plants in Spain and their role in the biodegradability of aromatic compounds. Environmental Technology. 39(2):172-181. https://doi.org/10.1080/09593330.2017.1296897S17218139

State estimation of a dehydration process by interval analysis

This article presents a general methodology of state estimation by interval analysis in a dynamic system modeled by difference equations. The methodology is applied to a pineapple osmotic dehydration process, in order to predict the behavior of the process within a range of allowed perturbation. The paper presents simulations and validations

Historical Legacies in World Amphibian Diversity Revealed by the Turnover and Nestedness Components of Beta Diversity

Historic processes are expected to influence present diversity patterns in combination with contemporary environmental factors. We hypothesise that the joint use of beta diversity partitioning methods and a threshold-based approach may help reveal the effect of large-scale historic processes on present biodiversity. We partitioned intra-regional beta diversity into its turnover (differences in composition caused by species replacements) and nestedness-resultant (differences in species composition caused by species losses) components. We used piecewise regressions to show that, for amphibian beta diversity, two different world regions can be distinguished. Below parallel 37, beta diversity is dominated by turnover, while above parallel 37, beta diversity is dominated by nestedness. Notably, these regions are revealed when the piecewise regression method is applied to the relationship between latitude and the difference between the Last Glacial Maximum (LGM) and the present temperature but not when present energy-water factors are analysed. When this threshold effect of historic climatic change is partialled out, current energy-water variables become more relevant to the nestedness-resultant dissimilarity patterns, while mountainous areas are associated with higher spatial turnover. This result suggests that nested patterns are caused by species losses that are determined by physiological constraints, whereas turnover is associated with speciation and/or Pleistocene refugia. Thus, the new threshold-based view may help reveal the role of historic factors in shaping present amphibian beta diversity patterns