7,552 research outputs found
PERLAKSANAAN DAN KEBERKESANAN KAEDAH LATTICE DALAM PENGAJARAN KEMAHIRAN MATEMATIK: SATU KAJIAN KES DI SEKOLAH RENDAH
Dalam pendidikan matematik, penguasaan pendaraban nombor merupakan salah satu kemahiran penting untuk matapelajaran matematik di sekolah rendah. Seandainya murid-murid tidak dapat menguasai kemahiran ini pada peringkat awal pembelajaran matematik, mereka bakal menghadapi pelbagai masalah dan cabaran dalam penguasaan kemahiran seterusnya yang memerlukan kemahiran pendaraban sebagai asas. Oleh yang demikian, satu kajian telah dijalankan untuk menilai sejauh manakah keberkesanan perlaksanaan kaedah Lattice dalam membantu meningkatkan kemahiran asas pendaraban, yang melibatkan pendaraban nombor dua dan tiga digit. Rekabentuk kajian yang digunakan ialah kajian kuasi-experimental yang melibatkan sampel murid sebanyak 15 orang murid darjah empat di Sekolah Jenis Kebangsaan Cina Chung Cheng, Batu Pahat, Johor. Ujian Pra dan Pos telah dilakukan bagi membandingkan tahap pencapaian sampel kajian sebelum dan selepas rawatan menerusi empat sesi intervensi. Secara keseluruhannya, hasil kajian telah mendapati peningkatan purata skor sebanyak 42.67 peratus selepas rawatan dengan penggunaan kaedah Lattice. Kesimpulannya, kaedah Lattice merupakan kaedah yang berkesan dalam meningkatkan pemahaman dan kemahiran responden dalam topik pendaraban
A pricing optimization modelling for assisted decision making in telecommunication product-service bundling
Product service bundle (PSB) is a marketing strategy that offers attractive product-service packages with competitive pricing to ensure sustained profitability. However, designing suitable pricing for PSB is a non-trivial task that involves complex decision-making. This paper explores the significance of pricing optimization in the telecommunication industry, focusing on product-service bundling (PSB). It delves into the challenges associated with pricing PSB and highlights the transformative impact of big data analytics on decision-making for PSB strategies. The study presents a data-driven pricing optimization model tailored for designing appropriate pricing structures for product-service bundles within the telecommunication services domain. This model integrates customer preference knowledge and involves intricate decision-making processes. To demonstrate the feasibility of the proposed approach, the paper conducts a case study encompassing two design scenarios, wherein the results reveal that the model offers competitive pricing compared to existing telecommunication service providers, facilitating PSB design and decision-making. The findings from the case study indicate that the data-driven pricing optimization model can significantly aid PSB design and decision-making, leading to competitive pricing strategies that open avenues for new market exploration and ensure business sustainability. By considering both product and service features concurrently, the proposed model provides a pricing reference for optimal decision-making. The case study validates the feasibility and effectiveness of the approach within the telecommunication industry and highlights its potential for broader applications. The model's capability to generate competitive pricing strategies offers opportunities for new market exploration, ensuring business growth and adaptability
Investigating the Day-to-Day Experiences of Users with Traumatic Brain Injury with Conversational Agents
Traumatic brain injury (TBI) can cause cognitive, communication, and
psychological challenges that profoundly limit independence in everyday life.
