Transferring and extrapolating estimates of cost-effectiveness for water quality outcomes: Challenges and lessons from the Great Barrier Reef

In recent decades the declining health of the Great Barrier Reef has led to a number of government policies being implemented to reduce pollutant loads from the adjacent agricultural-based catchments. There is increasing use of cost-effectiveness measures to help prioritise between different programs and actions to reduce pollutants, given limited resources and the scale of the issues. However there are a small number of primary studies available, and the consistency of cost-effectiveness measures and their application is limited, particularly given the various uncertainties that underlie the measures. Unlike Europe and the United States of America water policy or benefit transfer approaches, there are no procedural guidance studies that must be followed in the context of the Great Barrier Reef catchments. In this study we review the use of cost effectiveness estimates for pollutant reduction into the Great Barrier Reef in the context of a benefit transfer framework, where estimates of costs from a particular case study are transferred to various scenarios within different catchments. The conclusions suggest a framework be developed for the Great Barrier Reef, which is consistent, transparent, and rigorous

Method of moments solution of volume integral equations using parametric geometry modeling

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94709/1/rds4692.pd

UPDATING AND TESTING THE PASRR SCREEN IN KANSAS: REAL WORLD IMPLICATIONS

This work is licensed under a Creative Commons Attribution 4.0 International License.Kansas is updating the PASRR (Preadmission Screen and Resident Review) Level 1 screen per new guidance from the PASRR Technical Assistance Committee (PTAC), via a partnership between the State and university researchers. PTAC has directed states to screen for undiagnosed serious and persistent mental illness (SPMI) and also recommends screening for substance related disorders. Stakeholders were engaged through advisory workgroups and a content validity expert panel. These activities led to the creation of a revised PASRR Level-1 screen, but stakeholders also raised several concerns. PASRR law does not require Level-1 assessors to have professional training in mental health diagnoses or treatment, yet new guidelines asks them to screen for undiagnosed SPMI. Further, there are apparent discrepancies between these new guidelines and PASRR Level-2 criteria. Finally, current information management systems are not equipped to handle the higher security protocols associated substance use disorders. The draft instrument was tested with a sample of 103 nursing facility applicants by trained PASRR assessors and inter-rater reliability (IRR) was tested via a standardized vignette with 14 trained PASRR assessors. Only 3% of actual NF applicants were identified as possibly having an undiagnosed SPMI and only 43% of assessors correctly identified symptoms of a suspected SPMI in the standardized vignette, indicating poor validity and reliability in assessing for undiagnosed SPMI during the Level-1 screen. New PASRR guidelines may better ensure that nursing facility residents receive appropriate care for SPMI, however, there are many challenges to ensuring an accurate screen and supporting successful implementation

Evidence of a vertical kinematic oscillation beyond the Radcliffe Wave

The Radcliffe Wave (RW) is a recently discovered sinusoidal vertical feature of dense gas in the proximity of the Sun. In the disk plane, it is aligned with the Local Arm. However, the origin of its vertical undulation is still unknown. This study constrains the kinematics of the RW, using young stars and open clusters as tracers, and explores the possibility of this oscillation being part of a more extended vertical mode. We study the median vertical velocity trends of the young stars and clusters along with the RW and extend it further to the region beyond it. We discover a kinematic wave in the Galaxy, distinct from the warp, with the amplitude of oscillation depending on the age of the stellar population. We perform a similar analysis in the N-body simulation of a satellite as massive as the Sagittarius dwarf galaxy impacting the galactic disk. When projected in the plane, the spiral density wave induced by the satellite impact is aligned with the RW, suggesting that both may be the response of the disk to an external perturbation. However, the observed kinematic wave is misaligned. It appears as a kinematic wave travelling radially, winding up faster than the density wave matched by the RW, questioning its origin. If a satellite galaxy is responsible for this kinematic wave, we predict the existence of a vertical velocity dipole that should form across the disk and this may be measurable with the upcoming Gaia DR3 and DR4.Comment: Accepted for publication in Astronomy & Astrophysics Letter

Improved Determination of the Electroweak Penguin Contribution to epsilon'/epsilon in the Chiral Limit

We perform a finite energy sum rule analysis of the flavor ud two-point V-A current correlator, Delta Pi (Q^2). The analysis, which is performed using both the ALEPH and OPAL databases for the V-A spectral function, Delta rho, allows us to extract the dimension six V-A OPE coefficient, a_6, which is related to the matrix element of the electroweak penguin operator, Q_8, by chiral symmetry. The result for a_6 leads directly to the improved (chiral limit) determination epsilon'/epsilon = (- 15.0 +- 2.7) 10^{-4}. Determination of higher dimension OPE contributions also allows us to perform an independent test using a low-scale constrained dispersive analysis, which provides a highly nontrivial consistency check of the results.Comment: 17 pages, 4 figures, Revte

The Radcliffe Wave as the gas spine of the Orion Arm

The Radcliffe Wave is a $\sim3$ kpc long coherent gas structure containing most of the star-forming complexes near the Sun. In this Letter we aim to find a Galactic context for the Radcliffe Wave by looking into a possible relationship between the gas structure and the Orion (Local) Arm. We use catalogs of massive stars and young open clusters based on \textit{Gaia} EDR3 astrometry, in conjunction with kiloparsec-scale 3D dust maps, to investigate the Galactic \textit{XY} spatial distributions of gas and young stars. We find a quasi-parallel offset between the luminous blue stars and the Radcliffe Wave, in that massive stars and clusters are found essentially inside and downstream from the Radcliffe Wave. We examine this offset in the context of color gradients observed in the spiral arms of external galaxies, where the interplay between density wave theory, spiral shocks, and triggered star formation has been used to interpret this particular arrangement of gas/dust and OB stars, and outline other potential explanations as well. We hypothesize that the Radcliffe Wave constitutes the gas reservoir of the Orion (Local) Arm, and presents itself as a prime laboratory to study the interface between Galactic structure, the formation of molecular clouds in the Milky Way, and star formation.Comment: Published in A&A Letter

