4,073 research outputs found
Stability and Control Characteristics at Subsonic Speeds of a Flat-Top Arrowhead Wing-Body Combination
A wind-tunnel investigation was made to determine the longitudinal- and lateral-stability derivatives of a flat-top wing-body configuration at Mach numbers from 0.22 to 0.90 and Reynolds numbers of 3.5 and 17 million. The wing had a leading-edge sweepback of 78.9 deg and a cathedral of 45 deg on the outer panels. The tests included the determination of the effectiveness of elevon and rudder controls and also an investigation of ground effects. The model was tested at angles of attack up to 28 deg and angles of sideslip up to 18 deg. The dynamic response of this configuration has been determined from the wind-tunnel data for a simulated airplane having a wing loading of 17.7 pounds per square foot. The longitudinal data show a forward shift in aerodynamic center of 10 percent of the mean aerodynamic chord as the lift coefficient is increased above 0.1. Although flown in the lift range of decreasing stability, the simulated airplane did not encounter pitch-up in maneuvers initiated from steady level flight with zero static margin unless a load factor of 2.2 was exceeded. This maneuver margin was provided by a large value of pitching moment due to pitching velocity. The number of cycles to damp the Dutch roll mode to half amplitude, the time constants of the roll subsidence and spiral divergence modes, and control effectiveness in roll are computed. The lateral stability is shown to be positive but is marginal in meeting the military specifications for today's aircraft. An analog computer study has been made in five degrees of freedom (constant velocity) which illustrates that the handling characteristics are satisfactory. Several programed rolling maneuvers and coordinated turns also illustrate the handling qualities of the airplane
Open questions in the study of population III star formation
The first stars were key drivers of early cosmic evolution. We review the
main physical elements of the current consensus view, positing that the first
stars were predominantly very massive. We continue with a discussion of
important open questions that confront the standard model. Among them are
uncertainties in the atomic and molecular physics of the hydrogen and helium
gas, the multiplicity of stars that form in minihalos, and the possible
existence of two separate modes of metal-free star formation.Comment: 15 pages, 2 figures. To appear in the conference proceedings for IAU
Symposium 255: Low-Metallicity Star Formation: From the First Stars to Dwarf
Galaxie
Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases
The assessment of disease activity in various conditions may be performed using a range of different techniques. These include the use of non-invasive tests, such as acute phase inflammatory markers and simple radiological techniques, to more advanced invasive and complex modalities. Over the past two decades the analysis of volatile organic compounds (VOCs) in biological specimens has attracted a considerable amount of clinical interest. The investigation of VOCs, using a variety of analytical techniques, has shown a significant correlation between the pattern and concentration of VOCs and the occurrence of various diseases. This provides a potentially non-invasive means of diagnosis, monitoring of pathological processes and assessment of pharmacological response. It may be rapid, simple and acceptable to patients. In this paper we review the medical literature and research efforts that have been carried out over the past decades, and try to summarize the clinical implications of VOC analysis of various biological emanations including stool, breath and blood samples and their correlation with gastrointestinal and liver diseases
Measurement of the dynamic charge response of materials using low-energy, momentum-resolved electron energy-loss spectroscopy (M-EELS)
One of the most fundamental properties of an interacting electron system is
its frequency- and wave-vector-dependent density response function, . The imaginary part, , defines the
fundamental bosonic charge excitations of the system, exhibiting peaks wherever
collective modes are present. quantifies the electronic compressibility
of a material, its response to external fields, its ability to screen charge,
and its tendency to form charge density waves. Unfortunately, there has never
been a fully momentum-resolved means to measure at the
meV energy scale relevant to modern elecronic materials. Here, we demonstrate a
way to measure with quantitative momentum resolution by applying
alignment techniques from x-ray and neutron scattering to surface
high-resolution electron energy-loss spectroscopy (HR-EELS). This approach,
which we refer to here as "M-EELS," allows direct measurement of with meV resolution while controlling the momentum with an accuracy
better than a percent of a typical Brillouin zone. We apply this technique to
finite-q excitations in the optimally-doped high temperature superconductor,
BiSrCaCuO (Bi2212), which exhibits several phonons
potentially relevant to dispersion anomalies observed in ARPES and STM
experiments. Our study defines a path to studying the long-sought collective
charge modes in quantum materials at the meV scale and with full momentum
control.Comment: 26 pages, 10 sections, 7 figures, and an appendi
EQ-5D-3L Derived Population Norms for Health Related Quality of Life in Sri Lanka
Background Health Related Quality of Life (HRQoL) is an important outcome measure in health economic evaluation that guides health resource allocations. Population norms for HRQoL are an essential ingredient in health economics and in the evaluation of population health. The aim of this study was to produce EQ-5D-3L-derived population norms for Sri Lanka. Method A population sample (n =  780) was selected from four districts of Sri Lanka. A stratified cluster sampling approach with probability proportionate to size was employed. Twenty six clusters of 30 participants each were selected; each participant completed the EQ-5D-3L in a face-to-face interview. Utility weights for their EQ-5D-3L health states were assigned using the Sri Lankan EQ-5D-3L algorithm. The population norms are reported by age and socio-economic variables. Results The EQ-5D-3L was completed by 736 people, representing a 94% response rate. Sixty per cent of the sample reported being in full health. The percentage of people responding to any problems in the five EQ-5D-3L dimensions increased with age. The mean EQ-5D-3L weight was 0.85 (SD 0.008; 95%CI 0.84-0.87). The mean EQ-5D-3L weight was significantly associated with age, housing type, disease experience and religiosity. People above 70 years of age were 7.5 times more likely to report mobility problems and 3.7 times more likely to report pain/discomfort than those aged 18-29 years. Those with a tertiary education were five times less likely to report any HRQoL problems than those without a tertiary education. A person living in a shanty was 4.3 more likely to have problems in usual activities than a person living in a single house. Conclusion The population norms in Sri Lanka vary with socio-demographic characteristics. The socioeconomically disadvantaged have a lower HRQoL. The trends of population norms observed in this lower middle income country were generally similar to those previously reported in high income countries
