Self-declared benchmarks of equity mutual funds: an evaluation of suitability and value added

This paper analyses whether actively managed equity mutual funds have suitable primary self declared prospectus benchmarks and evaluates how much value funds add compared to their declared benchmarks from 2010 to 2021. Suitable self-declared benchmarks allow investors to adequately evaluate relative fund performance. Using panel data collected from the CRSP database and SEC filings, four independent time periods are analysed. The findings of this paper indicate that most funds choose suitable benchmarks and that funds mostly do not add value compared to their declared benchmarks. Moreover, a noteworthy observation is that the results of the analysis appear to be analysis period dependent

Bioeconomic fiction between narrative dynamics and a fixed imaginary: evidence from India and Germany

Bioeconomic ideas and visions have received increasing attention from scientists and policy makers to address socioecological challenges. However, the role of imagined futures in the design of bioeconomic innovations and transitions has hitherto been widely neglected. In this study, we therefore explore the role of imaginaries of the future to understand how they shape bioeconomic innovations and transitions. We thereby build on insights from economic sociology and compare two distinct case studies from Germany and India. Based on our results, we inductively develop an analytic model that describes the co-constitution of imaginaries, fictional expectations, narratives, and innovation dynamics. Our results show that narrative dynamics are caused by irritations in the political and discursive landscape; these irritations prompt economic actors to stabilize, adapt, or reject their own bioeconomic conceptions, while the underlying imaginary of a technological fix remains fixed. We discuss this reductionist imaginary and instead plead for an imaginary of a socioecological fix that reintertwines technologies with their underlying societal, cultural, and ecological factors. We conclude that this will support sustainability scholars and policy makers in remaining vigilant against premature mental and institutional lock-ins that could lead to a colonization of the future with severe negative implications for society's ability to mitigate and adapt to global environmental change in the future

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Infections with hepatitis C virus (HCV) represent a worldwide health burden and a prophylactic vaccine is still not available. Liver transplantation (LT) is often the only option for patients with HCV-induced end-stage liver disease. However, immediately after transplantation, the liver graft becomes infected by circulating virus, resulting in accelerated progression of liver disease. Although the effi cacy of HCV treatment using direct-acting antivirals has improved significantly, immune compromised LT-patients and patients with advanced liver disease remain difficult to treat. As an alternative approach, interfering with viral entry could prevent infection of the donor liver. We generated a human monoclonal antibody (mAb), designated 2A5, which targets the HCV envelope. The neutralizing activity of mAb 2A5 was assessed using multiple prototype and patient-derived HCV pseudoparticles (HCVpp), cell culture produced HCV (HCVcc), and a human-liver chimeric mouse model. Neutralization levels observed for mAb 2A5 were generally high and mostly superior to those obtained with AP33, a well-characterized HCV-neutralizing monoclonal antibody. Using humanized mice, complete protection was observed after genotype 1a and 4a HCV challenge, while only partial protection was achieved using gt1b and 6a isolates. Epitope mapping revealed that mAb 2A5 binding is conformation-dependent and identified the E2-region spanning amino acids 434 to 446 (epitope II) as the predominant contact domain. Conclusion : mAb 2A5 shows potent anti-HCV neutralizing activity both in vitro and in vivo and could hence represent a valuable candidate to prevent HCV recurrence in LT-patients. In addition, the detailed identification of the neutralizing epitope can be applied for the design of prophylactic HCV vaccines

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein

The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection by retroviral pseudoparticles incorporating a panel of full-length E1E2 clones representing the full spectrum of genotypes 1–6. We identified one antibody, CBH-5, that was capable of neutralizing every genotype tested. It also potently inhibited chimeric cell culture-infectious HCV, which had genotype 2b envelope proteins in a genotype 2a (JFH-1) background. Analysis using a panel of alanine-substitution mutants of HCV E2 revealed that the epitope of CBH-5 includes amino acid residues that are required for binding of E2 to CD81, a cellular receptor essential for virus entry. This suggests that CBH-5 inhibits HCV infection by competing directly with CD81 for a binding site on E2