Conversational Agents (CAs) can provide individuals with TBI with cognitive and
communication support, although little is known about how they make use of CAs
to address injury-related needs. In this study, we gave nine adults with TBI an
at-home CA for four weeks to investigate use patterns, challenges, and design
requirements, focusing particularly on injury-related use. The findings
revealed significant gaps between the current capabilities of CAs and
accessibility challenges faced by TBI users. We also identified 14 TBI-related
activities that participants engaged in with CAs. We categorized those
activities into four groups: mental health, cognitive activities, healthcare
and rehabilitation, and routine activities. Design implications focus on
accessibility improvements and functional designs of CAs that can better
support the day-to-day needs of people with TBI.Comment: In Proceedings The 25th International ACM SIGACCESS Conference on
Computers and Accessibility (ASSETS'23
A status report on the observability of cosmic bubble collisions
In the picture of eternal inflation as driven by a scalar potential with
multiple minima, our observable universe resides inside one of many bubbles
formed from transitions out of a false vacuum. These bubbles necessarily
collide, upsetting the homogeneity and isotropy of our bubble interior, and
possibly leading to detectable signatures in the observable portion of our
bubble, potentially in the Cosmic Microwave Background or other precision
cosmological probes. This constitutes a direct experimental test of eternal
inflation and the landscape of string theory vacua. Assessing this possibility
roughly splits into answering three questions: What happens in a generic bubble
collision? What observational effects might be expected? How likely are we to
observe a collision? In this review we report the current progress on each of
these questions, improve upon a few of the existing results, and attempt to lay
out directions for future work.Comment: Review article; comments very welcome. 24 pages + 4 appendices; 19
color figures. (Revised version adds two figures, minor edits.
Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.
MALT1 is the only known paracaspase and is a critical mediator of B- and T-cell receptor signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions arising from the recurrent t(11;18)(q21;q21) aberration, which is the most frequent translocation in mucosa-associated lymphoid tissue (MALT) lymphoma. API2-MALT1-positive MALT lymphomas manifest antibiotic resistance and aggressive clinical behaviour with poor clinical outcome. However, the mechanisms underlying API2-MALT1-induced MALT lymphomagenesis are not fully understood. Here we show that API2-MALT1 induces paracaspase-mediated cleavage of the tumour suppressor protein LIMA1. LIMA1 binding by API2-MALT1 is API2 dependent and proteolytic cleavage is dependent on MALT1 paracaspase activity. Intriguingly, API2-MALT1-mediated proteolysis generates a LIM domain-only (LMO)-containing fragment with oncogenic properties in vitro and in vivo. Importantly, primary MALT lymphomas harbouring the API2-MALT1 fusion uniquely demonstrate LIMA1 cleavage fragments. Our studies reveal a novel paracaspase-mediated oncogenic gain-of-function mechanism in the pathogenesis of MALT lymphoma.This work was
supported in part by NIH grants R01 DE119249 and R01 CA136905 (K.S.J.E-J.), R01
CA140806 (M.S.L.) and the Department of Pathology at the University of Michigan.This is the accepted manuscript. The final version is available from Nature at http://www.nature.com/ncomms/2015/150108/ncomms6908/full/ncomms6908.html
Design and Test of a Forward Neutron Calorimeter for the ZEUS Experiment
A lead scintillator sandwich sampling calorimeter has been installed in the
HERA tunnel 105.6 m from the central ZEUS detector in the proton beam
direction. It is designed to measure the energy and scattering angle of
neutrons produced in charge exchange ep collisions. Before installation the
calorimeter was tested and calibrated in the H6 beam at CERN where 120 GeV
electrons, muons, pions and protons were made incident on the calorimeter. In
addition, the spectrum of fast neutrons from charge exchange proton-lucite
collisions was measured. The design and construction of the calorimeter is
described, and the results of the CERN test reported. Special attention is paid
to the measurement of shower position, shower width, and the separation of
electromagnetic showers from hadronic showers. The overall energy scale as
determined from the energy spectrum of charge exchange neutrons is compared to
that obtained from direct beam hadrons.Comment: 45 pages, 22 Encapsulated Postscript figures, submitted to Nuclear
Instruments and Method
Ventral-aspect radar cross sections and polarization patterns of insects at X band and their relation to size and form
