Lawrence Livermore National Laboratory Safeguards and Security quarterly progress report ending March 31, 1996

LLNL carries out safeguards and security activities for DOE Office of Safeguards and Security (OSS) and other organizations within and outside DOE. LLNL is supporting OSS in 6 areas: safeguards technology, safeguards and materials accountability, computer security--distributed systems, complex-wide access control, standardization of security systems, and information technology and security center. This report describes the activities in each of these areas

Integrative and Conjugative Elements (ICEs): What They Do and How They Work

Horizontal gene transfer plays a major role in microbial evolution, allowing microbes to acquire new genes and phenotypes. Integrative and conjugative elements (ICEs, a.k.a. conjugative transposons) are modular mobile genetic elements integrated into a host genome and are passively propagated during chromosomal replication and cell division. Induction of ICE gene expression leads to excision, production of the conserved conjugation machinery (a type IV secretion system), and the potential to transfer DNA to appropriate recipients. ICEs typically contain cargo genes that are not usually related to the ICE life cycle and that confer phenotypes to host cells. We summarize the life cycle and discovery of ICEs, some of the regulatory mechanisms, and how the types of cargo have influenced our view of ICEs. We discuss how ICEs can acquire new cargo genes and describe challenges to the field and various perspectives on ICE biology

Lawrence Livermore National Laboratory Safeguards and Security quarterly progress report to the U.S. Department of Energy. Quarter ending December 31, 1995

The Safeguards Technology Program (STP) is a program in LLNL`s Isotope Sciences Division of the Chemistry and Materials Science Department that develops advanced, nondestructive analysis (NDA) technology for measurement of special nuclear materials. Our work focuses on R&D relating to x- and gamma-ray spectrometry techniques and to the development of computer codes for interpreting the spectral data obtained by these techniques

Upper and Middle Atmospheric Density Modeling Requirements for Spacecraft Design and Operations

Presented and discussed are concerns with applications of neutral atmospheric density models to space vehicle engineering design and operational problems. The area of concern which the atmospheric model developers and the model users considered, involved middle atmosphere (50 to 90 km altitude) and thermospheric (above 90 km) models and their engineering application. Engineering emphasis involved areas such as orbital decay and lifetime prediction along with attitude and control studies for different types of space and reentry vehicles

Power, Pathological Worldviews, and the Strengths Perspective in Social Work

This article takes up Blundo’s (2001) assertion in this journal that in order to practice from the strengths perspective, social workers need to alter their “frames.” Expanding on this assertion, we specify a particular frame that requires change: a pathological worldview. Examining the strengths perspective with regard to a Foucauldian analysis of power, we argue that to thoroughly implement the strengths perspective, we need to consider the dividing practices that allow us to maintain power and that reflect a pathological worldview. This article provides considerations for social work practice that will be of interest to practicing social workers and social work educators interested in continuing to develop their strengths-based practice

Exotic torus manifolds and equivariant smooth structures on quasitoric manifolds

In 2006 Masuda and Suh asked if two compact non-singular toric varieties having isomorphic cohomology rings are homeomorphic. In the first part of this paper we discuss this question for topological generalizations of toric varieties, so-called torus manifolds. For example we show that there are homotopy equivalent torus manifolds which are not homeomorphic. Moreover, we characterize those groups which appear as the fundamental groups of locally standard torus manifolds. In the second part we give a classification of quasitoric manifolds and certain six-dimensional torus manifolds up to equivariant diffeomorphism. In the third part we enumerate the number of conjugacy classes of tori in the diffeomorphism group of torus manifolds. For torus manifolds of dimension greater than six there are always infinitely many conjugacy classes. We give examples which show that this does not hold for six-dimensional torus manifolds.Comment: 21 pages, 2 figures, results about quasitoric manifolds adde

Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro.

Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease. This work aims to assess the influence of two distinct signaling moieties on CPCs: cyclic biaxial strain and extracellular matrix. We evaluate four endpoints for improving CPC therapy: paracrine signaling, proliferation, connexin43 expression, and alignment. Vascular endothelial growth factor A (about 900 pg/mL) was secreted by CPCs cultured on fibronectin and collagen I. The application of mechanical strain increased vascular endothelial growth factor A secretion 2-4-fold for CPCs cultured on poly-L-lysine, laminin, or a naturally derived cardiac extracellular matrix. CPC proliferation was at least 25% higher on fibronectin than that on other matrices, especially for lower strain magnitudes. At 5% strain, connexin43 expression was highest on fibronectin. With increasing strain magnitude, connexin43 expression decreased by as much as 60% in CPCs cultured on collagen I and a naturally derived cardiac extracellular matrix. Cyclic mechanical strain induced the strongest CPC alignment when cultured on fibronectin or collagen I. This study demonstrates that culturing CPCs on fibronectin with 5% strain magnitude is optimal for their vascular endothelial growth factor A secretion, proliferation, connexin43 expression, and alignment

Wind Tunnel Results of the B-52B with the X-43A Stack

A low-speed wind-tunnel test was performed with a three-percent-scale model of a booster rocket mated to an X-43A research vehicle, a combination referred to as the Hyper-X launch vehicle. The test was conducted both in free-stream air and in the presence of a partial model of the B-52B airplane. The objectives of the test were to obtain force and moment data to generate structural loads affecting the pylon of the B-52B airplane and to determine the aerodynamic influence of the B-52B airplane on the Hyper-X launch vehicle to evaluate launch separation characteristics. The wind-tunnel test was conducted at a low-speed wind tunnel in Hampton, Virginia. All moments and forces reported are based either on the aerodynamic influence of the B-52B airplane or are for the Hyper-X launch vehicle in free-stream air. Overall, the test showed that the B-52B airplane imparts a strong downwash onto the Hyper-X launch vehicle, reducing the net lift of the Hyper-X launch vehicle. Also, pitching and rolling moments are imparted onto the booster and are a strong function of the launch-drop angle of attack

Obtaining Stakeholder Consensus on the Core Components of a Parent Support and Training Model for Parents of Children With Serious Emotional Disturbances

This is the publisher's version, also available electronically from http://alliance1.metapress.com/content/y66232237182170g/?genre=article&id=doi%3a10.1606%2f1044-3894.4317Parent-to-parent peer interventions are nationally recognized as an important service within children's community-based mental health systems of care. Despite rapid growth, clearly defined models of professional parent services for statewide application do not exist. In this study, concept mapping was used to achieve stakeholder consensus on the core components of the Parent Support and Training (PST) peer intervention model developed within the Kansas community mental health system. Participants rated the importance and observed frequency of 49 distinct statements related to the service and sorted them into conceptual groups. Analyses reflected a high level of agreement across stakeholders on statements identified as most important and most frequently demonstrated in PST services statewide

Wind-Tunnel Results of the B-52B with the X-43A Stack

A low-speed wind-tunnel test was performed with a 3%-scale model of a booster rocket mated to an X-43A research vehicle, a combination referred to as the Hyper-X launch vehicle. The test was conducted both in freestream air and in the presence of a partial model of the B-52B airplane. The objectives of the test were to obtain force and moment data to generate structural loads affecting the pylon of the B-52B airplane and to determine the aerodynamic influence of the B-52B on the Hyper-X launch vehicle for evaluating launch separation characteristics. The windtunnel test was conducted at a low-speed wind tunnel in Hampton, Virginia. All moments and forces reported are based either on the aerodynamic influence of the B-52B airplane or are for the Hyper-X launch vehicle in freestream air. Overall, the test showed that the B-52B airplane imparts a strong downwash onto the Hyper-X launch vehicle, reducing the net lift of the Hyper-X launch vehicle. Pitching and rolling moments are also imparted onto the booster and are a strong function of the launch-drop angle of attack