The Grizzly, December 1, 2005

Memorial for Professor McLennan • Fate of The Egg • Jazz Legend Performs at Ursinus • Myrin Renovations • Murderball is Coming to Ursinus • Hot Discounts Warm up the Ski Season • Am I Pregnant? • What\u27s Hot and What\u27s Not This Gift-Giving Season • Wanted: Greek Presidents • Opinions: The Bigger Headache with PA Liquor Laws; How to Avoid Disastrous Holiday Parties; Addicted to Games, Are We? • Bears Ground Flying Dutchmen • Bears Fall Short of NCAA Titlehttps://digitalcommons.ursinus.edu/grizzlynews/1701/thumbnail.jp

The Grizzly, September 15, 2005

Gas Prices Continue to Rise • Campus and Local Community Begin Relief Efforts • Students Share Study Abroad Experiences • The Deal with the Meal Deal • One of Ursinus\u27 Own Performs Professionally • Watch Out, Employers: You Could be Next! • How Much is Too Much? Your Guide to Avoiding Portion Distortion • Excitement Building in Kaleidoscope • Beyond the Condom: Guide to Safe Sex • Opinions: New Price of Driving; Ursinus, U are Worth it • Irony of Work Study • Things They Didn\u27t Teach You at Freshman Orientation • Who Says Division III Players Can\u27t Go Pro?https://digitalcommons.ursinus.edu/grizzlynews/1692/thumbnail.jp

The Grizzly, December 8, 2005

Bomberger Gets a Face Lift • Ursinus Remembers Rosa Parks • Holiday Spotlight: Materialism vs. Family • Music to Celebrate By • It\u27s Spoken Word, Haven\u27t You Heard? • First Ever Ursinus College Bear Olympics Meets with Success • Holiday Fashion: What not to Wear • Misconceptions About Feminine Hygiene • Ursinus Professor Directs Performance at Prince Music Theater • Opinions: A Politically Correct Holiday Season; Flakes of Fury; Blog Addiction • Bears Beat at Buzzer • Guntli Leads Bears Past Bulletshttps://digitalcommons.ursinus.edu/grizzlynews/1702/thumbnail.jp

Challenges and Opportunities in Data Visualization Education: A Call to Action

This paper is a call to action for research and discussion on data visualization education. As visualization evolves and spreads through our professional and personal lives, we need to understand how to support and empower a broad and diverse community of learners in visualization. Data Visualization is a diverse and dynamic discipline that combines knowledge from different fields, is tailored to suit diverse audiences and contexts, and frequently incorporates tacit knowledge. This complex nature leads to a series of interrelated challenges for data visualization education. Driven by a lack of consolidated knowledge, overview, and orientation for visualization education, the 21 authors of this paper-educators and researchers in data visualization-identify and describe 19 challenges informed by our collective practical experience. We organize these challenges around seven themes People, Goals & Assessment, Environment, Motivation, Methods, Materials, and Change. Across these themes, we formulate 43 research questions to address these challenges. As part of our call to action, we then conclude with 5 cross-cutting opportunities and respective action items: embrace DIVERSITY+INCLUSION, build COMMUNITIES, conduct RESEARCH, act AGILE, and relish RESPONSIBILITY. We aim to inspire researchers, educators and learners to drive visualization education forward and discuss why, how, who and where we educate, as we learn to use visualization to address challenges across many scales and many domains in a rapidly changing world: viseducationchallenges.github.io.Comment: Accepted for publication at VIS 2023 Conference, Melbourne, VI

The Grizzly, November 3, 2005

Remembering Professor McLennan: A Passionate Teacher and a Beloved Friend • Renowned Writer Speaks at Ursinus • Building Plans for Spring 2006 and Beyond • Ovarian Cancer Walk • Chikara Wrasslin\u27 • EQ vs. IQ: Hirsh-Pasek on Education • The Many Faces of Muslim Women • Take Heed and Use Your Keys • Escape Velocity\u27s Just the Start is a Great Success • New Oktoberfest Policies Put into Effect • Popping the Pill • RHA Brings Halloween Fun to Ursinus • Opinions: The Right to Write Right; Raising Rates for Resident Assistants; Global Gag Rule and FGM; Harriet Miers: Aftermath; You Snooze, You Lose • Title Hopes Still Alive as Ursinus Upsets #16 Johns Hopkins • Bears Beat Blue Jays, Look to Defend Conference Crownhttps://digitalcommons.ursinus.edu/grizzlynews/1698/thumbnail.jp