A data set of ventral-aspect insect radar cross-sections (RCSs) and polarization patterns, measured at X band (9.4 GHz, linear polarization) in laboratory rigs, has been collated from a number of sources. The data have been analysed to identify relationships between RCS parameters (one representing size and two the polarization-pattern shape) and the insects’ masses and morphological dimensions and forms. An improved mass-estimation relationship, with appropriate asymptotes for very small and very large insects, is presented. This relationship draws only on the RCS size parameter and it is shown that incorporating one or both of the RCS shape parameters provides little additional benefit. Small insects have polarization-pattern shapes that fall within a relatively limited region of the range of parameter values allowed by electromagnetic scattering theory. Larger insects have shapes that extend beyond this region, following a broad trajectory as size and mass increases; at masses above ~0.6 g, the pattern becomes ‘perpendicular’, with maxima when the E-field is orthogonal to the body axis rather than parallel to it. RCS shape can be used to infer morphological form for small insects (<80 mg), but not for larger ones. These results are consistent with observations from X-band vertical-beam entomological radars and provide a basis for identification, at least to broad taxon classes, of the targets detected by such radars
Dispersively detected Pauli Spin-Blockade in a Silicon Nanowire Field-Effect Transistor
We report the dispersive readout of the spin state of a double quantum dot
formed at the corner states of a silicon nanowire field-effect transistor. Two
face-to-face top-gate electrodes allow us to independently tune the charge
occupation of the quantum dot system down to the few-electron limit. We measure
the charge stability of the double quantum dot in DC transport as well as
dispersively via in-situ gate-based radio frequency reflectometry, where one
top-gate electrode is connected to a resonator. The latter removes the need for
external charge sensors in quantum computing architectures and provides a
compact way to readout the dispersive shift caused by changes in the quantum
capacitance during interdot charge transitions. Here, we observe Pauli
spin-blockade in the high-frequency response of the circuit at finite magnetic
fields between singlet and triplet states. The blockade is lifted at higher
magnetic fields when intra-dot triplet states become the ground state
configuration. A lineshape analysis of the dispersive phase shift reveals
furthermore an intradot valley-orbit splitting of 145 eV.
Our results open up the possibility to operate compact CMOS technology as a
singlet-triplet qubit and make split-gate silicon nanowire architectures an
ideal candidate for the study of spin dynamics
Anisotropic colloids through non-trivial buckling
We present a study on buckling of colloidal particles, including
experimental, theoretical and numerical developments. Oil-filled thin shells
prepared by emulsion templating show buckling in mixtures of water and ethanol,
due to dissolution of the core in the external medium. This leads to
conformations with a single depression, either axisymmetric or polygonal
depending on the geometrical features of the shells. These conformations could
be theoretically and/or numerically reproduced in a model of homogeneous
spherical thin shells with bending and stretching elasticity, submitted to an
isotropic external pressure.Comment: submitted to EPJ
Identity development in disorientating times: the experiences of medical students during COVID-19
Introduction Professional identity development is a central aim of medical education, which has been disrupted during COVID-19. Yet, no research has qualitatively explored COVID-19’s impact across institutions or countries on medical students’ identities. Kegan proposes a cognitive model of identity development, where ‘disorientating dilemmas’ prompt student development. Given the potential of COVID-related disruption to generate disorientating dilemmas, the authors investigated the ways in which COVID-19 influenced students’ identity development. Methods The authors conducted an international qualitative study with second year medical students from Imperial College London, and third year students from Melbourne Medical School. Six focus groups occurred 2020–2021, with three to six students per group. Authors analysed data using reflexive thematic analysis, applying Kegan’s model as a sensitising theoretical lens. Results COVID-19 has resulted in a loss of clinical exposure, loss of professional relationships, and a shift in public perception of physicians. Loss of exposure to clinical practice removed the external validation from patients and seniors many students depended on for identity development. Students’ experiences encouraged them to assume the responsibilities of the profession and the communities they served, in the face of conflicting demands and risk. Acknowledging and actioning this responsibility facilitated identity development as a socially responsible advocate. Conclusions Educators should consider adapting medical education to support students through Kegan’s stages of development. Measures to foster relationships between students, patients, and staff are likely necessary. Formal curricula provisions, such as spaces for reflection and opportunities for social responsibility, may aid students in resolving the conflict many have recently experienced
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