Use of electronic medical records and biomarkers to manage risk and resource efficiencies

Peer reviewedPublisher PD

Mesoscale acid deposition modeling studies

The work performed in support of the EPA/DOE MADS (Mesoscale Acid Deposition) Project included the development of meteorological data bases for the initialization of chemistry models, the testing and implementation of new planetary boundary layer parameterization schemes in the MASS model, the simulation of transport and precipitation for MADS case studies employing the MASS model, and the use of the TASS model in the simulation of cloud statistics and the complex transport of conservative tracers within simulated cumuloform clouds. The work performed in support of the NASA/FAA Wind Shear Program included the use of the TASS model in the simulation of the dynamical processes within convective cloud systems, the analyses of the sensitivity of microburst intensity and general characteristics as a function of the atmospheric environment within which they are formed, comparisons of TASS model microburst simulation results to observed data sets, and the generation of simulated wind shear data bases for use by the aviation meteorological community in the evaluation of flight hazards caused by microbursts

Comparison of electromagnetic and gravitational radiation: What we can learn about each from the other

We compare the nature of electromagnetic fields and gravitational fields in linearized general relativity. We carry out this comparison both mathematically and visually. In particular, the “lines of force” visualizations of electromagnetism are contrasted with the recently introduced tendex/vortex eigenline technique for visualizing gravitational fields. Specific solutions, visualizations, and comparisons are given for an oscillating point quadrupole source. Among the similarities illustrated are the quasistatic nature of the near fields, the transverse 1/r nature of the far fields, and the interesting intermediate field structures connecting these two limiting forms. Among the differences illustrated are the meaning of field line motion and of the flow of energy

Tidal interaction in binary black hole inspiral

In rotating viscous fluid stars, tidal torque leads to an exchange of spin and orbital angular momentum. The horizon of a black hole has an effective viscosity that is large compared to that of stellar fluids, and an effective tidal torque may lead to important effects in the strong field interaction at the endpoint of the inspiral of two rapidly rotating holes. In the most interesting case both holes are maximally rotating and all angular momenta (orbital and spins) are aligned. We point out here that in such a case (i) the transfer of angular momentum may have an important effect in modifying the gravitational wave ``chirp'' at the endpoint of inspiral. (ii) The tidal transfer of spin energy to orbital energy may increase the amount of energy being radiated. (iii) Tidal transfer in such systems may provide a mechanism for shedding excess angular momentum. We argue that numerical relativity, the only tool for determining the importance of tidal torque, should be more specifically focused on binary configurations with aligned, large, angular momenta.Comment: 5 pages, 2 figure

NMR investigations of the interaction between the azo-dye sunset yellow and Fluorophenol

The interaction of small molecules with larger noncovalent assemblies is important across a wide range of disciplines. Here, we apply two complementary NMR spectroscopic methods to investigate the interaction of various fluorophenol isomers with sunset yellow. This latter molecule is known to form noncovalent aggregates in isotropic solution, and form liquid crystals at high concentrations. We utilize the unique fluorine-19 nucleus of the fluorophenol as a reporter of the interactions via changes in both the observed chemical shift and diffusion coefficients. The data are interpreted in terms of the indefinite self-association model and simple modifications for the incorporation of a second species into an assembly. A change in association mode is tentatively assigned whereby the fluorophenol binds end-on with the sunset yellow aggregates at low concentration and inserts into the stacks at higher concentrations

The close limit from a null point of view: the advanced solution

We present a characteristic algorithm for computing the perturbation of a Schwarzschild spacetime by means of solving the Teukolsky equation. We implement the algorithm as a characteristic evolution code and apply it to compute the advanced solution to a black hole collision in the close approximation. The code successfully tracks the initial burst and quasinormal decay of a black hole perturbation through 10 orders of magnitude and tracks the final power law decay through an additional 6 orders of magnitude. Determination of the advanced solution, in which ingoing radiation is absorbed by the black hole but no outgoing radiation is emitted, is the first stage of a two stage approach to determining the retarded solution, which provides the close approximation waveform with the physically appropriate boundary condition of no ingoing radiation.Comment: Revised version, published in Phys. Rev. D, 34 pages, 13 figures, RevTe

Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study

Background: Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared with Diskus and Turbohaler dry powder inhalers. Methods: Patients ≥18 years old with asthma and/or COPD who were current users of an inhaler but naïve to the study devices were assigned to inhaler technique assessment on Pulmojet and either Diskus or Turbohaler in a randomised order. Patients inhaled through empty devices after reading the patient information leaflet. If serious errors potentially affecting dose delivery were recorded, they repeated the inhalations after watching a training video. Inhaler technique was assessed by a trained nurse observer and an electronic inhalation profile recorder. Results: Baseline patient characteristics were similar between randomisation arms for the Pulmojet-Diskus (n = 277) and Pulmojet-Turbohaler (n = 144) comparisons. Non-inferiority in the proportions of patients recording no nurse-observed serious errors was demonstrated for both Pulmojet versus Diskus, and Pulmojet versus Turbohaler; therefore, superiority was tested. Patients were significantly less likely to make ≥1 nurse-observed serious errors using Pulmojet compared with Diskus (odds ratio, 0.31; 95 % CI, 0.19–0.51) or Pulmojet compared with Turbohaler (0.23; 0.12–0.44) after reading the patient information leaflet with additional video instruction, if required. Conclusions These results suggest Pulmojet is easier to learn to use correctly than the Turbohaler or Diskus for current inhaler users switching to a new dry powder inhaler