2017 Scientific Consensus Statement: land use impacts on the Great Barrier Reef water quality and ecosystem condition. Chapter 4: management options and their effectiveness

This chapter seeks to answer the following questions: 1. What are the values of the Great Barrier Reef? 2. How effective are better agricultural practices in improving water quality? 3. How can we improve the uptake of better agricultural practices? 4. What water quality improvement can non-agricultural land uses contribute? 5. How can Great Barrier Reef water quality improvement programs be improved? Each section summarises the currently available peer reviewed literature and comments on implications for management and research gaps. This chapter has a wider scope than previous Scientific Consensus Statements, including, for the first time, the social and governance dimensions of management and the management of non-agricultural land uses. These new sections are constrained by a lack of Great Barrier Reef–specific data and information. The relevance of information from other locations must be carefully considered. In comparison, the agricultural practice change and economics sections provide an update on material compiled as part of the 2013 Scientific Consensus Statement. This report has been confined to peer reviewed literature, which is generally published in books and journals or major reports. There is additional evidence in grey literature, such as project and program reports, that has not been included here. Each section of this chapter has been compiled by a writing team and then revised following a series of review processes

Physical activity and academic achievement across the curriculum (A + PAAC): rationale and design of a 3-year, cluster-randomized trial

Abstract Background Improving academic achievement and reducing the rates of obesity in elementary school students are both of considerable interest. Increased physical activity during academic instruction time during school offers a potential intervention to address both issues. A program titled “Physical Activity Across the Curriculum” (PAAC) was developed in which classroom teachers in 22 elementary schools were trained to deliver academic instruction using physical activity with a primary aim of preventing increased BMI. A secondary analysis of data assessed the impact of PAAC on academic achievement using the Weschler Individual Achievement Test-II and significant improvements were shown for reading, math and spelling in students who participated in PAAC. Based on the results from PAAC, an adequately powered trial will be conducted to assess differences in academic achievement between intervention and control schools called, “Academic Achievement and Physical Activity Across the Curriculum (A + PAAC).” Methods/design Seventeen elementary schools were cluster randomized to A + PAAC or control for a 3-year trial. Classroom teachers were trained to deliver academic instruction through moderate-to-vigorous physical activity with a target of 100+ minutes of A + PAAC activities per week. The primary outcome measure is academic achievement measured by the Weschler Individual Achievement Test-III, which was administered at baseline (Fall 2011) and will be repeated in the spring of each year by assessors blinded to condition. Potential mediators of any association between A + PAAC and academic achievement will be examined on the same schedule and include changes in cognitive function, cardiovascular fitness, daily physical activity, BMI, and attention-to-task. An extensive process analysis will be conducted to document the fidelity of the intervention. School and student recruitment/randomization, teacher training, and baseline testing for A + PAAC have been completed. Nine schools were randomized to the intervention and 8 to control. A random sample of students in each school, stratified by gender and grade (A + PAAC = 370, Control = 317), was selected for outcome assessments from those who provided parental consent/child assent. Baseline data by intervention group are presented. Discussion If successful, the A + PAAC approach could be easily and inexpensively scaled and disseminated across elementary schools to improve both educational quality and health. Funding source: R01- DK85317. Trial registration: US NIH Clinical Trials, http://NCT01699295.Peer Reviewe

A New Panel-Estimated GFR, Including beta(2)-Microglobulin and beta-Trace Protein and Not Including Race, Developed in a Diverse Population

RATIONALE AND OBJECTIVE: GFR estimation based on creatinine and cystatin C (eGFR(cr-cys)) is more accurate than eGFR based on either creatinine or cystatin C alone (eGFR(cr) or eGFR(cys)), but the inclusion of creatinine in eGFR(cr-cys) requires specification of a person’s race. Beta-2-microglobulin (B2M) and beta-trace protein (BTP) are alternative filtration markers that appear to be less influenced by race than creatinine. STUDY DESIGN: Study of diagnostic test accuracy. SETTING AND PARTICIPANTS: Development in pooled population of seven studies with 5017 participants with and without chronic kidney disease. External validation in a pooled population of seven other studies with 2245 participants. TESTS COMPARED: Panel eGFR using B2M and BTP in addition to cystatin C (three-marker panel) or creatinine and cystatin C (four-marker panel) with and without age and sex or race. OUTCOMES: GFR measured as the urinary clearance of iothalamate, plasma clearance of iohexol, or plasma clearance of Cr-EDTA RESULTS: Mean measured GFR was 58.1 and 83.2 ml/min/1.73m(2) and the proportion of blacks was 38.6% and 24.0%, in the development and validation populations, respectively. In development, addition of age and sex improved the performance of all equations compared to equations without age and sex, but addition of race did not further improve the performance. In validation, the four-marker panels were more accurate than the three-marker panels (p<0.001). The three-marker panel without race was more accurate than eGFR(cys) [1- P(30) of 15.6 vs 17.4% (p=0.014)], and the four-marker panel without race was as accurate as eGFR(cr-cys) [1- P(30) of 8.6 vs 9.4% (p=0.17)]. Results were generally consistent across subgroups. LIMITATIONS: No representation of participants with severe comorbid illness and from geographic areas outside of North America and Europe. CONCLUSIONS: The four-marker panel eGFR is as accurate as eGFR(cr-cys), without requiring specification of race. A more accurate race-free eGFR could be an important advance