Suspended Education in California

Analyzes data on risk of school suspension by race/ethnicity, gender, and disability status in nearly five hundred districts; highlights research showing suspensions to be ineffective and harmful; and calls for implementing evidence-based alternatives

How hot are the Cairngorms?

Heat flow measured over the East Grampians batholith in the 1980s was found to be unexpectedly low and at odds with high radiogenic heat production within the outcropping granites and a very large volume of granite predicted from an interpretation of gravity data. Past climate variations perturb temperature gradients in the shallow subsurface leading to erroneous estimates of heat flow. A reconstruction of the surface temperature history during the last glacial cycle has enabled a rigorous palaeoclimate correction to be applied to the heat flow that shows an increase of 25% over previously reported values; revised to 86 ± 7 mW m−2. An interpretation of recent mapping reveals that the surface exposures of the East Grampians granites are the roof zones of a highly evolved magma system. Rock composition, therefore, is likely to become more mafic with depth and the heat production will decrease with depth. This petrological model can be reconciled with the gravity data if the shape of the batholith is tabular with deep-seated feeder conduits. The increased heat flow value leads to revised predictions of subsurface temperatures of 129°C at 5 km depth and 176°C at 7 km depth, increases of 40% and 49%, respectively, compared to previous estimates. These temperatures are at the lower end of those currently required for power generation with Engineered Geothermal Systems, but could potentially be exploited as a direct heat use resource in the Cairngorm region by targeting permeable fractures with deep boreholes

Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH.

OBJECTIVES: The aim of this study was to gain an insight into the molecular mechanisms of the evolution of rifampicin resistance in response to controlled changes in the environment. METHODS: We determined the proportion of rpoB mutants in the chemostat culture and characterized the sequence of mutations found in the rifampicin resistance-determining region of rpoB in a steady-state chemostat at pH 7.0 and 6.2. RESULTS: The overall proportion of rpoB mutants of strain H37Rv remained constant for 37 days at pH 7.0, ranging between 3.6 x 10(-8) and 8.9 x 10(-8); however, the spectrum of mutations varied. The most commonly detected mutation, serine to leucine mutation at codon 531 (S531L), increased from 40% to 89%, while other mutations (S531W, H526Y, H526D, H526R, S522L and D516V) decreased over the 37 day sampling period. Changing the pH from 7.0 to 6.2 did not significantly alter the overall proportion of mutants, but resulted in a decrease in the percentage of strains harbouring S531L (from 89% to 50%) accompanied by an increase in the range of different mutations from 4 to 12. CONCLUSIONS: The data confirm that the fitness of strains with the S531L mutation is greater than that of strains containing other mutations. We also conclude that at low pH the environment is permissive for a wider spectrum of mutations, which may provide opportunities for a successful mutant to survive

Biomass gasification of hybrid seed Miscanthus in Glasgow's downdraft gasifier testbed system

Global energy problems, rise in CO2 emissions and their implications on climate change are well documented. Renewable energy provides a crucial role in reducing these emissions whilst providing sustainable energy; energy conversion of biomass forms a valuable part of a renewable energy portfolio, with capability for baseload provision, and gas and electricity production. Gasification is the thermochemical conversion of biomass (carbonaceous material) into producer gases. A small-scale throated downdraft gasifier was designed and manufactured at the University of Glasgow and built to easily assess the gasification performance under different conditions e.g. feedstock variety and with different instrumentation and control strategies. Various feedstock varieties of Miscanthus (OPM12, MxG, and OPM53) were gasified under the same equivalence ratio (ER 0.30). The elemental compositions of each Miscanthus varied with their genetic properties. A Gasifier Control Unit (G.C.U) was installed on the experimental gasifier to measure parameters: temperature, pressure, liquid flow and mass flow. The gasifier was operated in batch mode; to improve repeatability the throat, grate and assembly were cleaned after each experiment. The experimental work reported in this research is mainly focused on the comparative study and analysis of the producer gas compositions, carbon conversion efficiency, higher heating value (HHV), lower heating value (LHV), cold gas efficiency and gas yield with the different biomass feedstocks. The ultimate and proximate analysis was done for all Miscanthus varieties along with ash analysis. The major outcome of this research was to investigate the impact of feedstock variety on gasification performance and identify preferred Miscanthus varieties to grow at scale with optimised gasification

Determinants of fracture risk in a UK-population-based cohort of older women: a cross-sectional analysis of the Cohort for Skeletal Health in Bristol and Avon (COSHIBA)

Background: identification of individuals with high fracture risk from within primary care is complex. It is likely that the true contribution of falls to fracture risk is underestimated

Detecting regular sound changes in linguistics as events of concerted evolution

Background: Concerted evolution is normally used to describe parallel changes at different sites in a genome, but it is also observed in languages where a specific phoneme changes to the same other phoneme in many words in the lexicon—a phenomenon known as regular sound change. We develop a general statistical model that can detect concerted changes in aligned sequence data and apply it to study regular sound changes in the Turkic language family. Results: Linguistic evolution, unlike the genetic substitutional process, is dominated by events of concerted evolutionary change. Our model identified more than 70 historical events of regular sound change that occurred throughout the evolution of the Turkic language family, while simultaneously inferring a dated phylogenetic tree. Including regular sound changes yielded an approximately 4-fold improvement in the characterization of linguistic change over a simpler model of sporadic change, improved phylogenetic inference, and returned more reliable and plausible dates for events on the phylogenies. The historical timings of the concerted changes closely follow a Poisson process model, and the sound transition networks derived from our model mirror linguistic expectations. Conclusions: We demonstrate that a model with no prior knowledge of complex concerted or regular changes can nevertheless infer the historical timings and genealogical placements of events of concerted change from the signals left in contemporary data. Our model can be applied wherever discrete elements—such as genes, words, cultural trends, technologies, or morphological traits—can change in parallel within an organism or other evolving group