Comparison of Reprocessed ASAR WM Ocean Wave Spectra with

A major upgrade of the processing of Envisat ASAR Wave Mode (WM) products has been done followed by an extensive geophysical validation. The calibration/validation of the products are conducted using collocated WAM model as provided by ECMWF as well as available buoy data. Validation shows a significant improvement in the geophysical quality of the both the Level 1 WVS and the Level 2 WVW product. Less RMS deviation and bias between WVW and WAM or buoy wave spectra parameters are observed. We observe that the RMS error of H and 12 T p of the WVW is similar to values of WAM, both compared to the buoys. For the bias, the WVW values are slightly higher than the WAM values, both compared to buoy. For H these are RMS=0.57m (0.52m) an

Low-diffusivity scalar transport using a WENO scheme and dual meshing

Interfacial mass transfer of low-diffusive substances in an unsteady flow environment is marked by a very thin boundary layer at the interface and other regions with steep concentration gradients. A numerical scheme capable of resolving accurately most details of this process is presented. In this scheme, the fourth-order accurate WENO method developed by Liu et al. (1994) was implemented on a non-uniform staggered mesh to discretize the scalar convection while for the scalar diffusion a fourth-order accurate central discretization was employed. The discretization of the scalar convection-diffusion equation was combined with a fourth-order Navier-Stokes solver which solves the incompressible flow. A dual meshing strategy was employed, in which the scalar was solved on a finer mesh than the incompressible flow. The solver was tested by performing a number of two-dimensional simulations of an unstably stratified flow with low diffusivity scalar transport. The unstable stratification led to buoyant convection which was modelled using a Boussinesq approximation with a linear relationship between flow temperature and density. The order of accuracy for one-dimensional scalar transport on a stretched and uniform grid was also tested. The results show that for the method presented above a relatively coarse mesh is sufficient to accurately describe the fluid flow, while the use of a refined mesh for the low-diffusive scalars is found to be beneficial in order to obtain a highly accurate resolution with negligible numerical diffusion

Hourly resolved cloud modification factors in the ultraviolet

Cloud impacts on the transfer of ultraviolet (UV) radiation through the atmosphere can be assessed by using a cloud modification factor (CMF). CMF, which is based on total global solar irradiation (SOL<sub>CMF</sub>), has proved to be a solid basis to derive CMFs for the UV radiation (UV<sub>CMF</sub>). This is an advantage, because total global irradiance, the basis for SOL<sub>CMF</sub>, is frequently measured and forecasted by numerical weather prediction systems and includes all relevant effects for radiation transmission, such as cloud optical depth, different cloud layers, multiple reflection, as well as the distinct difference as to whether the solar disc is obscured by clouds or not. In the UV range clouds decrease the irradiance to a lesser extent than in the visible and infrared spectral range. Thus the relationship between CMFs for solar radiation and for UV-radiation is not straight forward, but will depend on whether, for example, the solar zenith angle (SZA) and wavelength band or action spectrum in the UV have been taken into consideration. Den Outer et al. provide a UV<sub>CMF</sub> algorithm on a daily basis, which accounts for these influences. It requires as input a daily SOL<sub>CMF</sub> and the SZA at noon. The calculation of SOL<sub>CMF</sub> uses the clear-sky algorithm of the European Solar Radiation Atlas to account for varying turbidity impacts. The algorithm's capability to derive hourly UV<sub>CMFs</sub> based on the SZA at the corresponding hour and its worldwide applicability is validated for erythemal UV using observational data retrieved from the databases of the COST-Action 726 on "Long-term changes and climatology of UV radiation over Europe" and the USDA UV-B Monitoring Program. The clear-sky part of the models has proved to be of good quality. Accumulated to daily doses it forms a tight cluster of points to the highest measured daily sums. All sky model performances for hourly resolution are shown to be comparable in accuracy with the well performing daily models of the COST-726 model intercomparison

Linear optical absorption spectra of mesoscopic structures in intense THz fields: free particle properties

We theoretically study the effect of THz radiation on the linear optical absorption spectra of semiconductor structures. A general theoretical framework, based on non-equilibrium Green functions, is formulated, and applied to the calculation of linear optical absorption spectrum for several non-equilibrium mesoscopic structures. We show that a blue-shift occurs and sidebands appear in bulk-like structures, i.e., the dynamical Franz-Keldysh effect [A.-P. Jauho and K. Johnsen, Phys. Rev. Lett. 76, 4576 (1996)]. An analytic calculation leads to the prediction that in the case of superlattices distinct stable steps appear in the absorption spectrum when conditions for dynamical localization are met.Comment: 13 Pages, RevTex using epsf to include 8 ps figures. Submitted to Phys. Rev. B (3 April 97

YKL-40, a Marker of Inflammation and Endothelial Dysfunction, Is Elevated in Patients With Type 1 Diabetes and Increases With Levels of Albuminuria

OBJECTIVE—The inflammation marker YKL-40 is elevated in patients with type 2 diabetes and is associated with atherosclerosis and increased cardiovascular mortality. In the present study, YKL-40 levels were examined in patients with type 1 diabetes with increasing levels of albuminuria, known to be associated with an increased risk of cardiovascular disease

The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells.

Extensive changes in posttranslational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However, the mechanisms controlling the changes in specific chromatin modifications and their function during differentiation remain only poorly understood. We show that histone H2B monoubiquitination (H2Bub1) significantly increases during differentiation of human mesenchymal stem cells (hMSCs) and various lineage-committed precursor cells and in diverse organisms. Furthermore, the H2B ubiquitin ligase RNF40 is required for the induction of differentiation markers and transcriptional reprogramming of hMSCs. This function is dependent upon CDK9 and the WAC adaptor protein, which are required for H2B monoubiquitination. Finally, we show that RNF40 is required for the resolution of the H3K4me3/H3K27me3 bivalent poised state on lineage-specific genes during the transition from an inactive to an active chromatin conformation. Thus, these data indicate that H2Bub1 is required for maintaining multipotency of hMSCs and plays a central role in controlling stem cell differentiation