639 research outputs found
Critical Exponents near a Random Fractal Boundary
The critical behaviour of correlation functions near a boundary is modified
from that in the bulk. When the boundary is smooth this is known to be
characterised by the surface scaling dimension \xt. We consider the case when
the boundary is a random fractal, specifically a self-avoiding walk or the
frontier of a Brownian walk, in two dimensions, and show that the boundary
scaling behaviour of the correlation function is characterised by a set of
multifractal boundary exponents, given exactly by conformal invariance
arguments to be \lambda_n = 1/48 (\sqrt{1+24n\xt}+11)(\sqrt{1+24n\xt}-1).
This result may be interpreted in terms of a scale-dependent distribution of
opening angles of the fractal boundary: on short distance scales these
are sharply peaked around . Similar arguments give the
multifractal exponents for the case of coupling to a quenched random bulk
geometry.Comment: 13 pages. Comments on relation to results in quenched random bulk
added, and on relation to other recent work. Typos correcte
Femto-Photography of Protons to Nuclei with Deeply Virtual Compton Scattering
Developments in deeply virtual Compton scattering allow the direct
measurements of scattering amplitudes for exchange of a highly virtual photon
with fine spatial resolution. Real-space images of the target can be obtained
from this information. Spatial resolution is determined by the momentum
transfer rather than the wavelength of the detected photon. Quantum photographs
of the proton, nuclei, and other elementary particles with resolution on the
scale of a fraction of a femtometer is feasible with existing experimental
technology.Comment: To be published in Physical Review D. Replaces previous version with
minor changes in presentatio
Renormalization Group Study of the A+B->0 Diffusion-Limited Reaction
The diffusion-limited reaction, with equal initial densities
, is studied by means of a field-theoretic renormalization
group formulation of the problem. For dimension an effective theory is
derived, from which the density and correlation functions can be calculated. We
find the density decays in time as a,b \sim C\sqrt{\D}(Dt)^{-d/4} for , with \D = n_0-C^\prime n_0^{d/2} + \dots, where is a universal
constant, and is non-universal. The calculation is extended to the
case of unequal diffusion constants , resulting in a new
amplitude but the same exponent. For a controlled calculation is not
possible, but a heuristic argument is presented that the results above give at
least the leading term in an expansion. Finally, we address
reaction zones formed in the steady-state by opposing currents of and
particles, and derive scaling properties.Comment: 17 pages, REVTeX, 13 compressed figures, included with epsf. Eq.
(6.12) corrected, and a moderate rewriting of the introduction. Accepted for
publication in J. Stat. Phy
Application of Pauli-Villars regularization and discretized light-cone quantization to a single-fermion truncation of Yukawa theory
We apply Pauli-Villars regularization and discretized light-cone quantization
to the nonperturbative solution of (3+1)-dimensional Yukawa theory in a
single-fermion truncation. Three heavy scalars, including two with negative
norm, are used to regulate the theory. The matrix eigenvalue problem is solved
for the lowest-mass state with use of a new, indefinite-metric Lanczos
algorithm. Various observables are extracted from the wave functions, including
average multiplicities and average momenta of constituents, structure
functions, and a form factor slope.Comment: 21 pages, 7 figures, RevTeX; published version: more extensive data
in the tables of v
Entanglement and correlation functions following a local quench: a conformal field theory approach
We show that the dynamics resulting from preparing a one-dimensional quantum
system in the ground state of two decoupled parts, then joined together and
left to evolve unitarily with a translational invariant Hamiltonian (a local
quench), can be described by means of quantum field theory. In the case when
the corresponding theory is conformal, we study the evolution of the
entanglement entropy for different bi-partitions of the line. We also consider
the behavior of one- and two-point correlation functions. All our findings may
be explained in terms of a picture, that we believe to be valid more generally,
whereby quasiparticles emitted from the joining point at the initial time
propagate semiclassically through the system.Comment: 19 pages, 4 figures, v2 typos corrected and refs adde
Search algorithms as a framework for the optimization of drug combinations
Combination therapies are often needed for effective clinical outcomes in the
management of complex diseases, but presently they are generally based on
empirical clinical experience. Here we suggest a novel application of search
algorithms, originally developed for digital communication, modified to
optimize combinations of therapeutic interventions. In biological experiments
measuring the restoration of the decline with age in heart function and
exercise capacity in Drosophila melanogaster, we found that search algorithms
correctly identified optimal combinations of four drugs with only one third of
the tests performed in a fully factorial search. In experiments identifying
combinations of three doses of up to six drugs for selective killing of human
cancer cells, search algorithms resulted in a highly significant enrichment of
selective combinations compared with random searches. In simulations using a
network model of cell death, we found that the search algorithms identified the
optimal combinations of 6-9 interventions in 80-90% of tests, compared with
15-30% for an equivalent random search. These findings suggest that modified
search algorithms from information theory have the potential to enhance the
discovery of novel therapeutic drug combinations. This report also helps to
frame a biomedical problem that will benefit from an interdisciplinary effort
and suggests a general strategy for its solution.Comment: 36 pages, 10 figures, revised versio
Consequence of the tumor-associated conversion to cyclin D1b.
Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D1 to cyclin D1b. Extensive analyses uncovered overlapping but non-redundant functions of cyclin D1b compared to cyclin D1 on developmental phenotypes, and illustrated the importance of the transcriptional regulatory functions of cyclin D1b in vivo. Data obtained identify cyclin D1b as an oncogene, wherein cyclin D1b expression under the endogenous promoter induced cellular transformation and further cooperated with known oncogenes to promote tumor growth in vivo. Further molecular interrogation uncovered unexpected links between cyclin D1b and the DNA damage/PARP1 regulatory networks, which could be exploited to suppress cyclin D1b-driven tumors. Collectively, these data are the first to define the consequence of cyclin D1b expression on normal cellular function, present evidence for cyclin D1b as an oncogene, and provide pre-clinical evidence of effective methods to thwart growth of cells dependent upon this oncogenic variant
Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
Dysregulation of the PI3K-AKT-mTOR signaling network is a prominent feature of breast cancers. However, clinical responses to drugs targeting this pathway have been modest, possibly because of dynamic changes in cellular signaling that drive resistance and limit drug efficacy. Using a quantitative chemoproteomics approach, we mapped kinome dynamics in response to inhibitors of this pathway and identified signaling changes that correlate with drug sensitivity. Maintenance of AURKA after drug treatment was associated with resistance in breast cancer models. Incomplete inhibition of AURKA was a common source of therapy failure, and combinations of PI3K, AKT or mTOR inhibitors with the AURKA inhibitor MLN8237 were highly synergistic and durably suppressed mTOR signaling, resulting in apoptosis and tumor regression in vivo. This signaling map identifies survival factors whose presence limits the efficacy of targeted therapies and reveals new drug combinations that may unlock the full potential of PI3K-AKT-mTOR pathway inhibitors in breast cancer
The Star-Forming Galaxy Contribution to the Cosmic MeV and GeV Gamma-Ray Background
While star-forming galaxies could be major contributors to the cosmic GeV
-ray background, they are expected to be MeV-dim because of the "pion
bump" falling off below ~100 MeV. However, there are very few observations of
galaxies in the MeV range, and other emission processes could be present. We
investigate the MeV background from star-forming galaxies by running one-zone
models of cosmic ray populations, including Inverse Compton and bremsstrahlung,
as well as nuclear lines (including Al), emission from core-collapse
supernovae, and positron annihilation emission, in addition to the pionic
emission. We use the Milky Way and M82 as templates of normal and starburst
galaxies, and compare our models to radio and GeV--TeV -ray data. We
find that (1) higher gas densities in high-z normal galaxies lead to a strong
pion bump, (2) starbursts may have significant MeV emission if their magnetic
field strengths are low, and (3) cascades can contribute to the MeV emission of
starbursts if they emit mainly hadronic -rays. Our fiducial model
predicts that most of the unresolved GeV background is from star-forming
galaxies, but this prediction is uncertain by an order of magnitude. About ~2%
of the claimed 1 MeV background is diffuse emission from star-forming galaxies;
we place a firm upper limit of <~10% based on the spectral shape of the
background. The star-formation contribution is constrained to be small, because
its spectrum is peaked, while the observed background is steeply falling with
energy through the MeV-GeV range.Comment: Published in ApJ, 27 pages, emulateapj format. Readers may be
interested in the concurrent paper by Chakraborty and Fields
(arXiv:1206.0770), a calculation of the Inverse Compton background from
star-forming galaxie
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