328 research outputs found

    An Ohio State University, Nationwide Children's Hospital and the Institute of Pediatric Oncology (IOP)/Federal University of São Paolo (UniFeSP), Brazil, Collaborative Proposal in Neuro-oncology

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    IMPACT. 1: Our long-term goal is improvement in the care of children and adolescents with CNS cancer in Brazil in general, and São Paolo in particular, as manifested by improved cure and quality of survival outcome measures as well as measures of successful education -- 2. Perform a quantitative needs assessment of the pediatric neuro-oncology programs at GRAACC and at Nationwide Children's. Formalization of educational visits for residents and fellows from IOP/GRAACC/UNIFESP to OSU/NCH for 3 month periods for advanced training. -- 3. Enhancement of neuropathology infrastructure and expertise at IOP/GRAACC/UNIFESP through educational interactions and training between NCH, OSU and IOP/GRAACC/UNIFESP neuropathologists.OSU PARTNERS: The Chakravarti and Bell laboratory is an internationally-recognized brain tumor translational laboratory; Arnab Chakravarti leads the NRG Oncology Brain Tumor Clinical & Translational Committee and is the current Chair of the NIH Biomarker Study Section. Erica Hlavin Bell, PhD (OSU) currently collaborating with Pl on a childhood CNS cancer grant for molecular profiling of medulloblastoma in an international study in which IOP/GRAACC/UNIFESP will also participate.; OSU Radiation Oncologist, Joshua Palmer, MD; OSU neuropathologist, Jose Otero MD, PhD; OSU Undergraduate student, Allison FischerCOMMUNITY PARTNERS: Sergio Cavalheiro MD (IOP/GRAACC/ UNIFESP), internationally prominent pediatric CNS cancer surgeon.; Andrea Cappellano MD and Nasjla Saba Da Silva MD (IOP/GRAACC/ UNIFESP neuro-oncologists) in developing the 2015 PLANO conference, and they are working together in planning the 2017 PLANO conference.; Sergio Petrilli MD, the Founder and Director of the IPO/GRAAC Institution, will be the senior leader in Brazil for this project, and will lead educational training initiatives with Andreza Senerchia MD (pediatric oncologist IOP/ GRAACC/UNIFESP).PRIMARY CONTACT: Diana Osorio ([email protected]); Jonathan Finlay ([email protected])The management of children with CNS cancers demands close collaboration between pediatric oncologists specifically trained in CNS tumors (neuro-oncologists), pediatric neurosurgeons, radiation oncologists, pediatric neuro-pathologists and other specialists; without such intimate cooperation, misdiagnoses, delays in initiation of appropriate therapy, and the age-appropriate selection of therapies become sub-optimal, as is seen widely throughout South America

    Manipulation of polar order in the “empty” tetragonal tungsten bronzes: Ba4-xSrxDy0.671.33Nb10O30, x = 0, 0.25, 0.5, 1, 2, 3

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    JG would like to thank the EPSRC for provision of a studentship via the doctoral training grant (EP/K503162/1).A series of “empty” tetragonal tungsten bronze (TTB) ferroelectrics, Ba4-xSrxDy0.67□1.33 Nb 10O30 (x = 0, 0.25, 0.5, 1, 2, 3; □ = vacancy), is reported. With increasing x the unit cell contracts in both the ab plane and c-axis; x ≤ 1 compounds are normal ferroelectrics (FE) with decreasing TC as x increases, while x ≥ 2 are relaxor ferroelectrics (RFE) with associated frequency dependent permittivity peaks and with similar Tm and Tf (Vogel-Fulcher freezing temperatures) values. This observation is rationalised by differing cation occupancies: for x ≤ 1, Sr2+ principally occupies the A2-site (co-occupied by Ba2+ with the A1-site occupied by Dy3+ and vacancies); for x ≥ 2 significant Sr A1-site occupation leads to the observed RFE characteristics. This FE to RFE crossover is consistent with a previously proposed TTB crystal chemical framework where both a decrease in average A-site size and concurrent increase in A1-site tolerance factor (tA1) favour destabilization of long range polar order and relaxor behaviour. The effect of increasing tA1 as a result of Sr occupancy at the A1 site is dominant in the compounds reported here.PostprintPeer reviewe