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Final Task Report on NRF Measurements of Photon Scattering Resonances in Plutonium at the High Voltage Research Laboratory of MIT
Conclusions of this report are that there are 13 new transitions associated with NRF states in {sup 239}Pu that have been discovered. These resonances are between 2- and 2.5-MeV relative to the ground state in {sup 239}Pu. The strengths of most these resonances are between 15 and 20 eV b. This approximately is the strength required for using the transmission detection method for NRF [Pruet et al J. Appl. Phys. 99 12310 (2006)] for six-sigma alarm confidence levels. Future measurements on {sup 239}Pu at higher photon energies are necessary to probe for NRF strengths at higher energies. Such resonances may be more advantageous to the NRF technique with FINDER if they are stronger or if the mean free path of these energetic photons is longer
Driver behaviour with adaptive cruise control
This paper reports on the evaluation of adaptive cruise control (ACC) from a psychological perspective. It was anticipated that ACC would have an effect upon the psychology of driving, i.e. make the driver feel like they have less control, reduce the level of trust in the vehicle, make drivers less situationally aware, but workload might be reduced and driving might be less stressful. Drivers were asked to drive in a driving simulator under manual and ACC conditions. Analysis of variance techniques were used to determine the effects of workload (i.e. amount of traffic) and feedback (i.e. degree of information from the ACC system) on the psychological variables measured (i.e. locus of control, trust, workload, stress, mental models and situation awareness). The results showed that: locus of control and trust were unaffected by ACC, whereas situation awareness, workload and stress were reduced by ACC. Ways of improving situation awareness could include cues to help the driver predict vehicle trajectory and identify conflicts
Measurement properties of the SF-MPQ-2 neuropathic qualities subscale in persons with CRPs: Validity, responsiveness, and Rasch analysis
© 2018 American Academy of Pain Medicine. All rights reserved. Objectives. The purpose of this study was to conduct classical psychometric evaluation and Rasch analysis on the Neuropathic Qualities subscale of the Short-Form McGill Pain Questionnaire-2 utilizing scores from persons with complex regional pain syndrome to consider reliability and person separation, validity (including unidimensionality), and responsiveness in this population. Methods. Secondary analysis of longitudinal data from persons with acute complex regional pain syndrome was utilized for analysis of the psychometric properties and fit to the Rasch model of the Neuropathic Qualities subscale. We followed an iterative process of Rasch analysis to evaluate and address data fitting challenges. Results. Repeated measures from 59 persons meeting the Budapest criteria were used for analysis. Both item-total correlations and unidimensionality analyses supported theoretical construct validity; all convergent construct validity hypotheses were also supported. Responsiveness was demonstrated comparing baseline and one-year data at d ¼ 0.92, with a standardized response mean of 0.97. Data were able to fit the Rasch model, but all Neuropathic Qualities items had disordered thresholds that required rescoring. Additionally, local dependency and differential item function were addressed by “bundling,” suggesting that no further item reduction would be possible. Conclusions. This study provided preliminary support for the validity and responsiveness of the Neuropathic Qualities subscale in persons with complex regional pain syndrome. Rasch analysis further endorses use of the Neuropathic Qualities subscale as a “stand-alone” measure for neuropathic features, but with substantial background data transformations. Replication with larger samples is recommended to increase confidence in these findings
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
Objective: To compare the effectiveness of alternative first line treatment options for women with WHO group II anovulation wishing to conceive. Design: Systematic review and network meta-analysis. Data Sources: Cochrane Central Register of Controlled Trials, Medline, and Embase, up to 11 April 2016. Study Selection: Randomised controlled trials comparing eight ovulation induction treatments in women with WHO group II anovulation: clomiphene, letrozole, metformin, clomiphene and metformin combined, tamoxifen, gonadotropins, laparoscopic ovarian drilling, and placebo or no treatment. Study quality was measured on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Pregnancy, defined preferably as clinical pregnancy, was the primary outcome; live birth, ovulation, miscarriage, and multiple pregnancy were secondary outcomes. Results: Of 2631 titles and abstracts initially identified, 57 trials reporting on 8082 women were included. All pharmacological treatments were superior to placebo or no intervention in terms of pregnancy and ovulation. Compared with clomiphene alone, both letrozole and the combination of clomiphene and metformin showed higher pregnancy rates (odds ratio 1.58, 95% confidence interval 1.25 to 2.00; 1.81, 1.35 to 2.42; respectively) and ovulation rates (1.99, 1.38 to 2.87; 1.55, 1.02 to 2.36; respectively). Letrozole led to higher live birth rates when compared with clomiphene alone (1.67, 1.11 to 2.49). Both letrozole and metformin led to lower multiple pregnancy rates compared with clomiphene alone (0.46, 0.23 to 0.92; 0.22, 0.05 to 0.92; respectively). Conclusions: In women with WHO group II anovulation, letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of ovulation and pregnancy. Compared with clomiphene alone, letrozole is the only treatment showing a significantly higher rate of live birth.Rui Wang, Bobae V Kim, Madelon van Wely, Neil P Johnson, Michael F Costello, Hanwang Zhang, Ernest Hung Yu Ng, Richard S Legro, Siladitya Bhattacharya, Robert J Norman, Ben Willem J Mo
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