    Structural and dielectric studies of the phase behaviour of the topological ferroelectric La1-xNdxTaO4

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    We thank the University of St Andrews and EPSRC (via DTG studentships to CALD and JG) for funding,The layered perovskite LaTaO4 has been prepared in its polar orthorhombic polymorphic form at ambient temperature. Although no structural phase transition is observed in the temperature interval 25° C < T < 500 °C, a very large axial thermal contraction effect is seen, which can be ascribed to an anomalous buckling of the perovskite octahedral layer. The non-polar monoclinic polymorph can be stabilised at ambient temperature by Nd-doping. A composition La0.90Nd0.10TaO4 shows a first-order monoclinic-orthorhombic (non-polar to polar) transition in the region 250° C < T < 350 °C. Dielectric responses are observed at both the above structural events but, despite the ‘topological ferroelectric’ nature of orthorhombic LaTaO4, we have not succeeded in obtaining ferroelectric P–E hysteresis behaviour. Structural relationships in the wider family of AnBnX3n+2 layered perovskites are discussed.Publisher PDFPeer reviewe

    Relaxor-to-ferroelectric crossover and disruption of polar order in "empty" tetragonal tungsten bronzes

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    JG would like to thank the EPSRC for provision of a studentship via the doctoral training grant (EP/K503162/1). The research data (and/or materials) supporting this publication can be accessed at [http://dx.doi.org/10.17630/a7a9bc13-b5cb-485d-914a-923832f25190]Combined temperature-dependent structural and electrical characterization of a series of “empty” ferroelectric tetragonal tungsten bronzes (TTBs) of composition Ba4(La1- xNdx)0.67□1.33Nb10O30 are reported. The La-material exhibits a temperature dependent crossover from relaxor-ferroelectric to polar (but non-ferroelectric) to linear dielectric behavior. The loss of ferroelectric switching in the polar, non-ferroelectric phase is accompanied by disorder associated with structural relaxation due the significant vacancy concentration at the A1-perovskite-like site. In this disordered regime, large polarization can be re-established with application of sufficient electric field, however relaxation back into the disordered phase occurs on removal of the field as indicated by the loss of remenant polarization. The field against which “backswitching” (depolarization) occurs increases with temperature indicating increasing stability of the disordered regime. The disordered phase can be de-stabilized by substituting Nd for La at the A1-site and which reintroduces “normal” ferroelectric behavior.PostprintPeer reviewe

    Assessing psychosocial distress in cystic fibrosis: validation of the ‘Distress in Cystic Fibrosis Scale’

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    Experiences of anxiety and depression are common in adults with Cystic Fibrosis (AwCF) (e.g. Quittner in Thorax 69:1090-1097, 2014) and may impact on a wide range of important health-related behaviours, such as adherence to medication and timely attendance for medical review when experiencing pulmonary exacerbation. Common screening measures used in CF such as the PHQ-9 and GAD-7 may reflect an absence of anxiety or depression when clinically significant emotional difficulties are apparent on further assessment. This study preliminarily validated the previously developed Distress in Cystic Fibrosis Scale (DCFS) (Patel in Journal of Cystic Fibrosis 15:S26, 2016); a 23-item questionnaire to assess psychosocial distress in AwCF. Inpatient and outpatient participants with CF (N = 119) completed a battery of questionnaires, including the DCFS. PCA results supported a single component model. The DCFS showed high internal consistency and correlated significantly with measures of mood and quality of life. The DCFS shows promise as a screening tool to assess clinically significant psychosocial distress in an adult CF population
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